Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1976499539', 'doi': 'https://doi.org/10.1210/endo-125-6-2868', 'title': 'The Regulation of Lipogenesis by Thyroid Hormone and Its Contribution to Thermogenesis*', 'display_name': 'The Regulation of Lipogenesis by Thyroid Hormone and Its Contribution to Thermogenesis*', 'publication_year': 1989, 'publication_date': '1989-12-01', 'ids': {'openalex': 'https://openalex.org/W1976499539', 'doi': 'https://doi.org/10.1210/endo-125-6-2868', 'mag': '1976499539', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2583043'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1210/endo-125-6-2868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041263734', 'display_name': 'H.C. Freake', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'HEDLEY C. FREAKE', 'raw_affiliation_strings': ['Department of Medicine, University of Minnesota, Minneapolis 55455'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Minnesota, Minneapolis 55455', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108524201', 'display_name': 'Harold L. Schwartz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'HAROLD L. SCHWARTZ', 'raw_affiliation_strings': ['Division of Endocrinology and Metabolism, Department of Medicine, University of MinnesotaMinneapolis, Minnesota 55455'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology and Metabolism, Department of Medicine, University of MinnesotaMinneapolis, Minnesota 55455', 'institution_ids': ['https://openalex.org/I130238516']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111946284', 'display_name': 'Jack H. Oppenheimer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'JACK H. OPPENHEIMER', 'raw_affiliation_strings': ['Division of Endocrinology and Metabolism, Department of Medicine, University of MinnesotaMinneapolis, Minnesota 55455'], 'affiliations': [{'raw_affiliation_string': 'Division of Endocrinology and Metabolism, Department of Medicine, University of MinnesotaMinneapolis, Minnesota 55455', 'institution_ids': ['https://openalex.org/I130238516']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.45, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 66, 'citation_normalized_percentile': {'value': 0.973821, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '125', 'issue': '6', 'first_page': '2868', 'last_page': '2874'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disorders and Treatments', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disorders and Treatments', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 0.9777, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lipogenesis', 'display_name': 'Lipogenesis', 'score': 0.8364085}, {'id': 'https://openalex.org/keywords/fatty-acid-synthesis', 'display_name': 'Fatty acid synthesis', 'score': 0.56594026}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.89179647}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.87726194}, {'id': 'https://openalex.org/C141359234', 'wikidata': 'https://www.wikidata.org/wiki/Q2734301', 'display_name': 'Lipogenesis', 'level': 3, 'score': 0.8364085}, {'id': 'https://openalex.org/C2777195454', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Euthyroid', 'level': 3, 'score': 0.7799788}, {'id': 'https://openalex.org/C526584372', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid', 'level': 2, 'score': 0.7646133}, {'id': 'https://openalex.org/C151279926', 'wikidata': 'https://www.wikidata.org/wiki/Q965695', 'display_name': 'Thermogenesis', 'level': 3, 'score': 0.6967077}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.6137887}, {'id': 'https://openalex.org/C2776941171', 'wikidata': 'https://www.wikidata.org/wiki/Q900209', 'display_name': 'Fatty acid synthesis', 'level': 3, 'score': 0.56594026}, {'id': 'https://openalex.org/C2778288131', 'wikidata': 'https://www.wikidata.org/wiki/Q327362', 'display_name': 'Triiodothyronine', 'level': 3, 'score': 0.52554643}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.52233493}, {'id': 'https://openalex.org/C543025807', 'wikidata': 'https://www.wikidata.org/wiki/Q61476', 'display_name': 'Fatty acid', 'level': 2, 'score': 0.46397525}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3100157}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.26601171}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26468474}, {'id': 'https://openalex.org/C171089720', 'wikidata': 'https://www.wikidata.org/wiki/Q193583', 'display_name': 'Adipose tissue', 'level': 2, 'score': 