Publication Information

{'id': 'https://openalex.org/W1976210792', 'doi': 'https://doi.org/10.1096/fj.14-255646', 'title': 'Pathological mutations H187R and E196K facilitate subdomain separation and prion protein conversion by destabilization of the native structure', 'display_name': 'Pathological mutations H187R and E196K facilitate subdomain separation and prion protein conversion by destabilization of the native structure', 'publication_year': 2014, 'publication_date': '2014-11-21', 'ids': {'openalex': 'https://openalex.org/W1976210792', 'doi': 'https://doi.org/10.1096/fj.14-255646', 'mag': '1976210792', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25416551'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fj.14-255646', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 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2511, 2525, 2561, 2574, 2601, 2634, 2684, 2691, 2735, 2773, 2789, 2808, 2818], 'E196K': [16, 483, 639], 'facilitate': [17, 640], 'subdomain': [18, 548, 603, 641, 804], 'separation': [19, 604, 642], 'prion': [21, 430, 438, 625, 644, 687, 741, 774, 806, 839, 885, 896, 929, 988, 1037, 1068, 1107, 1113, 1137, 1147, 1173, 1335, 1341, 1407, 1457, 1480, 1508, 1524, 1595, 1637, 1668, 1729, 1762, 1840, 1904, 1926, 1954, 1993, 2042, 2117, 2126, 2270, 2366, 2395, 2420, 2537, 2747, 2750, 2783, 2816], 'protein': [22, 431, 525, 575, 645, 775, 807, 840, 886, 897, 930, 989, 1038, 1069, 1108, 1138, 1245, 1336, 1342, 1408, 1525, 1669, 1685, 1730, 1763, 1841, 1905, 1955, 1994, 2043, 2084, 2271, 2421, 2572, 2646, 2748, 2784], 'conversion': [23, 471, 558, 646, 811, 1338, 1573, 1725, 2393], 'by': [24, 73, 101, 125, 168, 214, 242, 266, 309, 519, 647, 891, 939, 1071, 1565, 1603, 1839, 1956, 2155, 2644, 2780, 2874], 'destabilization': [25, 506, 648], 'of': [26, 35, 39, 56, 66, 80, 84, 108, 112, 118, 136, 140, 146, 151, 155, 176, 180, 197, 207, 221, 225, 249, 253, 259, 277, 281, 287, 292, 296, 332, 342, 381, 391, 404, 415, 429, 448, 507, 513, 541, 586, 591, 593, 609, 621, 649, 691, 738, 768, 772, 798, 805, 836, 883, 1036, 1098, 1134, 1141, 1252, 1332, 1339, 1397, 1404, 1453, 1478, 1503, 1507, 1559, 1563, 1572, 1574, 1636, 1644, 1661, 1726, 1737, 1800, 1806, 1846, 1900, 1921, 1933, 1953, 1961, 1963, 1992, 2039, 2049, 2109, 2123, 2149, 2193, 2196, 2231, 2294, 2334, 2357, 2364, 2390, 2394, 2417, 2443, 2464, 2472, 2479, 2505, 2535, 2567, 2612, 2640, 2742, 2746, 2791, 2869], 'the': [27, 359, 397, 407, 434, 451, 501, 505, 511, 539, 547, 574, 584, 610, 619, 650, 739, 773, 802, 833, 837, 884, 1042, 1106, 1135, 1177, 1249, 1333, 1344, 1405, 1450, 1483, 1560, 1570, 1577, 1628, 1633, 1642, 1664, 1767, 1844, 1924, 1930, 1949, 2036, 2040, 2046, 2050, 2120, 2124, 2150, 2232, 2291, 2361, 2383, 2387, 2391, 2418, 2469, 2533, 2698, 2743, 2865, 2875, 2887, 2891], 'native': [28, 587, 611, 651, 1768], 'structure': [29, 588, 612, 737, 767, 1295, 1401, 2416], 'San': [30, 32, 171, 173], 'Hadži,': [31, 172], 'Hadži': [33, 174], 'Department': [34, 55, 79, 107, 135, 150, 175, 196, 220, 248, 276, 291, 331], 'Biotechnology,': [36, 81, 109, 137, 152, 177, 222, 250, 278, 293], 'National': [37, 82, 110, 138, 153, 178, 223, 251, 279, 294], 'Institute': [38, 83, 111, 139, 154, 179, 224, 252, 280, 295], 'Chemistry,': [40, 58, 85, 113, 141, 156, 181, 199, 226, 254, 282, 297, 334], 'Ljubljana,': [41, 67, 68, 86, 114, 120, 142, 148, 160, 182, 208, 209, 227, 255, 261, 283, 289, 301, 343, 344], 'Slovenia': [42, 87, 115, 143, 183, 228, 256, 284], 'Current': [43, 53, 88, 184, 194, 229, 319, 329], 'affiliation:': [44, 54, 89, 185, 195, 230, 320, 330], 'Structural': [45, 186, 321, 2033], 'Biology': [46, 187, 322], 'Brussels,': [47, 51, 188, 192, 323, 327], 'Vrije': [48, 189, 324], 'Universiteit': [49, 190, 325], 'Brussel,': [50, 191, 326], 'Belgium.': [52, 193, 328], 'Physical': [57, 198, 333], 'Faculty': [59, 200, 335], 'for': [60, 70, 98, 122, 165, 201, 211, 239, 263, 306, 336, 618, 624, 990, 1476, 1641, 2152, 2235, 2864, 2890], 'Chemistry': [61, 