Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein

Name: Work Video:
Duration: 3 min 30 s
Subbiah Pugazhenthi; Albina Nesterova; Carol L. Sable; Kim A. Heidenreich; Linda M. Boxer; Lynn E. Heasley; Jane E.B. Reusch
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1539, 1561, 2748, 3070, 3182, 3203, 3276, 3671, 3777, 4361, 4532, 4887, 5050, 5125, 5297, 5363, 5407, 5502], 'insulin-like': [7, 299, 587, 4776], 'growth': [8, 186, 300, 478, 588, 628, 756, 1014, 3370, 4031, 4234, 4499, 4777, 5173, 5176, 5205, 5503], 'factor-I': [9, 301], 'induces': [10, 302], 'a': [11, 19, 67, 78, 94, 100, 112, 132, 224, 256, 303, 311, 359, 370, 386, 392, 404, 424, 516, 548, 1009, 1115, 1129, 1183, 1341, 1369, 1485, 1503, 1510, 1599, 1647, 1773, 2146, 2164, 2239, 2557, 2625, 2630, 2643, 2663, 2673, 2771, 2798, 2843, 3142, 3150, 3315, 3450, 3455, 3503, 3530, 3712, 3735, 3818, 3888, 3922, 3999, 4093, 4170, 4420, 4480, 4543, 4629, 5151, 5165, 5336, 5417], 'cAMP-response': [12, 304, 1116], 'element': [13, 305, 592, 1117], '(CRE)': [14, 306, 1118], 'site-containing': [15, 307, 1447, 1505, 1638, 3457, 5451], 'Bcl-2': [16, 75, 92, 110, 136, 190, 219, 235, 260, 286, 308, 367, 384, 402, 428, 482, 511, 527, 552, 578, 807, 820, 868, 1003, 1113, 1133, 1228, 1328, 1388, 1428, 1574, 1603, 2021, 2150, 2619, 2626, 2711, 2739, 2750, 2765, 2832, 2936, 2988, 3005, 3015, 3045, 3208, 3243, 3280, 3458, 3853, 3866, 3881, 3926, 3949, 4166, 4227, 5452, 5461, 5516, 5534], 'promoter': [17, 107, 137, 191, 287, 309, 399, 429, 483, 579, 1110, 1389, 1429, 1450, 1506, 1604, 1639, 2440, 2627, 2712, 2740, 2766, 2833, 3006, 3046, 3072, 3209, 3244, 3281, 3461, 3507, 4783, 5462, 5499], 'through': [18, 310, 906, 1221, 1248, 1345, 1592, 2755, 2870, 3245, 3282, 3373, 3962, 4169, 4240, 5184, 5506, 5525], 'novel': [20, 79, 312, 371, 1370, 4171], 'signaling': [21, 225, 282, 313, 517, 574, 1372, 1591, 3152, 3278, 4172, 4244, 4321, 5169, 5442, 5505], 'pathway': [22, 69, 314, 361, 1335, 2874, 3148, 3153, 3376, 4173, 4220, 5443], 'involving': [23, 315, 1374, 3248, 4152, 4221, 4323], 'mitogen-activated': [24, 29, 316, 321, 595], 'protein': [25, 30, 33, 36, 317, 322, 325, 328, 594, 596, 911, 1381, 3174, 3251, 3415, 4158, 4183, 4889, 5383], 'kinase': [26, 27, 125, 169, 318, 319, 417, 461, 585, 598, 610, 612, 746, 1334, 1376, 1377, 2704, 2779, 2799, 2907, 3175, 3252, 4177, 4178, 4890, 4975, 5186, 5365], '6/p38β': [28, 320, 1378, 4179], 'kinase/MAP': [31, 323, 4181], 'kinase-activated': [32, 324, 1380, 4182], 'kinase-3/cAMP-response': [34, 326], 'element-binding': [35, 327], '(CREB)': [37, 329], '(Pugazhenthi,': [38, 330], 'S.,': [39, 331], 'Miller,': [40, 332], 'E.,': [41, 333], 'Sable,': [42, 334], 'C.,': [43, 335], 'Young,': [44, 336], 'P.,': [45, 337], 'Heidenreich,': [46, 338], 'K.': [47, 339, 1195, 1518, 2953, 4299, 4564, 4959, 5069, 5343, 5385], 'A.,': [48, 340], 'Boxer,': [49, 341], 'L.': [50, 342], 'M.,': [51, 343], 'and': [52, 154, 211, 289, 344, 446, 503, 581, 627, 695, 713, 718, 818, 821, 852, 869, 872, 892, 1120, 1253, 1443, 1515, 1544, 1595, 1610, 1621, 1632, 1710, 1765, 1845, 1897, 1924, 1937, 1953, 1977, 2012, 2016, 2042, 2054, 2192, 2216, 2263, 2300, 2321, 2342, 2416, 2444, 2454, 2460, 2478, 2485, 2493, 2519, 2530, 2683, 2709, 2827, 2912, 2918, 2929, 2950, 3128, 3173, 3214, 3223, 3250, 3284, 3472, 3558, 3608, 3693, 3799, 4027, 4084, 4325, 4375, 4474, 4498, 4588, 4797, 4806, 4992, 5090, 5207, 5218, 5340, 5375, 5468, 5476, 5492, 5531, 5547], 'Reusch,': [53, 345], 'J.': [54, 346, 633, 637, 666, 726, 730, 975, 1025, 1063, 1065, 1072, 1093, 1149, 1198, 1278, 1306, 1404, 1466, 1521, 1856, 2090, 2378, 2584, 2807, 2811, 2889, 2956, 3098, 3397, 3979, 4199, 4562, 4566, 4572, 4642, 4668, 4696, 4715, 4754, 4819, 4867, 4915, 4941, 5030, 5105, 5190, 5234, 5253, 5263, 5319, 5346, 5388], 'E.-B.': [55, 347], '(1999)J.': [56, 348], 'Biol.': [57, 349, 670, 797, 1026, 1094, 1150, 1173, 1199, 1279, 1307, 1358, 1405, 1467, 1522, 1661, 2379, 2585, 2890, 2957, 3055, 3099, 3398, 3980, 4132, 4200, 4455, 4573, 4643, 4669, 4697, 4820, 4868, 4916, 4942, 5031, 5106, 5235, 5320, 5347, 5389], 'Chem.': [58, 350, 1027, 1095, 1151, 1200, 1280, 1308, 1406, 1468, 1523, 2380, 2586, 2891, 2958, 3100, 3399, 3981, 4201, 4574, 4644, 4670, 4698, 4821, 4869, 4917, 4943, 5032, 5107, 5236, 5321, 5348, 5390], '274,': [59, 351], '27529–27535).': [60, 352], 'the': [62, 87, 106, 123, 158, 175, 200, 234, 250, 264, 274, 354, 379, 398, 415, 450, 467, 492, 526, 542, 556, 566, 655, 719, 846, 888, 909, 965, 1121, 1324, 1332, 1385, 1422, 1490, 1542, 1545, 1549, 1559, 1567, 1571, 1576, 1582, 1784, 1789, 1818, 1842, 1848, 1925, 1938, 1944, 1957, 2001, 2074, 2077, 2083, 2128, 2135, 2140, 2173, 2193, 2278, 2283, 2332, 2353, 2429, 2432, 2445, 2470, 2499, 2532, 2544, 2550, 2610, 2616, 2636, 2650, 2654, 2657, 2684, 2699, 2721, 2764, 2823, 2932, 2942, 2974, 2993, 3003, 3031, 3038, 3042, 3071, 3081, 3117, 3120, 3145, 3191, 3212, 3227, 3234, 3329, 3435, 3441, 3445, 3470, 3480, 3486, 3517, 3571, 3580, 3635, 3655, 3685, 3697, 3720, 3741, 3761, 3791, 3803, 3826, 3836, 3841, 3847, 3857, 3862, 3870, 3894, 3911, 3935, 3948, 4003, 4015, 4020, 4028, 4041, 4048, 4156, 4163, 4241, 4295, 4423, 4484, 4539, 4550, 4799, 4840, 4981, 5000, 5010, 5120, 5129, 5368, 5377, 5380, 5426, 5431, 5437, 5445, 5455, 5485, 5498, 5513, 5557, 5572, 5579], 'present': [63, 355, 1583, 4142, 5044, 5432], 'investigation,': [64, 356, 5433], 'define': [66, 358], 'second': [68, 360, 3151], 'contributing': [70, 362], 'to': [71, 131, 284, 363, 423, 576, 625, 651, 660, 685, 741, 751, 882, 904, 951, 1191, 1339, 1384, 1498, 1586, 1598, 1646, 1679, 1931, 2245, 2306, 2344, 2398, 2490, 2542, 2706, 2729, 2791, 2867, 3037, 3166, 3180, 3218, 3263, 3289, 3357, 3369, 3431, 3551, 3560, 3598, 3909, 3953, 3959, 4002, 4033, 4238, 4282, 4294, 4367, 4433, 4478, 4774, 4789, 4839, 4848, 4893, 4980, 4999, 5042, 5123, 5128, 5140, 5180, 5301, 5419, 5496, 5521], 'CREB-dependent': [72, 364, 1600], 'up-regulation': [73, 365, 3863, 5532], 'of': [74, 82, 89, 96, 109, 119, 126, 147, 151, 163, 178, 189, 204, 207, 218, 366, 374, 381, 388, 401, 411, 418, 439, 443, 455, 470, 481, 496, 499, 510, 618, 703, 710, 715, 809, 812, 826, 848, 879, 908, 969, 1002, 1112, 1132, 1185, 1227, 1258, 1262, 1326, 1331, 1387, 1445, 1489, 1493, 1502, 1507, 1548, 1566, 1573, 1581, 1641, 1682, 1742, 2040, 2070, 2200, 2223, 2409, 2413, 2419, 2452, 2476, 2524, 2612, 2618, 2656, 2675, 2689, 2701, 2723, 2731, 2738, 2757, 2787, 2801, 2825, 2836, 2935, 2941, 2945, 2977, 2987, 2995, 2999, 3030, 3044, 3080, 3116, 3158, 3185, 3193, 3207, 3216, 3239, 3271, 3331, 3474, 3519, 3538, 3566, 3617, 3668, 3708, 3724, 3774, 