Enantioselective Synthesis of α-Stereogenic γ-Keto Esters via Formal Umpolung

Name: Work Video:
Duration: 3 min 30 s
Description: A feasible method has been developed for the enantioselective synthesis of α-stereogenic γ-keto esters. By employing nitro(phenylsulfonyl)methane as an acyl anion equivalent, the integrated Michael addition reaction-oxidative methanolysis protocol allows the preparation of various γ-keto esters with high optical purities.
G. K. Surya Prakash; Fang Wang; Zhe Zhang; Chuanfa Ni; Ralf Haiges; George A. Olah
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