Publication Information

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[0, 211, 1252], 'of': [1, 43, 47, 52, 108, 194, 206, 212, 254, 258, 263, 319, 405, 417, 451, 525, 571, 575, 589, 664, 683, 763, 798, 824, 858, 898, 902, 986, 996, 1038, 1103, 1188, 1206, 1253, 1271, 1277, 1280, 1297, 1303, 1320, 1324, 1339, 1442, 1538, 1580, 1582, 1595, 1711, 1781, 1794, 1798, 1814, 1850, 1857, 1861, 1886, 1899, 1911, 1922, 1937, 1943, 2036, 2044, 2078, 2167, 2245, 2298, 2319, 2361, 2395, 2480, 2523, 2588, 2597, 2633, 2664, 2694, 2704, 2710, 2717, 2743, 2782, 2800, 2831, 2841, 2915, 2930, 2934, 2965, 2982, 3039, 3045, 3053, 3114, 3136, 3190, 3240, 3257, 3296, 3318, 3477, 3488, 3510, 3526, 3538, 3540, 3548, 3561, 3576, 3695, 3869, 3897, 3912, 3923, 3937, 3944, 3950, 3961, 3976, 3981, 4013, 4036, 4089, 4100, 4111, 4145, 4190, 4230, 4240, 4251, 4257, 4262, 4314, 4355, 4425, 4428, 4448, 4454, 4479, 4533, 4561, 4578, 4585, 4591, 4598, 4639, 4834, 4848, 4866, 4914, 4926, 4938, 4962, 4999, 5054, 5092], 'serum': [2, 213, 455, 458, 728, 1378, 1816], 'response': [3, 214, 432, 456, 459, 729, 1817, 2197, 2371, 3399, 3435, 3444], 'factor': [4, 215, 460, 730, 1827], '(SRF)-mediated': [5, 216], 'gene': [6, 217, 1285, 1521, 1704, 1719, 1783, 1786, 1869, 1880, 2138, 2147, 2179, 2223, 2560, 2571, 2651, 2789, 2863, 3095, 4137], 'transcription': [7, 218, 1286, 1787, 1804, 1870, 2139, 2180, 2790, 3096, 3348, 3528, 4138, 4624], 'by': [8, 219, 722, 1053, 1257, 1322, 1452, 1462, 1511, 1559, 1734, 1746, 1759, 1773, 1790, 1802, 1873, 1958, 2038, 2337, 2342, 2401, 2528, 2577, 2856, 3273, 3300, 3465, 3492, 3650, 3915, 3928, 4009, 4103, 4193, 4259, 4782, 4792, 4840, 5006, 5094], 'G': [9, 13, 53, 204, 220, 224, 264, 415, 435, 452, 486, 526, 576, 665, 691, 903, 987, 1050, 1273, 1304, 1597, 1774, 1863, 1944, 1960, 2045, 2057, 2478, 2935, 3014, 3043, 3490, 3865, 3946, 4014, 4115, 4241, 4252, 4429, 4813, 4900, 4917], 'protein': [10, 221, 453, 527, 692, 988, 1092, 1183, 1274, 1598, 1864, 1961, 1969, 3688, 4253, 4814], 'subunits': [11, 46, 222, 257, 552, 555, 563, 1059, 1275, 1296, 1599, 1865, 1936, 1963, 3192, 3233, 3476, 3579, 3697, 4254, 4590, 4816, 4920], 'and': [12, 22, 34, 61, 79, 100, 123, 136, 150, 166, 174, 180, 182, 223, 233, 245, 272, 290, 311, 334, 347, 361, 377, 385, 391, 393, 444, 466, 533, 553, 581, 591, 676, 907, 1044, 1060, 1095, 1198, 1276, 1300, 1363, 1396, 1523, 1542, 1554, 1591, 1600, 1730, 1882, 1940, 2041, 2071, 2131, 2163, 2188, 2200, 2238, 2328, 2347, 2354, 2357, 2388, 2406, 2464, 2545, 2564, 2583, 2592, 2604, 2617, 2620, 2625, 2648, 2653, 2679, 2714, 2727, 2750, 2762, 2784, 2816, 2860, 2877, 2893, 2918, 2939, 2985, 3065, 3075, 3079, 3081, 3086, 3121, 3142, 3148, 3163, 3176, 3207, 3211, 3249, 3285, 3304, 3328, 3345, 3417, 3451, 3481, 3484, 3506, 3515, 3565, 3654, 3673, 3676, 3809, 3874, 3887, 3987, 4002, 4025, 4033, 4091, 4207, 4268, 4309, 4441, 4474, 4522, 4529, 4594, 4662, 4672, 4674, 4699, 4709, 4797, 4836, 4857, 4868, 4899, 4932, 4977, 4986, 4990, 5025, 5027, 5039, 5096, 5116, 5132], 'protein-coupled': [14, 225, 436], 'receptors': [15, 92, 152, 163, 171, 177, 199, 226, 303, 363, 374, 382, 388, 410, 437, 2052, 2068, 2160, 2235, 2363, 2461, 2622, 2659, 2682, 2834, 3040, 3054, 3063, 3072, 3083, 3175, 4473, 4519, 4538, 4563, 4676, 4687, 4701, 4784, 4799], 'was': [16, 28, 118, 227, 239, 329, 720, 765, 828, 1389, 1457, 1548, 1671, 1705, 1721, 1749, 1756, 1765, 1788, 2085, 2248, 2258, 2321, 2364, 2540, 2849, 2870, 3089, 3340, 3349, 3388, 3396, 4038, 4062, 4079, 4631, 4966, 5047], 'investigated': [17, 228, 767], 'in': [18, 23, 66, 105, 140, 189, 229, 234, 277, 316, 351, 400, 670, 686, 760, 772, 795, 905, 1310, 1369, 1503, 1586, 1603, 1675, 1739, 1750, 2140, 2181, 2193, 2196, 2213, 2217, 2240, 2251, 2295, 2312, 2370, 2393, 2525, 2595, 2688, 2756, 2766, 2809, 2828, 2881, 2900, 2970, 2987, 2999, 3055, 3097, 3156, 3199, 3238, 3259, 3316, 3342, 3360, 3392, 3413, 3438, 3447, 3508, 3519, 3552, 3940, 3994, 4070, 4105, 4169, 4218, 4255, 4357, 4412, 4446, 4456, 4466, 4494, 4549, 4580, 4625, 4653, 4692, 4788, 4822, 4894, 4924, 4973, 5033, 5100], 'transfected': [19, 230, 594, 1438, 2143, 2182, 2219, 2555, 2668], 'NIH3T3': [20, 67, 231, 278, 1875, 2141, 2156, 2241, 2611, 3343, 3393, 3520], 'cells': [21, 232, 688, 800, 1366, 1422, 1876, 1894, 2142, 2157, 2218, 2552, 2637, 2654, 2698, 2735, 2812, 2842, 2855, 2884, 3098, 3157, 3282, 3301, 3353, 3414, 3439, 3448, 4018, 4073, 4171, 4220, 4626, 4974], 'a': [24, 235, 849, 859, 993, 1278, 1288, 1311, 1353, 1504, 1803, 1812, 1984, 2076, 2123, 2531, 2689, 3051, 3397, 3469, 4260, 4495, 4905, 5034, 5052], 'cell': [25, 236, 671, 1387, 1552, 2533, 2608, 2973, 2989, 3001, 3030, 3058, 3998], 'line': [26, 237, 1388, 2534, 2974, 3031], 'that': [27, 38, 72, 197, 238, 249, 283, 408, 661, 725, 790, 831, 844, 998, 1177, 1293, 1317, 1335, 1357, 1776, 1893, 1933, 1953, 1965, 2031, 2118, 2128, 2155, 2230, 2303, 2316, 2333, 2385, 2404, 2511, 2553, 2891, 2909, 2976, 3006, 3173, 3231, 3309, 3458, 3472, 3500, 3539, 3850, 3910, 4143, 4198, 4266, 4278, 4310, 4416, 4439, 4564, 4646, 4660, 4817, 4879, 4957, 4995, 5028], 'derived': [29, 240, 2535], 'from': [30, 241, 1391, 1723, 2536, 3373, 4097], 'mice': [31, 242, 1392, 2537], 'lacking': [32, 243, 775, 826, 1393, 2538], 'Gαq': [33, 244, 562, 1395, 2848, 2878, 3248, 3278, 3327, 3505, 4356, 4931, 4985, 5007], 'Gα11.': [35, 246], 'We': [36, 69, 247, 280, 1291, 1314, 1891, 2126, 3049, 3668, 5112, 5123], 'found': [37, 71, 248, 282, 1098, 1292, 1316, 1892, 2127], 'the': [39, 44, 48, 73, 91, 106, 141, 145, 161, 169, 190, 207, 250, 255, 259, 284, 302, 317, 352, 356, 372, 380, 401, 418, 561, 569, 572, 723, 769, 783, 796, 819, 832, 842, 856, 896, 899, 1056, 1203, 1207, 1254, 1269, 1272, 1294, 1298, 1318, 1349, 1360, 1364, 1432, 1453, 1507, 1518, 1527, 1545, 1551, 1564, 1583, 1596, 1702, 1708, 1712, 