3814, 3830, 3843, 3859, 3864, 3940, 4005, 4022, 4030, 4040, 4047, 4081, 4095, 4155, 4165, 4226, 4230, 4289, 4317, 4379, 4388, 4419, 4466, 4486, 4493, 4546, 4552, 4619, 4843, 4851, 5013, 5135, 5284, 5293, 5370, 5379, 5410, 5440, 5447, 5474, 5484, 5488, 5515, 5527, 5533, 5561, 5581], 'expression': [76, 220, 368, 512, 1004, 1134, 1229, 1572, 2751, 4537, 4551, 4618, 5413], 'as': [77, 369, 620, 622, 1008, 1128, 1650, 1999, 2045, 2134, 2171, 2567, 3149, 3171, 3377, 3575, 3577, 3583, 3666, 3706, 3772, 3812, 3932, 4035, 4470, 4489, 4491, 4628, 5164], 'anti-apoptotic': [80, 372, 819, 893, 4036, 4157], 'function': [81, 373, 4149], 'Akt': [83, 90, 241, 265, 281, 375, 382, 533, 557, 573, 646, 707, 899, 970, 1219, 1540, 1562, 1596, 1782, 1907, 1926, 2774, 2788, 2938, 2985, 3123, 3181, 3196, 3230, 3429, 3448, 3466, 3512, 3548, 3581, 3591, 3860, 3930, 4085, 4151, 4222, 4324, 4364, 4533, 4548, 4610, 4633, 4785, 4858, 4995, 5014, 5085, 5149, 5298, 5493, 5519], 'signaling.': [84, 376, 2948], 'To': [85, 377, 2427, 2608, 2669, 2982, 3855], 'examine': [86, 378, 1587], 'role': [88, 380, 2611, 2665, 2772, 3143, 3858, 4482], 'on': [91, 383, 913, 2238, 2556, 2794, 2831, 3002, 3197, 3301, 3846, 4990, 5372], 'expression,': [93, 385, 2620, 3867], 'series': [95, 387, 2674], 'transient': [97, 389, 2676], 'transfections': [98, 390, 2348, 2677], 'using': [99, 249, 391, 541, 1698, 1837, 1993, 2028, 2163, 2357, 2549, 3449, 3893, 5425], 'luciferase': [101, 183, 393, 475, 1648, 1671, 1720, 2552, 3130, 3451, 3531, 3848, 5456, 5478], 'reporter': [102, 140, 394, 432, 1649, 1672, 2079, 2141, 2525, 2651, 2847, 2855, 2914, 3016, 3118, 3452, 3532, 3849, 3912, 5457], 'gene': [103, 395, 1643, 1673, 2436, 3160, 4536, 5412], 'driven': [104, 396, 1674, 2437, 3453, 3533, 3851, 5459], 'by': [105, 145, 157, 199, 221, 228, 242, 280, 397, 437, 449, 491, 513, 520, 534, 572, 649, 689, 696, 706, 755, 850, 887, 897, 947, 1012, 1230, 1246, 1675, 1735, 1847, 1910, 1928, 2009, 2024, 2047, 2352, 2438, 2604, 2718, 2733, 2796, 2857, 2863, 2916, 2980, 3020, 3132, 3221, 3454, 3534, 3852, 3887, 4092, 4167, 4175, 4233, 4285, 4496, 4780, 4857, 5007, 5172, 5214, 5280, 5289, 5416, 5460, 5529, 5535], 'region': [108, 400, 1111, 1640], 'containing': [111, 403, 1753, 1915, 2232, 2267, 2434, 2629, 3680, 3786, 5212], 'CRE': [113, 405, 1446, 1504, 1637, 1683, 2631, 3082, 3456, 3539, 5210, 5450], 'were': [114, 406, 1612, 1623, 1696, 1712, 1746, 1908, 1941, 1949, 1960, 1963, 1981, 2006, 2052, 2153, 2186, 2196, 2225, 2243, 2280, 2295, 2334, 2349, 2396, 2422, 2457, 2501, 2514, 2633, 2692, 3340, 3527, 3549, 3641, 3658, 3689, 3700, 3747, 3764, 3795, 3806, 5138, 5494], 'carried': [115, 407, 2350, 2565, 2693], 'out.': [116, 408, 2694, 3258], 'Pharmacological': [117, 409], 'inhibition': [118, 410], 'phosphatidylinositol': [120, 412, 601], '(PI)': [121, 413], '3-kinase,': [122, 209, 414, 501, 5286, 5490], 'upstream': [124, 416], 'Akt,': [127, 179, 419, 471, 1182, 4422, 5052, 5469], 'with': [128, 167, 269, 420, 459, 561, 1783, 1841, 1890, 1899, 1971, 2014, 2127, 2189, 2227, 2251, 2254, 2282, 2297, 2302, 2318, 2322, 2336, 2472, 2516, 2521, 2624, 2635, 2678, 2839, 3119, 3342, 3479, 3529, 3585, 3934, 3943, 5132, 5150, 5465], 'LY294002': [129, 421, 1609], 'led': [130, 422], '45%': [133, 425, 2644], 'decrease': [134, 426, 2645, 3505, 5497], 'in': [135, 181, 237, 259, 263, 427, 473, 529, 551, 555, 1236, 1323, 1435, 1551, 1570, 1602, 1748, 1772, 1817, 1913, 1920, 1946, 1965, 1983, 2179, 2286, 2402, 2449, 2503, 2615, 2649, 2653, 2720, 2753, 2780, 2842, 2846, 2854, 2931, 3010, 3041, 3178, 3211, 3233, 3267, 3307, 3322, 3325, 3328, 3354, 3359, 3379, 3444, 3465, 3469, 3485, 3497, 3502, 3506, 3516, 3568, 3579, 3594, 3603, 3611, 3643, 3675, 3711, 3734, 3749, 3781, 3817, 3861, 3884, 3917, 3925, 3929, 4275, 4370, 4426, 4483, 4554, 4590, 4612, 4616, 4804, 4807, 5145, 5275, 5304, 5444, 5512], 'activity.': [138, 184, 430, 476, 1605, 2713, 2834, 3007, 4784, 5479], 'The': [139, 431, 607, 700, 806, 877, 1109, 1579, 1606, 1636, 1719, 2018, 2038, 2057, 2149, 2235, 2293, 2394, 2483, 2512, 2561, 2714, 2852, 3237, 3269, 3413, 3460, 3660, 3702, 3717, 3766, 3808, 3823, 4038, 4079, 4141, 5116, 5156, 5480], 'activity': [141, 192, 279, 288, 433, 484, 571, 580, 1430, 1547, 2069, 2652, 2716, 2741, 2767, 2848, 2856, 2915, 2979, 3017, 3075, 3131, 3210, 3443, 3462, 5144], 'was': [142, 193, 434, 485, 1496, 1585, 1644, 1685, 1723, 1832, 1888, 1918, 1988, 2022, 2062, 2132, 2161, 2202, 2441, 2481, 2488, 2534, 2547, 2564, 2602, 2642, 2727, 2742, 2859, 3231, 3463, 3574, 3664, 3770, 3907, 5463, 5471, 5576], 'enhanced': [143, 182, 277, 435, 474, 569, 2551, 2861, 3363], '2.3-fold': [144, 436, 2719], 'overexpression': [146, 438], 'active': [148, 440, 2680, 3876, 4424], 'p110': [149, 441, 2681], 'subunit': [150, 162, 206, 442, 454, 498, 1492, 2682, 2688, 5487], 'PI': [152, 164, 208, 229, 444, 456, 500, 521, 656, 1222, 1254, 1452, 1494, 1593, 2613, 2637, 2667, 2690, 2702, 2758, 2782, 2802, 2927, 2946, 3146, 3844, 4082, 4242, 4290, 5285, 5489, 5507], '3-kinase': [153, 445, 602, 1223, 1255, 1453, 1495, 1594, 2614, 2638, 2691, 2783, 2803, 2928, 2947, 4083, 4291], 'inhibited': [155, 447], '44%': [156, 448], 'dominant': [159, 201, 451, 493, 1486, 2685, 2828, 2996, 3121, 3194, 3228, 4362, 5481], 'negative': [160, 202, 452, 494, 1342, 1487, 2686, 2829, 2997, 3122, 3195, 3229, 4363, 4849, 5482], 'p85': [161, 205, 453, 497, 2687], '3-kinase.': [165, 457, 2668, 2759], 'Cotransfection': [166, 458, 2835], '3-phosphoinositide-dependent': [168, 460, 584, 690], '(PDK1),': [170, 462], 'which': [171, 463, 898, 1013, 2124, 2139, 2160, 3654, 3760, 3955, 5053], 'is': [172, 464, 614, 647, 885, 902, 945, 2789, 2939, 3018, 3164, 3305, 3921, 4236, 4365, 4476, 4772, 4977, 4986, 5054, 5178, 5278, 5299, 5414], 'required': [173, 465, 2989], 'for': [174, 466, 964, 1693, 1706, 1902, 1934, 1973, 2020, 2155, 2275, 2309, 2424, 2465, 2495, 2506, 2539, 2666, 2773, 2926, 3144, 3155, 3292, 3346, 3650, 3756, 4086, 4150, 4223, 4632, 5119, 5167, 5551, 5569], 'full': [176, 468, 681], 'activation': [177, 469, 682, 714, 847, 1220, 1330, 1444, 2705, 2756, 2786, 3029, 3043, 3303, 3515, 4225, 4611, 5306, 5446], 'resulted': [180, 472, 2841, 3501], 'Insulin-like': [185, 477], 'factor-I-mediated': [187, 479], 'induction': [188, 480, 1386, 1501, 2869, 4164, 5409, 5514], 'decreased': [194, 486, 2728, 2910, 3019, 3126, 3220, 5279], 'significantly': [195, 487, 3420], '(p': [196, 488, 2646, 3134], '<': [197, 489, 2647, 3135, 3319, 3728], '0.01)': [198, 490, 2648, 3136, 3320], 'forms': [203, 495, 5483], 'PDK1,': [210, 502, 5467], 'Akt.': [212, 504, 2981, 3312, 3878], 'These': [213, 