Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1976976849', 'doi': 'https://doi.org/10.1046/j.1529-8027.2002.02011_16.x', 'title': 'Advanced glycation end products, their receptors and diabetic angiopathy', 'display_name': 'Advanced glycation end products, their receptors and diabetic angiopathy', 'publication_year': 2002, 'publication_date': '2002-06-01', 'ids': {'openalex': 'https://openalex.org/W1976976849', 'doi': 'https://doi.org/10.1046/j.1529-8027.2002.02011_16.x', 'mag': '1976976849'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1046/j.1529-8027.2002.02011_16.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91695523', 'display_name': 'Journal of the Peripheral Nervous System', 'issn_l': '1085-9489', 'issn': ['1085-9489', '1529-8027'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109943540', 'display_name': 'JL Wautier', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'JL Wautier', 'raw_affiliation_strings': ['Diabetes & Metabolism 27: 535–542, 2001. Reprinted with permission from Masson Editeur.'], 'affiliations': [{'raw_affiliation_string': 'Diabetes & Metabolism 27: 535–542, 2001. Reprinted with permission from Masson Editeur.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108394318', 'display_name': 'P.-J. Guillausseau', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'PJ Guillausseau', 'raw_affiliation_strings': ['Diabetes & Metabolism 27: 535–542, 2001. Reprinted with permission from Masson Editeur.'], 'affiliations': [{'raw_affiliation_string': 'Diabetes & Metabolism 27: 535–542, 2001. Reprinted with permission from Masson Editeur.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4120, 'currency': 'USD', 'value_usd': 4120, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.291, 'has_fulltext': False, 'cited_by_count': 166, 'citation_normalized_percentile': {'value': 0.999259, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '7', 'issue': '2', 'first_page': '138', 'last_page': '138'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13796', 'display_name': 'Neurological Disorders and Treatments', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11207', 'display_name': 'Alcohol Consumption and Health Effects', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rage', 'display_name': 'RAGE', 'score': 0.85895425}, {'id': 'https://openalex.org/keywords/diabetic-angiopathy', 'display_name': 'Diabetic angiopathy', 'score': 0.54132694}, {'id': 'https://openalex.org/keywords/angiopathy', 'display_name': 'Angiopathy', 'score': 0.49323195}, {'id': 'https://openalex.org/keywords/advanced-glycation-end-product', 'display_name': 'Advanced glycation end-product', 'score': 0.49206442}], 'concepts': [{'id': 'https://openalex.org/C147990577', 'wikidata': 'https://www.wikidata.org/wiki/Q25790', 'display_name': 'Glycation', 'level': 3, 'score': 0.9493775}, {'id': 'https://openalex.org/C2778857457', 'wikidata': 'https://www.wikidata.org/wiki/Q153641', 'display_name': 'Rage (emotion)', 'level': 2, 'score': 0.85895425}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.6701959}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6238176}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.553288}, {'id': 'https://openalex.org/C2777660278', 'wikidata': 'https://www.wikidata.org/wiki/Q489997', 'display_name': 'Diabetic angiopathy', 'level': 3, 'score': 0.54132694}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.5261421}, {'id': 'https://openalex.org/C2779703115', 'wikidata': 'https://www.wikidata.org/wiki/Q539702', 'display_name': 'Angiopathy', 'level': 3, 'score': 0.49323195}, {'id': 'https://openalex.org/C2776997535', 'wikidata': 'https://www.wikidata.org/wiki/Q2556837', 'display_name': 'Advanced glycation end-product', 'level': 4, 'score': 0.49206442}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.45605582}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.42949575}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.41535917}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.32844275}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22850952}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.12307188}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1046/j.1529-8027.2002.02011_16.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91695523', 'display_name': 'Journal of the Peripheral Nervous System', 'issn_l': '1085-9489', 'issn': ['1085-9489', '1529-8027'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.8}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 73, 'referenced_works': ['https://openalex.org/W1487900963', 'https://openalex.org/W1557253076', 'https://openalex.org/W1917988391', 'https://openalex.org/W1964586920', 'https://openalex.org/W1965787101', 'https://openalex.org/W1967871511', 'https://openalex.org/W1971209988', 'https://openalex.org/W1976068063', 'https://openalex.org/W1978146746', 'https://openalex.org/W1978611180', 'https://openalex.org/W1978996756', 'https://openalex.org/W1987298734', 'https://openalex.org/W1991635343', 'https://openalex.org/W1998614770', 'https://openalex.org/W1999470250', 'https://openalex.org/W2005640704', 'https://openalex.org/W2005653939', 'https://openalex.org/W2007644407', 'https://openalex.org/W2008181875', 'https://openalex.org/W2011467776', 'https://openalex.org/W201413446', 'https://openalex.org/W2019522259', 