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5031, 5057, 5125, 5180, 5192, 5219, 5240, 5249, 5273, 5289, 5303, 5673, 5697, 5728, 5836, 5850, 5859, 5879, 5966, 6022, 6053, 6136], '(translocase': [15, 155, 464], 'of': [16, 51, 56, 69, 77, 80, 83, 133, 156, 191, 196, 209, 217, 220, 223, 273, 289, 308, 321, 331, 341, 349, 355, 384, 465, 590, 728, 925, 951, 961, 983, 1018, 1033, 1063, 1071, 1223, 1233, 1249, 1346, 1355, 1371, 1382, 1408, 1412, 1415, 1449, 1560, 1590, 1611, 1663, 1720, 1736, 1760, 1785, 1803, 1887, 1946, 1954, 1984, 2103, 2151, 2180, 2193, 2221, 2232, 2249, 2284, 2346, 2401, 2440, 2452, 2573, 2587, 2679, 2691, 2704, 2715, 2743, 2755, 2762, 2778, 2801, 2813, 2875, 2884, 2893, 2988, 2997, 3036, 3071, 3097, 3104, 3141, 3176, 3269, 3277, 3379, 3388, 3395, 3425, 3442, 3454, 3470, 3483, 3500, 3556, 3574, 3577, 3583, 3586, 3597, 3614, 3633, 3666, 3695, 3698, 3705, 3720, 3731, 3747, 3764, 3834, 3837, 3859, 3864, 3883, 3897, 3917, 3925, 3951, 3972, 4025, 4030, 4043, 4060, 4076, 4082, 4123, 4136, 4216, 4223, 4242, 4270, 4310, 4339, 4382, 4435, 4456, 4466, 4472, 4481, 4487, 4493, 4559, 4583, 4600, 4666, 4715, 4726, 4739, 4752, 4756, 4793, 4796, 4808, 4827, 4835, 4847, 4865, 4901, 4930, 4966, 4985, 5011, 5029, 5055, 5098, 5113, 5116, 5123, 5196, 5199, 5211, 5217, 5237, 5245, 5261, 5270, 5283, 5287, 5301, 5316, 5338, 5342, 5507, 5534, 5549, 5597, 5603, 5605, 5612, 5628, 5652, 5710, 5748, 5771, 5792, 5799, 5807, 5826, 5833, 5842, 5869, 5955, 5963, 5973, 6003, 6019, 6028, 6039, 6047, 6140, 6148, 6152, 6168, 6172, 6207, 6216, 6240, 6259, 6266], 'membrane)': [20, 160, 469], 'complex.': [21, 72, 113, 161, 212, 253, 1363, 1746, 2718, 3107, 4586, 5126, 5204, 5241, 5274, 5304, 5856, 5967, 6042], 'The': [22, 73, 93, 162, 213, 233, 532, 711, 725, 1010, 1041, 1059, 1210, 1239, 1690, 1768, 1846, 2091, 2107, 2139, 2214, 2325, 2379, 2547, 2560, 2577, 2675, 3058, 3082, 3108, 3318, 3407, 3481, 4390, 4532, 4624, 4712, 4733, 4791, 4833, 4862, 4899, 5146, 5179, 5305, 5335, 5389, 5789, 5857], 'complex': [24, 59, 164, 199, 457, 534, 573, 1021, 1043, 1255, 1264, 1349, 1563, 1614, 1666, 3398, 3938, 3954, 4033, 4988, 5032, 5058, 5168, 5174, 5181, 5220, 5224, 5250, 5290, 5674, 5698, 5729, 5837, 5851, 5860, 5880, 5892, 6054, 6058], 'possesses': [25, 165, 3472], 'two': [26, 166, 1437, 5650], 'presequence': [27, 52, 61, 79, 97, 167, 192, 201, 219, 237, 1012, 1251, 1258, 1396, 1411, 1545, 1589, 1631, 1657, 1732, 1738, 2726, 2731, 3099, 3127, 3140, 3178, 3242, 3469, 3558, 3617, 3919, 3945, 4241, 5013, 5293, 5352, 5514, 5678, 5685, 5713, 5750, 5773], 'binding': [28, 62, 88, 168, 202, 228, 576, 597, 930, 1050, 1259, 1339, 1658, 1733, 2279, 2732, 2874, 2973, 3035, 3134, 3258, 3265, 3441, 3474, 3485, 3563, 3665, 3746, 3843, 3920, 3946, 3979, 4038, 4042, 5014, 5294, 5537, 5557, 5602, 5694, 5732], 'sites': [29, 68, 169, 208, 577, 598, 1345, 5300], 'on': [30, 38, 170, 178, 582, 602, 1055, 1445, 2111, 2337, 2393, 3451, 3580, 4642, 4675, 4689, 4699, 4760, 4917, 5120, 5175, 5983, 5990, 6156], 'cytosolic': [32, 172, 585, 604, 726, 923, 949, 3386, 3423, 5340], 'side': [33, 42, 173, 182, 605, 609, 4075, 4361], '(the': [34, 43, 174, 183, 5844], 'cis': [35, 65, 100, 175, 205, 240, 712, 737, 1016, 1225, 1342, 1643, 1661, 1675, 2709, 2735, 3109, 3132, 3181, 3195, 3256, 3405, 3949, 5297, 5306, 5502, 5523, 5555], 'site)': [36, 176], 'and': [37, 54, 66, 98, 123, 177, 194, 206, 238, 263, 287, 333, 343, 394, 406, 419, 438, 471, 480, 544, 586, 606, 615, 731, 921, 927, 963, 1073, 1231, 1343, 1419, 1442, 1500, 1554, 1580, 1600, 1605, 1715, 1748, 1762, 1791, 1875, 1943, 2059, 2061, 2098, 2119, 2175, 2187, 2351, 2361, 2375, 2383, 2412, 2429, 2518, 2535, 2553, 2583, 2849, 2877, 2949, 2981, 3080, 3173, 3351, 3431, 3458, 3502, 3611, 3618, 3627, 3653, 3660, 3675, 3681, 3753, 3766, 3777, 3870, 3876, 3901, 4000, 4039, 4063, 4078, 4131, 4250, 4258, 4373, 4384, 4398, 4475, 4509, 4530, 4545, 4557, 4572, 4588, 4602, 4630, 4645, 4652, 4669, 4682, 4685, 4741, 4758, 4775, 4778, 4802, 4806, 4811, 4816, 4873, 4891, 4893, 4941, 4953, 4975, 4989, 5136, 5139, 5285, 5298, 5319, 5398, 5473, 5546, 5610, 5644, 5686, 5795, 5817, 5949, 5975, 5989, 6005, 6154, 6174, 6198, 6221, 6253, 6261], 'intermembrane': [40, 130, 180, 270, 296, 304], 'space': [41, 131, 181, 271, 297], 'trans': [44, 67, 91, 121, 184, 207, 231, 261, 1047, 1060, 1211, 1240, 1344, 1558, 1609, 1639, 1688, 1703, 1728, 1741, 2713, 2737, 2913, 3102, 3185, 3189, 3250, 3874, 3892, 3923, 3983, 4016, 4092, 4581, 4606, 4983, 5017, 5299, 5654, 5735, 5753, 5804], 'site).': [45, 185], 'Here': [46, 186, 2888], 'we': [47, 187, 1621, 2889, 3593, 4021, 4051, 4320, 4442, 4613, 4971, 5279, 5497, 5530], 'analyzed': [48, 188, 2426, 2580, 2872, 3663, 5280], 'requirement': [50, 190, 4029], 'elements': [53, 193], 'subunits': [55, 195, 4795, 5286], 'for': [60, 87, 200, 227, 578, 599, 978, 1035, 1052, 1218, 1246, 1394, 1730, 1752, 1771, 1796, 1848, 1880, 2065, 2100, 2163, 2219, 2289, 2334, 2395, 2526, 2544, 2585, 2594, 2685, 2729, 3089, 3131, 3252, 3288, 3291, 3476, 3724, 3981, 4018, 4034, 4551, 4785, 4877, 4885, 4964, 5102, 5234, 5308, 5536, 5554, 5638, 5660, 5716, 5960, 6010, 6165, 6230, 6263], 'to': [63, 89, 105, 110, 119, 203, 229, 245, 250, 259, 318, 415, 539, 545, 549, 719, 932, 938, 1025, 1067, 1227, 1256, 1340, 1552, 1556, 1595, 1607, 1623, 1636, 1659, 1672, 1681, 1698, 1701, 1743, 1832, 1857, 1916, 2154, 2226, 2236, 2295, 2444, 2711, 2733, 2807, 2879, 2895, 2910, 2952, 2957, 2974, 3016, 3121, 3135, 3146, 3183, 3247, 3259, 3263, 3311, 3323, 3365, 3367, 3381, 3384, 3402, 3413, 3444, 3463, 3486, 3508, 3515, 3529, 3644, 3670, 3687, 3710, 3735, 3755, 3773, 3780, 3844, 3869, 3872, 3889, 3921, 3947, 3960, 3965, 3990, 4014, 4090, 4255, 4386, 4403, 4406, 4424, 4485, 4577, 4593, 4724, 4737, 4781, 4979, 5009, 5015, 5027, 5151, 5214, 5225, 5256, 5267, 5295, 5314, 5331, 5563, 5601, 5607, 5614, 5671, 5695, 5726, 5733, 5744, 5811, 5852, 6055, 6137, 6186, 6203], 'N-terminal': [74, 214, 429, 1602, 2676, 2990, 3083, 3603], '14': [75, 215, 2677, 2771, 2991, 3084, 4558, 5708, 5769], 'residues': [76, 216, 329, 339, 1784, 1802, 1861, 1886, 2459, 2772, 2992, 3085, 3613, 3866, 3885, 4507, 4554, 5709, 5770, 5887, 5947], 'subunit': [81, 221, 319, 1413, 1692, 3394], '9': [82, 222, 320, 1414], 'F0-ATPase': [84, 224], 'are': [85, 225, 281, 400, 610, 3086, 3886, 4088, 4977, 5521, 5622, 5657, 5691, 