1740, 1751, 1779, 1792, 1796, 1855, 1878, 1916, 1934, 1938, 1959, 1966, 1975, 2039, 2082, 2091, 2145, 2214, 2221, 2252, 2290, 2296, 2317, 2334, 2383, 2386, 2410, 2460, 2477, 2481, 2516, 2521, 2550, 2557, 2621, 2642, 2645, 2649, 2656, 2670, 2721, 2741, 2757, 2767, 2798, 2810, 2829, 2832, 2839, 2853, 2861, 2882, 2907, 2910, 2928, 2931, 2963, 2971, 3018, 3024, 3028, 3037, 3042, 3046, 3061, 3093, 3126, 3177, 3200, 3222, 3247, 3255, 3294, 3297, 3332, 3335, 3374, 3401, 3434, 3443, 3462, 3474, 3478, 3486, 3533, 3541, 3545, 3562, 3571, 3651, 3661, 3680, 3691, 3852, 3935, 3938, 3941, 3958, 3974, 3982, 3995, 4010, 4051, 4071, 4098, 4106, 4146, 4151, 4156, 4194, 4228, 4237, 4249, 4353, 4452, 4471, 4546, 4552, 4562, 4581, 4588, 4592, 4596, 4616, 4654, 4669, 4693, 4823, 4829, 4832, 4846, 4915, 4939, 4947, 4952, 4958, 4996, 5055, 5089, 5101, 5121], 'constitutively': [40, 251, 1887], 'active': [41, 252, 470, 1888], 'forms': [42, 253, 588], 'α': [45, 256, 528, 1295, 1897, 1935, 1962, 3475, 3696, 4815], 'Gqand': [49, 260], 'G12': [50, 208, 261, 419, 1301, 1941, 2042, 3047, 4011, 4238], 'class': [51, 262, 574, 663, 901, 2933, 4239, 4427], 'proteins,': [54, 133, 265, 344, 577, 1513, 2936, 3376, 3684, 3947], 'including': [55, 164, 266, 375, 2064, 2937, 3060, 4470], 'Gαq,': [56, 267, 532, 4419], 'Gα11,': [57, 268], 'Gα14,': [58, 269], 'Gα16,': [59, 270], 'Gα12,': [60, 271], 'Gα13,': [62, 273, 582, 592, 3516, 4684], 'can': [63, 102, 274, 313, 1306, 1358, 1946, 2053, 2574, 2995, 4270, 4431, 4491, 4524, 4575, 4818, 4853], 'activate': [64, 103, 187, 275, 314, 398, 1336, 2060, 2264, 2293, 2630, 2686, 2968, 3092, 3381, 4271, 4432, 4464, 4488, 4492, 4605, 4613, 4642, 4690, 4820], 'SRF': [65, 83, 104, 125, 138, 188, 276, 294, 315, 336, 349, 399, 908, 1308, 1321, 1337, 1822, 1949, 1956, 1976, 2028, 2037, 2294, 2305, 2330, 2335, 2368, 2526, 2631, 2687, 2901, 2969, 2997, 3154, 3194, 3260, 3271, 3382, 3648, 3876, 3904, 3989, 4004, 4068, 4093, 4167, 4181, 4192, 4258, 4272, 4281, 4358, 4433, 4449, 4457, 4465, 4493, 4530, 4579, 4614, 4643, 4691, 4780, 4821, 4838, 4859, 4876, 4935, 5093], 'cells.': [68, 143, 279, 354, 2184, 2242, 4108, 4695, 4827], 'also': [70, 281, 766, 1087, 1315, 1738, 2171, 2249, 2613, 2639, 2871, 3197, 3235, 3324, 3522, 3931, 3992, 4063, 4120, 4162, 4210, 4421, 4525, 4540, 4644, 4658, 4801, 4819, 4922, 4981, 5124], 'type': [74, 172, 285, 383, 442, 445, 2724, 3073, 3076, 3084], '1': [75, 173, 179, 286, 384, 390, 443, 2204, 2227, 3085, 3137], 'muscarinic': [76, 287, 439, 3402], 'receptor': [77, 81, 184, 288, 292, 395, 425, 441, 834, 852, 2084, 2356, 2647, 2723, 2730, 2994, 3008, 3101, 3129, 3180, 3338, 4476, 4796], '(m1R)': [78, 289], 'α1-adrenergic': [80, 291], '(AR)-mediated': [82, 293], 'activation': [84, 139, 295, 350, 909, 1102, 1309, 1319, 1957, 2306, 2331, 2336, 2527, 2998, 3155, 3195, 3272, 3317, 3487, 3649, 3877, 3905, 3990, 4005, 4069, 4094, 4168, 4182, 4217, 4256, 4359, 4447, 4531, 4577, 4781, 4839, 4860, 4877, 5091], 'is': [85, 296, 839, 1536, 1800, 1811, 1983, 2922, 3009, 3468, 3496, 3535, 3550, 3917, 3930, 3970, 4006, 4183, 4657, 4891, 4909, 4936, 4980], 'exclusively': [86, 297, 1327, 2897, 4445], 'dependent': [87, 298, 2896, 4184], 'on': [88, 299, 1328, 1854, 2310, 2898, 3193, 3269, 3985, 4113, 4185, 4887], 'Gαq/11,': [89, 195, 300, 406, 1329, 4534], 'while': [90, 301, 560, 1330, 3125, 4629], 'for': [93, 304, 1184, 1348, 1479, 1501, 2069, 2161, 2173, 2236, 2462, 2471, 2623, 2873, 3035, 3690, 3860, 4520, 5119, 5135], 'thrombin,': [94, 146, 305, 357, 477], 'lysophosphatidic': [95, 306, 422, 474], 'acid': [96, 307, 423, 475], '(LPA),': [97, 308], 'thromboxane': [98, 148, 309, 359, 850, 2728, 3067, 3127, 3178, 4475, 4697], 'A2,': [99, 149, 310, 360, 4477], 'endothelin': [101, 151, 312, 362, 2722, 2748, 3062, 3100, 3174, 4472, 4798], 'absence': [107, 193, 318, 404, 4584], 'Gαq/11.': [109, 320, 2634, 4204, 4586], 'Moreover,': [110, 321, 674, 3895, 4518], 'RGS12': [111, 322, 1731, 3786, 3870, 3898, 3916, 3929, 3969, 4042, 4061, 4078, 4104, 4112, 4122, 4231, 4841, 4852], 'but': [112, 129, 323, 340, 1823, 2017, 3242, 3855, 4420], 'not': [113, 130, 186, 324, 341, 397, 1201, 1261, 1824, 1928, 2018, 2025, 2391, 2467, 2792, 2979, 3109, 3123, 3380, 3432, 3555, 3857, 3890, 3900, 3907, 3918, 3956, 4075, 4131, 4233, 4417, 4604, 4610, 4621, 4689, 4885, 4944, 4982], 'RGS2,': [114, 325, 1728, 3670, 3882, 4028, 4054, 4126], 'RGS4,': [115, 326, 1729, 3671, 4029, 4055, 4127], 'or': [116, 192, 209, 327, 403, 420, 1905, 1925, 2022, 3106, 3209, 3277, 3287, 3423, 3953, 3963, 4031, 4056, 4128, 4573, 4583, 4601, 4683, 4874], 'Axin': [117, 328, 1743, 3810, 3883, 4057, 4129, 4160, 4903], 'able': [119, 155, 330, 366, 2134, 2322, 2365, 2567, 2628, 2684, 2923, 3010, 3090, 3183, 4064, 4080, 4163, 4211, 4542, 4632, 4803, 4967], 'to': [120, 156, 158, 202, 331, 367, 369, 413, 584, 600, 680, 782, 785, 836, 863, 895, 992, 1048, 1089, 1099, 1194, 1282, 1464, 1525, 1550, 1767, 1778, 1820, 1866, 1948, 2049, 2055, 2059, 2075, 2088, 2090, 2135, 2176, 2198, 2260, 2262, 2292, 2308, 2323, 2366, 2372, 2409, 2474, 2476, 2488, 2515, 2549, 2568, 2629, 2685, 2769, 2786, 2797, 2824, 2843, 2924, 2926, 2967, 3011, 3013, 3041, 3091, 3151, 3184, 3186, 3370, 3400, 3436, 3445, 3498, 3570, 3658, 3863, 3920, 3933, 3972, 4065, 4081, 4164, 4212, 4236, 4347, 4352, 4483, 4485, 4487, 4527, 4543, 4545, 4551, 4568, 4571, 4612, 4633, 4641, 4650, 4679, 4681, 4705, 4707, 4804, 4806, 4845, 4870, 4911, 4968, 5049, 5107], 'inhibit': [121, 332, 1049, 1100, 1195, 1359, 3433, 3665, 3901, 4066, 4082, 4150, 4165, 4203, 4213, 4854, 4871], 'Gα12': [122, 333, 534, 573, 580, 590, 675, 726, 3250, 3514, 3564, 3653, 3962, 4267, 4279, 4682, 4708, 4856], 'Gα13-mediated': [124, 335, 4858], 'activation.': [126, 337, 1950, 1977, 2902, 4458], 'And': [127, 338], 'RGS12,': [128, 339, 1356, 3672, 3951, 4030], 'other': [131, 