Enhanced botrocetin‐induced type iib von willebrand factor binding to platelet glycoprotein ib initiates hyperagglutination of normal platelets

Name: Work Video:
Duration: 3 min 30 s
Kenji Nishio; Yoshihiro Fujimura; K. Niinomi; Yukihiro Takahashi; Akira Yoshioka; Hiromu Fukui; Yoshiko Usami; Koiti Titani; Zaverio M. Ruggeri; T S Zimmerman
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'extending': [76], 'amino': [78], 'acid': [79], 'residue': [80], '449': [81], '728': [83], 'constituent': [86], 'subunit.': [87], 'In': [88], 'present': [90], 'report,': [91], 'we': [92, 165], 'demonstrate': [93], 'botrocetin': [95], 'does': [96], 'not': [97], 'induce': [98], 'agglutination': [99], 'formalin‐fixed': [101, 140, 150], 'platelets': [102, 141, 151], 'patient': [105], 'with': [106, 124], 'Bernard‐Soulier': [107], 'syndrome': [108], 'congenitally': [109], 'lacking': [110], 'GPIX': [113], 'as': [114, 116], 'well': [115], 'GPV,': [117], 'finding': [119], 'similar': [120], 'A': [126], 'monoclonal': [127], 'antibody': [128], 'against': [129], '(AP‐1)': [131], 'inhibits': [132], 'either': [133], 'ristocetin‐': [134], 'or': [135], 'botrocetin‐dependent': [136], 'normal': [143, 182], 'individuals.': [144], 'Therefore,': [145], 'botrocetin‐induced': [146, 171], 'may': [152], 'reflect': [153], 'GPIb.': [160], 'To': [161], 'strengthen': [162], 'this': [163], 'concept,': [164], 'now': [167], 'found': [168], 'heightened': [170], 'type': [172], 'IIB': [173], 'causes': [179], 'hyperagglutination': [180], 'platelets.': [183]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1975736714', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-11T12:08:40.894830', 'created_date': '2016-06-24'}
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