5714], 'required': [86, 226, 2728, 5101], 'site.': [92, 232, 1689, 3406, 5018, 5736], 'interaction': [94, 234], 'between': [95, 235, 328, 338, 1757, 2847, 5392, 5640], 'site': [101, 122, 241, 262, 713, 738, 1017, 1051, 1061, 1212, 1226, 1241, 1260, 1559, 1610, 1640, 1644, 1662, 1676, 1704, 1729, 1742, 2192, 2710, 2714, 2914, 3103, 3133, 3182, 3190, 3196, 3257, 3875, 3893, 3924, 3950, 3980, 4093, 4582, 4607, 4984, 5307, 5556, 5754, 5805], 'not': [103, 243, 1669, 2127, 2805, 2868, 2994, 3193, 3466, 3493, 3513, 3527, 3703, 3771, 3957, 4422, 4497, 4562, 4687, 4722, 4731, 4821, 4884, 5005, 5106, 5499, 5829, 6016, 6031], 'sufficient': [104, 244], 'anchor': [106, 246], 'precursor': [108, 248, 317, 409, 580, 939, 1372, 2693, 2747, 4045, 4863, 5396, 5642, 6033, 6049, 6141], 'protein': [109, 138, 249, 278, 1406, 1433, 2748, 2767, 3237, 4264, 4305, 4404, 4425, 4568, 4611, 4762, 4905, 4916, 4957, 4994, 5002, 5668, 5720, 5992, 6050, 6158, 6177, 6225], 'Tom7': [114, 254, 1714, 2164, 4011, 4344, 4436, 4449, 4474, 4571, 4574, 4587, 4601, 4619, 4635, 4670, 4740, 4757, 4828, 4952, 4974, 5025, 5117, 5184, 5200, 5246, 5812, 5827, 5974, 6004, 6132, 6153, 6173, 6197, 6220], 'constitutes': [115, 255, 4579], 'or': [116, 256, 1064, 1780, 1843, 1869, 1926, 1937, 1952, 2339, 2501, 2591, 3064, 3651, 3855, 4087, 4318, 4333, 4343, 4578, 4698, 4980, 5808], 'close': [118, 258, 1066, 4089, 4576, 4978, 5810], 'has': [124, 264, 535, 1511, 1546, 2781, 5021, 5311, 5346, 5400], 'overlapping': [125, 265, 1724, 4745, 6001], 'functions': [126, 266, 432, 714, 1213, 1725, 4231], 'with': [127, 267, 956, 1426, 1629, 1648, 1793, 1877, 1980, 2057, 2147, 2165, 2329, 2363, 2388, 2421, 2431, 2500, 2556, 2565, 2598, 2776, 2799, 2939, 2941, 2959, 3006, 3048, 3100, 3202, 3239, 3275, 3301, 3303, 3421, 3427, 3435, 3498, 3630, 3908, 3935, 4232, 4266, 4335, 4357, 4368, 4395, 4418, 4450, 4469, 4478, 4490, 4501, 4503, 4515, 4523, 4537, 4626, 4633, 4663, 5141, 5158, 5182, 5259, 5329, 5333, 5515, 5539, 5624, 5662, 5751, 5763, 5881], 'C-terminal': [129, 269, 346, 1717, 4840, 5845, 5885], 'domain': [132, 272, 348, 1453, 1486, 1496, 1576, 1719, 2906, 2969, 3320, 3331, 3387, 3424, 3730, 3802, 3905, 3997, 4081, 4842, 5097, 5341, 5543, 5690], 'Tom22': [134, 274, 928, 964, 1074, 1721, 4083, 4836, 5051, 5099, 5882, 5956], 'in': [135, 275, 284, 411, 422, 445, 458, 474, 1261, 1933, 2132, 2142, 2242, 2246, 2278, 2281, 2415, 2506, 2724, 2757, 2773, 2810, 2860, 2863, 2881, 3115, 3116, 3125, 3517, 3559, 3565, 3590, 3761, 3856, 3914, 4057, 4133, 4235, 4379, 4608, 4617, 4764, 4924, 4938, 4945, 4959, 4996, 5000, 5291, 5551, 5616, 5693, 5980, 5994, 6160, 6176, 6194, 6223], 'import.': [139, 279], 'Mitochondria': [280, 2251], 'essential': [282, 1393, 3088, 3130, 5715], 'organelles': [283], 'eukaryotic': [285], 'cells': [286, 985, 2121, 4777, 4940, 5138], 'consist': [288, 5315], 'four': [290], 'compartments,': [291], 'membrane,': [294, 393, 461, 477, 1599], '(IMS),': [298], '1The': [299], 'abbreviations': [300], 'used': [301, 2099, 2218, 2741, 2890, 4855, 5531], 'are:': [302], 'IMS,': [303], 'space;': [305], 'TOM,': [306], 'translocase': [307, 383], 'membrane;': [311, 387], 'DHFR,': [312], 'mouse': [313, 1420], 'dihydrofolate': [314, 1421], 'reductase;': [315], 'pSu9,': [316], 'Neurospora': [322], 'crassa': [323], 'F0-ATPase;': [324], 'pSD-(1-x),': [325], 'fusion': [326, 336, 1405, 1432, 1627, 1754, 2238, 2332, 2496, 2766, 3236, 3598, 3634, 3668, 3931, 3963, 3986, 5509, 5667, 5719], 'proteins': [327, 337, 399, 410, 418, 421, 548, 581, 1373, 1628, 1755, 2239, 2333, 2414, 2497, 2562, 2578, 2590, 2694, 2853, 3599, 3635, 3669, 3932, 3964, 3987, 4138, 4788, 5148, 5397, 5510, 5643, 6142], '1-x': [330], 'pSu9': [332, 342, 1591, 1761, 1786, 3616, 5712], 'DHFR;': [334, 344], 'pSD-(15-x),': [335, 3973], '15-x': [340], 'Tom22C,': [345, 4257], 'IMS': [347, 588, 608, 1057, 1718, 4074, 4080, 4841, 4860], 'Tom22;': [350], 'dTom20,': [351, 3510], 'C-terminally': [352, 2167, 2449, 3428, 4451], 'His6-tagged': [353], 'version': [354, 2451], 'rat': [356, 2453, 3389, 5343], 'Tom20': [357, 926, 962, 2447, 2454, 3390, 3426, 3455, 3464, 3479, 3490, 3516, 4803, 5324, 5344, 5542, 5550, 5615], 'lacking': [358, 2455, 2768], 'first': [360, 1773, 1798, 1882, 2457, 2720, 2770, 5707, 5768], '24': [361, 2458], 'residues;': [362], 'BN,': [363], 'blue': [364], 'native;': [365], 'BPA,': [366], 'dl-2-amino-5-p-benzoylpentanoic': [367, 2601], 'acid;': [368, 379], 'CCCP,': [369, 2374], 'carbonyl': [370, 2285], 'cyanide': [371, 2286], 'm-chlorophenylhydrazone;': [372], 'HA,': [373], 'influenza': [374, 2169], 'virus': [375, 2170], 'hemagglutinin;': [376], 'MOPS,': [377], '4-morpholinepropanesulfonic': [378], 'MTX,': [380, 3721, 3860], 'methotrexate;': [381], 'TIM,': [382], 'inner': [385, 392, 424, 476, 1376, 1388, 1400, 4903, 4914], 'WT,': [388, 4396, 5133], 'wild': [389], 'type.': [390], 'matrix.': [396, 447], 'Most': [397], 'encoded': [401], 'nuclear': [404], 'genome': [405, 2134], 'synthesized': [407, 2241], 'as': [408, 433, 715, 935, 937, 1214, 1709, 1766, 1987, 2463, 2606, 2797, 3023, 3025, 3046, 3496, 4260, 4909, 4911, 5171, 5407, 5631, 5721, 5813, 5815, 6143], 'cytosol.': [413], 'Precursors': [414], 'most': [416], 'matrix': [417, 4868, 4919], 'some': [420], 'possess': [426], 'a': [427, 434, 442, 536, 969, 1049, 1215, 1404, 1512, 1630, 2112, 2432, 2864, 3240, 3552, 3595, 3722, 4267, 4336, 4358, 4408, 4444, 4512, 4690, 4700, 4705, 5172, 5226, 5347, 5512, 5595, 5663, 5722, 5775, 5782, 5854, 5984, 6025], 'cleavable': [428], 'presequence,': [430, 2775, 3839], 'which': [431, 1029, 1391, 1510, 1934, 2780, 4350, 4517, 4618, 5096], 'targeting': [436, 542, 723, 1236], 'signal': [437, 1237], 'cleaved': [440], 'matrix-processing': [443], 'peptidase': [444], 'import': [449, 717, 967, 2759, 2792, 2855, 2861, 3268, 3283, 4135, 4763, 4958, 4995, 5003, 5993, 6159, 6226], 'into': [450, 2071, 2189, 2760, 2789, 3271, 3297, 6268], 'mitochondria': [451, 551, 1428, 2326, 2356, 2407, 2761, 2880, 2940, 2953, 2976, 3007, 3017, 3204, 3272, 3302, 3312, 3369, 3519, 3530, 3672, 3689, 3711, 3757, 3782, 4326, 4375, 4400, 4420, 4502, 4525, 5517, 5553, 6195], 'complex,': [470, 3928, 4799, 5193, 5228, 6023], 'complexes': [473, 482], 'TIM23': [479, 1745, 4810, 6057, 6138], 'TIM22': [481, 4812], '(1Herrmann': [483], 'J.M.': [484], 'Neupert': [485, 622, 640, 664, 1077, 1172, 1300, 2923, 3159, 4147, 