505, 1555, 2745, 2921, 3139], 'data': [214, 506, 2922, 3140, 3703, 3809, 4042], 'indicate': [215, 507, 2747, 4531], 'regulation': [217, 509, 1226, 2617, 2737, 2934, 2976, 2986, 3157, 4154, 4485, 4850], 'IGF-I': [222, 514, 1186, 1247, 1589, 3156, 3217, 3332, 3343, 3475, 3946, 3960, 4168, 5208], 'involves': [223, 515], 'cascade': [226, 518, 1373], 'mediated': [227, 519, 705, 1590, 2873, 3205, 4174, 5171], '3-kinase/PDK1/Akt/CREB.': [230, 522], 'Furthermore,': [231, 523, 3544, 3684, 3790, 4621], 'measured': [233, 525, 2023, 2133, 2162, 2203, 3880], 'mRNA': [236, 261, 528, 553, 2019, 2130, 2151, 3882, 3927, 3950], 'PC12': [238, 271, 530, 563, 1237, 1900, 1922, 1979, 2176, 2621, 2837, 3308, 3545, 3596, 3612, 3738, 3871, 5146, 5276], 'cells': [239, 531, 880, 1733, 1839, 1901, 1940, 1945, 1959, 1980, 1992, 2177, 2395, 2471, 2500, 2513, 2622, 2838, 3309, 3327, 3339, 3356, 3446, 3467, 3496, 3510, 3546, 3597, 3613, 3633, 3657, 3670, 3699, 3710, 3739, 3763, 3776, 3805, 3816, 3886, 3942, 4556, 4614, 5147, 5277], 'overexpressing': [240, 532, 3874], 'real-time': [243, 535, 2025, 3890], 'quantitative': [244, 536, 2026, 3891], 'reverse': [245, 537, 603, 2043], 'transcription-polymerase': [246, 538, 604], 'chain': [247, 539, 605], 'reaction': [248, 540, 606], 'TaqManTMfluorogenic': [251, 543], 'probe': [252, 544, 2060, 2075, 3897], 'system.': [253, 545, 3898, 5429], 'We': [254, 546, 1367, 2820, 3200, 3295, 3313, 3438, 3879, 4160, 5137, 5538, 5555, 5564], 'observed': [255, 547, 3069, 3484], '2.1-fold': [257, 549, 3923], 'increase': [258, 550, 1569, 1601, 2845, 2853, 3321, 3924, 5181], 'levels': [262, 554, 2152, 3416, 3883, 5134], 'cell': [266, 290, 558, 582, 753, 966, 1017, 2194, 3661, 3767, 3872, 4025, 4389, 4494, 5523], 'line': [267, 559, 3873], 'compared': [268, 560, 3584, 3933], 'control': [270, 562, 1921, 2732, 3355, 3495, 3587, 3604, 3713, 3819, 3936], 'cells,': [272, 564, 1238, 4431], 'supporting': [273, 565], 'observation': [275, 567], 'CREB': [278, 570, 1124, 1193, 1263, 1441, 1550, 1709, 1711, 2978, 3299, 3323, 3349, 3414, 3433, 3442, 3482, 4007, 5143, 5159, 5182, 5273, 5305, 5371, 5428], 'leads': [283, 575, 1597, 4432, 4838], 'increased': [285, 577, 2717, 3306, 3351, 3481, 3553, 3592, 3947, 4434, 4617, 5142], 'survival.': [291, 583], '1': [586, 2276, 2310, 2330, 2660, 2696, 2850], 'factor': [589, 1123, 3287, 3371, 4624, 4793, 4854, 5158, 5177, 5206], 'cAMP': [590], 'response': [591], 'CRE-binding': [593], '(MAP)': [597], 'phosphate-buffered': [599], 'saline': [600, 2253], 'serine': [608, 5373, 5418], 'threonine': [609], 'Akt/protein': [611, 745, 4974, 5364], 'B': [613, 747, 2697, 4976, 5366], 'an': [615, 4145, 4218, 4377, 5282, 5291, 5448], 'important': [616, 824, 2924, 3154], 'mediator': [617], 'metabolic': [619, 701, 743, 4487], 'well': [621, 2492, 4490], 'survival': [623, 754, 1018, 3554, 3572, 3593, 3662, 3768, 4232, 4390, 4435, 5524], 'responses': [624], 'insulin': [626, 704, 4497], 'factors': [629, 757, 1015, 1349, 4032, 4235, 4500], '(1.Coffer': [630, 723, 2804], 'P.J.': [631, 724, 2805], 'Jin': [632, 725, 2806], 'Woodgett': [634, 727, 2808], 'J.R.': [635, 728, 1020, 2809, 4965, 5075], 'Biochem.': [636, 729, 2207, 2810], '1998;': [638, 671, 731, 860, 993, 1050, 1201, 1524, 2812, 2959, 4308, 4456, 5349, 5391], '335:': [639, 732, 2813], '1-13Crossref': [640, 733, 2814], 'PubMed': [641, 674, 734, 784, 801, 839, 863, 938, 996, 1036, 1053, 1104, 1160, 1177, 1209, 1289, 1317, 1362, 1415, 1477, 1532, 1665, 1812, 1861, 1881, 2100, 2116, 2211, 2389, 2595, 2815, 2900, 2967, 3059, 3109, 3408, 3990, 4074, 4119, 4136, 4210, 4267, 4311, 4355, 4413, 4459, 4524, 4583, 4604, 4653, 4679, 4707, 4732, 4766, 4830, 4878, 4926, 4947, 5036, 5111, 5199, 5245, 5267, 5330, 5357, 5399], 'Scopus': [642, 675, 735, 785, 802, 840, 864, 939, 997, 1037, 1054, 1105, 1161, 1178, 1210, 1290, 1318, 1363, 1416, 1478, 1533, 1666, 1813, 1882, 2101, 2117, 2212, 2390, 2596, 2816, 2901, 2968, 3060, 3110, 3409, 3991, 4075, 4120, 4137, 4211, 4268, 4312, 4356, 4414, 4460, 4525, 4584, 4605, 4654, 4680, 4708, 4733, 4767, 4831, 4879, 4927, 4948, 5037, 5112, 5200, 5246, 5268, 5331, 5358, 5400], '(973)': [643, 736, 2817], 'Google': [644, 677, 737, 787, 804, 842, 866, 941, 980, 999, 1039, 1056, 1077, 1107, 1163, 1180, 1212, 1292, 1320, 1365, 1418, 1480, 1535, 1668, 1815, 1830, 1862, 1884, 2103, 2119, 2214, 2392, 2598, 2818, 2903, 2970, 3062, 3112, 3411, 3993, 4077, 4122, 4139, 4213, 4270, 4314, 4358, 4416, 4462, 4527, 4586, 4607, 4656, 4682, 4710, 4735, 4769, 4833, 4881, 4929, 4950, 4972, 5039, 5082, 5114, 5202, 5248, 5270, 5333, 5360, 5402], 'Scholar).': [645, 678, 738, 805, 843, 867, 942, 1000, 1108, 1181, 1213, 1321, 1366, 1419, 1481, 1669, 1885, 2120, 2393, 2599, 2819, 2904, 3063, 3113, 3412, 3994, 4078, 4140, 4214, 4271, 4315, 4417, 4463, 4528, 4608, 4770, 4834, 4882, 4973, 5040, 5115, 5203, 5271, 5334, 5403], 'activated': [648, 1245, 4987], 'translocation': [650, 712, 5012], 'plasma': [652, 4982, 5130], 'membrane': [653, 5131], 'when': [654, 3226, 4292], '3-kinase-generated': [657], '3-phosphoinositides': [658], 'bind': [659], 'its': [661, 680, 742, 952, 2868, 3293, 3514, 4782], 'pleckstrin': [662], 'homology': [663], 'domain': [664, 1347], '(2.Downward': [665], 'Curr.': [667], 'Opin.': [668], 'Cell': [669, 1618], '10:': [672], '262-267Crossref': [673], '(1194)': [676], 'For': [679], 'it': [683, 1215, 2726, 4985, 5046], 'needs': [684, 3288], 'be': [686, 3035, 3219, 3256, 3290, 3367, 3957, 4283, 4997, 5124, 5302, 5510], 'further': [687, 2007, 2316, 2860, 3952, 5435], 'phosphorylated': [688, 3291], 'kinase1': [691], '(PDK1)1': [692], 'at': [693, 698, 1575, 1769, 1776, 1788, 2138, 2272, 2289, 2312, 2462, 2536, 3434, 4538, 4794, 5422, 5578], 'Thr-308': [694, 2795, 4991], 'PDK2': [697], 'Ser-473.': [699, 4993], 'actions': [702], 'include': [708], 'stimulation': [709, 3206, 5019, 5473], 'GLUT4': [711], 'glycogen': [716, 4471], 'synthase': [717, 4472], 'glycolytic': [720], 'enzyme': [721], '6-phosphofructose-2-kinase': [722], 'addition': [740, 3179], 'actions,': [744], 'has': [748, 955, 1005, 1125, 1188, 1336, 3672, 3778, 4011, 4043, 4089, 4279, 4625, 4786, 5047, 5160], 'been': [749, 956, 1006, 1126, 1189, 1337, 3673, 3779, 4012, 4090, 4280, 4329, 4626, 4787, 5048, 5162], 'shown': [750, 1190, 1338, 3009, 3378, 3916, 4281, 4788, 4886], 'promote': [752, 1016, 5522], 'against': [758, 4436], 'several': [759, 5168], 'apoptotic': [760, 883, 4049, 4437], 'stimuli': [761], '(3.Dudek': [762, 4097, 4245, 4391], 'H.': [763, 918, 924, 4054, 4060, 4098, 4246, 4305, 4334, 4392, 4504, 4510], 'Datta': [764, 4099, 4247, 4335, 4393, 4958, 5068], 'S.R.': [765, 916, 4052, 