Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1976521197', 'doi': 'https://doi.org/10.1016/j.cmet.2006.04.015', 'title': 'The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification', 'display_name': 'The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification', 'publication_year': 2006, 'publication_date': '2006-07-01', 'ids': {'openalex': 'https://openalex.org/W1976521197', 'doi': 'https://doi.org/10.1016/j.cmet.2006.04.015', 'mag': '1976521197', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16814730'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cmet.2006.04.015', 'pdf_url': 'http://www.cell.com/article/S1550413106001550/pdf', 'source': {'id': 'https://openalex.org/S177533077', 'display_name': 'Cell Metabolism', 'issn_l': '1550-4131', 'issn': ['1550-4131', '1932-7420'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.cell.com/article/S1550413106001550/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048468194', 'display_name': 'Frédéric Gachon', 'orcid': 'https://orcid.org/0000-0002-9279-9707'}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Frédéric Gachon', 'raw_affiliation_strings': ['Department of Molecular Biology, National Center of Competence in Research “Frontiers in Genetics,” Sciences III, University of Geneva, 1211 Geneva 4, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, National Center of Competence in Research “Frontiers in Genetics,” Sciences III, University of Geneva, 1211 Geneva 4, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064124249', 'display_name': 'Fabienne Fleury Olela', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Fabienne Fleury Olela', 'raw_affiliation_strings': ['Department of Molecular Biology, National Center of Competence in Research “Frontiers in Genetics,” Sciences III, University of Geneva, 1211 Geneva 4, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, National Center of Competence in Research “Frontiers in Genetics,” Sciences III, University of Geneva, 1211 Geneva 4, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007388877', 'display_name': 'Olivier Schaad', 'orcid': 'https://orcid.org/0000-0003-1576-783X'}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Olivier Schaad', 'raw_affiliation_strings': ['Genomics Platform, National Center of Competence in Research “Frontiers in Genetics,” Medical Center of the University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Genomics Platform, National Center of Competence in Research “Frontiers in Genetics,” Medical Center of the University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013490912', 'display_name': 'Patrick Descombes', 'orcid': 'https://orcid.org/0000-0002-1274-247X'}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Patrick Descombes', 'raw_affiliation_strings': ['Genomics Platform, National Center of Competence in Research “Frontiers in Genetics,” Medical Center of the University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Genomics Platform, National Center of Competence in Research “Frontiers in Genetics,” Medical Center of the University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5008245784', 'display_name': 'U. Schibler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Ueli Schibler', 'raw_affiliation_strings': ['Department of Molecular Biology, National Center of Competence in Research “Frontiers in Genetics,” Sciences III, University of Geneva, 1211 Geneva 4, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biology, National Center of Competence in Research “Frontiers in Genetics,” Sciences III, University of Geneva, 1211 Geneva 4, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 8.63, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 476, 'citation_normalized_percentile': {'value': 0.999496, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '4', 'issue': '1', 'first_page': '25', 'last_page': '36'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10342', 'display_name': 'Mammalian Circadian Rhythms and Physiology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10342', 'display_name': 'Mammalian Circadian Rhythms and Physiology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11332', 'display_name': 'Role of Nrf2 Signaling in Oxidative Stress Response', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12745', 'display_name': 