342, 468, 2168, 3016, 4114, 4423], 'RGS': [132, 343, 984, 1001, 1190, 1258, 1354, 3662, 3683, 3853, 3983, 4147, 4157, 4195, 4200, 4882, 4897, 4906], 'blocked': [134, 345, 1955, 2576, 3460], 'thrombin-': [135, 346], 'LPA-mediated': [137, 348], 'Gαq/11-deficient': [142, 353, 1365, 1386, 2551, 2636, 2811, 2854, 2883, 2972, 3029, 3057, 3996, 4017, 4072, 4107, 4694, 4824], 'Therefore,': [144, 355, 2676, 2803, 2888, 3494, 3968, 4889], 'LPA,': [147, 358, 2072, 2543], 'may': [153, 364, 667, 792, 1179, 1341, 1973, 2120, 2513, 2794, 3032, 3181, 3234, 3311, 3367, 3567, 4095, 4202, 4232, 4539, 4800, 4842, 5003, 5098], 'be': [154, 365, 585, 668, 793, 2340, 2575, 2795, 3023, 3033, 3182, 3236, 3368, 3568, 3934, 4234, 4348, 4541, 4790, 4802, 4843, 5004], 'couple': [157, 201, 368, 412, 2054, 2089, 2261, 2408, 2475, 2514, 2925, 3012, 3185, 4484, 4544, 4570, 4649, 4680, 4706, 4805], 'Gα12/13.': [159, 370, 1344, 4793, 4849, 4888], 'On': [160, 371], 'contrary,': [162, 373], 'β2-': [165, 376], 'α2-ARs,': [167, 378], 'm2R,': [168, 379], 'dopamine': [170, 381, 3082, 3149, 3164], '2,': [175, 181, 386, 392, 446, 2345, 3077], 'angiotensin': [176, 387, 426, 3070], 'types': [178, 389], 'interleukin-8': [183, 394, 438], 'could': [185, 396, 854, 1200, 3664, 4149, 4688], 'presence': [191, 402, 2297, 2830, 4582], 'suggesting': [196, 407, 660, 2510, 4142], 'these': [198, 409, 1039, 1189, 2056, 2338, 2362, 2529, 2804, 3489, 3577, 4199, 4536, 4686, 4783, 4880, 5110], 'cannot': [200, 411, 4648], 'endogenous': [203, 414, 2067, 2159, 2234, 2615, 2678, 2801, 2983, 4101, 4651], 'proteins': [205, 416, 487, 666, 904, 990, 997, 1040, 1191, 1209, 1256, 1259, 1305, 1775, 1945, 2046, 2058, 2093, 2412, 2479, 2912, 3015, 3044, 3483, 3491, 3663, 3849, 3984, 4148, 4158, 4196, 4201, 4430, 4548, 4883, 4898], 'Gqclasses.': [210, 421], 'adrenergic': [424], 'C.': [427, 735, 935, 3742, 4285, 4361], 'butulinum': [428, 1980], 'C3': [429, 1755, 1954, 1978, 1981, 2013, 2032, 2320, 2578, 4965], 'transferase': [430], 'cAMP': [431], 'element': [433, 457, 1818], 'β-galactosidase': [434, 1918], 'cholinergic': [440], 'respectively': [447, 2202, 2600, 3166], 'pertussis': [448], 'toxin': [449, 3428, 3471], 'regulator': [450], 'signaling': [454, 1052, 4117], 'green': [461], 'fluorescence': [462, 1508, 1541, 1572], 'protein.': [463], 'Hormones,': [464], 'neurotransmitters,': [465], 'many': [467], 'biologically': [469], 'molecules,': [471], 'such': [472, 1041], 'as': [473, 846, 848, 1042, 1090, 1181, 1450, 1494, 1607, 1673, 1707, 2122, 2764, 4123, 4125, 4664, 4666], '(LPA),1': [476], 'catecholamines,': [478], 'endothelin,': [479], 'etc.,': [480], 'transduce': [481], 'their': [482, 1062, 2174, 2373, 2472, 3861], 'signals': [483], 'through': [484, 689, 732, 1343, 4282, 4435], 'heterotrimeric': [485], '(1Gilman': [488], 'A.G.': [489, 1070, 1111, 1215, 1234, 3703, 3723, 3746, 3769], 'Annu.': [490], 'Rev.': [491], 'Biochem.': [492, 648, 3797], '1987;': [493], '56:': [494], '615-649Crossref': [495], 'PubMed': [496, 545, 615, 655, 713, 754, 813, 883, 929, 954, 979, 1012, 1032, 1080, 1124, 1146, 1171, 1225, 1247, 1415, 1627, 1649, 1662, 1696, 1842, 2004, 2112, 2284, 2430, 2456, 2505, 2960, 3598, 3624, 3644, 3713, 3736, 3759, 3781, 3804, 3840, 4304, 4338, 4380, 4404, 4515, 4726, 4749, 4774, 5020, 5083], 'Scopus': [497, 513, 546, 616, 638, 656, 714, 755, 814, 884, 930, 955, 980, 1013, 1033, 1081, 1125, 1147, 1172, 1226, 1248, 1416, 1663, 1697, 1843, 2005, 2113, 2285, 2506, 3599, 3625, 3714, 3737, 3760, 3782, 3805, 3841, 4305, 4339, 4381, 4405, 4727, 4750, 4775, 5021, 5084], '(4700)': [498], 'Google': [499, 515, 548, 618, 640, 658, 716, 757, 816, 886, 932, 957, 982, 1015, 1035, 1083, 1127, 1149, 1174, 1228, 1250, 1418, 1628, 1650, 1665, 1699, 1845, 2007, 2115, 2287, 2431, 2457, 2508, 2961, 3601, 3627, 3645, 3716, 3739, 3762, 3784, 3807, 3843, 4307, 4341, 4383, 4407, 4516, 4729, 4752, 4777, 5023, 5086], 'Scholar,': [500, 619, 641, 933, 958, 1016, 1128, 1150, 1629, 1651, 1700, 2432, 3602, 3628, 3717, 3740, 3763, 4384, 4730, 4753], '2Birnbaumer': [501], 'L.': [502, 3790, 3812], 'Abramowitz': [503], 'J.': [504, 702, 918, 1020, 1021, 1135, 1411, 1618, 1640, 1685, 1832, 1994, 2273, 2421, 2447, 2951, 3612, 3613, 3635, 4327, 4393, 4505, 4506], 'Brown': [505, 4391, 4766], 'A.M.': [506, 627, 695, 911, 1678, 4320, 4763], 'Biochim.': [507, 2499], 'Biophys.': [508, 649, 2500, 3798], 'Acta.': [509, 2501], '1990;': [510], '90:': [511, 3833], '163-224Crossref': [512], '(961)': [514], 'Scholar).': [516, 549, 717, 758, 817, 887, 983, 1036, 1251, 1419, 1666, 1846, 2008, 2458, 3646, 3785, 4342, 4408, 4517, 4778, 5087], 'Molecular': [517], 'cloning': [518], 'has': [519, 1260, 2398, 3266], 'revealed': [520], 'at': [521, 1379, 4786], 'least': [522, 4787], 'four': [523], 'classes': [524, 1302, 1942], 'subunits:': [529], 'Gαs,': [530], 'Gαi,': [531], '(3Simon': [535], 'M.I.': [536, 609, 808, 1407, 1617, 1639, 1657, 2272, 2420, 2950, 4721, 5064], 'Strathman': [537], 'M.P.': [538], 'Gautum': [539], 'M.': [540, 4388], 'Science.': [541, 809, 1658, 4722], '1991;': [542, 635, 4509], '252:': [543], '802-808Crossref': [544], '(1580)': [547], 'The': [550, 759, 1385, 1455, 1530, 1667, 1716, 1859, 1951, 2314, 2635, 2696, 2732, 2780, 2819, 2867, 3188, 3512, 3557, 3647, 3926, 3979, 4016, 4109, 4343, 4437, 4637, 4696, 4794, 4864], 'Gαs': [551, 1208], 'Gαi': [554, 1924, 3378, 4602], 'regulate': [556, 564, 1867, 3864, 4912, 4988, 5031, 5050], 'adenylyl': [557], 'cyclase': [558], 'activities,': [559, 2599], 'phospholipase': [565, 1104, 2265, 4215, 4489], 'C': [566, 2266, 3120, 3141, 4216], 'activities.': [567, 1093], 'However,': [568, 888, 2838, 3385, 4154], 'function': [570, 762, 797, 1180, 2121, 3975], 'which': [578, 1085, 1514, 1799, 1821, 1988, 2051, 2073, 2257, 2573, 3021, 3366, 3430, 3685, 4480], 'includes': [579], 'remains': [583], 