202, 337], 'Chemical': [63, 204, 339], 'Technology,': [64, 205, 340], 'University': [65, 206, 341], 'Slovenia.Search': [69, 210], 'more': [71, 99, 123, 166, 212, 240, 264, 307, 523], 'papers': [72, 100, 124, 167, 213, 241, 265, 308], 'this': [74, 102, 126, 169, 215, 243, 267, 310, 356, 416, 563], 'authorAndrej': [75, 216], 'Ondračka,': [76, 217, 628], 'Andrej': [77, 218], 'Ondračka': [78, 219], 'Rockefeller': [91, 232], 'University,': [92, 233], 'New': [93, 95, 234, 236], 'York,': [94, 96, 235, 237], 'USA.Search': [97, 238], 'authorRoman': [103, 244], 'Jerala,': [104, 245, 630, 794, 878, 1622, 1657, 1758, 1829, 1873, 2377], 'Roman': [105, 246], 'Jerala': [106, 247], 'EN-FIST': [116, 144, 257, 285], 'Centre': [117, 145, 258, 286], 'Excellence,': [119, 147, 260, 288], 'SloveniaSearch': [121, 262], 'authorIva': [127, 268], 'Hafner-Bratkovič,': [128, 269, 633, 1654], 'Corresponding': [129, 270], 'Author': [130, 271], 'Iva': [131, 272], 'Hafner-Bratkovič': [132, 273], '[email': [133, 163, 274, 304], 'protected]': [134, 275], 'SloveniaCorrespondence:': [149, 290], 'Hajdrihova': [157, 298], '19,': [158, 299, 2161], 'SI-1000': [159, 300], 'Slovenia.': [161, 302, 345], 'E-mail:': [162, 303], 'protected]Search': [164, 305], 'author': [170, 311, 2889], 'First': [312], 'published:': [313], '21': [314], 'November': [315], '2014': [316], 'https://doi.org/10.1096/fj.14-255646Citations:': [317], '13': [318], 'This': [346], 'article': [347, 417], 'includes': [348], 'supplemental': [349], 'data.': [350], 'Please': [351, 2857], 'visit': [352], 'http://www.fasebj.org': [353], 'obtain': [355], 'information.': [357], 'full': [360, 371], 'textAboutPDF': [361], 'ToolsRequest': [362], 'permissionExport': [363], 'citationAdd': [364], 'favoritesTrack': [366], 'citation': [367], 'ShareShare': [368], 'Give': [369], 'accessShare': [370, 373], 'text': [372], 'full-text': [374, 389, 413], 'accessPlease': [375], 'review': [376], 'our': [377], 'Terms': [378, 401], 'Conditions': [380, 403], 'Use': [382], 'check': [384], 'box': [385], 'below': [386, 409], 'share': [388, 411], 'version': [390, 414], 'article.I': [392], 'have': [393], 'read': [394], 'accept': [396], 'Wiley': [398], 'Online': [399], 'Library': [400], 'UseShareable': [405], 'LinkUse': [406], 'link': [408], 'a': [412, 542, 553, 580, 615, 769, 1182, 1223, 1257, 1454, 1897, 2156, 2330, 2689], 'with': [418, 532, 1115, 1176, 1226, 1288, 1379, 1449, 1734, 2508], 'your': [419], 'friends': [420], 'colleagues.': [422], 'Learn': [423], 'more.Copy': [424], 'URL': [425], 'Abstract': [426], 'mechanism': [428, 1640], '(PrP)': [432], 'conversion,': [433], 'key': [435], 'event': [436], 'in': [437, 801, 812, 815, 832, 928, 987, 1067, 1105, 1111, 1256, 1382, 1482, 1528, 1531, 1598, 1808, 1835, 2089, 2290, 2325, 2440, 2532, 2571, 2608, 2752], 'diseases,': [439], 'is': [440, 565, 571, 1526, 2861], 'still': [441], 'not': [442, 566, 1534, 2862], 'understood.': [443], 'We': [444, 476, 578], 'investigated': [445], 'how': [446], 'perturbations': [447], 'interactions': [449, 2439], 'between': [450, 583, 1766, 2284], 'subdomains': [452], 'β1-α1-β2': [453], 'α2-α3': [455], 'affect': [456], 'PrP': [457, 470, 485, 508, 594, 1228, 1564, 1575], 'conversion.': [458, 898, 992, 1509, 1670], 'In': [459, 1723], 'vitro': [460, 813, 1724, 2326], 'fibrillization': [461, 592], 'biophysical': [463], 'methods': [464], 'were': [465], 'used': [466], 'relate': [468], 'mouse': [469, 2419], 'kinetics': [472, 590], 'thermodynamic': [474, 2121, 2477], 'stability.': [475, 1686], 'show': [477, 537, 598, 1293], 'that': [478, 538, 556, 599, 607, 2696], 'pathologic': [479, 600], 'destabilize': [484], '(by': [486, 526], '3.2': [487], '1.1': [489], 'kJ/mol,': [490], 'respectively,': [491], 'at': [492, 529, 573, 1041, 2616], 'pH': [493, 530, 1398, 1922], '7)': [494], 'accelerate': [496], 'fibrillization.': [497, 534], 'At': [498], 'acidic': [499], 'pH,': [500], 'major': [502], 'contribution': [503], 'comes': [509], 'from': [510, 934, 1033, 1803, 