6094], 'W.': [486, 623, 641, 665, 1078, 1173, 1301, 2924, 3160, 4148, 6095], 'Biochim.': [487, 556], 'Biophys.': [488, 557, 852, 5486], 'Acta.': [489, 558], '2000;': [490, 905, 2482, 5376, 5431], '1459:': [491], '331-338Crossref': [492], 'PubMed': [493, 510, 527, 562, 633, 655, 679, 706, 752, 774, 796, 842, 883, 913, 1005, 1092, 1119, 1137, 1159, 1182, 1205, 1287, 1310, 1333, 1478, 1533, 1827, 1911, 1975, 2000, 2026, 2050, 2086, 2209, 2273, 2320, 2490, 2631, 2670, 2842, 2932, 3168, 3227, 3828, 4116, 4157, 4180, 4206, 4295, 5048, 5090, 5384, 5439, 5468, 5585, 5911, 5934, 6081, 6104, 6127], 'Scopus': [494, 511, 528, 563, 634, 656, 680, 707, 753, 775, 797, 821, 843, 858, 884, 914, 1006, 1093, 1120, 1138, 1160, 1183, 1206, 1288, 1311, 1334, 1479, 1534, 1828, 1912, 2001, 2027, 2051, 2087, 2210, 2321, 2491, 2632, 2671, 2843, 2933, 3169, 3228, 3829, 4117, 4158, 4181, 4207, 4296, 5091, 5385, 5440, 5469, 5492, 5586, 5912, 5935, 6082, 6105, 6128], '(19)': [495, 2844], 'Google': [496, 513, 530, 565, 636, 658, 682, 709, 755, 777, 799, 823, 845, 860, 886, 916, 1008, 1095, 1122, 1140, 1162, 1185, 1208, 1290, 1313, 1336, 1481, 1536, 1830, 1914, 1976, 2003, 2029, 2053, 2089, 2212, 2274, 2323, 2493, 2634, 2673, 2845, 2935, 3171, 3230, 3831, 4119, 4160, 4183, 4209, 4298, 5049, 5093, 5387, 5442, 5471, 5494, 5588, 5914, 5937, 6084, 6107, 6130], 'Scholar,': [497, 514, 637, 659, 683, 756, 778, 800, 824, 846, 861, 887, 1096, 1123, 1141, 1163, 1186, 1291, 1314, 2004, 4161, 4184, 5915, 6085, 6108], '2Pfanner': [498], 'N.': [499, 784, 816, 871, 1194, 1198, 1322, 1326, 2664, 4169, 4173, 5085, 5578, 5900, 5904, 5925, 6116, 6120], 'Geissler': [500], 'A.': [501, 621, 663, 702, 804, 1115, 1196, 1283, 1324, 1474, 1823, 1907, 2200, 2316, 2627, 3223, 4112, 4171, 4291, 5083, 5576, 5902, 5919, 6077, 6118], 'Nat.': [502, 1527, 3822], 'Rev.': [503], 'Mol.': [504, 1176, 1199, 1304, 1327, 4151, 4174, 5579, 5905, 5928, 6098, 6121], 'Cell': [505, 522], 'Biol.': [506, 645, 669, 764, 786, 873, 995, 1082, 1178, 1201, 1306, 1329, 1529, 1967, 2040, 2265, 2832, 3824, 4153, 4176, 5040, 5581, 5907, 5930, 6100, 6123], '2001;': [507], '2:': [508], '339-349Crossref': [509], '(421)': [512], '3Endo': [515], 'T.': [516, 553, 685, 695, 742, 746, 826, 891, 893, 901, 1098, 1108, 1127, 1131, 1143, 1266, 1276, 1457, 1467, 1518, 1526, 1806, 1816, 1890, 1900, 1961, 1963, 2010, 2016, 2038, 2299, 2309, 2468, 2470, 2478, 2610, 2620, 2818, 2820, 2830, 3206, 3216, 3813, 3821, 4095, 4105, 4190, 4196, 4274, 4284, 5362, 5364, 5372, 5417, 5419, 5427, 5452, 6060, 6070], 'Yamamoto': [517], 'H.': [518, 897, 989, 1169, 1297, 1965, 2006, 2196, 2474, 2656, 4144, 4186, 5368, 5423, 5574, 6091], 'Esaki': [519, 2007, 2821, 4187], 'M.': [520, 689, 814, 850, 991, 1102, 1188, 1192, 1270, 1316, 1320, 1461, 1516, 1810, 1894, 1959, 1995, 2008, 2034, 2303, 2614, 2660, 2822, 2828, 2926, 3162, 3210, 3811, 4099, 4163, 4167, 4188, 4278, 5075, 5079, 5484, 5894, 5898, 6064, 6110, 6114], 'J.': [521, 644, 668, 748, 763, 780, 785, 838, 863, 869, 872, 994, 1081, 1133, 1155, 1966, 2039, 2264, 2662, 2666, 2831, 2928, 3164, 5039, 5071, 5464, 5572], 'Sci.': [523, 699, 1112, 1280, 1471, 1820, 1904, 2313, 2624, 3220, 4109, 4288, 6074], '2003;': [524, 997, 1530, 3825, 5931], '116:': [525], '3259-3267Crossref': [526], '(150)': [529], 'Scholar).': [531, 566, 710, 917, 1009, 1209, 1337, 1482, 2030, 2090, 2213, 2324, 2494, 2635, 2936, 3231, 4120, 4210, 5050, 5388, 5495, 5589, 5938], 'receptor': [537, 718, 1217, 3393], 'function': [538, 1514, 6002], 'recognize': [540, 720, 4858], 'signals': [543], 'allow': [546], 'enter': [550, 1582], '(4Endo': [552], 'Kohda': [554, 902, 2479, 5373, 5428], 'D.': [555, 639, 661, 903, 1076, 2480, 5374, 5429], '2002;': [559, 2018, 4198], '1592:': [560], '3-14Crossref': [561], '(108)': [564], 'Accumulated': [567], 'evidence': [568], 'suggests': [569, 4212], 'that': [570, 973, 1632, 1655, 1685, 1693, 1713, 2777, 2800, 2898, 2902, 2966, 2986, 3049, 3128, 3243, 3276, 3328, 3399, 3410, 3768, 3798, 4072, 4213, 4227, 4244, 4416, 4432, 4447, 4486, 4567, 4573, 4837, 4951, 4973, 4990, 5024, 5230, 5257, 5611, 5705, 5766, 5779, 5802, 5823, 5839, 5877, 5946, 5970, 6007], 'contains': [574, 1045], 'multiple': [575], 'both': [583, 2852, 2947, 4247, 4473, 4643, 4667, 5683], 'sides': [589], 'membrane.': [593, 1040, 1401, 6182], 'In': [594, 1617, 3002, 3717, 3941, 3969, 5163, 5275, 5527, 5871], 'particular,': [595], 'presequences': [601, 934, 959, 1054, 1220, 2706, 3585, 3863, 3882, 3976, 5284, 5310, 5394], '"cis': [613], 'site"': [614], '"trans': [617], 'site,"': [618], 'respectively': [619, 4346], '(5Mayer': [620], 'Lill': [624, 642, 666, 1079, 1174, 1302, 4149, 6096], 'R.': [625, 643, 667, 832, 1080, 1149, 1175, 1303, 4150, 5077, 5458, 6097], 'Cell.': [626, 904, 1177, 1200, 1305, 1328, 2017, 2481, 4152, 4175, 4197, 5375, 5430, 5580, 5906, 5929, 6099, 6122], '1995;': [627, 749, 1134, 1997, 2042], '80:': [628], '127-137Abstract': [629], 'Full': [630, 650, 652, 674, 676, 769, 771, 791, 793, 878, 880, 908, 910, 1000, 1002, 1087, 1089, 1972, 2021, 2023, 2045, 2047, 2270, 2485, 2487, 2837, 2839, 4201, 4203, 5045, 5379, 5381, 5434, 5436], 'Text': [631, 651, 653, 675, 677, 770, 772, 792, 794, 879, 881, 909, 911, 1001, 1003, 1088, 1090, 1973, 2022, 2024, 2046, 2048, 2271, 2486, 2488, 2838, 2840, 4202, 4204, 5046, 5380, 5382, 5435, 5437], 'PDF': [632, 654, 678, 773, 795, 882, 912, 1004, 1091, 1974, 2025, 2049, 2272, 2489, 2841, 4205, 5047, 5383, 5438], '(140)': [635], '6Rapaport': [638], 'Chem.': [646, 670, 765, 787, 874, 996, 1083, 1968, 2041, 2266, 2833, 5041], '1997;': [647, 766, 788, 818, 1084, 1202, 1330, 2667, 4177, 5908, 6124], '272:': [648, 767, 789, 1085], '18725-18731Abstract': [649, 1086], '(107)': [657, 1094], '7Rapaport': [660], 'Mayer': [662], '1998;': [671, 839, 855, 1156, 2929, 3165, 5465, 5489, 5582], '273:': [672], '8806-8813Abstract': [673], '(42)': [681], '8Kanamori': [684, 1097], 'Nishikawa': [686, 898, 1099, 1267, 1458, 1519, 1807, 1891, 2013, 2300, 2475, 2611, 2823, 3207, 3814, 4096, 4193, 4275, 5369, 5424, 6061], 'S.': [687, 701, 828, 865, 899, 1100, 1114, 1145, 1268, 1282, 1459, 1473, 1520, 1808, 1822, 1892, 1906, 2014, 2301, 2315, 2476, 2612, 2626, 2824, 3208, 3222, 3815, 4097, 4111, 4194, 4276, 4290, 5061, 5370, 5425, 5454, 6062, 6076], 'Nakai': [688, 849, 1101, 1269, 1460, 1809, 1893, 2302, 2613, 2827, 3209, 4098, 4277, 5483, 