'elucidated.': [586], 'Activated': [587], 'when': [593, 2847, 2875, 3386, 3517, 3544], 'into': [595, 1429, 2852], 'fibroblast': [596, 687, 2532, 3997, 4826], 'cells,': [597, 2063, 2612, 3344, 3394, 3521], 'were': [598, 678, 890, 1046, 1097, 1192, 1367, 1427, 1437, 1474, 1484, 1498, 1557, 1569, 1576, 1602, 1737, 1871, 2133, 2170, 2485, 2547, 2554, 2566, 2638, 2699, 2736, 2807, 2821, 2845, 2879, 3196, 3323, 3991, 4019, 4119, 4161, 4209, 4702], 'shown': [599, 679, 1047, 2086, 2486, 3299, 4703, 5048], 'induce': [601, 681, 1307, 2996, 4576], 'transformation': [602], 'phenotypes': [603], '(4Jiang': [604], 'H.': [605, 1637, 2270, 2948], 'Wu': [606], 'D.': [607, 1611, 1631, 1653, 2268, 2414, 2942, 4765, 5040], 'Simon': [608, 807, 1406, 1616, 1638, 1656, 2271, 2419, 2949, 4720], 'FESB': [610], 'Lett.': [611], '1993;': [612, 1659], '330:': [613], '319-322Crossref': [614], '(101)': [617], '5Hermouet': [620], 'S.': [621, 633, 739, 749, 802, 866, 878, 939, 949, 974, 1119, 1166, 1242, 1399, 2095, 2107, 3581, 3593, 3731, 3754, 3792, 4289, 4299, 4365, 4375, 4715, 4732, 4744, 5078], 'Merendino': [622], 'J.J.': [623, 3765, 3824], 'Gutkind': [624, 646, 742, 942, 4292, 4368], 'J.S.': [625, 647, 743, 943, 4293, 4369], 'Spiegel': [626], 'Proc.': [628, 744, 873, 944, 969, 1114, 1161, 1237, 2102, 3588, 3726, 3749, 4294, 4370, 4739, 5073], 'Natl.': [629, 745, 874, 945, 970, 1115, 1162, 1238, 2103, 3589, 3727, 3750, 4295, 4371, 4740, 5074], 'Acad.': [630, 746, 875, 946, 971, 1116, 1163, 1239, 2104, 3590, 3728, 3751, 4296, 4372, 4741, 5075], 'Sci.': [631, 747, 876, 947, 972, 1117, 1164, 1240, 2105, 3591, 3729, 3752, 4297, 4373, 4742, 5076], 'U.': [632, 748, 877, 948, 973, 1118, 1165, 1241, 2106, 3592, 3730, 3753, 4298, 4374, 4743, 5077], 'A.': [634, 750, 879, 950, 975, 1120, 1167, 1243, 1403, 1633, 2108, 2944, 3594, 3732, 3755, 4300, 4376, 4501, 4745, 5066, 5079], '88:': [636], '455-459Crossref': [637], '(104)': [639], '6Xu': [642], 'N.': [643, 699, 741, 915, 941, 962, 1154, 1682, 3604, 4291, 4324, 4367], 'Voyno-Yasenetskaya': [644], 'T.': [645, 1113, 1236, 2440, 3725, 3816, 5013], 'Res.': [650, 3799], 'Commun.': [651, 3800], '1994;': [652, 880, 2109, 3595, 3638, 4746], '201:': [653], '603-609Crossref': [654], '(87)': [657], 'Scholar),': [659, 1084, 1175, 2288, 2509, 2962], 'this': [662, 1265, 2607, 2988, 3000, 3007, 3056, 4244, 4413, 4426], 'involved': [669, 794, 2392, 3237, 4923], 'growth': [672], 'regulation.': [673], 'Gα13': [677, 764, 776, 791, 827, 864, 3276, 3305, 3310, 3507, 3566, 3655, 3964, 4269, 4710, 4987], 'formation': [682, 4313], 'stress': [684, 4315], 'fibers': [685, 4316], 'small': [690, 1967], 'RhoA': [693, 733, 906, 1970, 1986, 1990, 2343, 2917, 4283, 4318, 4528, 4963, 4989, 5032], '(7Buhl': [694, 910, 4319], 'Johnson': [696, 700, 912, 916, 1679, 1683, 4321, 4325], 'N.L.': [697, 913, 1680, 4322], 'Dhanasekaran': [698, 914, 1681, 4323], 'G.L.': [701, 917, 1684, 4326], 'Biol.': [703, 919, 1008, 1022, 1136, 1619, 1641, 1686, 2274, 2422, 2448, 2952, 3614, 3636, 4328, 4394, 4507, 4769], 'Chem.': [704, 920, 1023, 1137, 1620, 1642, 1687, 2275, 2423, 2449, 2953, 3615, 3637, 4329, 4395, 4508], '1995;': [705, 921, 1688, 1836, 1998, 2276, 2502, 4330], '270:': [706, 922, 1689, 2277, 4331], '24631-24634Abstract': [707, 923, 1690, 4332], 'Full': [708, 710, 924, 926, 1027, 1029, 1075, 1077, 1141, 1143, 1220, 1222, 1624, 1646, 1691, 1693, 1839, 2001, 2279, 2281, 2427, 2453, 2957, 3619, 3621, 3641, 3708, 3710, 3776, 3778, 3835, 3837, 4333, 4335, 4399, 4401, 4512], 'Text': [709, 711, 925, 927, 1028, 1030, 1076, 1078, 1142, 1144, 1221, 1223, 1625, 1647, 1692, 1694, 1840, 2002, 2280, 2282, 2428, 2454, 2958, 3620, 3622, 3642, 3709, 3711, 3777, 3779, 3836, 3838, 4334, 4336, 4400, 4402, 4513], 'PDF': [712, 928, 1031, 1079, 1145, 1224, 1626, 1648, 1695, 1841, 2003, 2283, 2429, 2455, 2959, 3623, 3643, 3712, 3780, 3839, 4337, 4403, 4514], '(422)': [715, 931, 1698, 4340], 'This': [718, 838, 1931, 2152, 2301, 2903, 3228, 3307], 'observation': [719, 843, 2384], 'supported': [721], 'report': [724, 4414], 'activated': [727, 1896, 1923, 3275, 3902, 4599], '(SRF)': [731], '(8Fromm': [734, 4284, 4360], 'Coso': [736, 936, 4286, 4362], 'O.A.': [737, 937, 4287, 4363], 'Montaner': [738, 938, 4288, 4364], 'Xu': [740, 940, 4290, 4366], '1997;': [751, 810, 951, 976, 1009, 1024, 1121, 1138, 1168, 1244, 3616, 3733, 3756, 3773, 3801, 3832, 4301, 4377, 4723, 5017, 5080], '94:': [752, 952, 977, 1122, 1169, 1245, 3734, 3757, 4302, 4378, 5081], '10098-10103Crossref': [753, 953, 4303, 4379], '(196)': [756, 956, 4306, 4382], 'vivo': [761], 'using': [768, 1287, 1444, 1486, 1563, 4711], 'gene-targeting': [770], 'technique': [771], 'mice.': [773], 'Mice': [774], 'are': [777, 1086, 1515, 2232, 2380, 2390, 2627, 2683, 2760, 2895, 2913, 2978, 3678, 3845, 4273, 4481, 4565, 4677, 4921, 4960, 5105], 'embryonic': [778], 'lethal': [779], 'apparently': [780], 'due': [781, 2796, 3569, 3919], 'failure': [784], 'develop': [786], 'vasculature': [787], 'structures,': [788], 'indicating': [789, 830, 2030, 2229, 3909], 'endothelial': [799], '(9Offermanns': [801, 4714], 'Mancino': [803, 4716], 'V.': [804, 4717], 'Revel': [805, 4718], 'J.P.': [806, 4719], '275:': [811, 4724], '533-536Crossref': [812, 4725], '(287)': [815, 4728], 'In': [818, 1264, 1345, 2009, 2080, 4243, 4607, 4850, 5044], 'same': [820, 1565, 2253, 2868, 3201, 3546, 4830], 'study,': [821], 'thrombin-mediated': [822, 3988, 4003, 4067, 4875], 'chemotaxis': [823], 'fibroblasts': [825], 'blocked,': [829], 'thrombin': [833, 845, 2070, 2083, 2130, 2162, 2463, 2563, 2616, 2624, 2646, 2658, 2681, 2744, 4521, 4700], 'couples': [835], 'Gα13.': [837, 4933], 'consistent': [840, 2381, 4274], 'with': [841, 893, 1055, 1439, 1517, 1877, 2144, 2220, 2382, 2556, 2641, 2669, 2701, 2753, 2858, 3111, 3243, 3279, 3314, 3326, 3390, 3504, 4021, 4275, 4350, 