Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1975635900', 'doi': 'https://doi.org/10.1016/s0092-8674(00)81046-6', 'title': 'Regulation of the Drosophila Protein Timeless Suggests a Mechanism for Resetting the Circadian Clock by Light', 'display_name': 'Regulation of the Drosophila Protein Timeless Suggests a Mechanism for Resetting the Circadian Clock by Light', 'publication_year': 1996, 'publication_date': '1996-03-01', 'ids': {'openalex': 'https://openalex.org/W1975635900', 'doi': 'https://doi.org/10.1016/s0092-8674(00)81046-6', 'mag': '1975635900', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8625406'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0092-8674(00)81046-6', 'pdf_url': 'http://www.cell.com/article/S0092867400810466/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.cell.com/article/S0092867400810466/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089004165', 'display_name': 'Melissa Hunter-Ensor', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Melissa Hunter-Ensor', 'raw_affiliation_strings': ['Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024688520', 'display_name': 'Andrea Ousley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrea Ousley', 'raw_affiliation_strings': ['Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101828185', 'display_name': 'Amita Sehgal', 'orcid': 'https://orcid.org/0000-0001-7149-8588'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Amita Sehgal', 'raw_affiliation_strings': ['Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA', 'Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}, {'raw_affiliation_string': 'Center for Sleep and Respiratory Neurobiology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5101828185'], 'corresponding_institution_ids': ['https://openalex.org/I79576946'], 'apc_list': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'apc_paid': {'value': 10100, 'currency': 'USD', 'value_usd': 10100, 'provenance': 'doaj'}, 'fwci': 13.213, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 396, 'citation_normalized_percentile': {'value': 0.999187, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '84', 'issue': '5', 'first_page': '677', 'last_page': '685'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10342', 'display_name': 'Mammalian Circadian Rhythms and Physiology', 'score': 0.9868, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10342', 'display_name': 'Mammalian Circadian Rhythms and Physiology', 'score': 0.9868, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11268', 'display_name': 'Light Signal Transduction in Plants', 'score': 0.963, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11007', 'display_name': 'Hydrogen Energy Systems and Technologies', 'score': 0.9335, 'subfield': {'id': 'https://openalex.org/subfields/2102', 'display_name': 'Energy Engineering and Power Technology'}, 'field': {'id': 'https://openalex.org/fields/21', 'display_name': 'Energy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/timeless', 'display_name': 'Timeless', 'score': 0.9931182}, {'id': 'https://openalex.org/keywords/oscillating-gene', 'display_name': 'Oscillating gene', 'score': 0.6022773}, {'id': 'https://openalex.org/keywords/circadian-clock', 'display_name': 'Circadian Clock', 'score': 0.517934}, {'id': 'https://openalex.org/keywords/peripheral-clocks', 'display_name': 'Peripheral Clocks', 'score': 0.511635}], 'concepts': [{'id': 'https://openalex.org/C2778880379', 'wikidata': 'https://www.wikidata.org/wiki/Q7805543', 'display_name': 'Timeless', 'level': 3, 'score': 0.9931182}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8983928}, {'id': 'https://openalex.org/C121446783', 'wikidata': 'https://www.wikidata.org/wiki/Q208353', 'display_name': 'Circadian rhythm', 'level': 2, 'score': 0.82640505}, {'id': 'https://openalex.org/C38606739', 'wikidata': 'https://www.wikidata.org/wiki/Q5121352', 'display_name': 'Circadian clock', 'level': 3, 'score': 0.6864908}, {'id': 'https://openalex.org/C2781291010', 'wikidata': 'https://www.wikidata.org/wiki/Q178580', 'display_name': 'Period (music)', 'level': 2, 'score': 0.62474346}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.61282796}, {'id': 'https://openalex.org/C125168821', 'wikidata': 'https://www.wikidata.org/wiki/Q7106408', 'display_name': 'Oscillating gene', 'level': 5, 'score': 0.6022773}, {'id': 'https://openalex.org/C144543706', 'wikidata': 'https://www.wikidata.org/wiki/Q85754737', 'display_name': 'Cryptochrome', 'level': 4, 'score': 0.58261114}, {'id': 'https://openalex.org/C2776041557', 'wikidata': 'https://www.wikidata.org/wiki/Q3715451', 'display_name': 'Drosophila (subgenus)', 'level': 3, 'score': 0.4805839}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.46198046}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.4252733}, {'id': 'https://openalex.org/C130679736', 'wikidata': 'https://www.wikidata.org/wiki/Q3454009', 'display_name': 'Bacterial circadian rhythms', 'level': 4, 'score': 0.3989474}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.329598}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.32733852}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.19315347}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C24890656', 