Title: Mechanism of in vivo carbon tetrachloride-induced liver microsomal cytochrome P-450 destruction
Abstract: Prior administration of aminotriazole (3-amino-1,2,4-triazole) or pyrazole to rats resulted in a significant prevention of the CCl4-induced decrease in the liver microsomal P-450 content. In A/J mice the CCl4 activation and P-450 destruction occurred in absolute absence of lipid peroxidation as determined by uv absorption. The data suggest that P-450 destruction is mainly mediated by direct attack of CCl4 metabolites rather than by CCl4-induced lipid peroxidation.
Publication Year: 1975
Publication Date: 1975-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 30
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