4930, 4951], 'well': [847, 3681, 4124, 4665], 'A2': [851, 2729, 3068, 3128, 3179, 4698], 'agonist': [853, 3130, 4134, 4618], 'stimulate': [855, 1202, 1283, 2136, 2177, 2367, 2489, 2569, 4622, 4634], 'binding': [857], 'photo-affinity': [860], 'GTP': [861], 'analog': [862], '(10Offermanns': [865, 2094, 3580], 'Laugwitz': [867, 2096, 3582, 4733], 'K.L.': [868, 2097, 3583, 4734], 'Spicher': [869, 2098, 3584, 4735], 'K.': [870, 2099, 3585, 4736, 5009], 'Schultz': [871, 2100, 3586, 3609, 4737], 'G.': [872, 2101, 2434, 3587, 3610, 4738], '91:': [881, 2110, 3596, 4747], '504-508Crossref': [882, 2111, 3597, 4748], '(392)': [885, 2114, 3600, 4751], 'there': [889, 2231, 2977, 3395, 4809, 4890], 'contradictory': [891], 'reports': [892, 4277], 'regard': [894, 4351], 'involvement': [897, 4250, 4354, 4453], 'Gq': [900, 1299, 1939, 2040, 2411, 2482, 2517, 2911, 2932, 3019, 4455, 4486, 4553, 4593], '8Fromm': [934], '16Heximer': [959, 1151], 'S.P.': [960, 1152], 'Watson': [961, 1153], 'Linder': [963, 1155], 'M.E.': [964, 1156], 'Blumer': [965, 1157], 'K.J.': [966, 1158], 'Hepler': [967, 1159, 3743], 'J.R.': [968, 1107, 1160, 1230, 3719, 3744], '14389-14393Crossref': [978, 1170], '(312)': [981, 1173], '(regulator': [985], 'signaling)': [989], 'belong': [991, 2074], 'growing': [994], 'family': [995, 2043, 4012, 4998], 'contains': [999, 2614, 4904], 'homologous': [1000], 'domains': [1002, 3854], '(11Koelle': [1003], 'M.R.': [1004], 'Curr.': [1005], 'Opin.': [1006], 'Cell': [1007, 1472, 1496], '9:': [1010], '143-147Crossref': [1011], '(174)': [1014], '12Dohlman': [1017], 'H.G.': [1018], 'Thorner': [1019], '272:': [1025, 1139, 3617], '3871-3874Abstract': [1026], '(449)': [1034], 'Some': [1037], 'GIAP': [1043], 'RGS4': [1045, 1096, 3677, 3888, 4208, 4869], 'protein-mediated': [1051, 3866, 4116], 'interacting': [1054], 'Gαiand': [1057], 'Gαo': [1058, 1926, 4600], 'stimulating': [1061], 'GTPase': [1063, 1204, 3574], 'activities': [1064, 1556, 2195, 3292, 3298, 3362, 3412, 3560, 3575, 3689, 4047], '(13Berman': [1065, 1210, 3698], 'D.M.': [1066, 1109, 1211, 1232, 3699, 3721, 3767], 'Wilkie': [1067, 1212, 1408, 3700], 'T.M.': [1068, 1213, 1409, 3701], 'Gilman': [1069, 1110, 1214, 1233, 3702, 3722, 3745, 3768], 'Cell.': [1071, 1216, 1835, 1997, 3704, 3772, 3831, 4770], '1996;': [1072, 1217, 3705, 4396, 4771], '86:': [1073, 1218, 3706], '445-452Abstract': [1074, 1219, 3707], '(649)': [1082, 1227, 3715], 'referred': [1088], 'GTPase-activating': [1091, 1182, 3687], 'RGS2': [1094, 3675, 3954, 4206, 4867], 'Gαq-mediated': [1101], 'Cβ': [1105], '(14Hepler': [1106], 'Berman': [1108, 1231, 3720, 3766], 'Kozasa': [1112, 1235, 3724, 5012], '428-432Crossref': [1123, 1246, 3735], '(335)': [1126, 1249, 3738], '15Yan': [1129], 'Y.': [1130], 'Chi': [1131], 'P.P.': [1132], 'Bourne': [1133], 'H.R.': [1134], '11924-11927Abstract': [1140], '(126)': [1148], 'implying': [1176], 'they': [1178, 1199, 2484, 2512], 'Gαq.': [1185], 'Interestingly,': [1186, 3281, 4555], 'most': [1187], 'unable': [1193, 2259, 2823, 4678, 4910], 'Gs-mediated': [1196], 'signaling,': [1197], 'activity': [1205, 1793, 1856, 2216, 2369, 3218, 3534], 'Scholar,14Hepler': [1229], 'G12/13': [1255, 2092, 3025, 4652], 'been': [1262, 2399, 2468, 3858], 'investigated.': [1263, 4121], 'report,': [1266, 4245], 'we': [1267, 2350, 2889, 3262, 4246, 4558, 4942], 'characterized': [1268, 3682, 4248], 'abilities': [1270, 1860, 2175, 2473, 3862], 'number': [1279, 2166, 3052, 4261], 'GPCRs': [1281, 1325, 1601, 2169], 'SRF-mediated': [1284, 1785, 3347, 3527, 4623], 'cotransfection': [1289, 1763, 2254, 2857, 3202], 'system.': [1290, 2255, 3203], 'C3-dependent': [1312, 5035], 'manner.': [1313, 5036], 'some': [1323], 'depends': [1326, 1853], 'others': [1331], 'do': [1332, 4884, 4943], 'not.': [1333], 'Those': [1334], 'independently': [1338, 4532], 'Gαq/11': [1340, 2311, 2524, 2899, 4186, 4444], 'act': [1342, 4886], 'addition,': [1346, 2081, 4608, 5045], 'we,': [1347], 'first': [1350, 1499], 'time,': [1351], 'identified': [1352, 4812], 'protein,': [1355], 'Gα12/13function.': [1361], '-NIH3T3': [1362], 'maintained': [1368], "Dulbecco's": [1370], 'modified': [1371], "Eagle's": [1372], 'medium': [1373, 1466], 'containing': [1374, 1467], '10%': [1375], 'fetal': [1376, 1469], 'calf': [1377], '37': [1380], '°C': [1381], 'under': [1382], '5%': [1383], 'CO2.': [1384], 'established': [1390], 'both': [1394, 1540, 2129, 2677, 4478], 'Gα11': [1397], '(17Offermanns': [1398], 'Zhao': [1400], 'L.P.': [1401], 'Gohla': [1402], 'Sarosi': [1404], 'I.': [1405], 'EMBO': [1410], '1998;': [1412], '17:': [1413], '4304-4312Crossref': [1414], '(203)': [1417], 'For': [1420], 'transfection,': [1421], '(5': [1423], '×': [1424], '104': [1425], 'cells/well)': [1426], 'seeded': [1428], '24-well': [1430], 'plates': [1431], 'day': [1433], 'before': [1434], 'transfection.': [1435], 'Cells': [1436, 2185, 3204, 4040], '0.5': [1440], 'μg': [1441, 2703, 2709, 2716], 'DNA/well': [1443], 'LipofectAMINE': [1445], 'Plus': [1446], '(Life': [1447], 'Technologies,': [1448], 'Inc.),': [1449], 'suggested': [1451, 4994], 'manufacturer.': [1454], 'transfection': [1456, 1528, 1579, 2011, 3553], 'stopped': [1458], 'after': [1459, 2740], '3': [1460, 2580, 2674, 2836, 2865, 2886, 3104, 3140, 3168], 'h': [1461, 1477, 2739], 'switching': [1463], 'culture': [1465], '0.5%': [1468], 'bovine': [1470], 'serum.': [1471], 'extracts': [1473], 'collected': [1475], '24': [1476], 'later': [1478], 'luciferase': [1480, 1519, 1546, 1555, 1703, 1851, 1912, 2194, 2215, 2598, 2665, 3217, 3291, 3361, 3411, 4037, 4046], 'assays.': [1481], 'Luciferase': [1482, 1491], 'assays': [1483], 'performed': [1485], 'Boehringer': [1487], 'Mannheim': [1488], 'Constant': [1489], 'Light': [1490], 'Assay': [1492], 'Kit': [1493], 'instructed.': [1495], 'lysates': [1497], 'taken': [1500], 'determining': [1502, 