'https://openalex.org/W2019970574', 'https://openalex.org/W2021976201', 'https://openalex.org/W2023739408', 'https://openalex.org/W2025016154', 'https://openalex.org/W2026703782', 'https://openalex.org/W2026798333', 'https://openalex.org/W2032055976', 'https://openalex.org/W2035759625', 'https://openalex.org/W2041416461', 'https://openalex.org/W2051620428', 'https://openalex.org/W2052059287', 'https://openalex.org/W2056196448', 'https://openalex.org/W2059736408', 'https://openalex.org/W2060895623', 'https://openalex.org/W2061689566', 'https://openalex.org/W2062219794', 'https://openalex.org/W2067246958', 'https://openalex.org/W2068793587', 'https://openalex.org/W2068933177', 'https://openalex.org/W2071675524', 'https://openalex.org/W2073713671', 'https://openalex.org/W2073714833', 'https://openalex.org/W2073931886', 'https://openalex.org/W2078540617', 'https://openalex.org/W2087511197', 'https://openalex.org/W2089878313', 'https://openalex.org/W2090205376', 'https://openalex.org/W2092661802', 'https://openalex.org/W2099486635', 'https://openalex.org/W2106697731', 'https://openalex.org/W2108448809', 'https://openalex.org/W2109180048', 'https://openalex.org/W2111867309', 'https://openalex.org/W2115293825', 'https://openalex.org/W2121527030', 'https://openalex.org/W2122361269', 'https://openalex.org/W2130771001', 'https://openalex.org/W2136294641', 'https://openalex.org/W2138928713', 'https://openalex.org/W2140504464', 'https://openalex.org/W2143025008', 'https://openalex.org/W2150912407', 'https://openalex.org/W2169235788', 'https://openalex.org/W2173998026', 'https://openalex.org/W2285241979', 'https://openalex.org/W2330884206', 'https://openalex.org/W2335364913', 'https://openalex.org/W2337292567', 'https://openalex.org/W2471014497', 'https://openalex.org/W2499973181', 'https://openalex.org/W53499084'], 'related_works': ['https://openalex.org/W2903451130', 'https://openalex.org/W2410332845', 'https://openalex.org/W2405120577', 'https://openalex.org/W2139372505', 'https://openalex.org/W2091930066', 'https://openalex.org/W2069514570', 'https://openalex.org/W2053863266', 'https://openalex.org/W2025979305', 'https://openalex.org/W1995801352', 'https://openalex.org/W1976976849'], 'abstract_inverted_index': {'The': [0, 142, 174, 196], 'role': [1, 59, 143, 218], 'of': [2, 8, 46, 51, 60, 63, 74, 88, 94, 100, 106, 119, 144, 192, 201, 219, 226, 229], 'chronic': [3, 227], 'hyperglycemia': [4, 47], 'in': [5, 13, 68, 104, 146, 151, 155, 160, 162, 168, 185, 198, 223], 'the': [6, 23, 34, 44, 49, 58, 69, 75, 82, 86, 117, 152, 224], 'development': [7, 225], 'diabetic': [9, 199], 'microvascular': [10, 175], 'complications': [11, 228], 'and': [12, 33, 56, 62, 71, 109, 127, 135, 139, 150, 178, 210, 221], 'neuropathy': [14], 'has': [15], 'been': [16], 'clearly': [17], 'established': [18], 'by': [19, 85, 182, 189], 'intervention': [20], 'studies.': [21], 'However,': [22], 'biochemical': [24], 'or': [25], 'cellular': [26], 'links': [27], 'between': [28], 'elevated': [29], 'blood': [30], 'glucose': [31], 'levels,': [32], 'vascular': [35, 76, 156, 211], 'lesions': [36, 180], 'remain': [37], 'incompletely': [38], 'understood.': [39], 'This': [40], 'review': [41], 'focuses': [42], 'on': [43, 48, 57, 90], 'consequences': [45], 'formation': [50], 'advanced': [52], 'glycation': [53], 'end‐products': [54], '(AGEs),': [55], 'AGEs': [61, 78, 120, 145, 193, 220], 'their': [64], 'specific': [65, 110], 'receptors': [66], '(RAGE)': [67], 'functional': [70, 153], 'anatomical': [72], 'alterations': [73, 154], 'wall.': [77], 'are': [79, 187], 'formed': [80], 'during': [81], 'Mailiard': [83], 'reaction': [84], 'binding': [87, 118], 'aldoses': [89], 'free': [91], 'NH2': [92], 'groups': [93], 'proteins,': [95], 'which,': [96], 'after': [97], 'a': [98, 166, 216], 'cascade': [99], 'molecular': [101], 'rearrangements,': [102], 'result': [103], 'molecules': [105, 138], 'brown': [107], 'color': [108], 'fluorescence.': [111], 'Experimental': [112], 'studies': [113], 'have': [114], 'indicated': [115], 'that': [116], 'to': [121, 165], 'RAGE': [122, 222], 'activates': [123], 'cells,': [124], 'particularly': [125], 'monocytes': [126], 'endothelial': [128, 131], 'calls.': [129], 'Activated': [130], 'cells': [132], 'produce': [133], 'cytokines,': [134], 'express': [136], 'adhesion': [137], 'tissue': [140], 'factor.': [141], 'increased': [147], 'oxidative': [148], 'stress,': [149], 'tone': [157], 'control': [158], 'observed': [159], 'diabetes,': [161], 'part': [163], 'related': [164], 'reduction': [167], 'nitric': [169], 'oxide,': [170], 'is': [171], 'also': [172], 'discussed.': [173], 'retinal,': [176], 'glomerular': [177], 'nerve': [179], 'induced': [181], 'experimental': [183], 'diabetes': [184], 'animals': [186, 200], 'prevented': [188], 'an': [190], 'inhibitor': [191], 'formation,': [194], 'aminoguanidine.': [195], 'administration': [197], 'recombinant': [202], 'RAGE,': [203], 'which': [204], 'hinders': [205], 'AGEs‐RAGE': [206], 'interaction,': [207], 'prevents': [208], 'hyperpermeability': [209], 'lesions.': [212], 'These': [213], 'data': [214], 'suggest': [215], 'central': [217], 'diabetes.': [230]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1976976849', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-14T07:22:35.955350', 'created_date': '2016-06-24'}