0.17629224}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.087102056}], 'mesh': [{'descriptor_ui': 'D001833', 'descriptor_name': 'Body Temperature Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D014284', 'descriptor_name': 'Triiodothyronine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002940', 'descriptor_name': 'Circadian Rhythm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005227', 'descriptor_name': 'Fatty Acids', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D005227', 'descriptor_name': 'Fatty Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006980', 'descriptor_name': 'Hyperthyroidism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006980', 'descriptor_name': 'Hyperthyroidism', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010101', 'descriptor_name': 'Oxygen Consumption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014284', 'descriptor_name': 'Triiodothyronine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1210/endo-125-6-2868', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2583043', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.73}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2416283038', 'https://openalex.org/W2168238417', 'https://openalex.org/W2119095302', 'https://openalex.org/W2084374361', 'https://openalex.org/W2033265097', 'https://openalex.org/W2014423219', 'https://openalex.org/W1970871311', 'https://openalex.org/W1968681980', 'https://openalex.org/W1907936648', 'https://openalex.org/W1491946786'], 'abstract_inverted_index': {'We': [0], 'have': [1], 'used': [2], 'the': [3, 9, 17, 22, 60, 84, 88, 91, 98, 104, 128, 158, 161, 175, 218, 249], 'tritiated': [4], 'water': [5], 'method': [6], 'to': [7, 27, 35, 111, 124, 204, 232, 248], 'quantitate': [8], 'effects': [10], 'of': [11, 24, 46, 62, 90, 106, 147, 160, 174, 184, 197, 217, 243], 'thyroid': [12, 28, 32, 81, 152, 213], 'hormone': [13, 33, 153], 'on': [14, 235], 'lipogenesis': [15], 'in': [16, 65, 71, 79, 87, 103, 116, 120, 131, 142, 157, 169, 180, 190, 211, 221], 'rat': [18], 'and': [19, 49, 202, 226], 'then': [20], 'determined': [21], 'contribution': [23, 173], 'this': [25, 198, 244], 'process': [26], 'hormone-induced': [29], 'thermogenesis.': [30], 'After': [31], 'administration': [34], 'hypothyroid': [36, 132, 170, 191, 227], 'animals,': [37], 'fatty': [38, 148, 186], 'acid': [39, 101, 149, 187], 'synthesis': [40, 102, 150, 199], 'rose': [41], 'after': [42, 53], 'a': [43, 51], 'lag': [44], 'time': [45], '12-16': [47], 'h': [48], 'reached': [50], 'plateau': [52], '4-5': [54], 'days.': [55], 'This': [56], 'is': [57], 'consistent': [58], 'with': [59, 83, 163], 'kinetics': [61], 'an': [63], 'increase': [64], 'oxygen': [66, 209, 222], 'consumption': [67, 210, 223], 'measured': [68, 141, 156], 'by': [69, 151], 'others': [70], 'similar': [72, 137], 'animals.': [73, 171], 'A': [74, 145], 'diurnal': [75], 'variation': [76], 'was': [77, 109, 122, 154, 177, 246], 'maintained': [78], 'all': [80], 'states,': [82], 'peak': [85], 'value': [86], 'middle': [89], 'dark': [92], 'period': [93], 'being': [94, 166], '3-fold': [95], 'higher': [96, 113, 126], 'than': [97, 114, 127, 189], 'nadir.': [99], 'Fatty': [100], 'livers': [105], 'hyperthyroid': [107, 164, 181, 225], 'animals': [108, 192, 228], '3-': [110, 123], '4-fold': [112], 'that': [115], 'euthyroid': [117], 'rats,': [118], 'which,': [119], 'turn,': [121], '5-fold': [125], 'rate': [129], 'observed': [130], 'rats.': [133], 'Slightly': [134], 'smaller': [135], 'but': [136], 'fold': [138], 'increases': [139], 'were': [140, 200, 239], 'epididymal': [143], 'fat.': [144], 'stimulation': [146], 'also': [155], 'rest': [159], 'carcass,': [162], 'rates': [165], 'twice': [167], 'those': [168], 'The': [172, 194], 'liver': [176, 250], 'much': [178], 'greater': [179], 'rats': [182], '(34%': [183], 'total': [185, 208, 219], 'synthesis)': [188], '(5%).': [193], 'energy': [195], 'costs': [196], 'calculated': [201], 'compared': [203], 'published': [205, 237], 'values': [206], 'for': [207], 'different': [212], 'states.': [214], 'Thus,': [215], '6-10%': [216], 'increment': [220, 245], 'between': [224], 'could': [229], 'be': [230], 'attributed': [231], 'lipogenesis,': [233], 'depending': [234], 'which': [236], 'figures': [238], 'used.': [240], 'About': [241], '3%': [242], 'due': [247], 'alone.': [251]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1976499539', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-08T20:13:41.952818', 'created_date': '2016-06-24'}