Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1976896312', 'doi': 'https://doi.org/10.3109/13880209.2015.1005753', 'title': 'Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction', 'display_name': 'Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction', 'publication_year': 2015, 'publication_date': '2015-04-13', 'ids': {'openalex': 'https://openalex.org/W1976896312', 'doi': 'https://doi.org/10.3109/13880209.2015.1005753', 'mag': '1976896312', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25864557'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3109/13880209.2015.1005753', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.3109/13880209.2015.1005753?needAccess=true', 'source': {'id': 'https://openalex.org/S130009153', 'display_name': 'Pharmaceutical Biology', 'issn_l': '1388-0209', 'issn': ['1388-0209', '1744-5116'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.tandfonline.com/doi/pdf/10.3109/13880209.2015.1005753?needAccess=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101575251', 'display_name': 'Huilin Hu', 'orcid': 'https://orcid.org/0000-0003-1619-4682'}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huilin Hu', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112670383', 'display_name': 'Changlin Zhai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Changlin Zhai', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102877404', 'display_name': 'Gang Qian', 'orcid': 'https://orcid.org/0000-0001-7324-1102'}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Gang Qian', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014153296', 'display_name': 'Aiming Gu', 'orcid': 'https://orcid.org/0000-0002-8574-5524'}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Aiming Gu', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100358346', 'display_name': 'Jialiang Liu', 'orcid': 'https://orcid.org/0000-0002-4679-370X'}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jialiang Liu', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057644948', 'display_name': 'Ying Fang', 'orcid': 'https://orcid.org/0000-0003-2313-9139'}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fang Ying', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088700209', 'display_name': 'Wenbo Xu', 'orcid': 'https://orcid.org/0000-0002-5558-3018'}, 'institutions': [{'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}, {'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenbo Xu', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210092870', 'https://openalex.org/I4210139237']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034336160', 'display_name': 'Dandan Jin', 'orcid': 'https://orcid.org/0000-0002-7003-5255'}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dandan Jin', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100701116', 'display_name': 'Huawei Wang', 'orcid': 'https://orcid.org/0000-0001-7534-2863'}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huawei Wang', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102190413', 'display_name': 'Haizhen Hu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Haizhen Hu', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103040888', 'display_name': 'Yingqing Zhang', 'orcid': 'https://orcid.org/0000-0002-0395-8033'}, 'institutions': [{'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}, {'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yingqing Zhang', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210092870', 'https://openalex.org/I4210139237']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061757825', 'display_name': 'Guping Tang', 'orcid': 'https://orcid.org/0000-0003-3256-740X'}, 'institutions': [{'id': 'https://openalex.org/I4210139237', 'display_name': 'First Hospital of Jiaxing', 'ror': 'https://ror.org/03q5hbn76', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139237']}, {'id': 'https://openalex.org/I4210092870', 'display_name': 'Jiaxing University', 'ror': 'https://ror.org/00j2a7k55', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210092870']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Guanmin Tang', 'raw_affiliation_strings': ['Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, First Affiliated Hospital of Jiaxing University , Jiaxing, Zhejiang , PR China.', 'institution_ids': ['https://openalex.org/I4210139237', 