'Intermittent Fasting and Health Effects', 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bzip-domain', 'display_name': 'bZIP domain', 'score': 0.614013}, {'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.5321196}, {'id': 'https://openalex.org/keywords/metabolism', 'display_name': 'Metabolism', 'score': 0.436251}, {'id': 'https://openalex.org/keywords/atf3', 'display_name': 'ATF3', 'score': 0.42104125}, {'id': 'https://openalex.org/keywords/xenobiotic', 'display_name': 'Xenobiotic', 'score': 0.41493404}], 'concepts': [{'id': 'https://openalex.org/C156860981', 'wikidata': 'https://www.wikidata.org/wiki/Q2565229', 'display_name': 'Leucine zipper', 'level': 4, 'score': 0.8434195}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.715325}, {'id': 'https://openalex.org/C19408993', 'wikidata': 'https://www.wikidata.org/wiki/Q24784063', 'display_name': 'bZIP domain', 'level': 5, 'score': 0.614013}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.55898}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.5557978}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.5321196}, {'id': 'https://openalex.org/C157880135', 'wikidata': 'https://www.wikidata.org/wiki/Q17832633', 'display_name': 'ATF3', 'level': 5, 'score': 0.42104125}, {'id': 'https://openalex.org/C115448650', 'wikidata': 'https://www.wikidata.org/wiki/Q409205', 'display_name': 'Xenobiotic', 'level': 3, 'score': 0.41493404}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.30703855}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.29243445}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.25175315}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.24361837}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21535254}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.09508234}], 'mesh': [{'descriptor_ui': 'D050976', 'descriptor_name': 'Basic-Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002940', 'descriptor_name': 'Circadian Rhythm', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015262', 'descriptor_name': 'Xenobiotics', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050976', 'descriptor_name': 'Basic-Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050976', 'descriptor_name': 'Basic-Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D050976', 'descriptor_name': 'Basic-Leucine Zipper Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002940', 'descriptor_name': 'Circadian Rhythm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000090702', 'descriptor_name': 'Constitutive Androstane Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000072467', 'descriptor_name': 'Cytochrome P450 Family 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015971', 'descriptor_name': 'Gene Expression Regulation, Enzymologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018160', 'descriptor_name': 'Receptors, Cytoplasmic and Nuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013250', 'descriptor_name': 'Steroid Hydroxylases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013250', 'descriptor_name': 'Steroid Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015262', 'descriptor_name': 'Xenobiotics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cmet.2006.04.015', 'pdf_url': 'http://www.cell.com/article/S1550413106001550/pdf', 'source': {'id': 'https://openalex.org/S177533077', 'display_name': 'Cell Metabolism', 'issn_l': '1550-4131', 'issn': ['1550-4131', '1932-7420'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-00086900', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-00113073', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-00086900', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16814730', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.cmet.2006.04.015', 'pdf_url': 'http://www.cell.com/article/S1550413106001550/pdf', 'source': {'id': 'https://openalex.org/S177533077', 'display_name': 'Cell Metabolism', 'issn_l': '1550-4131', 'issn': ['1550-4131', '1932-7420'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.83, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1493541967', 'https://openalex.org/W1592070037', 'https://openalex.org/W1602656876', 'https://openalex.org/W1967904535', 'https://openalex.org/W1977055737', 'https://openalex.org/W1982056201', 'https://openalex.org/W1983773316', 'https://openalex.org/W1989481014', 