1999, 2336], 'protonation': [512, 1962], 'histidine': [514, 544, 560, 1964], '187': [515], 'because': [516], 'its': [517, 2820], 'replacement': [518], 'tyrosine': [520], 'led': [521], 'stable': [524], '4.2': [527, 2853], 'kJ/mol': [528], '4)': [531], 'slower': [533], 'Furthermore,': [535], 'we': [536], 'introduction': [540], 'novel': [543, 622, 1100, 1178], 'residue': [545, 570], 'into': [546, 1663, 1929], 'interface': [549], '(F198H)': [550], 'acts': [551], 'as': [552, 937, 1843, 2386], 'pH-inducible': [554], 'switch': [555], 'promotes': [557, 1667], 'upon': [559], 'protonation,': [561], 'whereas': [562], 'effect': [564, 1960, 2356], 'observed': [567, 579, 2615], 'when': [568], 'His': [569], 'introduced': [572], 'surface': [576], '(Y155H).': [577], 'strong': [581], 'correlation': [582, 2283], 'stability': [585, 809, 1403, 1701, 2122, 2502, 2817], 'variants.': [595, 2272], 'Our': [596], 'results': [597, 933], 'promote': [602, 842], 'suggest': [606], 'stabilization': [608, 2741], 'might': [613], 'be': [614, 889, 2884], 'viable': [616], 'strategy': [617], 'development': [620], 'therapeutics': [623], 'diseases.—Hadži,': [626], 'S.,': [627, 754, 976, 1018, 1200, 1309, 1323, 1425, 1434, 1517, 1714, 1786, 1788, 1876, 2103, 2404, 2558, 2657, 2725, 2770], 'A.,': [629, 681, 714, 788, 874, 1003, 1008, 1198, 1274, 1315, 1353, 1356, 1422, 1469, 1495, 1825, 1880, 2027, 2168, 2214, 2217, 2495, 2550, 2556, 2581, 2666, 2680], 'R.,': [631, 712, 718, 752, 756, 856, 1015, 1312, 1370, 1428, 1440, 1467, 1586, 1861, 1874, 1943, 2076, 2176, 2402, 2410, 2492, 2586, 2677], 'I.,': [634, 784, 792, 854, 876, 1054, 1613, 1655, 1748, 1756, 1820, 1872, 2375, 2723], 'structure.': [652], 'J.': [654, 847, 899, 1002, 1012, 1020, 1094, 1149, 1230, 1284, 1317, 1411, 1421, 1459, 1486, 1540, 1580, 1647, 1697, 1739, 1773, 1936, 1967, 2005, 2160, 2175, 2203, 2273, 2300, 2368, 2431, 2494, 2499, 2516, 2539, 2585, 2619, 2636, 2665, 2682, 2712, 2775, 2794, 2810, 2823], '882–893': [656], '(2015).': [657], 'www.fasebj.org': [658], 'REFERENCES': [659], '1Chiti,': [660], 'F.,': [661, 724, 906, 1085, 1431, 1515, 2133, 2171, 2252, 2592], 'Dobson,': [663, 1789, 2143, 2188, 2221, 2602], 'C.': [664, 1156, 1202, 1311, 1358, 1500, 1679, 1790, 2144, 2189, 2222, 2488, 2603, 2654], 'M.': [665, 684, 824, 1306, 1314, 1355, 1436, 1443, 1794, 1886, 1914, 2021, 2030, 2075, 2145, 2170, 2180, 2190, 2226, 2280, 2456, 2591, 2604, 2766, 2769], '(2006)': [666, 1221, 1987], 'Protein': [667, 1700, 2340], 'misfolding,': [668], 'functional': [669], 'amyloid,': [670], 'human': [672, 740, 838, 1146, 1334, 1406, 1925, 2041, 2116, 2365, 2536, 2613], 'disease.': [673], 'Annu.': [674], 'Rev.': [675], 'Biochem.': [676, 778, 1671], '75,': [677], '333–': [678], '366': [679, 2579], '2Aguzzi,': [680], 'Polymenidou,': [683, 869, 2018], '(2004)': [685, 1242, 1947, 2354], 'Mammalian': [686], 'biology:': [688], 'one': [689], 'century': [690], 'evolving': [692], 'concepts.': [693], 'Cell': [694, 2754], '116,': [695], '313–': [696], '327': [697], '3Prusiner,': [698], 'S.': [699, 983, 1028, 1216, 1269, 1276, 1433, 1472, 2072, 2451, 2588], 'B.': [700, 1473, 2498], '(1998)': [701], 'Prions.': [702], 'Proc.': [703, 743, 945, 993, 1811, 2094, 2701], 'Natl.': [704, 744, 946, 994, 1812, 2095, 2702], 'Acad.': [705, 745, 947, 995, 1813, 2096, 2703], 'Sci.': [706, 746, 779, 948, 996, 1814, 1854, 2097, 2341, 2704], 'USA': [707, 747, 949, 997, 1815, 2098, 2705], '95,': [708], '13363–': [709], '13383': [710], '4Zahn,': [711], 'Liu,': [713], 'Lührs,': [715], 'T.,': [716, 908, 958, 1363, 2589, 2633, 2671], 'Riek,': [717, 755], 'von': [719, 1587], 'Schroetter,': [720, 1588], 'C.,': [721, 872, 1021, 1124, 1419, 1589, 1865, 2316, 2347, 2524, 2663, 2761, 2803], 'López': [722], 'García,': [723], 'Billeter,': [725, 759, 2407], 'M.,': [726, 760, 866, 868, 870, 913, 972, 1005, 1157, 1166, 1190, 1203, 1359, 1618, 1620, 1653, 1750, 1754, 1791, 1822, 1859, 1863, 1882, 1972, 2017, 2019, 2137, 2178, 2223, 2408, 2560, 2594, 2598, 