4100, 4248, 4336, 4394, 4502], 'Franke': [766, 4101, 4249, 4337, 4395, 4954, 5064], 'T.F.': [767, 4102, 4250, 4338, 4396, 4955, 5065], 'Birnbaum': [768, 4103, 4251, 4339, 4397], 'M.J.': [769, 794, 974, 4104, 4129, 4252, 4340, 4398, 4742, 4750, 5261], 'Yao': [770, 4105, 4253, 4341, 4399], 'R.': [771, 1067, 4106, 4254, 4342, 4400, 4900, 4932, 5021, 5096], 'Cooper': [772, 4107, 4255, 4343, 4401], 'G.M.': [773, 4108, 4256, 4344, 4402], 'Segal': [774, 4109, 4257, 4345, 4403], 'R.A.': [775, 4110, 4258, 4346, 4404, 4571, 4599], 'Kaplan': [776, 4111, 4259, 4347, 4405], 'D.R.': [777, 1855, 4112, 4260, 4348, 4406, 4898, 4934, 5023, 5098], 'Greenberg': [778, 927, 4063, 4113, 4261, 4349, 4407, 4513, 4755, 5193], 'M.E.': [779, 928, 4064, 4114, 4262, 4350, 4408, 4514, 4756, 5194], 'Science.': [780, 859, 4115, 4263, 4351, 4409, 5195], '1997;': [781, 798, 836, 930, 1074, 1809, 4066, 4116, 4133, 4264, 4352, 4410, 4516, 4601, 4918, 4944, 5033, 5108], '275:': [782, 4117, 4265, 4353, 4411], '661-664Crossref': [783, 4118, 4266, 4354, 4412], '(2245)': [786, 4121, 4269, 4357, 4415], 'Scholar,': [788, 981, 1040, 1057, 1078, 1164, 1293, 2104, 4123, 4657, 4683, 4711, 4736, 4930, 4951, 5249], '4.Kulik': [789, 4124], 'G.': [790, 4125, 4637, 4659, 4687, 4810, 4862], 'Klippel': [791, 4126], 'A.': [792, 992, 1797, 1808, 1877, 4127, 4444, 4558, 4593, 4728, 4738, 4740, 4902, 4957, 5067, 5255], 'Weber': [793, 4128], 'Mol.': [795, 1047, 1171, 1356, 1659, 3053, 4130, 4453], 'Cell.': [796, 929, 1172, 1357, 1660, 3054, 4065, 4131, 4454, 4515, 4757], '17:': [799, 4134], '1595-1606Crossref': [800, 4135], '(968)': [803, 4138], 'family': [808], 'proteins': [810, 2236, 4468], 'consisting': [811], 'pro-apoptotic': [813, 910], 'Bad,': [814], 'Bik,': [815], 'Bid.': [816], 'Etc.': [817], 'Bcl-xL': [822], 'are': [823, 1256, 3183, 3261, 3704, 3719, 3810, 3825], 'regulators': [825], 'mammalian': [827], 'apoptosis': [828, 901, 3610, 4274, 4369], '(5.Merry': [829], 'D.E.': [830], 'Korsmeyer': [831], 'S.J.': [832], 'Annu.': [833], 'Rev.': [834], 'Neurosci.': [835], '20:': [837], '245-267Crossref': [838], '(551)': [841], 'Bcl-2/Bcl-xL': [844], 'prevents': [845, 900], 'caspase-9': [849], 'Apaf-1': [851], 'cytochrome': [853], 'c': [854], '(6.Adams': [855], 'J.M.': [856, 4912], 'Cory': [857], 'S.': [858, 922, 991, 1044, 1061, 1080, 1136, 1265, 1295, 1391, 1455, 1807, 1876, 2365, 2571, 2876, 3085, 3384, 3966, 4058, 4186, 4508, 4661, 4685, 4689, 4727, 4812, 5221, 5257, 5308], '281:': [861], '1322-1326Crossref': [862], '(4855)': [865], 'Bad': [870, 912, 944, 4475, 5528], 'heterodimerize': [871], 'neutralize': [873], 'each': [874, 2425, 2491], "other's": [875], 'function.': [876], 'fate': [878], 'exposed': [881, 2343], 'signal': [884, 4438, 5153], 'determined': [886], 'balance': [889], 'between': [890], 'pro-': [891], 'proteins.': [894], 'One': [895, 2407], 'mechanism': [896, 1011, 4021], 'considered': [903], 'proceed': [905, 4239], 'phosphorylation': [907, 1261, 1442, 1543, 2793, 3300, 3324, 3350, 3483, 4465, 4801, 4989, 5183, 5274, 5369, 5530], 'Ser-136': [914], '(7.Datta': [915, 4051, 4501], 'Dudek': [917, 4053, 4331, 4503], 'Tao': [919, 4055, 4505], 'X.': [920, 4056, 4506, 4691], 'Masters': [921, 4057, 4507], 'Fu': [923, 4059, 4509], 'Gotoh': [925, 4061, 4511], 'Y.': [926, 4062, 4512, 4597, 5251], '91:': [931, 4067, 4517], '231-241Abstract': [932, 4068, 4518], 'Full': [933, 935, 1031, 1033, 1099, 1101, 1155, 1157, 1204, 1206, 1284, 1286, 1312, 1314, 1410, 1412, 1472, 1474, 1527, 1529, 2384, 2386, 2590, 2592, 2785, 2895, 2897, 2962, 2964, 3104, 3106, 3403, 3405, 3985, 3987, 4069, 4071, 4205, 4207, 4519, 4521, 4578, 4580, 4648, 4650, 4674, 4676, 4702, 4704, 4761, 4763, 4825, 4827, 4873, 4875, 4921, 4923, 5240, 5242, 5325, 5327, 5352, 5354, 5394, 5396], 'Text': [934, 936, 1032, 1034, 1100, 1102, 1156, 1158, 1205, 1207, 1285, 1287, 1313, 1315, 1411, 1413, 1473, 1475, 1528, 1530, 2385, 2387, 2591, 2593, 2896, 2898, 2963, 2965, 3105, 3107, 3404, 3406, 3986, 3988, 4070, 4072, 4206, 4208, 4520, 4522, 4579, 4581, 4649, 4651, 4675, 4677, 4703, 4705, 4762, 4764, 4826, 4828, 4874, 4876, 4922, 4924, 5241, 5243, 5326, 5328, 5353, 5355, 5395, 5397], 'PDF': [937, 1035, 1103, 1159, 1208, 1288, 1316, 1414, 1476, 1531, 2388, 2594, 2899, 2966, 3108, 3407, 3989, 4073, 4209, 4523, 4582, 4652, 4678, 4706, 4765, 4829, 4877, 4925, 5244, 5329, 5356, 5398], '(5003)': [940, 4076, 4526], 'Phosphorylated': [943], 'sequestered': [946], '14-3-3': [948], 'protein,': [949], 'leading': [950, 1383, 4847], 'down-regulation.': [953], 'It': [954, 4771], 'also': [957, 5057, 5161, 5405], 'suggested': [958, 4044], 'additional': [960, 4146, 4219], 'mechanisms': [961], 'might': [962], 'exist': [963], 'survival-promoting': [967], 'action': [968, 3372, 3961], '(8.Hinton': [971], 'H.J.': [972], 'Welham': [973], 'Immunol.': [976, 1073], '1999;': [977, 1096, 1152, 1281, 1309, 1407, 1469, 2381, 2587, 2892, 3101, 3400, 3982, 4202, 4575, 4645, 4671, 4699, 4729, 4758, 4822, 4870, 5237, 5322], '162:': [978], '7002-7009PubMed': [979], '9.Scheid': [982], 'M.P.': [983], 'Duronio': [984], 'V.': [985], 'Proc.': [986, 1802, 1871, 4722], 'Natl.': [987, 1803, 1872, 4723], 'Acad.': [988, 1804, 1873, 4724], 'Sci.': [989, 1805, 1874, 4725], 'U.': [990, 1806, 1875, 4726], '95:': [994], '7439-7444Crossref': [995], '(276)': [998], 'Up-regulation': [1001], 'identified': [1007, 1127, 1240, 1368, 4627, 5163], 'critical': [1010, 4147, 4481], '(10.Singleton': [1019], 'Dixit': [1021], 'V.M.': [1022], 'Feldman': [1023], 'E.L.': [1024], '1996;': [1028, 1174, 1359, 1662, 2097, 2113, 3056, 5196, 5264], '271:': [1029], '31791-31794Abstract': [1030], '(156)': [1038], '11.Tamatani': [1041], 'M.': [1042, 1046, 1197, 1520, 2955, 4301, 4896, 4906, 4938, 5027, 5102, 5345, 5387], 'Ogawa': [1043], 'Tohyama': [1045], 'Brain': [1048], 'Res.': [1049, 2096, 2112], '58:': [1051], '27-39Crossref': [1052], '(89)': [1055], '12.Minshall': [1058], 'C.': [1059, 1084, 1140, 1269, 1395, 2369, 2575, 2880, 3089, 3388, 3970, 4190, 5225], 'Arkins': [1060], 'Straza': [1062], 'Conners': [1064], 'Dantzer': [1066], 'Freund': [1068], 'G.G.': [1069], 'Kelley': [1070], 'K.W.': [1071], '159:': [1075], '1225-1232PubMed': [1076], '13.Pugazhenthi': [1079], 'Miller': [1081, 1137, 1266, 1392, 2366, 2572, 2877, 3086, 3385, 3967, 4187, 5222], 'E.': [1082, 1138, 1168, 1267, 1353, 1393, 1656, 2367, 2573, 2878, 3050, 3087, 3386, 3968, 4188, 5223], 'Sable': [1083, 1139, 1268, 1394, 2368, 2574, 2879, 3088, 3387, 3969, 4189, 5224], 'Young': [1085, 1141, 1270, 1396, 2370, 2576, 2881, 3090, 3389, 3971, 4191, 5226], 'P.': [1086, 1142, 1271, 1397, 2371, 2577, 2882, 3091, 3390, 3972, 4192, 4667, 4693, 4746, 4818, 4908, 4910, 4936, 5025, 5100, 5227, 5259], 'Heidenreich': [1087, 1143, 1272, 1302, 1398, 1462, 2372, 2578, 2883, 3092, 3391, 3973, 4193, 5228, 5315], 'K.A.': [1088, 1144, 1273, 1303, 1399, 1463, 2373, 2579, 2884, 3093, 3392, 3974, 4194, 5229, 5316], 'Boxer': [1089, 1145, 1169, 1274, 1354, 1400, 1657, 2374, 2580, 2885, 3051, 3094, 3393, 3975, 4195, 5230], 'L.M.': [1090, 1146, 1170, 1275, 1355, 1401, 1658, 2375, 2581, 2886, 3052, 3095, 3394, 3976, 4196, 5231], 'Reusch': [1091, 1147, 1276, 1304, 1402, 1464, 2376, 2582, 2887, 3096, 3395, 3977, 4197, 5232, 5317], 'J.E.