6063], 'Shin': [690, 1103, 1271, 1462, 1521, 1811, 1895, 2304, 2615, 3211, 3816, 4100, 4279, 6065, 6246], 'I.': [691, 1104, 1272, 1463, 1522, 1812, 1896, 2198, 2305, 2616, 3212, 3817, 4101, 4280, 6066, 6245], 'Schultz': [692, 1105, 1273, 1464, 1523, 1813, 1897, 2306, 2617, 3213, 3818, 4102, 4281, 6067, 6237], 'P.G.': [693, 1106, 1274, 1465, 1524, 1814, 1898, 2307, 2618, 3214, 3819, 4103, 4282, 6068], 'Endo': [694, 900, 1107, 1275, 1466, 1525, 1815, 1899, 1960, 2015, 2037, 2308, 2477, 2619, 2829, 3215, 3820, 4104, 4195, 4283, 5371, 5426, 6069], 'Proc.': [696, 1109, 1277, 1468, 1817, 1901, 2310, 2621, 3217, 4106, 4285, 6071], 'Natl.': [697, 1110, 1278, 1469, 1818, 1902, 2311, 2622, 3218, 4107, 4286, 6072], 'Acad.': [698, 1111, 1279, 1470, 1819, 1903, 2312, 2623, 3219, 4108, 4287, 6073], 'U.': [700, 806, 1113, 1190, 1281, 1318, 1472, 1821, 1905, 2314, 2625, 2654, 3221, 4110, 4165, 4289, 5896, 6075, 6112], '1999;': [703, 875, 1116, 1284, 1475, 1824, 1908, 2317, 2628, 3224, 4113, 4292, 5087, 6078], '96:': [704, 1117, 1285, 1476, 1825, 1909, 2318, 2629, 3225, 4114, 4293, 6079], '3634-3639Crossref': [705, 1118, 1286, 1477, 1826, 1910, 2319, 2630, 3226, 4115, 4294, 6080], '(74)': [708, 1121, 1289, 1480, 1829, 1913, 2322, 2633, 3229, 4118, 4297, 6083], 'an': [716, 4259, 6184], 'signal.': [724], 'domains': [727], 'Tom20,': [729, 5317], 'Tom22,': [730, 4849, 5318], 'Tom5': [732, 952], 'may': [733, 953, 1242, 3792, 5004, 5957, 6015], 'well': [734, 936, 954, 3793, 4910, 5814], 'constitute': [735, 1686, 4086, 4981], '(9Bolliger': [739], 'L.': [740, 1125, 2081], 'Junne': [741, 1126], 'Schatz': [743, 833, 1128, 1150, 2262, 5037, 5459], 'G.': [744, 834, 1129, 1151, 2259, 2263, 5034, 5038, 5460, 6236], 'Lithgow': [745, 1130], 'EMBO': [747, 837, 1132, 1154, 2665, 2927, 3163, 5463], '14:': [750, 1135], '6318-6326Crossref': [751, 1136], '(138)': [754, 1139], '10Schleiff': [757], 'E.': [758, 1993], 'Shore': [759], 'G.C.': [760], 'Goping': [761], 'I.S.': [762], '17784-17789Abstract': [768], '(50)': [776, 1007], '11Brix': [779], 'Dietmeier': [781], 'K.': [782, 802, 836, 848, 895, 993, 1153, 1991, 2036, 2472, 2826, 5065, 5366, 5421, 5462, 5482], 'Pfanner': [783, 815, 870, 1197, 1325, 2663, 4172, 5084, 5577, 5903, 5924, 6119], '20730-20735Abstract': [790], '(219)': [798], '12Dietmeier': [801], 'Hönlinger': [803, 1195, 1323, 4170, 5901, 6117], 'Bömer': [805, 1189, 1317, 4164, 5895, 6111], 'Dekker': [807, 5072], 'P.J.T.': [808, 2648], 'Eckersorn': [809], 'C.': [810, 830, 987, 1147, 2918, 2920, 3154, 3156, 5069, 5456], 'Lottspeich': [811], 'F.': [812, 1167, 1295, 2650, 4142, 6089], 'Kübrich': [813, 1191, 1319, 4166, 5897, 6113], 'Nature.': [817, 5086], '288:': [819], '195-200Crossref': [820], '(223)': [822], '13Komiya': [825, 1142], 'Rospert': [827, 1144, 5453], 'Koehler': [829, 1146, 5455], 'Looser': [831, 1148, 5457], 'Mihara': [835, 894, 992, 1152, 2471, 5365, 5420, 5461], '17:': [840, 1157, 1203, 1331, 2930, 3166, 4178, 5466, 5909, 6125], '3886-3898Crossref': [841, 1158, 5467], '(137)': [844, 1161, 5470], '14Iwata': [847], 'Biochem.': [851, 5485], 'Res.': [853, 5487], 'Commun.': [854, 5488], '253:': [856, 5490], '649-652Crossref': [857, 5491], '(13)': [859, 5493], '15Brix': [862], 'Rüdiger': [864], 'Bukau': [866], 'B.': [867, 2658, 2916, 2922, 3152, 3158, 5081, 5701, 5923], 'Schneider-Mergener': [868], '274:': [876], '16522-16530Abstract': [877], '(186)': [885], '16Abe': [888], 'Y.': [889, 2012, 2202, 2204, 2466, 4192, 5360, 5415], 'Shodai': [890, 2467, 5361, 5416], 'Muto': [892, 2469, 5363, 5418], 'Torii': [896, 2473, 5367, 5422], '100:': [906, 2483, 5377, 5432], '551-560Abstract': [907, 2484, 5378, 5433], '(425)': [915, 2492, 5386, 5441], 'Indeed,': [918, 4234, 5019], 'expressed': [920, 4448], 'purified': [922, 2462, 3509, 5541, 5608], 'fragments': [924, 1770, 1849], 'exhibit': [929], 'abilities': [931], 'proteins.': [940, 4046, 6269], 'On': [941, 1566, 3353, 3848, 4657, 5205, 5646], 'other': [943, 1568, 3355, 3850, 3942, 4659, 5207, 5648], 'hand,': [944, 1569, 3356, 3851, 4660, 5208, 5649], 'although': [945, 3013, 3505, 3861, 5095, 6035], 'negatively': [947], 'charged': [948, 958, 5784], 'part': [950, 975, 1603, 3791], 'interact': [955, 3907], 'positively': [957, 5783], 'downstream': [960, 1222], 'along': [965], 'pathway,': [968], 'recent': [970], 'report': [971, 5875], 'showed': [972, 1654, 5801, 5876], 'this': [974, 1542, 4049, 6188], 'dispensable': [977], 'normal': [980], 'cell': [981, 4129, 4767, 5981], 'growth': [982, 4130, 4465, 5982], 'yeast': [984, 2075, 2223, 2255, 4445], '(17Horie': [986], 'Suzuki': [988], 'Sakaguchi': [990], '278:': [998], '41462-42471Abstract': [999], 'recognized': [1013], 'subsequently': [1023], 'guided': [1024, 2700], 'channel,': [1028, 1509], 'mainly': [1031, 5757], 'composed': [1032], 'Tom40': [1034, 1072, 1508, 1550, 1584, 3345, 3808, 3910, 4004, 4077, 5816, 6193], 'also': [1044, 1243, 1679, 4922, 5052], 'site,': [1048, 3186, 3251, 3984], 'side.': [1058], 'consists': [1062, 5806], 'IMS-facing': [1069], 'region': [1070, 2179, 3124, 3475], '(6Rapaport': [1075], '9Bolliger': [1124], '18Court': [1164, 1292, 6086], 'S.A.': [1165, 1293, 4140, 6087], 'Nargang': [1166, 1294, 4141, 6088], 'Steiner': [1168, 1296, 4143, 6090], 'Hodges': [1170, 1298, 4145, 6092], 'R.S.': [1171, 1299, 4146, 6093], '1996;': [1179, 1307, 4154, 6101], '16:': [1180, 1308, 2668, 4155, 6102], '4035-4042Crossref': [1181, 1309, 4156, 6103], '(65)': [1184, 1312, 4159, 6106], '19Moczko': [1187, 1315, 4162, 6109], 'Zudall': [1193, 1321, 4168, 5899, 6115], '6574-6584Crossref': [1204, 1332, 4179, 5910, 6126], '(112)': [1207, 1335, 4182, 5913, 6129], 'second': [1216], 'located': [1221, 4056], 'enhance': [1228], 'specificity': [1230], 'fidelity': [1232], 'recognition.': [1238], 'be': [1244, 1351, 1699, 3804, 4308, 5006, 5564, 5756, 5958, 6017, 6163], 'important': [1245, 3554, 5233, 5959], 'efficient': [1247, 3842, 4035], 'transfer': [1248, 1735, 2703, 3175, 6046, 6139], 'from': [1252, 1739, 1850, 2253, 2707, 3179, 3641, 4328, 4771, 5132, 5201, 5221, 5247, 5951, 6051], 'TIM': [1263], '(8Kanamori': [1265, 1456, 1805, 1889, 2298, 2609, 3205, 4094, 4273, 6059], 'Precursor': [1338], 'can': [1350, 3803, 3867, 5354], 'characterized': [1352, 5328], 'analyses': [1354, 4782, 5152, 5413, 5450], 'intermediates': [1358, 1645, 1705, 3579, 4066, 4393, 5798], 'accumulated': [1359, 1435, 3199, 