2659, 2727], 'Calzolai,': [727], 'L.,': [728, 786, 860, 1161, 1196, 1205, 1304, 1391, 1711, 1784, 1979, 2064, 2310, 2630, 2661, 2674, 2713, 2719], 'Wider,': [729, 757, 2405], 'G.,': [730, 758, 920, 1010, 1052, 1056, 1087, 1210, 1217, 1272, 1884, 2062, 2141, 2406], 'Wüthrich,': [732, 762, 1591, 2412], 'K': [733], '(2000)': [734, 1096, 1171, 2146], 'NMR': [735, 766, 1072, 1400, 2415], 'solution': [736], 'protein.': [742, 1458, 2127, 2158, 2367, 2396, 2538], '97,': [748], '145–': [749], '150': [750], '5Glockshuber,': [751], 'Hornemann,': [753, 1875, 2403], 'K.': [763, 1163, 1424, 1592, 1824, 2353, 2413, 2528, 2738], '(1997)': [764, 1593], 'Three-dimensional': [765], 'self-folding': [770], 'domain': [771, 882, 892, 935, 2038, 2384, 2422, 2745], 'PrP(121-231).': [776, 2423], 'Trends': [777, 1687], '22,': [780], '241–': [781], '242': [782], '6Hafner-Bratkovič,': [783], 'Gaedtke,': [785, 859], 'Ondracka,': [787], 'Veranič,': [789], 'P.,': [790, 858, 862, 916, 1081, 1083, 1159, 1318, 1368, 1752, 1779, 2139, 2184, 2220, 2256, 2258, 2546, 2548, 2552, 2554, 2627, 2734, 2764, 2767], 'Vorberg,': [791, 875, 1755], 'R.': [795, 879, 1327, 1394, 1439, 1554, 1623, 1658, 1759, 1830, 2106, 2378, 2629, 2673, 2686], '(2011)': [796, 880, 1659, 2191, 2379, 2777], 'Effect': [797], 'hydrophobic': [799, 834], 'H2-H3': [803], 'on': [808, 1399, 1923, 2035, 2119, 2360, 2468], 'vivo.': [816, 2753], 'PLoS': [817, 1510, 1907], 'One': [818, 1908], '6,': [819], 'e24238': [820], '7Van': [821], 'der': [822, 918, 1912], 'Kamp,': [823, 1913], 'W.,': [825, 1207, 1781, 1915, 2683, 2729], 'Daggett,': [827, 1917], 'V.': [828, 1427, 1430, 1716, 1721, 1918, 1946, 1981, 1986, 2312, 2320], '(2010)': [829, 1029, 1130, 1328, 1760, 1919, 2605], 'Pathogenic': [830], 'core': [835], 'can': [841], 'structural': [843, 2392], 'instability': [844], 'misfolding.': [846, 1934], 'Mol.': [848, 1150, 1262, 1740, 1852, 2006, 2274, 2301], 'Biol.': [849, 900, 1151, 1412, 1460, 1487, 1741, 2007, 2056, 2275, 2302, 2369, 2517, 2540], '404,': [850], '732–': [851], '748': [852], '8Hafner-Bratkovic,': [853], 'Bester,': [855], 'Pristovsek,': [857], 'Veranic,': [861, 1751], 'Gaspersic,': [863, 1614], 'J.,': [864, 922, 963, 978, 1025, 1058, 1193, 1320, 1549, 1615, 1694, 1746, 2260, 2668], 'Mancek-Keber,': [865], 'Avbelj,': [867], 'Julius,': [871], 'Aguzzi,': [873, 1891, 2026], 'Globular': [881], 'needs': [887], 'unlocked': [890], 'swapping': [893, 2385], 'support': [895], 'Chem.': [901, 1413, 1461, 1488, 2205, 2240, 2370, 2518, 2541, 2621, 2796], '286,': [902], '12149–': [903], '12156': [904], '9Eghiaian,': [905], 'Daubenfeld,': [907], 'Quenet,': [909], 'Y.,': [910, 974, 980, 1164, 1238, 2250, 2454, 2772, 2805], 'van': [911, 917], 'Audenhaege,': [912], 'Bouin,': [914], 'A.': [915, 1326, 1418, 1444, 1698, 1713, 1892, 2165, 2211, 2315, 2346, 2436, 2461, 2474, 2523], 'Rest,': [919], 'Grosclaude,': [921, 2259], 'Rezaei,': [924], 'H.': [925, 967, 1129, 1283, 2435, 2460], '(2007)': [926, 984, 1796, 2281], 'Diversity': [927], 'oligomerization': [931], 'pathways': [932], 'expansion': [936], 'revealed': [938], 'hydrogen/deuterium': [940], 'exchange': [941], 'disulfide': [943, 2514], 'linkage.': [944], '104,': [950, 998, 1649, 1816], '7414–': [951], '7419': [952], '10Kuwata,': [953], 'K.,': [954, 965, 968, 970, 1079, 1126, 1878, 2013, 2166, 2212, 2349, 2721], 'Nishida,': [955], 'N.,': [956, 1091, 1887, 1889, 1977, 2025, 2135, 2173, 2432, 2489, 2583], 'Matsumoto,': [957], 'Kamatari,': [959], 'Y.': [960, 1867], 'O.,': [961, 2066], 'Hosokawa-Muto,': [962], 'Kodama,': [964], 'Nakamura,': [966], 'Kimura,': [969], 'Kawasaki,': [971], 'Takakura,': [973], 'Shirabe,': [975], 'Takata,': [977], 'Kataoka,': [979], 'Katamine,': [982], 'Hot': [985], 'spots': [986], 'pathogenic': [991, 1289], '11921–': [999], '11926': [1000], '11Beck,': [1001], 'Poulter,': [1004], 'Campbell,': [1006], 'T.': [1007, 1373, 1778, 2183, 2219, 2263, 2676, 2760, 2802], 'Adamson,': [1009], 'Uphill,': [1011], 'B.,': [1013, 1214, 1277, 