'https://openalex.org/W1992633277', 'https://openalex.org/W2003302378', 'https://openalex.org/W2004117621', 'https://openalex.org/W2009415249', 'https://openalex.org/W2025397614', 'https://openalex.org/W2026383483', 'https://openalex.org/W2039336124', 'https://openalex.org/W2042763169', 'https://openalex.org/W2047821701', 'https://openalex.org/W205992603', 'https://openalex.org/W2061362984', 'https://openalex.org/W2071219983', 'https://openalex.org/W2074120747', 'https://openalex.org/W2075091287', 'https://openalex.org/W2083135851', 'https://openalex.org/W2084770232', 'https://openalex.org/W2085019221', 'https://openalex.org/W2098096628', 'https://openalex.org/W2098189120', 'https://openalex.org/W2100554725', 'https://openalex.org/W2115276406', 'https://openalex.org/W2119736042', 'https://openalex.org/W2120366984', 'https://openalex.org/W2133960000', 'https://openalex.org/W2135248587', 'https://openalex.org/W2141628779', 'https://openalex.org/W2146007051', 'https://openalex.org/W2149790761', 'https://openalex.org/W2154514232', 'https://openalex.org/W2159112194', 'https://openalex.org/W2161672948', 'https://openalex.org/W2162871532', 'https://openalex.org/W2163381213', 'https://openalex.org/W2171106895', 'https://openalex.org/W2317160372', 'https://openalex.org/W2576734941', 'https://openalex.org/W28955537'], 'related_works': ['https://openalex.org/W2461087582', 'https://openalex.org/W2432170829', 'https://openalex.org/W2267454943', 'https://openalex.org/W2108839301', 'https://openalex.org/W2058215940', 'https://openalex.org/W2057932317', 'https://openalex.org/W2051181331', 'https://openalex.org/W2015278341', 'https://openalex.org/W2010615752', 'https://openalex.org/W1977525264'], 'abstract_inverted_index': {'The': [0], 'PAR-domain': [1], 'basic': [2], 'leucine': [3], 'zipper': [4], '(PAR': [5], 'bZip)': [6], 'transcription': [7], 'factors': [8], 'DBP,': [9], 'TEF,': [10], 'and': [11, 25, 50, 71, 83, 110, 115, 124, 140], 'HLF': [12], 'accumulate': [13], 'in': [14, 19, 113, 143], 'a': [15], 'highly': [16], 'circadian': [17], 'manner': [18], 'several': [20], 'peripheral': [21], 'tissues,': [22], 'including': [23], 'liver': [24, 82], 'kidney.': [26], 'Mice': [27], 'devoid': [28], 'of': [29, 32, 56, 73, 86, 91, 107], 'all': [30], 'three': [31], 'these': [33, 87], 'proteins': [34, 103], 'are': [35, 42, 135], 'born': [36], 'at': [37, 46], 'expected': [38], 'Mendelian': [39], 'ratios,': [40], 'but': [41], 'epilepsy': [43], 'prone,': [44], 'age': [45], 'an': [47], 'accelerated': [48], 'rate,': [49], 'die': [51], 'prematurely.': [52], 'In': [53], 'the': [54, 68, 81, 105, 141], 'hope': [55], 'identifying': [57], 'PAR': [58, 74, 101, 130], 'bZip': [59, 75, 102, 131], 'target': [60], 'genes': [61], 'whose': [62], 'altered': [63], 'expression': [64, 106], 'might': [65], 'contribute': [66, 146], 'to': [67, 89, 137, 147], 'high': [69], 'morbidity': [70], 'mortality': [72], 'triple': [76, 132], 'knockout': [77, 133], 'mice,': [78], 'we': [79], 'compared': [80], 'kidney': [84], 'transcriptomes': [85], 'animals': [88], 'those': [90], 'wild-type': [92], 'or': [93], 'heterozygous': [94], 'mutant': [95], 'mice.': [96], 'These': [97], 'experiments': [98], 'revealed': [99], 'that': [100], 'control': [104], 'many': [108], 'enzymes': [109], 'regulators': [111], 'involved': [112], 'detoxification': [114, 144], 'drug': [116], 'metabolism,': [117], 'such': [118], 'as': [119], 'cytochrome': [120], 'P450': [121], 'enzymes,': [122], 'carboxylesterases,': [123], 'constitutive': [125], 'androstane': [126], 'receptor': [127], '(CAR).': [128], 'Indeed,': [129], 'mice': [134], 'hypersensitive': [136], 'xenobiotic': [138], 'compounds,': [139], 'deficiency': [142], 'may': [145], 'their': [148], 'early': [149], 'aging.': [150]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1976521197', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 18}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 38}, {'year': 2019, 'cited_by_count': 25}, {'year': 2018, 'cited_by_count': 22}, {'year': 2017, 'cited_by_count': 38}, {'year': 2016, 'cited_by_count': 28}, {'year': 2015, 'cited_by_count': 24}, {'year': 2014, 'cited_by_count': 35}, {'year': 2013, 'cited_by_count': 26}, {'year': 2012, 'cited_by_count': 29}], 'updated_date': '2024-09-09T02:18:23.102059', 'created_date': '2016-06-24'}