-B.': [1092, 1148, 1277, 1305, 1403, 1465, 2377, 2583, 2888, 3097, 3396, 3978, 4198, 5233, 5318], '274:': [1097, 1153, 1282, 1310, 1408, 1470, 2382, 2588, 2893, 3102, 3401, 3983, 4203, 4576, 4646, 4672, 4700, 4823, 4871, 5238, 5323], '27529-27535Abstract': [1098, 1154, 1283, 1409, 2383, 2589, 2894, 3103, 3402, 3984, 4204, 5239], '(183)': [1106, 1162, 1291, 1417, 2391, 2597, 2902, 3111, 3410, 3992, 4212, 5247], 'contains': [1114], 'site,': [1119], 'transcription': [1122, 1348, 3286, 4623, 4792, 4845, 4853, 5157], 'positive': [1130, 2664, 2975], 'regulator': [1131], '(13.Pugazhenthi': [1135, 1264, 1390, 2364, 2570, 2875, 3084, 3383, 3965, 4185, 5220], '14.Wilson': [1165], 'B.E.': [1166, 1351, 1654, 3048], 'Mochon': [1167, 1352, 1655, 3049], '16:': [1175, 1360, 1663, 3057], '5546-5556Crossref': [1176, 1361, 1664, 3058], '(380)': [1179, 1364, 1667, 3061], 'target': [1184, 2129, 4631, 5166], 'signaling,': [1187], 'activate': [1192, 3432], '(15.Du': [1194, 1517, 2952, 5342, 5384], 'Montminy': [1196, 1516, 1519, 2951, 2954, 5341, 5344, 5386], '273:': [1202, 1525, 2960, 5197, 5350, 5392], '32377-32379Abstract': [1203, 1526, 2961, 5351, 5393], '(835)': [1211, 1534, 2969, 5359, 5401], 'Thus,': [1214], 'seemed': [1216], 'possible': [1217], 'could': [1224, 1563, 3034, 3366, 3956, 5509], 'mediate': [1225, 1564], 'IGF-I.': [1231], 'studies': [1235, 3260, 3837, 4530], 'three': [1242, 3725, 3831], 'post-receptor': [1243], 'pathways': [1244, 3247, 3266, 4322, 4488, 5170], 'extracellular-regulated': [1249, 1333], 'kinase,': [1250, 4319, 4382], 'p38β': [1251, 2871, 3374, 3963], 'MAPK,': [1252], 'capable': [1257, 3184], 'mediating': [1259, 2781], 'Ser-133': [1260, 3302], '16.Pugazhenthi': [1294], 'Boras': [1296, 1456, 5309], 'T.': [1297, 1457, 4303, 4695, 4717, 4963, 5073, 5310], "O'Connor": [1298, 1458, 5311], 'D.': [1299, 1459, 1870, 5312], 'Meintzer': [1300, 1460, 5313], 'M.K.': [1301, 1461, 5314], '2829-2837Abstract': [1311, 1471, 5324], '(109)': [1319, 1479, 5332], 'However,': [1322, 1420, 3022], 'context': [1325], 'CREB-driven': [1327], 'promoter,': [1329], 'have': [1340, 3167, 3552, 4328, 4884, 5005], 'regulatory': [1343, 1491, 4148, 5486], 'effect': [1344, 3192], 'Ets': [1346], '(14.Wilson': [1350, 1653, 3047], 'IGF-I-mediated': [1371, 1440, 1500, 2736, 2913, 4224], 'MAP': [1375, 4176, 4180], 'MAPK/MAP': [1379], 'kinase-3/CREB,': [1382], 'SB203580,': [1421], 'p38': [1423, 5216], 'MAPK': [1424, 2872, 3964, 5217], 'inhibitor': [1425, 2639, 2658, 4378, 5283, 5292], 'blocked': [1426, 5415], 'IGF-I-induced': [1427, 1568, 2749, 5477], 'only': [1431], 'partially.': [1432], 'Earlier': [1433], 'work': [1434], 'laboratory': [1437], 'demonstrated': [1438, 1537, 3275, 5006, 5049, 5362], 'chromogranin': [1448, 1508], 'A': [1449, 1670, 1779, 3335], 'requires': [1451], '(16.Pugazhenthi': [1454, 5307], 'study,': [1484, 3067, 5045, 5338], 'form': [1488, 2998, 4425], 'able': [1497, 4366, 5139, 5495], 'block': [1499, 3027, 4385], 'A,': [1509, 3013], 'neuro': [1511], 'endocrine-specific': [1512], 'gene.': [1513], 'Du': [1514, 2949, 5339], 'Scholar)': [1536, 1816, 1831, 2971, 4359, 4587, 5361], 'recently': [1538, 2972, 4161], 'stimulates': [1541, 5367], 'transcriptional': [1546, 1577, 2933, 4153, 4540, 5536], 'HEK': [1552], '293': [1553], 'cells.': [1554, 3361, 3588], 'reports': [1556], 'clearly': [1557, 3274, 3997], 'raise': [1558], 'possibility': [1560, 3238], 'part': [1565, 2754], 'level.': [1578, 2148, 3437], 'objective': [1580], 'whether': [1588, 2984, 3298], 'pharmacological': [1607], 'inhibitors': [1608], 'rapamycin': [1611], 'from': [1613, 1625, 1687, 1713, 1725, 1990, 2082, 2169, 3352, 3600, 3835], 'Biomol': [1614], '(Plymouth': [1615], 'Meeting,': [1616], 'PA).': [1617], 'culture': [1619, 3567, 3714, 3820, 4296], 'media': [1620], 'supplies': [1622], 'purchased': [1624, 1686, 1724], 'Gemini': [1626], 'Bio': [1627], 'Products,': [1628], 'Inc': [1629], '(Calabasas,': [1630], 'CA)': [1631, 1701], 'Life': [1633], 'Technologies,': [1634, 1997, 2362], 'Inc.': [1635], 'bcl-2': [1642, 3159], 'linked': [1645], 'described': [1651, 1850, 2355, 2568, 3838], 'previously': [1652, 1851], 'TATA': [1676], 'box': [1677], 'joined': [1678], 'tandem': [1680, 3536], 'repeats': [1681, 3537], '(4×)': [1684], 'Stratagene': [1688], '(La': [1689], 'Jolla,': [1690], 'CA).': [1691, 1729], 'Plasmids': [1692], 'transfection': [1694, 1974, 2430], 'experiments': [1695, 3273], 'purified': [1697, 2008], "Qiagen's": [1699], '(Valencia,': [1700], 'maxi': [1702], 'kit.': [1703], 'Antibodies': [1704], 'specific': [1705], 'Phospho': [1707], '(Ser-133)': [1708], 'New': [1714], 'England': [1715, 2340], 'Biolabs': [1716], '(Beverly,': [1717], 'MA).': [1718], 'assay': [1721, 2553, 2563], 'kit': [1722, 2165, 2554], 'Pharmingen': [1726], '(San': [1727], 'Diego,': [1728], 'Rat': [1730], 'pheochromocytoma': [1731], '(PC12)': [1732], '(provided': [1734], 'Dr.': [1736, 5540, 5543, 5548, 5566], 'Derek': [1737], 'LeRoith': [1738], '(NIDDK,': [1739], 'National': [1740], 'Institutes': [1741], 'Health,': [1743], 'Bethesda,': [1744], 'MD)': [1745], 'maintained': [1747, 3513], "Dulbecco's": [1749, 3644, 3676, 3750, 3782], 'modified': [1750, 3645, 3677, 3751, 3783], "Eagle's": [1751, 3646, 3678, 3752, 3784], 'medium': [1752, 1914, 1933, 1948, 2456, 2480, 2505, 3500, 3647, 3679, 3753, 3785, 4297], '10%': [1754], 'fetal': [1755], 'bovine': [1756], 'serum,': [1757, 1761], '5%': [1758, 2268], 'heat-inactivated': [1759], 'horse': [1760, 3682, 3788], '100': [1762, 1766, 2233, 2450, 2522, 3944], 'μg/ml': [1763], 'streptomycin,': [1764], 'microunits/ml': [1767], 'penicillin': [1768], '37': [1770, 2917], '°C': [1771, 2291], 'humidified': [1774], 'atmosphere': [1775], '8%': [1777], 'CO2.': [1778], 'cDNA': [1780], 'encoding': [1781], 'Src': [1785], 'myristoylation': [1786, 5089, 5152], 'sequence': [1787, 2035, 3904], 'N': [1790], 'terminus': [1791], '(17.Ahmed': [1792], 'N.N.': [1793, 4953, 5063], 'Grimes': [1794], 'H.L.': [1795], 'Bellacosa': [1796, 4443, 4956, 5066], 'Chan': [1798], 'T.O.': [1799], 