1546, 1870, 2015, 2068, 2073, 2078, 2715, 2807], 'Guerreiro,': [1014], 'Jackson,': [1016, 1321], 'G.': [1017, 1061, 1170, 1322, 1365, 1548, 1783, 2491], 'Stevens,': [1019], 'Manji,': [1022], 'H.,': [1023, 1270, 1307, 2022, 2248, 2452], 'Collinge,': [1024, 1319], 'Mead,': [1027], 'PRNP': [1030, 1179, 1375], 'allelic': [1031], 'series': [1032], '19': [1034], 'years': [1035], 'gene': [1039, 1109], 'sequencing': [1040], 'MRC': [1043], 'Prion': [1044, 1286, 2083, 2397], 'Unit.': [1045], 'Hum.': [1046, 1119], 'Mutat.': [1047, 1120], '31,': [1048], 'E1551–': [1049], 'E1563': [1050], '12Giachin,': [1051], 'Biljan,': [1053], 'Ilc,': [1055], 'Plavec,': [1057], 'Legname,': [1060, 1271], '(2013)': [1062, 2739], 'Probing': [1063], 'early': [1064, 1931], 'misfolding': [1065, 2647], 'events': [1066], 'mutants': [1070, 1143], 'spectroscopy.': [1073], 'Molecules': [1074], '18,': [1075], '9451–': [1076], '9476': [1077], "13Peoc'h,": [1078], 'Manivet,': [1080], 'Beaudry,': [1082], 'Attane,': [1084], 'Besson,': [1086], 'Hannequin,': [1088], 'D.,': [1089, 1366, 1551, 1827, 2070, 2429, 2596, 2732], 'Delasnerie-Lauprêtre,': [1090], 'Laplanche,': [1093], 'L.': [1095, 1169, 1209, 1303, 1617, 2563, 2776, 2811], 'Identification': [1097, 1502], 'three': [1099], '(E196K,': [1102], 'V203I,': [1103], 'E211Q)': [1104], '(PRNP)': [1110], 'inherited': [1112, 2115], 'diseases': [1114, 2118], 'Creutzfeldt-Jakob': [1116, 2338], 'disease': [1117, 2643], 'phenotype.': [1118], '15,': [1121], '482': [1122], '14Gerum,': [1123], 'Schlepckow,': [1125], 'Schwalbe,': [1128], 'unfolded': [1132], 'state': [1133, 2570, 2611], 'murine': [1136, 2781], 'properties': [1140, 1736], 'single-point': [1142], 'related': [1144, 2113], 'diseases.': [1148], '401,': [1152], '7–': [1153], '12': [1154], '15Bütefisch,': [1155], 'Gambetti,': [1158, 1219, 2733], 'Cervenakova,': [1160, 1204], 'Park,': [1162], 'Hallett,': [1165], 'Goldfarb,': [1168, 1208], 'Inherited': [1172], 'encephalopathy': [1174], 'associated': [1175, 1378], 'mutation:': [1181], 'clinical': [1183], 'study.': [1184], 'Neurology': [1185, 1386], '55,': [1186], '517–': [1187], '522': [1188], '16Colucci,': [1189], 'Moleres,': [1191], 'F.': [1192, 2081, 2731], 'Xie,': [1194], 'Z.': [1195], 'Ray-Chaudhury,': [1197], 'Gutti,': [1199], 'Butefisch,': [1201], 'Wang,': [1206, 2660], 'Kong,': [1211], 'Q.,': [1212, 2710], 'Ghetti,': [1213, 2077], 'Chen,': [1215], 'P.': [1220, 1279, 2012], 'Gerstmann-Sträussler-Scheinker:': [1222], 'new': [1224, 1639], 'phenotype': [1225, 1251], "'curly'": [1227], 'deposits.': [1229], 'Neuropathol.': [1231], 'Exp.': [1232], 'Neurol.': [1233], '65,': [1234, 1582], '642–': [1235], '651': [1236], '17Gu,': [1237], 'Singh,': [1240], 'N.': [1241, 1680, 2024, 2031], 'Doxycycline': [1243], 'folding': [1246, 2362, 2470, 2534, 2573], 'agents': [1247], 'rescue': [1248], 'abnormal': [1250], 'familial': [1253], 'CJD': [1254], 'cell': [1258, 1537, 1837], 'model.': [1259], 'Brain': [1260, 1263], 'Res.': [1261, 1264, 1673], '123,': [1265], '37–': [1266], '44': [1267], '18Bae,': [1268], 'Serban,': [1273, 2069], 'Prusiner,': [1275, 1471, 2071], 'Wright,': [1278], 'E.,': [1280, 1361, 1941, 2181, 2254, 2457, 2655], 'Dyson,': [1282], '(2009)': [1285, 1501], 'proteins': [1287, 1481, 1596], 'protective': [1291], 'similar': [1294, 2328], 'dynamics.': [1297], 'Biochemistry': [1298, 1347, 2128, 2483], '48,': [1299], '8120–': [1300], '8128': [1301], '19Hosszu,': [1302], 'Tattum,': [1305], 'Jones,': [1308], 'Trevitt,': [1310], 'Wells,': [1313], 'Waltho,': [1316], 'Clarke,': [1325], 'mutation': [1331, 1377], 'induces': [1337], 'recombinant': [1340, 2782], 'PrP(Sc)-like': [1345], 'form.': [1346], '49,': [1348], '8729–': [1349], '8738': [1350], '20Hall,': [1351], 'D.': [1352, 1466, 2216, 2763], 'Leehey,': [1354], 'Filley,': [1357], 'Steinbart,': [1360], 'Montine,': [1362], 'Schellenberg,': [1364], 'Bosque,': [1367], 'Nixon,': [1369], 'Bird,': [1372], '(2005)': [1374, 1521, 1722, 2321], 'neuropsychiatric': [1380], 