4245], 'at': [1360, 1436, 1490, 1538, 1570, 1726, 1854, 1862, 2292, 2340, 2523, 2541, 2944, 3010, 3026, 3050, 3306, 3359, 3531, 3543, 3673, 3691, 3712, 3739, 3758, 3852, 4006, 4246, 4363, 4376, 4506, 4553, 4649, 4678, 4693, 4704, 5679, 5699], 'To': [1364, 1929, 3570, 4047, 4427], 'generate': [1365, 1673, 4407, 5853], 'such': [1366], 'intermediates,': [1368], 'blocked': [1379], 'dissipation': [1381], 'potential': [1385], '(Δψ),': [1390], 'passage': [1397], 'When': [1402, 2937, 3299, 4499], 'pSD-(1–69),': [1403, 2779, 3292, 3624], 'consisting': [1407], '69-residue': [1410, 1588], 'Fo-ATPase': [1417], '(pSu9)': [1418], 'reductase': [1422], '(DHFR),': [1423], 'incubated': [1425, 1647, 2328, 2499, 2540, 2938, 3005, 3300, 3358, 4367, 4500], 'de-energized': [1427, 1649, 3203, 3260, 3368, 3671, 3688, 3756, 5516], 'without': [1429, 2502, 3008, 3894, 5251, 5883, 6196], 'Δψ,': [1430], 'distinct': [1438], 'stages,': [1439], 'stages': [1440], 'A': [1441, 2160, 2689, 3074, 3093, 3568, 3680, 3880, 4037, 4062, 4249, 5724, 5740, 5794], 'B,': [1443], 'depending': [1444], 'folding': [1447], 'state': [1448], 'mature': [1451, 1494, 1574, 5689], 'DHFR': [1452, 1485, 1495, 1575, 1763, 2905, 2968, 3067, 3319, 3330, 3459, 3619, 3654, 3726, 3729, 3790, 3801, 3899, 3904, 3996], '(Fig.': [1454, 2886, 2977, 3076, 3279, 3347, 3437, 3456, 3678, 3715, 3784, 4009, 4300, 4347, 4526, 4541, 4655, 4710, 4789, 4804, 4818, 4831, 4897, 5161, 5518, 5544, 5559, 5987, 5996], '1)': [1455], 'Because': [1483, 3138, 3439, 4304, 5737, 6043], 'more': [1488, 3591, 4942], 'labile': [1489], 'higher': [1491], 'temperatures,': [1492], 'undergoes': [1497], 'transient': [1498], 'unfolding,': [1499], 'unfolded': [1502, 2971, 3333, 3796, 3800, 3999, 5688], 'form': [1503, 1642, 3403, 5504, 5781], 'trapped': [1505, 3342, 3805, 4001], 'chaperone-like': [1513], '(20Esaki': [1515, 3810], 'Kanamori': [1517, 2009, 3812, 4189], 'Struct.': [1528, 3823], '10:': [1531, 3826], '988-994Crossref': [1532, 3827], '(52)': [1535, 3830], 'Scholar),': [1537, 5094, 5443, 5472, 6131], '30': [1539, 2341, 2396, 2507, 2515, 2574, 2945, 3027, 3051, 3307, 3544, 3676, 3692, 3740, 3759, 3787, 4007, 4377, 4683], '°C.': [1540, 2342, 3741], 'At': [1541, 3786], 'point,': [1543], 'already': [1547], 'passed': [1548], 'channel': [1551, 3346, 3809, 3911, 4005], 'reach': [1553, 1637, 2911, 3248, 3868, 3890], 'bind': [1555, 3366, 3382, 3462, 3514, 3528, 3772, 3871, 3989, 5355], '(stage': [1564, 1615], 'B).': [1565, 3682], '0': [1571, 2293, 3011, 3360, 3532, 3674, 3713, 3853], '°C': [1572, 2294, 2525, 3028, 3052, 3533, 3545, 3677, 3693, 3714, 3760, 3854, 4008, 4378, 4654], 'tightly': [1578, 3065, 3737], 'folded': [1579, 3066, 3903, 3930], 'cannot': [1581, 3461, 3906, 3933, 3988], 'channel.': [1585], 'However,': [1586, 4121, 5496, 6183], 'long': [1593, 2908, 3144, 5664], 'enough': [1594, 1671, 2909, 3145, 3959], 'cross': [1596], 'its': [1601, 2176, 3254, 4859, 5677, 5731], 'reaches': [1604], 'binds': [1606, 3507], 'A).': [1616], 'present': [1619, 3522, 5277, 5592, 5620], 'study,': [1620, 5278], 'tested': [1622, 3376, 3744, 4749], 'find': [1624], 'out': [1625, 4429], 'whether': [1626], 'too': [1634, 3245, 3887], 'short': [1635, 3246, 3888, 5513], 'could': [1641, 4307, 4672, 4686, 5498, 5780, 5943], 'when': [1646, 3004, 3357], '(–Δψ)': [1650], 'mitochondria.': [1651, 3137, 3261, 3298, 5617, 6209], 'Obtained': [1652], 'results': [1653, 3408, 4548, 4565, 4949, 5621, 5942], 'alone': [1667, 3460, 3955, 4495], 'strong': [1670, 3958], 'stable': [1674, 3918], 'intermediates.': [1677], 'We': [1678, 1711, 2719, 2739, 2870, 3232, 3375, 3662, 3742, 4747, 5108, 5702, 5819, 5968, 6233], 'tried': [1680, 3120], 'characterize': [1682], 'components': [1684, 4055], 'had': [1694], 'been': [1695, 5022, 5312, 5401], 'shown': [1696, 5023], 'previously': [1697, 1989, 2608, 2646], 'cross-linked': [1700, 4254, 4402, 4423, 4513, 4533], 'was': [1706, 1978, 2055, 2069, 2094, 2109, 2145, 2183, 2217, 2386, 2461, 2533, 2549, 2640, 2787, 2794, 2970, 3043, 3273, 3285, 3294, 3321, 3432, 4253, 4366, 4421, 4483, 4518, 4535, 4721, 4843, 5169, 6189], 'thus': [1707, 2740, 3233, 3743, 5109], 'identified': [1708], 'Tom7.': [1710, 4458, 5870], 'found': [1712, 3767, 5258, 5703, 5820], '(Tom22C)': [1722, 4084], 'share': [1723], 'and/or': [1734, 2736, 4620, 4829, 5118, 5395], 'Plasmids': [1747], 'Yeast': [1749], 'Strains—The': [1750], 'DNA': [1751, 1769, 2161, 4729], '(pSD)': [1756], 'various': [1758, 4786], 'lengths': [1759, 3582], 'were': [1764, 1787, 1871, 2137, 2240, 2276, 2327, 2357, 2381, 2408, 2419, 2425, 2498, 2538, 2563, 2579, 2604, 2955, 4401, 4549, 4622, 4769, 4779, 4820, 4875, 5130, 5149, 5405], 'constructed': [1765, 4614], 'follows.': [1767], '38,': [1774, 1864, 3604, 3646], '48,': [1775, 1865, 3605, 3647, 3751], '58,': [1776, 1866, 3606, 3648, 3708], '63,': [1777, 3607, 3701], '78,': [1778, 1868, 3609, 3650], '85,': [1779, 3610], '93': [1781, 3612], 'amino': [1782, 1800, 1859, 1884, 4355], 'acid': [1783, 1801, 1860, 1885, 2530, 2602, 3416, 3447, 4356], 'amplified': [1788, 1872, 2184], 'PCR': [1790, 1874, 2186], 'replaced': [1792, 1876, 1979, 2146], 'fragment': [1795, 1879, 2064, 2162], '69': [1799, 1883], 'pSu9-(1–69)-DHFR': [1804], 'Scholar)': [1831, 1915, 1977, 2054, 2275, 2674, 2846, 3172, 3832, 4299], 'yield': [1833, 1917, 2155, 2227, 3877], 'plasmids': [1835, 1919], 'encoding': [1836, 1920], 'pSD-(1–38),': [1837, 3238], 'pSD-(1–48),': [1838, 3621], 'pSD-(1–58),': [1839, 3622], 'pSD-(1–63),': [1840, 3623], 'pSD-(1–78),': [1841, 3625], 'pSD-(1–85),': [1842, 3626], 'pSD-(1–93),': [1844], 'respectively.': [1845, 1928], 'genes': [1847], 'methionine': [1852], 'residue': [1853, 3642, 3645], 'position': [1855, 4364], '15': [1856, 3643, 4508], 'positions': [1863], '69,': [1867, 3608, 3649, 3752], '85': [1870, 3652], 'pSD-(1–69)': [1888, 2599, 2848, 3142, 3278, 3588, 3776, 4243, 4560, 5606, 5800], 'pSD-(15–38),': [1921], 'pSD-(15–48),': [1922, 3656], 'pSD-(15–58),': [1923, 3657], 'pSD-(15–68),': [1924], 'pSD-(15–78),': [1925, 3659], 'pSD-(15–85),': [1927], 'construct': [1930], 'mutant': [1931, 2157, 4615], 'strains': [1932, 4330, 4616, 4889], 'TOM5,': [1935, 1950], 'TOM6,': [1936, 1951], 'TOM7': [1938, 1953, 2140], 'disrupted': [1940], '(Δtom5,': [1941], 'Δtom6,': [1942, 4332, 4372], 'Δtom7),': [1944], 'one': [1945, 2384, 4309], 'genomic': [1948], 'genes,': [1949], 'strain': [1956, 