'https://openalex.org/I4210092870']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2085, 'currency': 'GBP', 'value_usd': 2557, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 18.92, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 71, 'citation_normalized_percentile': {'value': 0.999902, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '53', 'issue': '12', 'first_page': '1752', 'last_page': '1758'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11709', 'display_name': 'Traditional Chinese Medicine Analysis', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11709', 'display_name': 'Traditional Chinese Medicine Analysis', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hmgb1', 'display_name': 'HMGB1', 'score': 0.71826005}, {'id': 'https://openalex.org/keywords/creatine-kinase', 'display_name': 'Creatine kinase', 'score': 0.60881895}, {'id': 'https://openalex.org/keywords/intraperitoneal-injection', 'display_name': 'Intraperitoneal injection', 'score': 0.41301882}], 'concepts': [{'id': 'https://openalex.org/C2780545709', 'wikidata': 'https://www.wikidata.org/wiki/Q21130552', 'display_name': 'HMGB1', 'level': 3, 'score': 0.71826005}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.62638485}, {'id': 'https://openalex.org/C36880943', 'wikidata': 'https://www.wikidata.org/wiki/Q409458', 'display_name': 'Creatine kinase', 'level': 2, 'score': 0.60881895}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.5932282}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5812432}, {'id': 'https://openalex.org/C2780114680', 'wikidata': 'https://www.wikidata.org/wiki/Q1413991', 'display_name': 'Reperfusion injury', 'level': 3, 'score': 0.57351863}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.44471127}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.44319206}, {'id': 'https://openalex.org/C3017461755', 'wikidata': 'https://www.wikidata.org/wiki/Q844935', 'display_name': 'Myocardial ischemia', 'level': 3, 'score': 0.42733184}, {'id': 'https://openalex.org/C2780159080', 'wikidata': 'https://www.wikidata.org/wiki/Q1400536', 'display_name': 'Intraperitoneal injection', 'level': 2, 'score': 0.41301882}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33168924}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29596406}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22933525}], 'mesh': [{'descriptor_ui': 'D045784', 'descriptor_name': 'Abietanes', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002316', 'descriptor_name': 'Cardiotonic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D045784', 'descriptor_name': 'Abietanes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045784', 'descriptor_name': 'Abietanes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002316', 'descriptor_name': 'Cardiotonic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002316', 'descriptor_name': 'Cardiotonic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3109/13880209.2015.1005753', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.3109/13880209.2015.1005753?needAccess=true', 'source': {'id': 'https://openalex.org/S130009153', 'display_name': 'Pharmaceutical Biology', 'issn_l': '1388-0209', 'issn': ['1388-0209', '1744-5116'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25864557', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3109/13880209.2015.1005753', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.3109/13880209.2015.1005753?needAccess=true', 'source': {'id': 'https://openalex.org/S130009153', 'display_name': 'Pharmaceutical Biology', 'issn_l': '1388-0209', 'issn': ['1388-0209', '1744-5116'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.71, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1490094768', 'https://openalex.org/W1577460994', 'https://openalex.org/W1885981884', 'https://openalex.org/W1967095679', 'https://openalex.org/W1968408901', 'https://openalex.org/W1984991357', 'https://openalex.org/W1995901449', 'https://openalex.org/W1997339907', 'https://openalex.org/W2000048140', 'https://openalex.org/W2004831480', 'https://openalex.org/W2010217891', 'https://openalex.org/W2017234408', 'https://openalex.org/W2017612306', 'https://openalex.org/W2027589607', 'https://openalex.org/W2031941651', 'https://openalex.org/W2040200395', 'https://openalex.org/W2045116801', 'https://openalex.org/W2050744280', 'https://openalex.org/W2052596629', 