'disorders': [1381], 'childhood': [1383], 'dementia.': [1385], '64,': [1387], '1304–': [1388], '1306': [1389], '21Calzolai,': [1390], 'Zahn,': [1393], '(2003)': [1395, 2638], 'Influence': [1396, 1920, 2108, 2463], 'globular': [1409, 2157], 'domain.': [1410], '278,': [1414], '35592–': [1415], '35596': [1416], '22Magalhães,': [1417], 'Silva,': [1420, 2774, 2809], 'Lee,': [1423], 'Martins,': [1426], 'Prado,': [1429, 1442], 'Ferguson,': [1432], 'Gomez,': [1435], 'V.,': [1437, 1497, 1709, 1717, 1975, 1982, 2308, 2313], 'Brentani,': [1438], '(2002)': [1445, 2264, 2529], 'Endocytic': [1446], 'intermediates': [1447, 2267], 'involved': [1448], 'intracellular': [1451, 1505], 'trafficking': [1452], 'fluorescent': [1455], 'cellular': [1456, 2125], '277,': [1462, 1774, 2542], '33311–': [1463], '33318': [1464], '23Borchelt,': [1465], 'Taraboulos,': [1468], '(1992)': [1474, 2082], 'Evidence': [1475], 'synthesis': [1477], 'scrapie': [1479, 1523], 'endocytic': [1484], 'pathway.': [1485], '267,': [1489], '16188–': [1490], '16199': [1491], '24Marijanovic,': [1492], 'Z.,': [1493, 1868], 'Caputo,': [1494], 'Campana,': [1496], 'Zurzolo,': [1499], 'an': [1504, 1997, 2465, 2568, 2609], 'site': [1506, 1571], 'Pathog.': [1511], '5,': [1512, 2398], 'e1000426': [1513], '25Pimpinelli,': [1514], 'Lehmann,': [1516], 'Maridonneau-Parini,': [1519], 'I.': [1520, 1720, 1985, 2319, 2679], 'present': [1527], 'flotillin-1-positive': [1529], 'vesicles': [1530], 'central-': [1532], 'but': [1533], 'peripheral-derived': [1535], 'neuronal': [1536, 1849], 'lines.': [1538], 'Eur.': [1539], 'Neurosci.': [1541], '21,': [1542], '2063–': [1543], '2072': [1544], '26Caughey,': [1545], 'Raymond,': [1547], 'Ernst,': [1550], 'Race,': [1553], 'E.': [1555, 1795, 2227, 2564, 2632, 2670], '(1991)': [1556], 'N-terminal': [1557], 'truncation': [1558], 'scrapie-associated': [1561], 'form': [1562, 1635, 1733], 'lysosomal': [1566], 'protease(s):': [1567], 'implications': [1568], 'regarding': [1569], 'protease-resistant': [1578], 'state.': [1579], 'Virol.': [1581], '6597–': [1583], '6603': [1584], '27Zahn,': [1585], 'Human': [1594], 'expressed': [1597], 'Escherichia': [1599], 'coli': [1600], 'purified': [1602], 'high-affinity': [1604], 'column': [1605], 'refolding.': [1606], 'FEBS': [1607, 1772], 'Lett.': [1608], '417,': [1609], '400–': [1610], '404': [1611], '28Hafner-Bratkovic,': [1612], 'Smid,': [1616], 'Bresjanac,': [1619], '(2008)': [1624, 1893], 'Curcumin': [1625], 'binds': [1626], 'alpha-helical': [1629], 'intermediate': [1630, 2531, 2569], 'amyloid': [1634, 1732, 1801, 1995, 2087, 2153, 2200, 2236, 2642, 2699], 'protein—a': [1638], 'inhibition': [1643], 'PrP(Sc)': [1645], 'accumulation.': [1646], 'Neurochem.': [1648], '1553–': [1650], '1564': [1651], '29Avbelj,': [1652], 'Introduction': [1660], 'glutamines': [1662], 'B2-H2': [1665], 'loop': [1666], 'Biophys.': [1672, 1935, 1966], 'Commun.': [1674], '413,': [1675], '521–': [1676], '526': [1677], '30Pace,': [1678], '(1990)': [1681], 'Measuring': [1682], 'increasing': [1684], 'Biotechnol.': [1688], '8,': [1689], '93–': [1690], '98': [1691], '31Becktel,': [1692], 'W.': [1693, 2352, 2527, 2637, 2737], 'Schellman,': [1696], '(1987)': [1699], 'curves.': [1702], 'Biopolymers': [1703, 2446], '26,': [1704], '1859–': [1705], '1877': [1706], '32Bocharova,': [1707], 'O.': [1708, 1974, 2307], 'Breydo,': [1710, 1978, 2309], 'Parfenov,': [1712], 'Salnikov,': [1715, 1980, 2311], 'Baskakov,': [1719, 1984, 2318], 'full-length': [1727], 'mammalian': [1728], 'produces': [1731], 'physical': [1735], 'PrP(Sc).': [1738], '346,': [1742], '645–': [1743], '659': [1744], '33Gaspersic,': [1745], 'Hafner-Bratkovic,': [1747, 1871], 'Stephan,': [1749], 'Bencina,': [1753], 'Tetracysteine-tagged': [1761], 'allows': [1764], 'discrimination': [1765], 'converted': [1770], 'forms.': [1771], '2038–': [1775], '2050': [1776], '34Knowles,': [1777], 'Shu,': [1780], 'Devlin,': [1782], 'Meehan,': [1785], 'Auer,': [1787], 'Welland,': [1793, 2179, 2225], 'Kinetics': [1797], 