2105, 2143, 2158, 2224, 2256, 4446, 4468, 4489, 4625, 4632, 4662, 4719], 'W303-1A': [1957], '(21Nakai': [1958], 'Hase': [1962], 'Matsubara': [1964], '1993;': [1969], '268:': [1970], '24262-24269Abstract': [1971], 'HIS3': [1982, 2149], 'gene': [1983, 2068, 2077, 2131, 2141, 2150], 'Candida': [1985, 2152], 'glabrata': [1986, 2153], 'described': [1988, 2464, 2607, 2645], '(22Kitada': [1990], 'Yamaguchi': [1992], 'Arisawa': [1994], 'Gene.': [1996], '165:': [1998], '203-206Crossref': [1999], '(129)': [2002], '23Yamamoto': [2005, 4185], 'Tamura': [2011, 4191], '111:': [2019, 4199], '519-528Abstract': [2020, 4200], '(191)': [2028, 4208], 'pRS314:': [2031], 'MAS17Δ120–152': [2032], '(24Nakai': [2033], 'Kinoshita': [2035], '270:': [2043], '30571-30575Abstract': [2044], '(34)': [2052], 'digested': [2056], 'BamHI': [2058], 'SalI,': [2060], '1.3-kbp': [2063], 'TOM22Δ120–152': [2067, 2124], 'ligated': [2070], 'pJJ244': [2072], 'containing': [2073, 2114, 2122, 2569, 3601, 3637], 'URA3': [2076], '(25Jones': [2078], 'J.S.': [2079], 'Prakash': [2080], 'Yeast.': [2082, 2205], '1990;': [2083], '6:': [2084], '363-366Crossref': [2085], '(327)': [2088], 'resulting': [2092, 2215], 'plasmid': [2093, 2216], 'linearized': [2095], 'NaeI': [2097], 'transformation': [2102, 2220], 'W303-1A.': [2106], 'transformant': [2108], 'grown': [2110], 'plate': [2113], '1': [2115, 2347, 2352, 2376], 'mg/ml': [2116], '5-fluoroorotic': [2117], 'acid,': [2118], 'gene,': [2125, 4345], 'but': [2126, 2954, 3192, 3539, 3702, 4477, 4883, 5838], 'authentic': [2129], 'TOM22': [2130], '(strain': [2135], 'Δtom22C),': [2136], 'selected.': [2138], 'Δtom22C': [2144, 4890, 4939], 'Δtom22C/Δtom7.': [2159], 'tagged': [2168, 3429, 4452], 'hemagglutinin': [2171], '(HA)': [2172], 'epitope': [2173], 'YPYDVPDYA': [2174], 'upstream': [2177], 'noncoding': [2178], '580': [2181], 'bp': [2182], 'introduced': [2188], 'KpnI-SacI': [2191], 'pYO324': [2194], '(26Qadota': [2195], 'Ishii': [2197], 'Fujiyama': [2199], 'Ohya': [2201], 'Anraku': [2203], '1992;': [2206], '8:': [2207], '735-741Crossref': [2208], '(53)': [2211], 'Δtom7': [2225, 4334, 4374, 4419, 4892], 'Tom7-HA': [2229, 4459, 4482], 'strain.': [2230], 'Binding': [2231, 2439], 'pSD': [2233, 2441, 2765, 5508, 5661], 'Fusion': [2234, 2442], 'Proteins': [2235, 2424, 2443], 'Mitochondria—The': [2237], 'rabbit': [2243], 'reticulocyte': [2244], 'lysate': [2245], 'presence': [2248, 2283, 3453, 3719, 3763, 3858, 4222], '[35S]methionine.': [2250], 'isolated': [2252, 2358, 2409, 2550, 3136, 3478, 4327, 5131], 'D273-10B': [2257], '(27Daum': [2258, 5033], 'Bohni': [2260, 5035], 'P.C.': [2261, 5036], '1982;': [2267, 5042], '257:': [2268, 5043], '13028-13033Abstract': [2269, 5044], 'preincubated': [2277], 'buffer': [2280, 2568, 2862], 'm-chlorophenylhydrazone': [2287], '(CCCP)': [2288], '3': [2290], 'min': [2291, 2336], 'dissipate': [2296], 'Δψ': [2297, 2885, 2943, 3009, 3305, 4383], 'radiolabeled': [2331, 2589], '10': [2335, 2364, 2372, 2527, 2545], 'ice': [2338, 2394], 'After': [2343, 2398], 'addition': [2345, 2400], 'μm': [2348, 2373, 2377, 2403, 5409, 5445, 5475, 5533, 5566, 5599], 'methotrexate': [2349], '(MTX)': [2350], 'mm': [2353, 2365, 2370, 2508, 2513, 2516, 2571, 2575], 'NADPH,': [2354], 'centrifugation': [2360, 2552], 'resuspended': [2362], 'MOPS-KOH,': [2366], 'pH': [2367, 2510], '7.2,': [2368], '250': [2369], 'sucrose,': [2371], 'MTX.': [2378], 'samples': [2380, 2537], 'halved,': [2382], 'aliquot': [2385], 'treated': [2387], '100': [2389, 2503], 'μg/ml': [2390, 2504], 'proteinase': [2391], 'K': [2392], 'min.': [2397, 2528, 2546], '2': [2402, 3079, 5529], 'phenylmethylsulfonyl': [2404], 'fluoride,': [2405], 'centrifugation,': [2411], 'supernatant': [2417], 'fractions': [2418, 5129], 'precipitated': [2420], 'trichloroacetic': [2422], 'acid.': [2423], 'SDS-PAGE': [2428, 2582], 'radioimaging': [2430, 2584], 'Storm': [2433], '860': [2434], 'image': [2435], 'analyzer': [2436], '(Amersham': [2437], 'Biosciences).': [2438], 'Recombinant': [2446], '—The': [2448], 'hexahistidine-tagged': [2450], '(dTom20)': [2460, 5345], '(16Abe': [2465, 5359, 5414], 'Radiolabeled': [2495], 'dTom20': [2505, 5399, 5535, 5609], 'Tris-HCl,': [2509], '8,': [2511, 4556], '50': [2512], 'KCl,': [2514], 'imidazole,': [2517], '0.1%': [2519], 'bovine': [2520], 'serum': [2521], 'albumin': [2522], '25': [2524], 'Nickel-nitrilotriacetic': [2529], 'resin': [2531, 2548, 3417, 3448], '(Qiagen)': [2532], 'added,': [2534], 'further': [2539, 6166], 'room': [2542], 'temperature': [2543, 4707], 'washed': [2554], 'once': [2555], 'same': [2558, 2567, 5863], 'buffer.': [2559], 'bound': [2561, 2951, 3015, 3059, 3310, 3412, 3686, 3709, 3779], 'eluted': [2564, 3433], '300': [2570], 'instead': [2572, 2892, 4455], 'imidazole.': [2576], 'detection': [2586], 'immunoblotting': [2593, 4784, 5157], 'dTom20.': [2595], 'Miscellaneous—Photo-cross-linking': [2596], 'experiments': [2597, 4323], 'bearing': [2600, 5511], '(BPA)': [2603], 'performed': [2605, 2641, 4321], 'Blue': [2636], 'native': [2637], 'PAGE': [2638], '(BN-PAGE)': [2639], 'method': [2644], '(28Dekker': [2647], 'Martin': [2649], 'Maarse': [2651, 5066], 'A.C.': [2652, 5067], 'Bomer': [2653], 'Muller': [2655, 5573], 'Guiard': [2657, 2921, 3157, 5080, 5922], 'Meijer': [2659, 5078], 'Rassow': [2661], '5408-5419Crossref': [2669], '(239)': [2672], 'Residues': [2678], 'Su9': [2681], 'Presequence': [2682, 4019], 'Are': [2683], 'Required': [2684], 'Generating': [2686], 'Stage': [2688], 'Intermediate—Translocation': [2690], 'their': [2705, 4744, 4998], 'asked': [2721, 4022], 'what': [2722, 4026], 'element': [2723], 'sites.': [2738], 'derivatives': [2742, 3589], 'model': [2745], 'pSD-(1–69).': [2749, 2802], 'Fig.': [2750, 3019, 3030, 3039, 3054, 3314, 3371, 3535, 3547, 5528], '2A': [2751], 'shows': [2752], 'comparison': [2754], 'vitro': [2758, 4134, 6161], 'pSD-(15–69),': [2763, 2850, 3658], 'full-length': [2783, 4848], 'presequence.': [2784], 'Although': [2785, 3281, 3683], 'pSD-(15–69)': [2786, 2894], 'imported': [2788, 3296], 'mitochondria,': [2790, 2964, 3774], 'rate': [2793, 3284], 'significantly': [2795, 3044, 3494, 4822, 4943], 'reduced': [2796, 3495], 'compared': [2798, 3047, 3274, 3497], 'This': [2803, 2983, 4211, 5759], 'due': [2806, 4723, 4736], 'difference': [2809], 'amounts': [2812, 4792, 4900], 'soluble': [2814], 'import-competent': [2815], 'forms': [2816, 