1791], 'Wallac': [1505, 1531], 'multicounter': [1506], 'intensity': [1509, 1562], 'emitted': [1510], 'GFP': [1512, 2711], 'cotransfected': [1516, 2640, 2700, 3945, 4020], 'reporter': [1520, 1669, 1709, 1718, 1879, 2146, 2222, 2559, 2650, 2706, 2788, 2862, 4023], 'plasmid': [1522, 1670, 1720, 1881, 2224, 2672], 'used': [1524, 1706, 1766, 3034, 3551], 'normalize': [1526], 'efficiency.': [1529], 'counter': [1532], '(Wallac': [1533], 'AG&G,': [1534], 'Finland)': [1535], 'capable': [1537, 2914], 'counting': [1539], 'luminescence.': [1543], 'Then,': [1544], 'substrate': [1547], 'added': [1549, 2548], 'lysates,': [1553], 'determined': [1558, 1872], 'measuring': [1560], 'luminescence': [1561], 'counter.': [1566], 'Luminescence': [1567], 'intensities': [1568], 'normalized': [1570, 1590], 'against': [1571], 'intensities.': [1573], 'DNA': [1574, 3549], 'concentrations': [1575, 2754], 'adjusted': [1577], 'if': [1578, 2992, 3264, 3660], 'any': [1581, 2211, 2993, 3153, 3267, 4913], 'cDNAs': [1584], 'resulted': [1585], 'significant': [1587, 3524], 'differences': [1588], 'between': [1589, 4896], 'non-normalized': [1592], 'data.': [1593, 4226, 5043], 'All': [1594], 'pCMV': [1604, 1741], 'expression': [1605, 1921, 2318, 2712, 3896, 3942, 3959, 4597], 'vectors': [1606], 'described': [1608, 1674, 2765, 4411], 'previously': [1609, 2087, 2487, 4566, 4704], '(18Wu': [1610, 2413], 'Lee': [1612, 1634, 2415, 2945, 3823], 'C.-H.': [1613, 1635, 2416, 2946], 'Rhee': [1614, 2417, 2497], 'S.G.': [1615, 2418, 2498], '1992;': [1621, 1643, 2424, 2450, 2954], '267:': [1622, 1644, 2425, 2451, 2955], '1811-1817Abstract': [1623, 2426], '19Wu': [1630], 'Katz': [1632, 2943], 'Jiang': [1636, 2269, 2947, 5115], '25798-25802Abstract': [1645, 2956], '20Wu': [1652], 'LaRosa': [1654], 'G.J.': [1655], '261:': [1660], '101-103Crossref': [1661], '(332)': [1664], 'SRE.L-luciferase': [1668, 2558, 2705], 'constructed': [1672], 'Ref.': [1676], '7Buhl': [1677], 'except': [1701, 4159], 'instead': [1710], 'chloramphenicol': [1713], 'acetyltransferase': [1714], 'gene.': [1715], 'CRE-luciferase': [1717], 'purchased': [1722], 'Strategene,': [1724], 'La': [1725], 'Jolla,': [1726], 'CA.': [1727], '(kindly': [1732, 1744], 'provided': [1733, 1745, 1758], 'Sheng-Cai': [1735, 5130], 'Lin)': [1736], 'vector.': [1742], 'F.': [1747, 3606, 3814, 3830, 5133], 'Costantini)': [1748], 'pcDNA3': [1752], 'vector': [1753], '(Invitrogen).': [1754], 'kindly': [1757], 'Alan': [1760, 5126], 'Hall.': [1761], 'A': [1762, 2165, 2243, 2346, 2603], 'system': [1764], 'characterize': [1768], 'signal': [1769, 4940], 'transduction': [1770], 'pathways': [1771, 4118, 4949], 'mediated': [1772, 2341, 4008, 4791], 'lead': [1777, 1947, 4526], 'regulation': [1780, 2394, 3239, 3509, 4925], 'SRF-dependent': [1782], 'transcription.': [1784, 4636], 'evaluated': [1789], 'luciferase,': [1795], 'production': [1797, 1849, 2663, 4035], 'regulated': [1801, 5005], 'regulatory': [1805], 'sequence': [1806], 'element,': [1807], 'called': [1808], 'SRE.L.': [1809], 'SRE.L': [1810, 4022], 'derivative': [1813], 'c-Fos': [1815], '(SRE),': [1819], 'tertiary': [1825], 'complex': [1826], 'binds': [1828], '(21Hill': [1829, 1991], 'C.S.': [1830, 1992], 'Wynne': [1831, 1993], 'Treisman': [1833, 1995], 'R.': [1834, 1996], '81:': [1837, 1999], '1159-1170Abstract': [1838, 2000], '(1202)': [1844, 2006], 'Thus,': [1847, 2606, 2991, 3027, 4188, 4227, 4779, 5088], 'SRE.L-mediated': [1848, 1868, 2137, 2178, 2570], 'mainly': [1852], 'SRF.': [1858, 2061, 2396, 2695, 2919, 3319, 3511, 4606, 4991], 'various': [1862, 2402], 'cotransfecting': [1874], 'cDNA': [1883, 2643, 4026], 'encoding': [1884, 2644, 4027], 'one': [1885], 'Gα': [1889, 3578, 4589, 5095], 'subunits.': [1890, 3251], 'expressing': [1895, 1915, 2186, 2655, 2814, 3099, 3158, 3221, 3354, 3421, 3440, 4041, 4050, 4172, 4627], 'subunit': [1898], 'Gq,': [1900], 'G11,': [1901], 'G14,': [1902], 'G16,': [1903], 'G12,': [1904], 'G13,': [1906], 'produced': [1907], 'markedly': [1908], 'higher': [1909, 2661, 3290], 'levels': [1910, 2981, 3943, 3960], 'than': [1913, 2666, 3017, 3219, 3246, 3293, 3419, 4048], 'those': [1914, 2667, 3220, 3420, 4049, 4557], 'control': [1917, 2671, 3223, 4052], '(LacZ),': [1919], 'whereas': [1920, 3881], 'did': [1927, 3431, 3899, 3955, 4130, 4620], '(Fig.': [1929, 1971, 2020, 2149, 2203, 2226, 2344, 2375, 2579, 2601, 2673, 2835, 2864, 2885, 3103, 3118, 3167, 3225, 3363, 3383, 3405, 3453, 3529, 3878, 3884, 3965, 4058, 4084, 4139, 4174, 4861], '1).': [1930, 3384], 'indicates': [1932, 4878], 'finding': [1952], 'suggests': [1964, 2154, 2302, 2332, 2975, 3230, 3308, 4197, 4645], 'GTP-binding': [1968], '1)': [1972, 2021], 'mediate': [1974], '(Clostridium': [1979], 'transferase)': [1982], 'specific': [1985, 4235], 'inactivator,': [1987], 'ADP-ribosylates': [1989, 3473], 'our': [2010], 'system,': [2012], 'inhibited': [2014, 3442, 3872], 'only': [2015, 3461, 4418], 'RhoA-induced': [2016], 'Cdc42-': [2019], 'Rac1-': [2023], '(data': [2024, 2791, 3108, 3554, 3889, 3906, 4074], 'shown)': [2026, 2793, 3110, 3891], 'induced': [2027, 3409], 'activation,': [2029, 3261], 'acted': [2033], 'specifically.': [2034], 'Activation': [2035], 'allows': [2047], 'us': [2048, 3657], 'determine': [2050], 'Many': [2062], 'fibroblasts,': [2065], 'contain': [2066, 2158, 3851], 'superfamily': [2077], 'GPCR.': [2079], 'Scholar)': [2116, 3808, 3844, 4308, 5024], 'so': [2117], 'it': [2119, 3003, 3495, 4908], 'positive': [2124], 'control.': [2125], 'LPA': [2132, 2465, 2565, 2584, 2618, 2626, 2746, 3986, 4001, 4090, 4523, 4795, 4835], 'plasmids': [2148, 4024], '2': [2150, 2376], 'A).': [2151, 2581, 2675, 3227, 4863], 'result': [2153, 2869, 3229, 3936, 4096], 'LPA.': [2164], 'tested': [2172, 2250, 2351, 2470, 2808, 3050, 3198, 3263, 3669, 3859, 3993, 4559], '3T3': [2183, 4170], 'm1R': [2187, 2405, 2876, 2894, 3391, 