'Tsichlis': [1800, 4447, 4966, 5076], 'P.N.': [1801, 4448, 4967, 5077], '94:': [1810], '3627-3632Crossref': [1811], '(490)': [1814], 'retroviral': [1819], 'vector': [1820, 3636, 3742], 'pLNCX': [1821], '(18.Miller': [1822], 'A.D.': [1823, 4595], 'Rosman': [1824], 'G.J.': [1825], 'Biotechniques.': [1826], '1989;': [1827], '7:': [1828], '980-990PubMed': [1829], 'packaged': [1833], 'into': [1834], 'replication-defective': [1835], 'retrovirus': [1836, 1887], '293T': [1838], 'along': [1840], 'plasmids': [1843], 'SV-ψ-A-MLV': [1844], 'SV-ψ-env−-MLV': [1846], 'procedure': [1849, 2354], '(19.Landau': [1852], 'N.R.': [1853], 'Littman': [1854], 'Virol.': [1857], '1992;': [1858], '66:': [1859], '5110-5113Crossref': [1860], 'Scholar,20.Pear': [1863], 'W.S.': [1864], 'Nolan': [1865], 'G.P.': [1866], 'Scott': [1867], 'M.L.': [1868], 'Baltimore': [1869], '1993;': [1878, 4969, 5079], '90:': [1879], '8392-8396Crossref': [1880], '(2331)': [1883], 'Secreted': [1886], 'supplemented': [1889], 'polybrene': [1891], '(8': [1892], 'μg/ml),': [1893], 'filtered': [1894], '(0.45': [1895], 'μm),': [1896], 'incubated': [1898, 2301, 2461, 2494], '24': [1903, 1954, 2507, 3695, 3801], 'h.': [1904, 2497], 'Cells': [1905, 1962], 'expressing': [1906, 3310, 3447, 3511, 3547, 3614, 3634, 3740, 5148], 'selected': [1909], 'culturing': [1911, 3493], 'them': [1912, 1930], 'G418.': [1916], 'Apoptosis': [1917], 'induced': [1919], '(Neo-21)': [1923, 3638, 3744], 'clone': [1927, 3582, 3931], 'exposing': [1929], 'serum-free': [1932, 3569], '72': [1935, 3564, 3651, 3757], 'h,': [1936, 2277, 3652, 3696, 3758, 3802], 'viable': [1939, 1958, 3656, 3669, 3698, 3709, 3762, 3775, 3804, 3815], 'counted.': [1942, 1961, 3659, 3701, 3765, 3807], 'Alternatively,': [1943], 'regular': [1947, 1984, 2504], 'UV-irradiated': [1950, 3690, 3796], '(32': [1951, 3691, 3797], 'J/M2),': [1952], 'h': [1955, 2311, 2508, 3565], 'later,': [1956], 'cultured': [1964, 1982, 2178, 2397, 2502, 3642, 3674, 3748, 3780], '6': [1966, 2403], '×': [1967, 2404], '35-mm': [1968, 2405], 'wells': [1969], 'coated': [1970], 'poly-l-lysine': [1972], 'studies.': [1975], 'Control': [1976], 'Akt-overexpressing': [1978], 'medium.': [1985], 'Total': [1986], 'RNA': [1987, 2004], 'isolated': [1989], 'these': [1991, 2671, 3265, 3326, 3338, 3885, 3941, 4087], 'TRIzol': [1994], 'reagent': [1995, 2338, 2360, 2421, 2447], '(Life': [1996, 2361], 'Inc.)': [1998, 2363], 'per': [2000, 2172], "manufacturer's": [2002, 2174], 'protocol.': [2003, 2175], 'samples': [2005, 2219], 'DNase': [2010], 'digestion': [2011], 'extraction': [2013], 'phenol': [2015], 'chloroform.': [2017], 'RT-PCR': [2027, 3892, 5575], 'PE': [2029], 'Applied': [2030, 3899], 'Biosystems': [2031, 3900], 'prism': [2032, 3901], 'model': [2033, 3902], '7700': [2034, 3903], 'detection': [2036, 3905], 'instrument.': [2037], 'sequences': [2039], 'forward': [2041], 'primers': [2044], 'designed': [2046], 'Primer': [2048], 'Express': [2049], '(PE': [2050], 'ABI)': [2051], '5′-TGGGATGCCTTTGTGGAACT-3′': [2053], '5′-GAGACAGCCAGGAGAAATCAAAC-3′,': [2055], 'respectively.': [2056, 2920], 'TaqManTM': [2058, 3895], 'fluorogenic': [2059, 3896], 'used': [2061, 2423, 3869, 3908], '5′-6FAM-TGGCCCCAGCATGCGACCTC-TAMRA-3′.': [2063], 'During': [2064], 'PCR': [2065], 'amplification,': [2066], '5′': [2067, 2078], 'nucleolytic': [2068], 'Taq': [2071], 'polymerase': [2072], 'cleaves': [2073], 'separating': [2076], 'fluorescent': [2080, 2142], 'dye': [2081, 2086], '3′': [2084], 'quencher': [2085], '(21.Heid': [2087], 'C.A.': [2088, 2108], 'Stevens': [2089], 'Livak': [2091], 'K.J.': [2092], 'Williams': [2093, 2109], 'P.M.': [2094, 2110], 'Genome': [2095, 2111], '6:': [2098, 2114], '986-994Crossref': [2099], '(5089)': [2102], '22.Gibson': [2105], 'U.E.M.': [2106], 'Heid': [2107], '995-1001Crossref': [2115], '(1795)': [2118], 'Threshold': [2121], 'cycle,': [2122], 'Ct,': [2123], 'correlates': [2125], 'inversely': [2126], 'levels,': [2131], 'cycle': [2136], 'number': [2137, 4094], 'emission': [2143], 'increases': [2144, 4549], 'above': [2145, 3686, 3792, 3839], 'threshold': [2147], 'corrected': [2154], '18': [2156], 'S': [2157], 'ribosomal': [2158], 'RNA,': [2159], '(PEABI,': [2166], 'P/N': [2167], '4308310)': [2168], 'Perkin-Elmer': [2170], 'poly-l-lysine-coated': [2180], '60-mm': [2181], 'dishes': [2182], 'under': [2183, 3421], 'appropriate': [2184, 2510], 'conditions': [2185, 3424], 'washed': [2187, 2296, 2515], 'twice': [2188], 'ice-cold': [2190], 'PBS,': [2191, 2473], 'lysates': [2195, 2201], 'prepared.': [2197], 'Protein': [2198], 'content': [2199], '(23.Bradford': [2204], 'M.M.': [2205], 'Anal.': [2206], '1976;': [2208], '72:': [2209], '248-254Crossref': [2210], '(225068)': [2213], 'Scholar),': [2215, 5083], 'appropriately': [2217], 'diluted': [2218, 2448], '(containing': [2220], 'equal': [2221], 'amounts': [2222], 'protein)': [2224], 'mixed': [2226, 2458], '2×': [2228], 'Laemmli': [2229], 'sample': [2230], 'buffer': [2231, 2288, 2299, 2320], 'mmdithiothreitol.': [2234], 'resolved': [2237], '12%': [2240], 'SDS-polyacrylamide': [2241], 'gels': [2242], 'transferred': [2244], 'polyvinylidene': [2246], 'difluoride': [2247], 'membranes.': [2248], 'After': [2249, 2315, 2468, 2528, 3563], 'blocking': [2250, 2287, 2298, 2319], 'Tris-buffered': [2252], 'Tween': [2255, 2265], '(20': [2256], 'mm': [2257, 2328], 'Tris-HCl': [2258], '(pH': [2259, 2325], '7.9),': [2260], '8.5%': [2261], 'NaCl,': [2262, 2329], '0.1%': [2264], '20)': [2266], 'non-fat': [2269], 'dry': [2270], 'milk': [2271], 'room': [2273, 2313, 2463], 'temperature': [2274, 2464], 'blots': [2279, 2294, 2333], 'treated': [2281, 2634, 3341], 'primary': [2284], 'antibody': [2285], '4': [2290], 'overnight.': [2292], 'anti-rabbit': [2303], 'IgG': [2304], 'conjugated': [2305], 'alkaline': [2307], 'phosphatase': [2308], 'temperature.': [2314], 'washes': [2317], '10': [2323, 2327, 2417, 3347], 'mmTris-HCl': [2324], '9.5),': [2326], 'mmMgCl2,': [2331], 'developed': [2335], 'CDP-Star': [2337], '(New': [2339], 'Biolabs)': [2341], 'x-ray': [2345], 'film.': [2346], 'Transient': [2347], 'out': [2351, 2566], 'earlier': [2356, 2569], 'LipofectAMINE': [2358, 2420, 2446, 2486], 'Plus': [2359, 2414], 'around': [2399], '70%': [2400], 'confluence': [2401], 'plates.': [2406], 'μg': [2408, 2418], 'plasmid,': [2410], '3': [2411, 2703, 3426, 3490, 3523], 'μl': [2412, 2451, 2475, 2523], 'reagent,': [2415], 'well.': [2426], 'normalize': [2428], 'efficiency,': [2431], 'plasmid': [2433, 2484], 'β-galactosidase': [2435, 2562], 'SV40': [2439], 'included.': [2442], 'DNA': [2443], 'serum': [2453, 2477, 3499, 3521, 3556, 3649, 3755], 