4864, 5525, 5656], '(29Asai': [2817], 'Tkahashi': [2819], 'Ohtsuka': [2825], '2004;': [2834], '279:': [2835], '19464-19470Abstract': [2836], 'because': [2851, 3974, 4463, 4851, 5195, 6024, 6192], 'lose': [2854], 'competence': [2856], 'during': [2857, 6205], 'prolonged': [2858], 'incubation': [2859, 3201, 5506], 'similar': [2865, 4484, 5255], 'manner': [2866], '(data': [2867, 3465, 4496, 4561, 4730], 'shown).': [2869, 4498, 4563, 4732, 5788], 'then': [2871], 'pSD-(15–85)': [2876, 2891, 2948, 3037], 'pSD-(1–85)': [2878, 2950, 3014, 3060, 3778], 'absence': [2883, 3916, 4381], '2B).': [2887], 'make': [2896], 'sure': [2897], 'presequence-containing': [2900], 'segment': [2901, 5776], 'precedes': [2903], '(30Gaume': [2915, 3151], 'Klaus': [2917, 3153], 'Ungermann': [2919, 3155], 'Brunner': [2925, 3161], '6497-6507Crossref': [2931, 3167], '(79)': [2934, 3170], 'dissipated': [2942, 3304], '°C,': [2946, 3012, 3308, 3361, 3788], 'sensitive': [2956, 3322, 5743], 'digestion': [2958], 'protease': [2960], 'added': [2961, 3325], 'outside': [2962], 'suggesting': [2965, 3327, 5229], 'upon': [2972, 3200, 4411], '2B,': [2978, 3020, 3031, 3040, 3055, 3077, 3315, 3348, 3372, 3536, 3548], 'lanes': [2979, 3078, 3349, 4528, 4543], '5': [2980, 3350, 4529, 5532], '7).': [2982, 3352], 'finding': [2984], 'indicates': [2985], 'deletion': [2987, 4122, 4215, 4338, 4434, 4471, 4492, 4665, 4738, 4755, 4826, 4880, 4888, 5115, 5210, 5244, 5260, 5825, 5841, 5868, 5972, 6027, 6151], 'does': [2993, 3512], 'affect': [2995, 5830], 'generation': [2996], 'stage': [2999, 3073, 3092, 3337, 3561, 3567, 3879, 4036, 4040, 4061, 4064, 4248, 4251, 4391, 5680, 5700, 5723, 5739, 5793, 5796], 'B': [3000, 3338, 3562, 4041, 4065, 4252, 4392, 5797], 'intermediate.': [3001], 'contrast,': [3003, 5872], '(33.9%;': [3018], 'lane': [3021, 3032, 3041, 3056, 3316, 3373, 3537, 3549, 4302], '2)': [3022, 3042], 'efficiently': [3024, 3690, 3783, 5658], '(50.9%;': [3029], '5),': [3033, 3550], '(7%;': [3038], 'suppressed': [3045], '(37.4%;': [3053], '5).': [3057, 3317, 4656, 4711], 'contained': [3061], 'protease-resistant': [3063], 'domain,': [3068, 3727, 3900], 'indicating': [3069, 3551], 'formation': [3070, 3576], 'intermediate': [3075, 3094, 5725, 5741], '4).': [3081], 'therefore': [3087], 'generating': [3090], 'through': [3095, 5356, 5676], 'interactions': [3096, 5332, 5358, 5639, 5747], 'Site-bound': [3110], 'Form': [3111], 'Is': [3112, 4012, 4962], 'Not': [3113], 'Stable': [3114], 'Organello': [3117], 'Experiments—We': [3118], 'next': [3119, 4748], 'identify': [3122], 'span': [3147], 'allows': [3174], 'only': [3187, 3418, 4125, 4674, 5675], 'intermediate,': [3191, 3197, 3339, 3881], 'made': [3234, 3594, 4443], '38-residue': [3241], 'analyzing': [3253], 'possible': [3255], 'Prior': [3262], 'experiments,': [3266, 4239], 'pSD-(1–38)': [3270, 3289, 3293, 3309, 3362, 3380, 3411, 3443, 3471, 3484, 3506], '2A).': [3280], 'much': [3286, 6211], 'smaller': [3287], 'than': [3290, 3564, 4521, 4845, 5189], 'substantially': [3295], '(36.4%;': [3313], 'externally': [3324], 'protease,': [3326], 'and,': [3334], 'like': [3335, 4638], 'likely': [3341, 4085, 6133], 'nearly': [3363], 'failed': [3364], '(2.6%;': [3370], '2).': [3374, 4303, 5519], 'ability': [3378], 'directly': [3383], '(dTom20),': [3391], 'supposed': [3401], 'show': [3409], 'nickel-nitrilotriacetic': [3415, 3446, 3488], 'after': [3419, 5505, 5865], 'preincubation': [3420], 'hexahistidine': [3430], 'specifically': [3434], 'imidazole': [3436], '2C).': [3438], 'strictly': [3449], 'depended': [3450], '2C),': [3457, 5545], 'shown),': [3467], 'domain.': [3480, 4861], 'efficiency': [3482], 'acid-bound': [3489], '(∼50%)': [3491], 'those': [3499, 4522, 4807, 4846, 5632], 'pSD-(1–58)': [3501], 'pSD-(1–63).': [3503], 'Therefore,': [3504, 3913, 5264, 5618, 6210], 'it': [3511, 3540, 5020, 6036], 'intact': [3518, 5552], 'under': [3520], 'experimental': [3523, 5593], 'conditions.': [3524], 'pSD-(15–38)': [3525], 'did': [3526, 3542, 3770, 5828, 6030], '(1.2%;': [3534], '2),': [3538], 'still': [3541, 5888, 6228], '(8.1%;': [3546], 'less': [3553], 'role': [3555, 4599], 'binding.': [3569], 'reveal': [3571], 'dependence': [3573], 'surface-bound': [3578], 'detail,': [3592], 'series': [3596, 3632], '(pSD-(1-x))': [3600], '(pSD-(1–38),': [3620], 'pSD-(1–93))': [3628], 'together': [3629], 'another': [3631], '(pSD-(15-x))': [3636], 'segments': [3639], 'starting': [3640], '(pSD-(15–38),': [3655], 'pSD-(1–85)).': [3661], 'these': [3667, 5322], '3,': [3679], 'all': [3684], 'pSD-(1-x)': [3685, 3697, 3704, 3732, 3748], 'irrespective': [3694, 3833], '"x,"': [3696], 'x': [3699, 3706], '≥': [3700], '≤': [3707], '3A).': [3716], 'ligand': [3723], 'expected': [3734], 'fold': [3736], 'even': [3738, 4703, 5864], '(x': [3749], '=': [3750], '85)': [3754], 'MTX': [3765], 'pSD-(1–48)': [3769], 'whereas': [3775, 4415, 5682], '3C).': [3785], 'become': [3794], 'transiently': [3795], 'so': [3797], 'length': [3836], 'thereby': [3840], 'yielding': [3841], 'surface.': [3847, 3968], '≥63': [3865], '≤58': [3884], 'unfolding': [3896], 'either.': [3912], 'associate': [3934], 'any': [3939], 'more.': [3940], 'words,': [3943], 'tether': [3961], 'cases': [3971], 'lack': [3977, 5198], 'surface': [3993, 5477], 'unless': [3994], '3B).': [4010], 'Close': [4013], 'Site': [4017], 'Binding—Next,': [4020], 'question': [4024], 'address': [4048], 'question,': [4050], 're-analyzed': [4052], 'proximity': [4059], 'photo-cross-linking.': [4068], 'Previous': [4069], 'studies': [4070], 'suggested': [4071, 5313], 'Tom22C': [4124, 4217, 4476, 4494, 4589, 4603, 4621, 4628, 4668, 4742, 4759, 4830, 4954, 4961, 4976, 5119, 5212, 5231, 5252, 5262, 5265, 5843, 5976, 6006, 6029, 6044, 6155, 6175, 6199, 6222], 'mildly': [4126], 'affects': [4127], '(18Court': [4139], 'compensated': [4219], 'unknown': [4225], 'component': [4226], 'shares': [4228], 'common': [4230], 'Tom22C.': [4233, 5818], 'site-specific': [4237, 5790, 6264], 'photo-cross-linking': [4238, 5791], 'Tom40,': [4256, 4800], 'yet': [4261], 'unidentified': [4262], 'small': [4263, 4313], 'X': [4265, 4306, 4405, 4569], 'molecular': [4268], 'mass': [4269], '∼5': [4271], 'kDa': [4272], '4A,': [4301], 'three': [4312], 'Tom': [4314], 'proteins,': [4315, 4869, 6034], 'Tom5,': [4316, 4341], 'Tom6,': [4317, 4342], 'Tom7,': [4319], 'cross-linking': [4322, 4440], 'using': [4325], 'Δtom5,': [4331, 