3416, 3422, 3450, 4440, 4661, 4976], 'α1-AR': [2189, 2407, 2815, 2859, 2892, 2921, 2966, 4173, 4442, 4663], 'showed': [2190, 2585, 2660, 3213, 3289, 3356, 3523, 3892, 4043], 'marked': [2191], 'increases': [2192, 3359], 'carbachol': [2199, 2207, 2237, 2785, 2874, 3404, 3408, 3437, 3446], 'norepinephrine,': [2201, 3146], 'B).': [2205, 2348, 2377, 2605, 2837, 2866, 2887, 3455, 4060], 'Neither': [2206], 'nor': [2208], 'norepinephrine': [2209, 2239, 2546, 2783, 2844], 'elicited': [2210], 'change': [2212], 'alone': [2225], 'A),': [2228, 3365, 3531, 3880, 3886, 4086], 'no': [2233], 'mutant': [2244, 3543], 'α1-AR,': [2246, 3161], 'α1-ARΔ2,': [2247, 2256], 'Gαq/11to': [2263], '(22Wu': [2267], '9828-9832Abstract': [2278], '(70)': [2286], 'lost': [2289], 'ability': [2291], 'ligand': [2299, 3403], 'norepinephrine.': [2300], 'α1-AR-mediated': [2304, 4180, 4191], 'appears': [2307, 3457, 4346, 4956], 'depend': [2309], 'fibroblasts.': [2313, 4655], 'fact': [2315, 4438], 'abolish': [2324, 4970], 'thrombin-,': [2325], 'LPA-,': [2326, 4873], 'norepinephrine-,': [2327], 'carbachol-induced': [2329, 3346], 'ligands': [2339, 2374, 2806, 2820], 'Furthermore,': [2349, 3426], 'Gi-coupling': [2352], 'm2R': [2353, 3355, 3387, 3418, 3424, 3452], 'IL-8': [2355, 4670], 'Gs-coupling': [2358], 'β2-AR.': [2359], 'None': [2360], 'These': [2378, 3170], 'results': [2379, 3171], 'Gi': [2387, 3375, 3692, 4547, 4572], 'Go': [2389], 'It': [2397, 3456, 4656, 4955, 4979], 'demonstrated': [2400, 4178], 'approaches': [2403], '23Berstein': [2433], 'Blank': [2435], 'J.L.': [2436, 3608], 'Smrcka': [2437, 4500], 'A.V.': [2438], 'Higashijima': [2439], 'Sternweis': [2441, 3633, 4502], 'P.C.': [2442, 3634], 'Exton': [2443, 4504], 'J.H.': [2444, 4392, 4767], 'Ross': [2445], 'E.M.': [2446], '8081-8088Abstract': [2452], 'Although': [2459, 4902], 'have': [2466, 3856, 4247], 'rigorously': [2469], 'family,': [2483, 5057], 'inositol': [2490], 'phosphate': [2491], 'accumulation': [2492], '(24Noh': [2493], 'D.Y.': [2494], 'Shin': [2495], 'S.H.': [2496], '1242:': [2503], '99-113Crossref': [2504], '(254)': [2507], 'proteins.': [2518, 3026, 3925, 4015, 4187, 4242, 4554, 4901, 4918], 'To': [2519, 3252, 3330], 'test': [2520, 3659], 'roles': [2522], 'receptors,': [2530, 2619, 3160, 3165, 4462], 'Gq/11': [2539], 'used.': [2541], 'Thrombin,': [2542], 'carbachol,': [2544], 'plasmid.': [2561], 'Both': [2562, 4205], 'transcription,': [2572], 'Thrombin': [2582], 'EC50': [2586, 3112, 3134], 'values': [2587, 3113], 'about': [2589, 3115], '5': [2590, 3226, 3364, 3406, 3454], 'units': [2591], '4': [2593, 3119, 3143], 'μm': [2594], 'stimulation': [2596, 2693, 3525], '4,': [2602], 'line,': [2609, 3002, 3059, 3999], 'like': [2610], 'independent': [2632], 'plasmid,': [2652, 2707], 'recombinant': [2657, 2680, 2833, 4855], 'thrombin-induced': [2662, 4092, 4837], 'Gαq/11-independent': [2690, 4496], 'way.Figure': [2691], '4Dose-dependent': [2692], 'Gq/11-deficient': [2697], '0.15': [2702, 2708], 'construct,': [2713], '0.2': [2715], 'LacZ': [2718, 3224], '(A,': [2719], 'B),': [2720], '1a': [2725, 3064, 3074, 3102], '(C),': [2726, 2749], '(D).': [2731], 'next': [2733], 'day,': [2734], 'lysed': [2737], '6': [2738, 3530, 3879, 3885, 3966, 4059, 4085, 4140, 4175, 4862], 'addition': [2742, 4550], '(A),': [2745], '(B),': [2747], 'U46619': [2751, 3131], '(D)': [2752], 'indicated': [2755], 'figure.': [2758], 'Data': [2759], 'processed': [2761], 'presented': [2763], 'legend': [2768], 'Fig.': [2770], '1.View': [2771], 'Large': [2772], 'Image': [2773], 'Figure': [2774], 'ViewerDownload': [2775], 'Hi-res': [2776], 'image': [2777], 'Download': [2778], '(PPT)': [2779], 'inability': [2781, 2964, 4638, 4865], 'elicit': [2787, 2825, 3152], 'lack': [2799], 'receptors.': [2802, 3493], 'two': [2805, 3846, 4537, 4881], 'transiently': [2813], 'm1R,': [2817, 3441], 'respectively.': [2818], 'still': [2822], 'responses,': [2826], 'even': [2827], 'responses': [2840], 'restored': [2846], 'reintroduced': [2850], 'back': [2851], 'observed': [2872, 3325], 'coexpressed': [2880, 3389], 'conclude': [2890, 3499], 'conclusion': [2904], 'further': [2905, 3253], 'strengthens': [2906], 'idea': [2908], 'activating': [2916], 'Since': [2920, 4077, 4934], 'all': [2927, 4155, 4422, 4460], 'members': [2929, 4424], 'Gα14': [2938, 2984], 'Gα16': [2940, 2986], '(19Wu': [2941], 'sufficient': [2980], 'line.': [2990], 'would': [3004, 3022], 'suggest': [3005, 3172], 'class,': [3020], 'testing': [3036], 'coupling': [3038], 'class.': [3048], '1b,': [3066], 'receptor,': [3069, 4671], '(AT)': [3071], 'α2-': [3078], 'β2-AR,': [3080, 3162, 4628], '2.': [3087], 'Endothelin': [3088], 'SRF.L-mediated': [3094], 'C)': [3105], '1b': [3107], '0.25': [3116], 'nm': [3117, 3138], 'data': [3122], 'shown),': [3124, 3908], 'gave': [3132], 'an': [3133], 'value': [3135], '(Figs.': [3139], 'D).': [3144, 4176], 'Angiotensin,': [3145], 'isoprenaline,': [3147], 'failed': [3150], 'AT': [3159], 'C).': [3169], 'G12/13.': [3187], 'effects': [3189, 3322, 3914, 3980, 4110, 4972], 'Gβγ': [3191, 3232, 3258, 3265, 3303, 3315, 3371, 3501, 4919, 5046, 5097], 'coexpressing': [3205, 3274, 3283, 3415, 3449, 4221, 4975], 'β1': [3206, 3210], 'γ1': [3208], 'γ5': [3212], 'approximately': [3214], '1-fold': [3215], 'more': [3216, 3410], 'SRF,': [3241, 4927], 'less': [3244], 'potency': [3245], 'investigate': [3254], 'role': [3256], 'effect': [3268], 'Gα-mediated': [3270, 4948], 'Gβγ.': [3280, 3329], 'Gα13QL': [3284], 'Gβ1γ1': [3286], 'Gβ1γ5': [3288], 'sum': [3295], 'expressed': [3302, 3341, 3518], 'alone.': [3306, 3425], 'work': [3312], 'synergistically': [3313, 3503], 'Similar': [3320], 'synergistic': [3321, 3398, 5090], 'confirm': [3331], 'above': [3333], 'observation,': [3334], 'Gi-coupled': [3336], 'm2-muscarinic': [3337], '(m2R)': [3339], 'determined.': [3350, 4039], 'As': [3351, 4177], 'expected,': [3352], 