'antibiotic-free': [2455, 2479], 'together': [2459], '30': [2466, 2540], 'min.': [2467], 'washing': [2469], '800': [2474], 'added.': [2482], 'mixture': [2487], 'added': [2489, 4293], '5': [2496], 'Then': [2498], 'before': [2509], 'treatment.': [2511], 'cold': [2517], 'PBS': [2518], 'lysed': [2520], 'lysis': [2526], 'buffer.': [2527], 'freezing': [2529], 'thawing,': [2531], 'lysate': [2533], 'centrifuged': [2535], '14,000': [2537], 'rpm': [2538], 'min': [2541, 5016], 'collect': [2543], 'supernatant.': [2545], 'Luciferase': [2546], 'assayed': [2548], '(Pharmingen)': [2555], 'Monolight': [2558], '2010': [2559], 'luminometer.': [2560], 'Statistical': [2600], 'analysis': [2601], 'performed': [2603, 5577], "Student's": [2605], 't': [2606], 'test.': [2607], 'investigate': [2609], 'transfected': [2623, 3494], 'construct': [2628, 3850, 5086, 5458], 'site': [2632, 3083, 3304, 4545], 'LY294002.': [2640], 'There': [2641], 'presence': [2655, 2722, 3215, 3473, 3518], '(Fig.': [2659, 2849, 3333, 3425, 3489, 3522], 'A),': [2661, 2769], 'suggesting': [2662, 2770, 4542, 5296, 5501], 'confirm': [2670, 3856], 'observations,': [2672], 'constitutively': [2679, 3875], 'Fig.': [2695, 3011], 'demonstrates': [2698], 'ability': [2700, 4029], 'augment': [2707], 'basal': [2708, 2715, 2911, 3127, 5475], 'IGF-I-stimulated': [2710, 3129, 5272], 'p110,': [2724, 5466], 'whereas': [2725, 3509, 5084], '56%': [2730], 'Δ': [2734], 'p85.': [2735], 'similarly': [2743], 'affected.': [2744], 'observations': [2746], 'proceeds': [2752], 'Rapamycin': [2760], 'did': [2761, 3024, 3201, 3417], 'not': [2762, 3025, 3418, 3542, 4384, 5094, 5288], 'inhibit': [2763], '(Fig.1': [2768], 'rather': [2775], 'than': [2776], 'p70': [2777, 4326, 4380, 5294], 's6': [2778, 4381], 'action.': [2784, 4547], 'known': [2790, 3165, 4237, 4477, 4773, 5179], 'require': [2792], 'PDK-1,': [2797], 'downstream': [2800, 2943], 'therefore': [2821, 3296], 'examined': [2822, 2992, 3190, 3297, 3440], 'impact': [2824, 2994, 3842], 'PDK1': [2826, 2830, 2840, 2858, 2909, 2930, 3163, 3204, 3240], '2.0-fold': [2844], 'C).': [2851, 3524, 5155], '66%': [2862], 'IGF-I,': [2864], 'probably': [2865], 'due': [2866, 3036, 3368, 3958], 'contrast,': [2906], 'dead': [2908], '62%,': [2919], 'demonstrate': [2923, 3840, 5436], 'roles': [2925], 'expression.': [2937, 3161, 5517], 'one': [2940], 'targets': [2944, 3169], 'reported': [2973, 4091, 4162], 'explore': [2983, 3264], 'CREB,': [2990, 3000, 3283], 'KCREB,': [3001], 'Akt-stimulated': [3004, 3014], 'As': [3008, 3915], '2': [3012], 'KCREB.': [3021], 'KCREB': [3023], 'completely': [3026], 'Akt-mediated': [3028, 3277, 4006, 4464, 5408], 'reporter.': [3032], 'This': [3033, 3362, 3995, 4835], 'CREB-independent': [3039], 'component': [3040], 'retained': [3073], 'modest': [3074], 'after': [3076, 3555, 3653, 3694, 3759, 3800, 5017], 'deletion': [3077], 'or': [3078, 3639, 3745], 'mutation': [3079, 5421], 'Furthermore': [3114], 'cotransfection': [3115, 3235], '(T308A;': [3124], 'S473A)': [3125], '40%': [3133, 3504], '(Fig.2': [3137], 'B).': [3138, 3427], 'support': [3141, 5560], '3-kinase/PDK1/Akt/CREB': [3147], 'However': [3162], 'potential': [3168], 'such': [3170, 4469], 'p90rsk': [3172, 3249], 'C': [3176, 3253], 'isoforms': [3177, 3254], 'activating': [3186, 3242, 5215], 'CREB.': [3187], 'Hence': [3188, 3428, 5518], 'PDK1-mediated': [3198], 'induction.': [3199], 'observe': [3202, 5141], 'absence': [3213, 3330, 3471], '51': [3222], '48%,': [3224], 'respectively,': [3225], 'included': [3232], 'experiments.': [3236, 3833], 'modestly': [3241], 'other': [3246], 'cannot': [3255], 'ruled': [3257], 'Further': [3259], 'needed': [3262], 'detail.': [3268], 'results': [3270, 3526, 3718, 3824, 4615], 'activates': [3279], 'this': [3285, 4318, 4888, 5441], 'activation.': [3294, 4008, 5537], 'myristoylated': [3311, 3877, 4421, 5051], 'noted': [3314], 'significant': [3316, 5472], '(90%;': [3317], 'p': [3318], '3,': [3334], 'andB).': [3336], 'When': [3337, 5454], '(100': [3344], 'ng/ml)': [3345], 'min,': [3348], '2.2-fold': [3353], '2.9-fold': [3358], 'Akt-expressing': [3360], 'PCREB': [3364], 'formation': [3365], 'MAPK-mediated': [3375], 'change': [3419], 'different': [3422, 5133], 'experimental': [3423], 'seems': [3430, 5122, 5520], 'post-translational': [3436, 4045], 'next': [3439], 'promoter.': [3459, 3854, 4228, 5453], 'elevated': [3464], 'both': [3468, 4803, 5088], '(Fig.3': [3476, 5154], 'C),': [3477], 'correlating': [3478], 'experiment': [3488, 3996], 'A).': [3491], 'Interestingly,': [3492], 'low': [3498, 3520], 'activity,': [3508, 5500], 'Similar': [3525], 'obtained': [3528], 'four': [3535], 'sites': [3540, 4802], '(results': [3541], 'shown).': [3543], 'found': [3550], 'withdrawal': [3557], 'exposure': [3559], 'UV': [3561], '(TableI).': [3562], 'medium,': [3570], 'rate': [3573, 3663, 3769], 'high': [3576], '86%': [3578], '26%': [3586], 'addition,': [3590], 'UV-exposed': [3595], '76%': [3599], '38%': [3601], 'seen': [3602], 'cells.Table': [3605], 'ISerum': [3606], 'withdrawal-mediated': [3607], 'UV-induced': [3609], 'AktCell': [3615], 'survivalSerum-freeUV%': [3616], 'controlNeo-2126.0': [3618], '±': [3619, 3621, 3623, 3628, 3722, 3828], '9.937.9': [3620], '11.4Akt86.2': [3622], '14.5a<': [3624], '0.01': [3625, 3630, 3729], 'vs.': [3626, 3631, 3730], 'Neo-21.75.6': [3627], '14.2a<': [3629], 'Neo-21.PC12': [3632], 'LNCX': [3637, 3743], 'LNCX-Myr-Akt': [3640, 3746], 'without': [3648, 3715, 3754, 3821], 'expressed': [3665, 3771], 'percentage': [3667, 3707, 3773, 3813], '1%': [3681, 3787], 'serum.': [3683, 3789], 'mentioned': [3687, 3793], 'clones': [3688, 3794], 'J/m2),': [3692, 3798], 'presented': [3705, 3811], 'radiation.': [3716, 3822], 'mean': [3721, 3827], 'S.E.': [3723, 3829], 'independent': [3726, 3832], 'experiments.a': [3727], 'Neo-21.': [3731], 'Open': [3732], 'table': [3733], 'new': [3736], 'tab': [3737], 'Data': [3834], '3-kinase/PDK1/Akt': [3845, 5508], 'endogenous': [3865, 5449], 'sensitive': [3889], 'instrument': [3906], 'measure': [3910], 'fluorescence': [3913], 'emission.': [3914], 'Fig.3': [3918], 'D,': [3919], 'there': [3920, 5470], 'level': [3928, 3951], 'vector-only': [3937], 'clone.': [3938], 'Treatment': [3939], 'ng/ml': [3945], '3.0-fold,': [3954], 'provides': [3998], 'physiological': [4000, 5438], 'relevance': [4001], 'significance': [4004], 'Great': [4009], 'insight': [4010], 'gained': [4013], 'over': [4014], 'recent': [4016, 5337], 'few': [4017], 'years': [4018], 'regarding': [4019], 'neuronal': [4023, 4231, 4430], 'programmed': [4024], 'death': [4026, 4495], 'serve': [4034], 'agents.': [4037], 'majority': [4039], 'modification': [4046, 4837], 'machinery': [4050], 'importance': [4080, 5439], 'effects': [4088], 'groups': [4096], 'defines': [4144], 'Bcl-2.': [4159, 4620], 'kinase-3': [4184, 4473], 'Now': [4215], 'identify': [4217], 'Regulation': [4229], '3-kinase-mediated': [4243], 'Low': [4272], 'potassium-induced': [4273], 'cerebellar': [4276, 4372], 'granule': [4277], 'neurons': [4278], 'prevented': [4284], 'synthetic': [4286], 'lipid': [4287], 'products': [4288], '(24.Shimoke': [4298], 'Yamada': [4300], 'Ikeuchi': [4302], 'Hatanaka': [4304], 'FEBS': [4306], 'Lett.': [4307], '437:': [4309], '221-224Crossref': [4310], '(18)': [4313], 'Downstream': [4316], 'two': [4320], 's6k': [4327], 'identified.': [4330], 'et': [4332, 5003], 'al.