'thermodynamics': [1799], 'formation': [1802, 2154, 2293, 2790], 'direct': [1804], 'measurements': [1805], 'fluctuations': [1807], 'fibril': [1809, 2201, 2237], 'mass.': [1810], '10016–': [1817], '10021': [1818], '35Hafner-Bratkovič,': [1819], 'Benčina,': [1821], 'Fitzgerald,': [1823], 'Golenbock,': [1826], '(2012)': [1831, 2032, 2228, 2565, 2687], 'NLRP3': [1832], 'inflammasome': [1833], 'activation': [1834], 'macrophage': [1836], 'lines': [1838], 'fibrils': [1842], 'source': [1845], 'IL-1β': [1847], 'toxicity.': [1850], 'Cell.': [1851], 'Life': [1853], '69,': [1855], '4215–': [1856], '4228': [1857], '36Polymenidou,': [1858], 'Moos,': [1860], 'Scott,': [1862], 'Sigurdson,': [1864], 'Shi,': [1866], 'Yajima,': [1869], 'Wuthrich,': [1877], 'Bellon,': [1879], 'Vey,': [1881], 'Garen,': [1883], 'James,': [1885, 2029], 'Kav,': [1888, 2023], 'POM': [1895], 'monoclonals:': [1896], 'comprehensive': [1898], 'set': [1899], 'antibodies': [1901], 'non-overlapping': [1903], 'epitopes.': [1906], '3,': [1909], 'e3872': [1910], '37Van': [1911], 'protein:': [1927], 'insights': [1928], 'steps': [1932], '99,': [1937], '2289–': [1938], '2298': [1939], '38Langella,': [1940], 'Improta,': [1942], 'Barone,': [1945], 'Checking': [1948], 'pH-induced': [1950], 'conformational': [1951], 'transition': [1952], 'molecular': [1957], 'dynamics': [1958], 'simulations:': [1959], 'residues.': [1965], '87,': [1968], '3623–': [1969], '3632': [1970], '39Anderson,': [1971], 'Bocharova,': [1973], 'Makarava,': [1976], 'Polymorphism': [1988], 'ultrastructural': [1990], 'organization': [1991], 'fibrils:': [1996], 'insight': [1998], 'high': [2000], 'resolution': [2001], 'atomic': [2002, 2617], 'force': [2003], 'microscopy.': [2004], '358,': [2008], '580–': [2009], '596': [2010], '40Baral,': [2011], 'Wieland,': [2014], 'Swayampakula,': [2016], 'Rahman,': [2020], 'studies': [2034], 'folded': [2037, 2744], 'bound': [2044], 'Fab': [2047], 'fragment': [2048], 'antibody': [2051], 'POM1.': [2052], 'Acta': [2053], 'Crystallogr.': [2054, 2057], 'D': [2055], '68,': [2058], '1501–': [2059], '1512': [2060], '41Giaccone,': [2061], 'Verga,': [2063], 'Bugiani,': [2065], 'Frangione,': [2067], 'Farlow,': [2074], 'Tagliavini,': [2080], 'preamyloid': [2085], 'deposits': [2088], 'Gerstmann-Sträussler-Scheinker': [2090], 'disease,': [2091], 'Indiana': [2092], 'kindred.': [2093], '89,': [2099], '9349–': [2100], '9353': [2101], '42Liemann,': [2102], 'Glockshuber,': [2105, 2409], '(1999)': [2107], 'amino': [2110], 'acid': [2111], 'substitutions': [2112], '38,': [2129], '3258–': [2130], '3267': [2131], '43Chiti,': [2132], 'Taddei,': [2134], 'Bucciantini,': [2136], 'White,': [2138, 2215], 'Ramponi,': [2140], 'Mutational': [2147], 'analysis': [2148, 2230, 2478], 'propensity': [2151], 'EMBO': [2159], '1441–': [2162], '1449': [2163], '44Buell,': [2164], 'Dhulesia,': [2167, 2213], 'Mossuto,': [2169, 2590], 'Cremades,': [2172, 2582], 'Kumita,': [2174, 2584], 'Dumoulin,': [2177, 2593], 'Knowles,': [2182, 2218], 'Salvatella,': [2185, 2599], 'X.,': [2186, 2600, 2717], 'Population': [2192], 'nonnative': [2194], 'states': [2195], 'lysozyme': [2197, 2614], 'variants': [2198], 'drives': [2199], 'formation.': [2202], 'Am.': [2204, 2620, 2795], 'Soc.': [2206, 2622, 2797], '133,': [2207, 2798], '7737–': [2208], '7743': [2209], '45Buell,': [2210], 'Detailed': [2229], 'energy': [2233], 'barriers': [2234], 'growth.': [2238], 'Angew.': [2239], 'Int.': [2241], 'Ed.': [2242], 'Engl.': [2243], '51,': [2244], '5247–': [2245], '5251': [2246], '46Rezaei,': [2247], 'Choiset,': [2249], 'Eghiaian,': [2251], 'Treguer,': [2253], 'Mentre,': [2255], 'Debey,': [2257], 'Haertle,': [2262], 'Amyloidogenic': [2265], 'unfolding': [2266], 'differentiate': [2268], 'sheep': [2269], '322,': [2276], '799–': [2277], '814': [2278], '47Fändrich,': [2279], 'Absolute': [2282], 'lag': [2285], 'time': [2286], 'growth': [2288], 'rate': [2289], 'spontaneous': [2292], 'several': [2295], 'amyloid-like': [2296], 'aggregates': [2297], 