'marginal': [3357], 'carbachol-mediated': [3358, 4971], 'attributed': [3369, 4844], 'released': [3372], 'since': [3377, 3948], 'does': [3379, 4603], 'B),i.e.': [3407], 'Pertussis': [3427], '(Ptx),': [3429], 'Ptx': [3459, 3467], 'part': [3463, 4789], 'contributed': [3464], 'm2R.': [3466, 4978], 'bacteria': [3470], 'Gi,': [3479], 'Go,': [3480], 'Gt': [3482], 'blocks': [3485], 'reasonable': [3497], 'works': [3502], 'wild-type': [3513, 3563, 3652], 'although': [3532, 4535], 'usually': [3536], 'one-fifth': [3537], 'QL': [3542], 'amount': [3547], 'shown).': [3556, 4076], 'relative': [3558], 'high': [3559], 'slow': [3572], 'intrinsic': [3573], '25Macrez-Lepretre': [3603], 'Kalkbrenner': [3605], 'Morel': [3607], 'Mironneau': [3611], '10095-10102Abstract': [3618], '(75)': [3626], '26Singer': [3629], 'W.D.': [3630], 'Miller': [3631], 'R.T.': [3632], '269:': [3639], '19796-19802Abstract': [3640], 'allowed': [3656], 'Gα12/13-mediated': [3666, 3913], 'effects.': [3667, 3894], 'Axin.': [3674], 'among': [3679, 4556], 'show': [3686], 'and/or': [3693], 'Gqfamilies': [3694], '14Hepler': [3718], '27Huang': [3741], 'Mumby': [3747], 'S.M.': [3748, 3826], '6159-6163Crossref': [3758], '(150)': [3761], '28Tesmer': [3764], 'Sprang': [3770], 'S.R.': [3771], '89:': [3774], '251-261Abstract': [3775], '(682)': [3783], '(29Snow': [3787], 'B.E.': [3788], 'Antonio': [3789], 'Suggs': [3791], 'Gutstein': [3793], 'H.B.': [3794], 'Siderovski': [3795], 'D.P.': [3796], '233:': [3802], '770-777Crossref': [3803], '(99)': [3806], '(30Zeng': [3811], 'Fagotto': [3813], 'Zhang': [3815], 'Hsu': [3817], 'W.': [3818, 5011], 'Vasicek': [3819], 'T.J.': [3820], 'Perry': [3821], 'W.L.R.': [3822], 'Tilghman': [3825], 'Gumbiner': [3827], 'B.M.': [3828], 'Costantini': [3829, 5134], '181-192Abstract': [3834], '(784)': [3842], 'recently': [3847], 'cloned': [3848], 'signaling.': [3867], 'Coexpression': [3868], 'significantly': [3871], 'Gα12-': [3873], 'Gα13-induced': [3875], 'little': [3893], 'RhoA-mediated': [3903], 'inhibition': [3911, 3922, 3927, 4099, 4189, 4833, 4847], 'nonspecific': [3921], 'downstream': [3924, 4937], 'unlikely': [3932], 'changes': [3939], 'coexpression': [3949], 'Axin,': [3952, 4032], 'alter': [3957], 'E).': [3967], 'likely': [3971], 'affect': [3973, 4132], 'Gα12/13': [3977, 4083, 4311, 4807, 5026], 'directly.': [3978], 'where': [4000, 4946], 'presumably': [4007], 'LPA-induced': [4034], 'consistently': [4044], 'lower': [4045], 'LacZ,': [4053], 'RGS12-mediated': [4087], 'attenuation': [4088], 'Gα12/13proteins': [4102], 'β-adrenergic': [4133], 'isoprenaline-induced': [4135], 'CRE-mediated': [4136, 4635], 'C),': [4141], 'none': [4144, 4560], 'Gs': [4152, 4574], 'function.': [4153], 'norepinephrine-induced': [4166, 4214], 'earlier,': [4179], 'COS-7': [4219], 'α1-AR.': [4222], '2D.': [4223], 'Wu,': [4224, 5041], 'unpublished': [4225, 5042], 'action': [4229], 'GPCRs.': [4263], 'Our': [4264, 4409], 'findings': [4265, 4410], 'previous': [4276], 'activates': [4280], 'induces': [4312], 'via': [4317, 5058], 'literature,': [4344], 'however,': [4345, 4463], 'inconsistent': [4349], '31Sah': [4385], 'V.P.': [4386], 'Hoshijima': [4387], 'Chien': [4389], 'K.R.': [4390], '271:': [4397], '31185-31190Abstract': [4398], '(206)': [4406], 'demonstrate': [4415], 'probably': [4434], 'RhoA.': [4436], 'use': [4443], 'strongly': [4450], 'supports': [4451], 'Not': [4459], 'Gq-coupled': [4461], 'Gαq/11-dependent': [4467], 'pathways.': [4468], 'Receptors,': [4469], 'known': [4482, 4567, 4916], 'C,': [4490], 'way': [4497], '(32Wange': [4498], 'R.L.': [4499], 'P.': [4503], '266:': [4510], '11409-11412Abstract': [4511], 'predominantly': [4569], 'Unlike': [4587], 'G12classes,': [4595], 'Gsdoes': [4609], 'appear': [4611], 'because': [4615, 4685, 4964], 'β-AR': [4617, 4640], 'isoprenaline': [4619, 4630], 'β2-AR': [4647], 'apparent': [4659, 4892], 'α2-AR,': [4667], 'β1-AR,': [4668], 'D1': [4673], 'D2': [4675], 'different': [4712], 'methods': [4713], '10Offermanns': [4731], '33Post': [4754], 'G.R.': [4755], 'Collins': [4756], 'L.R.': [4757, 5068], 'Kennedy': [4758], 'E.D.': [4759], 'Moskowitz': [4760], 'S.A.': [4761], 'Aragay': [4762], 'Goldstein': [4764], 'Mol.': [4768], '7:': [4772], '1679-1690Crossref': [4773], '(66)': [4776], 'should': [4785], 'unless': [4808], 'exist': [4810], 'yet-to-be': [4811], 'mouse': [4825], 'Under': [4828], 'premise,': [4831], 'fact,': [4851], 'Gα12/13-,': [4872], 'specificity': [4893], 'interactions': [4895, 4959], 'domain,': [4907], 'especially': [4928], 'together': [4929], 'cascade,': [4941], 'know': [4945], 'interact': [4950], 'Gβγ-mediated': [4953], 'ones.': [4954], 'upstream': [4961], 'completely': [4969], 'clear': [4983], 'how': [4984], 'Recent': [4992], 'studies': [4993, 5104], 'Tec': [4997, 5029, 5056], 'nonreceptor': [5000], 'tyrosine': [5001], 'kinases': [5002, 5030], '(34Bence': [5008], 'Ma': [5010], 'Huang': [5014], 'X.Y.': [5015], 'Nature.': [5016], '389:': [5018], '296-299Crossref': [5019], '(167)': [5022], '3J.': [5037], 'Mao': [5038], 'Btk,': [5051], 'member': [5053], 'phosphatidylinositide': [5059], '3-kinase': [5060], '(35Li': [5061], 'Z.M.': [5062], 'Wahl': [5063], 'Eguinoa': [5065], 'Stephens': [5067], 'Hawkins': [5069], 'P.T.': [5070], 'Witte': [5071], 'O.N.': [5072], '13820-13825Crossref': [5082], '(186)': [5085], 'lie': [5099], 'kinases.': [5102], 'Further': [5103], 'needed': [5106], 'better': [5108], 'understand': [5109], 'questions.': [5111], 'thank': [5113, 5125], 'Huiping': [5114], 'Mark': [5117], 'Betz': [5118], 'reading': [5120], 'manuscript.': [5122], 'Hall,': [5127], 'Solvio': [5128], 'Gutkind,': [5129], 'Lin,': [5131], 'providing': [5136], 'cDNAs.': [5137]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1976547902', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-24T16:00:43.484052', 'created_date': '2016-06-24'}