Publication Information

{'id': 'https://openalex.org/W1977254979', 'doi': 'https://doi.org/10.2468/jbes.55.380', 'title': 'The Role of Gastroesophageal Reflux in Chronic Respiratory Diseases', 'display_name': 'The Role of Gastroesophageal Reflux in Chronic Respiratory Diseases', 'publication_year': 2004, 'publication_date': '2004-01-01', 'ids': {'openalex': 'https://openalex.org/W1977254979', 'doi': 'https://doi.org/10.2468/jbes.55.380', 'mag': '1977254979'}, 'language': 'ja', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2468/jbes.55.380', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S39610269', 'display_name': 'Nihon Kikan Shokudoka Gakkai Kaiho', 'issn_l': '0029-0645', 'issn': ['0029-0645', '1880-6848'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4323283805', 'host_organization_name': 'Japan Broncho-esophagological Society', 'host_organization_lineage': ['https://openalex.org/P4323283805'], 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'https://openalex.org/W1815081820', 'https://openalex.org/W1963799705', 'https://openalex.org/W1971442238', 'https://openalex.org/W1983948911', 'https://openalex.org/W1985866011', 'https://openalex.org/W2007067172', 'https://openalex.org/W2031501096', 'https://openalex.org/W2055931257', 'https://openalex.org/W2062071217', 'https://openalex.org/W2088358534', 'https://openalex.org/W2144107597', 'https://openalex.org/W2416103943'], 'related_works': ['https://openalex.org/W4256223137', 'https://openalex.org/W3149092123', 'https://openalex.org/W3148071176', 'https://openalex.org/W3139631746', 'https://openalex.org/W3034559735', 'https://openalex.org/W2992861500', 'https://openalex.org/W2782603977', 'https://openalex.org/W2562956091', 'https://openalex.org/W2382072563', 'https://openalex.org/W2100506238'], 'abstract_inverted_index': {'呼吸器疾患と胃食道逆流(GERD)との関連性が注目されている。GERDによる咳嗽や喘鳴の発症機序は，おもに迷走神経反射説とマイクロアスピレーション説の2つがあり，まだ定まってはいない。慢性咳嗽の原因として，欧米ではGERDと後鼻漏と喘息で原因の約86%を占める。また，潜在性GERD患者の唯一の症状が，咳嗽であるという報告もある。喘息患者のGERD合併率は，われわれの内視鏡による検討では，50歳以上の喘息患者で，83.6%にロサンゼルス分類でグレードM以上の所見がみられた。治療的には，GERDをもつH2ブロッカーの無効な慢性咳嗽患者に，プロトンポンプインヒビター(PPI)を投与により，全例症状の改善がみられたとの報告もある。われわれは，喘息患者にPPIを投与し，ピークフロー値の改善を検討したところ，3例中2例に4～8週後に改善が認められた。GERDが慢性呼吸器疾患の難治化に関係しているか否かに関しては，はっきりとした結論は出ていない。咳嗽がなかなかおさまらない場合，GERDを念頭に入れ検査・治療を検討することは必要であろう。今後，各種慢性呼吸器疾患とGERDとの関係をさらに明らかとさせる必要がある。': [0]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1977254979', 'counts_by_year': [], 'updated_date': '2024-12-11T23:14:06.705678', 'created_date': '2016-06-24'}