'https://openalex.org/W2052860799', 'https://openalex.org/W2055545648', 'https://openalex.org/W2055988798', 'https://openalex.org/W2057647241', 'https://openalex.org/W2057939308', 'https://openalex.org/W2058581351', 'https://openalex.org/W2059118326', 'https://openalex.org/W2072907883', 'https://openalex.org/W2074498636', 'https://openalex.org/W2092114527', 'https://openalex.org/W2092787487', 'https://openalex.org/W2094964008', 'https://openalex.org/W2106039427', 'https://openalex.org/W2111296715', 'https://openalex.org/W2114276035', 'https://openalex.org/W2117796628', 'https://openalex.org/W2117981319', 'https://openalex.org/W2118098537', 'https://openalex.org/W2121430062', 'https://openalex.org/W2141186418', 'https://openalex.org/W2147993424', 'https://openalex.org/W2157042020', 'https://openalex.org/W2171028311', 'https://openalex.org/W2239430203', 'https://openalex.org/W2260518403', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W615305073', 'https://openalex.org/W2965511311', 'https://openalex.org/W2416797295', 'https://openalex.org/W2386936892', 'https://openalex.org/W2352259223', 'https://openalex.org/W2157119957', 'https://openalex.org/W2116849720', 'https://openalex.org/W2064185357', 'https://openalex.org/W2022096294', 'https://openalex.org/W2016169910'], 'abstract_inverted_index': {'Although': [0], 'there': [1], 'were': [2, 46, 110, 130, 200], 'reports': [3], 'on': [4, 12, 35, 89, 212], 'the': [5, 16, 30, 90, 115, 159, 189, 223, 229, 233], 'protective': [6, 31, 208], 'functions': [7], 'of': [8, 33, 67, 87, 121, 210, 225, 235], 'tanshinone': [9], 'IIA': [10], '(TSA)': [11], 'rat': [13], 'myocardial': [14, 36, 213], 'ischemia,': [15], 'exerting': [17], 'mechanism': [18], 'has': [19], 'not': [20], 'been': [21], 'completely': [22], 'clarified.An': [23], 'attempt': [24], 'was': [25, 70], 'made': [26], 'to': [27, 81, 231], 'further': [28], 'verify': [29], 'effect': [32], 'TSA': [34, 48, 88, 211], 'ischemia': [37, 214], 'reperfusion': [38, 84, 215, 230], 'injury': [39, 216], 'and': [40, 51, 75, 106, 108, 127, 135, 143, 146, 163, 167, 171, 178, 197, 205, 237], 'elucidate': [41], 'its': [42], 'underlying': [43], 'mechanism.The': [44], 'rats': [45], 'given': [47], '(10,': [49], '20,': [50], '40': [52], 'mg/kg': [53], 'bw': [54], 'per': [55], 'day)': [56], 'in': [57, 114, 124, 158, 175, 188, 194], 'intraperitoneal': [58], 'injection': [59], 'for': [60, 72, 78], '15': [61], 'd.': [62], 'Rami': [63], 'anterior': [64], 'descending': [65], 'branch': [66], 'coronary': [68], 'artery': [69], 'ligated': [71], '30': [73], 'min': [74, 80], 'then': [76], 're-perfused': [77], '120': [79], 'establish': [82], 'a': [83], 'model.': [85], 'Effects': [86], 'infarct': [91, 118], 'area,': [92], 'creatine': [93], 'kinase': [94], '(CK),': [95], 'aspartate': [96], 'aminotransferase': [97], '(AST),': [98], 'high': [99], 'mobility': [100], 'group': [101], 'box': [102], 'B1': [103], 'protein': [104], '(HMGB1),': [105], 'inflammation': [107], 'oxidation': [109], 'investigated.Compared': [111], 'with': [112, 156, 186], 'those': [113, 157, 187], 'IR': [116, 160, 190], 'group,': [117, 161, 191], 'size': [119], 'percentages': [120], "rats'": [122], 'myocardium': [123], 'L-TSA,': [125, 176, 195], 'M-TSA,': [126, 177, 196], 'H-TSA': [128, 179, 198], 'groups': [129, 180, 199], 'reduced': [131], 'by': [132, 140, 202, 221, 228], '1.21,': [133], '4.26,': [134], '12.50%,': [136], 'respectively,': [137, 145], 'CK': [138], 'activities': [139, 148, 165], '7.4,': [141], '11.2,': [142], '12.5%,': [144], 'AST': [147], 'also': [149], 'declined': [150], '(p': [151, 181], '<': [152, 182], '0.05).': [153, 183], 'Furthermore,': [154], 'compared': [155, 185], 'SOD': [162], 'GSH-Px': [164], 'increased,': [166], 'MDA,': [168], 'TNF-α,': [169], 'IL-6,': [170], 'iNOS': [172], 'levels': [173], 'decreased': [174], 'Meanwhile,': [184], 'HMGB1': [192, 236], 'expressions': [193], 'lowered': [201], '21.9,': [203], '32.4,': [204], '35.6%,': [206], 'respectively.The': [207], 'function': [209], 'may': [217], 'be': [218], 'possibly': [219], 'exerted': [220], 'inhibiting': [222], 'increase': [224], 'ROS': [226], 'caused': [227], 'attenuate': [232], 'expression': [234], 'inhibit': [238], 'inflammation.': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1976896312', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-07T15:45:31.709074', 'created_date': '2016-06-24'}