(3.Dudek': [4333], 'show': [4360], 'induce': [4368, 4775, 5209], 'rat': [4371, 4428], 'granular': [4373], 'neurons,': [4374], 'rapamycin,': [4376, 5290], 'does': [4383, 5093], 'insulin-mediated': [4386], 'promotion': [4387], 'Expression': [4418], 'immortalized': [4427], 'hippocampal': [4429], '(25.Eves': [4439], 'E.M.': [4440], 'Xiong': [4441], 'W.': [4442], 'Kennedy': [4445], 'S.G.': [4446], 'Rosner': [4449], 'M.R.': [4450], 'Hay': [4451], 'N.': [4452], '18:': [4457], '2143-2152Crossref': [4458], '(176)': [4461], 'cytosolic': [4467], 'play': [4479], 'prevention': [4492], 'Recent': [4529], 'can': [4534, 4891, 4996, 5056], 'regulate': [4535], 'level,': [4541], 'nuclear': [4544, 4630, 4841, 5011, 5060], 'GLUT1': [4553], 'hepatoma': [4555], '(26.Barthel': [4557], 'Okino': [4559], 'S.T.': [4560], 'Liao': [4561], 'Nakatani': [4563], 'Li': [4565], 'Whitlock': [4567], 'Jr.,': [4568], 'J.P.': [4569], 'Roth': [4570, 4598], '20281-20286Abstract': [4577], '(263)': [4585], 'leptin': [4589], 'adipocytes': [4591], '(27.Barthel': [4592], 'Kohn': [4594], 'Luo': [4596], 'Endocrinology.': [4600], '138:': [4602], '3559-3562Crossref': [4603], '(31)': [4606], 'Interleukin-2-mediated': [4609], 'BAF/3': [4613], 'forkhead': [4622, 4791, 4844, 4852], '(28.Tang': [4634, 4859], 'E.D.': [4635, 4860], 'Nunez': [4636, 4861], 'Barr': [4638, 4863], 'F.G.': [4639, 4864], 'Guan': [4640, 4865], 'K.-L.': [4641, 4866], '16741-16746Abstract': [4647, 4872], '(669)': [4655, 4880], '29.Rena': [4658], 'Guo': [4660, 4811], 'Cichy': [4662, 4688, 4813], 'S.C.': [4663, 4814], 'Unterman': [4664, 4694, 4815], 'T.G.': [4665, 4816], 'Cohen': [4666, 4692, 4817, 4909, 5258], '17179-17183Abstract': [4673, 4824], '(622)': [4681, 4832], '30.Guo': [4684], 'Rena': [4686], 'He': [4690], '17184-17192Abstract': [4701], '(475)': [4709], '31.Biggs': [4712], 'W.H.': [4713], 'Meisenhelder': [4714], 'Hunter': [4716], 'Cavenee': [4718], 'W.K.': [4719], 'Arden': [4720, 4751], 'K.C.': [4721, 4752], '96:': [4730, 4759], '7421-7426Crossref': [4731], '(955)': [4734], '32.Brunet': [4737], 'Bonni': [4739], 'Zigmond': [4741], 'Lin': [4743], 'M.Z.': [4744], 'Juo': [4745], 'Hu': [4747], 'L.S.': [4748], 'Anderson': [4749], 'Blenis': [4753], '857-868Abstract': [4760], '(5526)': [4768], 'factor-binding': [4778], 'protein-1': [4779], 'stimulating': [4781], 'phosphorylate': [4790], 'Thr-24,': [4795], 'Ser-256,': [4796], 'Ser-319,': [4798], 'consensus': [4800], 'vitro': [4805], 'vivo': [4808], '(29.Rena': [4809], 'covalent': [4836], 'exclusion': [4842], 'factor,': [4846], '-responsive': [4855], 'genes': [4856], 'Studies': [4883], 'indeed': [4885], 'translocate': [4892], 'nucleus': [4894], '(33.Andjelkovic': [4895], 'Alessi': [4897, 4933, 5022, 5097], 'Meier': [4899, 5002], 'Fernandez': [4901], 'Lamb': [4903], 'N.J.C.': [4904], 'Frech': [4905], 'Cron': [4907, 4935, 5024, 5099], 'Lucocq': [4911], 'Hemmings': [4913, 4939, 5028, 5103], 'B.A.': [4914, 4940, 5029, 5104], '272:': [4919, 4945, 5034, 5109], '31515-31524Abstract': [4920], '(907)': [4928], '34.Meier': [4931], 'Andjelkovic': [4937, 5026, 5101], '30491-30497Crossref': [4946, 5035, 5110], '(331)': [4949, 5038, 5113], '35.Ahmed': [4952], 'Gonzalez-Portal': [4960, 5070], 'M.-E.': [4961, 5071], 'Taguchi': [4962, 5072], 'Testa': [4964, 5074], 'Oncogene.': [4968, 5078], '8:': [4970, 5080], '1957-1963PubMed': [4971, 5081], 'first': [4978], 'translocated': [4979, 4998], 'membrane,': [4983], 'where': [4984], 'following': [4988], 'Subsequently,': [4994], 'nucleus.': [5001], 'al.': [5004], 'confocal': [5008], 'microscopy': [5009], '20–30': [5015], 'mitogenic': [5018], '(34.Meier': [5020, 5095], 'Significant': [5041], 'membrane-directed,': [5055], 'undergo': [5058], 'partial': [5059], 'localization': [5061], '(35.Ahmed': [5062], 'having': [5087], 'palmitoylation': [5091], 'signals': [5092], 'probable': [5117], 'explanation': [5118], 'difference': [5121], 'they': [5126], 'anchor': [5127], 'affinity.': [5136], 'factors.': [5174], 'Nerve': [5175], 'Ras/MAP': [5185], 'kinase/extracellular-regulated': [5187], 'kinase/Rsk2': [5188], '(36.Xing': [5189], 'Ginty': [5191], 'D.D.': [5192], '959-963Crossref': [5198], '(1094)': [5201], 'Fibroblast': [5204], 'site-': [5211], 'promoters': [5213], 'MAPKAP-K2/3': [5219], '37.Tan': [5250], 'Rouse': [5252], 'Zhang': [5254], 'Cariati': [5256], 'Comb': [5260], 'EMBO': [5262], '15:': [5265], '4629-4642Crossref': [5266], '(571)': [5269], 'wortmannin,': [5281], 'but': [5287], 's6k,': [5295], 'likely': [5300], 'involved': [5303, 5511], '133': [5374, 5424], 'promotes': [5376], 'recruitment': [5378], 'coactivator': [5381], 'CREB-binding': [5382], 'They': [5404], 'CRE-driven': [5411], 'alanine': [5420], 'position': [5423], 'Gal4': [5427], 'cotransfected': [5464], 'Δp85,': [5491], 'factor-mediated': [5504], 'inactivation': [5526], 'thank': [5539, 5565], 'Nicholas': [5541], 'Webster,': [5542], 'Emmanuel': [5544], 'Van': [5545], 'Obberghen,': [5546], 'Richard': [5549], 'Goodman': [5550], 'providing': [5552], 'valuable': [5553], 'reagents.': [5554], 'acknowledge': [5556], 'excellent': [5558], 'secretarial': [5559], 'Gloria': [5562], 'Smith.': [5563], 'Boris': [5567], 'Draznin': [5568], 'critically': [5570], 'reading': [5571], 'manuscript.': [5573], 'Quantitative': [5574], 'University': [5580], 'Colorado': [5582], 'Cancer': [5583], 'Center': [5584], 'core': [5585], 'facility.': [5586]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1975290731', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 29}, {'year': 2019, 'cited_by_count': 27}, {'year': 2018, 'cited_by_count': 35}, {'year': 2017, 'cited_by_count': 33}, {'year': 2016, 'cited_by_count': 26}, {'year': 2015, 'cited_by_count': 34}, {'year': 2014, 'cited_by_count': 33}, {'year': 2013, 'cited_by_count': 43}, {'year': 2012, 'cited_by_count': 35}], 'updated_date': '2024-12-23T22:26:11.844100', 'created_date': '2016-06-24'}
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