'wikidata': 'https://www.wikidata.org/wiki/Q82811', 'display_name': 'Acoustics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002940', 'descriptor_name': 'Circadian Rhythm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001683', 'descriptor_name': 'Biological Clocks', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003624', 'descriptor_name': 'Darkness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004331', 'descriptor_name': 'Drosophila melanogaster', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005455', 'descriptor_name': 'Fluorescent Antibody Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008027', 'descriptor_name': 'Light', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056950', 'descriptor_name': 'Period Circadian Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017956', 'descriptor_name': 'Photoreceptor Cells, Invertebrate', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017956', 'descriptor_name': 'Photoreceptor Cells, Invertebrate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0092-8674(00)81046-6', 'pdf_url': 'http://www.cell.com/article/S0092867400810466/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8625406', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0092-8674(00)81046-6', 'pdf_url': 'http://www.cell.com/article/S0092867400810466/pdf', 'source': {'id': 'https://openalex.org/S110447773', 'display_name': 'Cell', 'issn_l': '0092-8674', 'issn': ['0092-8674', '1097-4172'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310320990', 'https://openalex.org/P4310315673'], 'host_organization_lineage_names': ['Elsevier BV', 'Cell Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.45, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1589364054', 'https://openalex.org/W1795493695', 'https://openalex.org/W1940049677', 'https://openalex.org/W1963684521', 'https://openalex.org/W1968410906', 'https://openalex.org/W1970785480', 'https://openalex.org/W1982326120', 'https://openalex.org/W1986465162', 'https://openalex.org/W1992494470', 'https://openalex.org/W1992749367', 'https://openalex.org/W1995139743', 'https://openalex.org/W1996454474', 'https://openalex.org/W1997031571', 'https://openalex.org/W2005811101', 'https://openalex.org/W2018873867', 'https://openalex.org/W2022374934', 'https://openalex.org/W2028214516', 'https://openalex.org/W2030063045', 'https://openalex.org/W2035550196', 'https://openalex.org/W2040142812', 'https://openalex.org/W2043772894', 'https://openalex.org/W2056393772', 'https://openalex.org/W2060138058', 'https://openalex.org/W2073036589', 'https://openalex.org/W2084548353', 'https://openalex.org/W2088347811', 'https://openalex.org/W2102492814', 'https://openalex.org/W2107478358', 'https://openalex.org/W2112210924', 'https://openalex.org/W2121075147', 'https://openalex.org/W2132687554', 'https://openalex.org/W2158482293', 'https://openalex.org/W2162754674', 'https://openalex.org/W2170377207', 'https://openalex.org/W2175171485', 'https://openalex.org/W2346964101'], 'related_works': ['https://openalex.org/W54685189', 'https://openalex.org/W4200027960', 'https://openalex.org/W307094963', 'https://openalex.org/W2390348595', 'https://openalex.org/W2169982116', 'https://openalex.org/W2145024015', 'https://openalex.org/W2140241157', 'https://openalex.org/W2089112135', 'https://openalex.org/W2084887961', 'https://openalex.org/W2061470029'], 'abstract_inverted_index': {'Circadian': [0], 'behavioral': [1], 'rhythms': [2], 'in': [3, 53], 'Drosophila': [4], 'depend': [5], 'on': [6, 125], 'the': [7, 32, 37, 47, 79, 88, 107, 121], 'appropriate': [8], 'regulation': [9], 'of': [10, 25, 50, 64, 75, 81, 90, 106, 123], 'at': [11], 'least': [12], 'two': [13], 'genes,': [14], 'period': [15], '(per)': [16], 'and': [17, 27, 35, 39, 56, 113], 'timeless': [18], '(tim).': [19], 'Previous': [20], 'studies': [21], 'demonstrated': [22], 'that': [23, 36, 58, 72, 87, 101], 'levels': [24, 63], 'PER': [26, 38, 82, 112], 'TIM': [28, 40, 51, 65, 76, 102, 114, 126], 'RNA': [29, 66, 115], 'cycle': [30], 'with': [31], 'same': [33], 'phase': [34], 'proteins': [41], 'interact': [42], 'directly.': [43], 'Here': [44], 'we': [45, 85], 'show': [46], 'cyclic': [48], 'expression': [49, 74, 80, 89], 'protein': [52], 'adult': [54], 'heads': [55], 'report': [57, 86], 'it': [59], 'lags': [60], 'behind': [61], 'peak': [62], 'by': [67, 98, 118], 'several': [68], 'hours.': [69], 'We': [70], 'alsoshow': [71], 'nuclear': [73], 'depends': [77], 'upon': [78], 'protein.': [83], 'Finally,': [84], 'TIM,': [91], 'but': [92], 'not': [93], 'PER,': [94], 'is': [95], 'rapidly': [96], 'reduced': [97], 'light,': [99], 'suggesting': [100], 'mediates': [103], 'light-induced': [104], 'resetting': [105], 'circadian': [108], 'clock.': [109], 'Since': [110], 'both': [111], 'are': [116], 'unaffected': [117], 'light': [119, 124], 'treatment,': [120], 'effects': [122], 'appear': [127], 'to': [128], 'be': [129], 'posttranscriptional.': [130]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1975635900', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-09-01T02:22:35.373781', 'created_date': '2016-06-24'}