'fibrils.': [2299], '365,': [2303], '1266–': [2304], '1270': [2305], '48Bocharova,': [2306], 'Gill,': [2314], 'Synthetic': [2322], 'prions': [2323], 'generated': [2324], 'are': [2327], 'newly': [2331], 'identified': [2332], 'subpopulation': [2333], 'PrPSc': [2335], 'sporadic': [2337], 'Disease.': [2339], '14,': [2342], '1222–': [2343], '1232': [2344], '49Apetri,': [2345], 'Surewicz,': [2348, 2351, 2526, 2720, 2736], 'disease-associated': [2358], 'pathway': [2363, 2471], '279,': [2371], '18008–': [2372], '18014': [2373], '50Hafner-Bratkovič,': [2374], 'Disulfide': [2380], 'mapping': [2381], 'reveals': [2382], 'crucial': [2388], 'process': [2389], '56–': [2399], '59': [2400], '51Riek,': [2401], '(1996)': [2414], 'Nature': [2424], '382,': [2425], '180–': [2426], '182': [2427], '52Poland,': [2428], 'Vournakis,': [2430], 'Scheraga,': [2434, 2459], '(1966)': [2437], 'Cooperative': [2438], 'single-strand': [2441], 'oligomers': [2442], 'adenylic': [2444], 'acid.': [2445], '4,': [2447, 2756], '223–': [2448], '235': [2449], '53Lin,': [2450], 'Konishi,': [2453], 'Denton,': [2455], '(1984)': [2462], 'extrinsic': [2466], 'cross-link': [2467], 'ribonuclease': [2473, 2506], 'Conformational': [2475, 2501], 'cross-linked': [2480], '(lysine7-lysine41)-ribonuclease': [2481], 'a.': [2482], '23,': [2484], '5504–': [2485], '5512': [2486], '54Pace,': [2487], 'Grimsley,': [2490], 'Thomson,': [2493], 'Barnett,': [2497], '(1988)': [2500], 'activity': [2504], 'T1': [2507], 'zero,': [2509], 'one,': [2510], 'two': [2512], 'intact': [2513], 'bonds.': [2515], '263,': [2519], '11820–': [2520], '11825': [2521], '55Apetri,': [2522], 'Kinetic': [2530], '44589–': [2543], '44592': [2544], '56Neudecker,': [2545], 'Robustelli,': [2547], 'Cavalli,': [2549], 'Walsh,': [2551], 'Lundström,': [2553], 'Zarrine-Afsar,': [2555], 'Sharpe,': [2557], 'Vendruscolo,': [2559], 'Kay,': [2562], 'Structure': [2566], 'aggregation.': [2575, 2821], 'Science': [2576, 2649], '336,': [2577], '362–': [2578], '57Dhulesia,': [2580], 'Hsu,': [2587], 'Nietlispach,': [2595], 'Akke,': [2597], 'Local': [2606], 'cooperativity': [2607], 'amyloidogenic': [2610], 'resolution.': [2618], '132,': [2623], '15580–': [2624], '15588': [2625], '58Hammarström,': [2626], 'Wiseman,': [2628, 2672], 'Powers,': [2631, 2669], 'Kelly,': [2635, 2681], 'Prevention': [2639], 'transthyretin': [2641, 2693], 'changing': [2645], 'energetics.': [2648], '299,': [2650], '713–': [2651], '716': [2652], '59Bulawa,': [2653], 'Connelly,': [2656], 'Devit,': [2658], 'Weigel,': [2662], 'Fleming,': [2664], 'Packman,': [2667], 'Foss,': [2675], 'Wilson,': [2678], 'Labaudinière,': [2685], 'Tafamidis,': [2688], 'potent': [2690], 'selective': [2692], 'kinetic': [2694], 'stabilizer': [2695], 'inhibits': [2697, 2749], 'cascade.': [2700], '109,': [2706], '9629–': [2707], '9634': [2708], '60Kong,': [2709], 'Mills,': [2711], 'Kundu,': [2714], 'Li,': [2716], 'Qing,': [2718], 'Cali,': [2722], 'Huang,': [2724], 'Zheng,': [2726], 'Swietnicki,': [2728], 'Sonnichsen,': [2730], 'Thermodynamic': [2740], 'infection': [2751], 'Rep.': [2755], '248–': [2757], '254': [2758], '61Vieira,': [2759], 'Reynaldo,': [2762], 'Gomes,': [2765], 'Almeida,': [2768], 'Cordeiro,': [2771, 2804], 'Heparin': [2778, 2813], 'binding': [2779, 2814], 'leads': [2785], 'transient': [2787], 'aggregation': [2788], 'RNA-resistant': [2792], 'species.': [2793], '334–': [2799], '344': [2800], '62Vieira,': [2801], 'Caughey,': [2806], '(2014)': [2812], 'confers': [2815], 'impairs': [2819], '28,': [2824], '2667–': [2825], '2676': [2826], 'Citing': [2827], 'Literature': [2828], 'Supporting': [2829], 'Information': [2830], 'Filename': [2831], 'Description': [2832], 'fsb2029003016-sup-0001.pdfPDF': [2833], 'document,': [2834, 2840, 2846, 2852], '271.4': [2835], 'KB': [2836, 2842, 2848], 'Supplementary': [2837, 2843, 2849, 2855], 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'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-17T20:17:55.249163', 'created_date': '2016-06-24'}