4371, 4397], 'single': [4337, 4887, 6026], '4A).': [4348], 'pSu9-(1–69),': [4349], 'carried': [4351], 'BPA': [4352, 4505, 4552, 6267], '(an': [4353], 'unnatural': [4354], 'photoactive': [4359], 'benzophenone': [4360], 'chain)': [4362], '18,': [4365], 'wild-type': [4369, 4457, 5164, 5191], '(WT),': [4370], 'subjected': [4385, 4780, 5150], 'UV': [4387, 4412], 'light': [4388, 4413], 'irradiation.': [4389], 'formed': [4394, 4417, 5889], 'Δtom6': [4399], '34-kDa': [4409], 'product': [4410, 4514, 4534], 'irradiation,': [4414], 'X.': [4426], 'rule': [4428], 'possibility': [4431], 'indirectly': [4437], 'affected': [4438, 4823], 'patterns,': [4441], 'HA': [4453], '(Tom7-HA)': [4454], 'fully': [4461], 'functional': [4462], 'expression': [4480], 'Tom7-HA,': [4504], '18': [4510], 'generated': [4511, 5659], 'X,': [4516], 'slightly': [4519, 5186], 'larger': [4520], 'WT': [4524, 4640, 4895], '4B,': [4527, 4542], '11).': [4531], 'immunoprecipitated': [4536], 'anti-HA': [4539], 'antibody': [4540], '6': [4544], '12).': [4546], 'Similar': [4547], 'obtained': [4550], '6,': [4555], 'These': [4564, 4948, 5939], 'indicate': [4566, 4950], 'Have': [4590], 'Overlapping': [4591], 'Functions': [4592], 'Facilitate': [4594], 'Translocation—To': [4596], 'probe': [4597], 'around': [4604], 'mediating': [4609], 'import,': [4612], 'deleted.': [4623], 'deleted': [4627, 4634, 4718, 5183], '(Δtom22C)': [4629], '(Δtom7)': [4636], 'grew,': [4637], 'strain,': [4641, 4881], 'fermentable': [4644, 4676, 4691], 'non-fermentable': [4646, 4701, 5985], 'carbon': [4647], 'sources': [4648], '23,': [4650], '30,': [4651], '37': [4653], '(Δtom22C/Δtom7)': [4671, 4720], 'grow': [4673, 4688], 'media': [4677], 'low': [4679, 4706], 'temperatures': [4680, 4695], '(23': [4681, 4708], '°C),': [4684], 'source': [4692, 4702], 'high': [4694], '(37': [4696], '°C)': [4697, 4709], 'respiratory': [4713], 'defect': [4714], 'double': [4717, 4754, 4879, 6150], 'loss': [4725], 'synthetic': [4734, 5978, 6012], 'defects': [4735, 5979], 'suggest': [4743, 5945], 'functions.': [4746], 'effects': [4751, 5112, 6147], 'vivo.': [4765, 4960], 'Total': [4766, 5127], 'extracts': [4768], 'prepared': [4770], 'wild-type,': [4772], 'Δtom7,': [4773, 5134], 'Δtom22C,': [4774, 5135], 'Δtom22C/Δtom7': [4776, 4925, 4946, 5137], '6).': [4790, 5997], 'Tom70,': [4801], '6A),': [4805], 'complexes,': [4813], 'Tim50,': [4814], 'Tim23,': [4815], 'Tim22': [4817], '6B),': [4819], '6B).': [4832], 'band': [4834], 'lacked': [4838], 'fainter': [4844], 'probably': [4850, 5194], 'anti-Tom22': [4853], 'antibodies': [4854, 5160], 'here': [4856, 5704], 'partly': [4857], 'Mdj1p,': [4870], 'Ssc1p,': [4871], 'mtHsp60,': [4872], 'Yge1p,': [4874], 'observed': [4876, 5969], 'Δtom22C/Δtom7,': [4882], 'stain': [4896], '6C).': [4898], 'PiC': [4906], '(phosphate': [4907], 'carrier),': [4908], 'peripheral': [4913], 'side,': [4920], 'pCox4p,': [4921], 'decreased': [4923, 4937, 4944], 'cells.': [4926, 4947], 'Interestingly,': [4927], 'amount': [4929], 'protein,': [4934], 'porin,': [4935], 'moderately': [4936], 'facilitate': [4955], 'Important': [4963], 'Stabilization': [4965], '440-kDa': [4968, 5173, 5203, 5223, 5239, 5272, 5835, 5891, 5965, 6021, 6041], 'Complex—Although': [4970], 'revealed': [4972], 'they': [4991], 'mediate': [4992], 'vivo,': [4997], 'roles': [4999, 6171, 6215], 'necessarily': [5007], 'limited': [5008], 'facilitation': [5010], 'contributes': [5026, 5266], 'assembly': [5028, 5054, 5104], 'promotes': [5053], '(31van': [5059], 'Wilpe': [5060], 'Ryan': [5062, 5569], 'M.T.': [5063, 5570], 'Hill': [5064], 'Meisinger': [5068], 'Brix': [5070, 5571], 'P.J.': [5073, 5568], 'Moczko': [5074], 'Wagner': [5076], 'Honlinger': [5082, 5575], '401:': [5088], '485-489Crossref': [5089], '(230)': [5092], 'clear.': [5107], 'examined': [5110], 'stability': [5122, 5236, 5269, 5832], 'solubilized': [5140, 5147], 'non-ionic': [5143], 'detergent': [5144], 'digitonin.': [5145], 'BN-PAGE': [5154, 5177, 5822], 'followed': [5155], 'anti-Tom40': [5159], '6D).': [5162], 'cells,': [5165], 'holo-TOM': [5167], 'detected': [5170], 'gel.': [5178], 'exhibited': [5185, 5253], 'faster': [5187], 'mobility': [5188, 5254], 'led': [5213], 'shift': [5216], '120-kDa': [5227, 5855, 5858], 'An': [5242], 'additional': [5243, 5867], 'alone.': [5263], 'requirements': [5282], 'Tom5.': [5320], 'Among': [5321], 'subunits,': [5323], 'best': [5327], 'respect': [5330], 'presequences.': [5334], 'NMR': [5336, 5411, 5635], 'structure': [5337], 'hydrophobic': [5348, 5357], 'groove': [5349], 'where': [5350], 'amphiphilic': [5351, 5785], 'peptides': [5353], 'affinity': [5390], '(Kd)': [5391], 'reported;': [5402], 'Kd': [5403, 5596, 5629], 'values': [5404], 'determined': [5406, 5633], '20–30': [5408], 'titration': [5412, 5636], '0.003': [5444], 'sucrose': [5447], 'density': [5448], 'gradient': [5449], '(13Komiya': [5451], '∼0.05–0.12': [5474], 'plasmon': [5478], 'resonance': [5479], 'measurements': [5480], '(14Iwata': [5481], 'detect': [5500], 'site-bound': [5503, 5524, 5655], 'Why': [5520], 'unstable?': [5526], 'assays': [5538, 5558], 'concentration': [5548], '2B)': [5560], 'estimated': [5562], '0.03': [5565], '(32Dekker': [5567], '18:': [5583], '6515-6524Crossref': [5584], '(195)': [5587], 'Under': [5590], 'conditions,': [5594], '20': [5598], 'leads': [5600], '20%': [5604], '0.15%': [5613], 'our': [5619], 'consistent': [5623, 5762], 'submicromolar': [5626], 'range': [5627], '(such': [5630], 'analyses)': [5637], 'Tom20.': [5645], 'types': [5651], 'presequence;': [5665], 'anchored': [5670], 'A,': [5681], 'involved': [5692], 'anchoring': [5717], 'salt': [5745], 'treatment,': [5746], 'should': [5755], 'electrostatic.': [5758], 'probability': [5760], 'fact': [5765], 'contain': [5774], '(residues': [5777], '10–27)': [5778], 'helix': [5786], '(not': [5787], '33': [5846, 5950], 'residues)': [5847], 'destabilized': [5848], 'remains': [5861], 'previous': [5874], '31': [5886], '(19Moczko': [5893], '33Frazier': [5916], 'A.E.': [5917], 'Chacinska': [5918], 'Truscott': [5920], 'K.N.': [5921], 'Rehling': [5926], 'P.': [5927, 6235], '23:': [5932], '7818-7828Crossref': [5933], '(54)': [5936], 'apparently': [5940], 'divergent': [5941], 'perhaps': [5944], '32': [5948], 'C': [5953], 'terminus': [5954], 'stabilization': [5962, 6018], 'caused': [5977, 6037], 'medium': [5986], '5)': 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