Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1974462651', 'doi': 'https://doi.org/10.1073/pnas.97.4.1856', 'title': 'Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa <i>in vivo</i> by dopamine D <sub>1</sub> , dopamine D <sub>2</sub> , and adenosine A <sub>2A</sub> receptors', 'display_name': 'Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa <i>in vivo</i> by dopamine D <sub>1</sub> , dopamine D <sub>2</sub> , and adenosine A <sub>2A</sub> receptors', 'publication_year': 2000, 'publication_date': '2000-02-15', 'ids': {'openalex': 'https://openalex.org/W1974462651', 'doi': 'https://doi.org/10.1073/pnas.97.4.1856', 'mag': '1974462651', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10677546', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/26526'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.97.4.1856', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc26526?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036364090', 'display_name': 'Per Svenningsson', 'orcid': 'https://orcid.org/0000-0001-6727-3802'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['BE', 'SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'P. Svenningsson', 'raw_affiliation_strings': ['Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021'], 'affiliations': [{'raw_affiliation_string': 'Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021', 'institution_ids': ['https://openalex.org/I83399316', 'https://openalex.org/I132053463', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022769082', 'display_name': 'Maria Lindskog', 'orcid': 'https://orcid.org/0000-0002-4178-2825'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['BE', 'SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'M. Lindskog', 'raw_affiliation_strings': ['Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021'], 'affiliations': [{'raw_affiliation_string': 'Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021', 'institution_ids': ['https://openalex.org/I83399316', 'https://openalex.org/I132053463', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044096868', 'display_name': 'C. Ledent', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['BE', 'SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'C. Ledent', 'raw_affiliation_strings': ['Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021'], 'affiliations': [{'raw_affiliation_string': 'Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021', 'institution_ids': ['https://openalex.org/I83399316', 'https://openalex.org/I132053463', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079381808', 'display_name': 'Marc Parmentier', 'orcid': 'https://orcid.org/0000-0001-8081-4685'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['BE', 'SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'M. Parmentier', 'raw_affiliation_strings': ['Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021'], 'affiliations': [{'raw_affiliation_string': 'Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021', 'institution_ids': ['https://openalex.org/I83399316', 'https://openalex.org/I132053463', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052825834', 'display_name': 'Paul Greengard', 'orcid': 'https://orcid.org/0000-0002-4437-0893'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}], 'countries': ['BE', 'SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'P. Greengard', 'raw_affiliation_strings': ['Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021'], 'affiliations': [{'raw_affiliation_string': 'Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021', 'institution_ids': ['https://openalex.org/I28166907', 'https://openalex.org/I83399316', 'https://openalex.org/I132053463']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112182860', 'display_name': 'B.B. Fredholm', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['BE', 'SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'B. B. Fredholm', 'raw_affiliation_strings': ['Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021'], 'affiliations': [{'raw_affiliation_string': 'Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021', 'institution_ids': ['https://openalex.org/I83399316', 'https://openalex.org/I132053463', 'https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036646593', 'display_name': 'Gilberto Fisone', 'orcid': 'https://orcid.org/0000-0002-0719-8000'}, 'institutions': [{'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I132053463', 'display_name': 'Université Libre de Bruxelles', 'ror': 'https://ror.org/01r9htc13', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I132053463']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['BE', 'SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'G. Fisone', 'raw_affiliation_strings': ['Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021'], 'affiliations': [{'raw_affiliation_string': 'Departments of Physiology and Pharmacology, and Neuroscience, Karolinska Institutet, S-171 77 Stockholm, Sweden; Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucléaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021', 'institution_ids': ['https://openalex.org/I83399316', 'https://openalex.org/I132053463', 'https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.102, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 193, 'citation_normalized_percentile': {'value': 0.999852, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '97', 'issue': '4', 'first_page': '1856', 'last_page': '1860'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/eticlopride', 'display_name': 'Eticlopride', 'score': 0.83122253}, {'id': 'https://openalex.org/keywords/adenosine-a2a-receptor', 'display_name': 'Adenosine A2A receptor', 'score': 0.48850024}], 'concepts': [{'id': 'https://openalex.org/C2778125517', 'wikidata': 'https://www.wikidata.org/wiki/Q12745201', 'display_name': 'Eticlopride', 'level': 5, 'score': 0.83122253}, {'id': 'https://openalex.org/C2779917531', 'wikidata': 'https://www.wikidata.org/wiki/Q7389148', 'display_name': 'SCH-23390', 'level': 4, 'score': 0.7539128}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.61191297}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.6049761}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5689042}, {'id': 'https://openalex.org/C120750228', 'wikidata': 'https://www.wikidata.org/wiki/Q2035393', 'display_name': 'Dopamine receptor D1', 'level': 4, 'score': 0.56597424}, {'id': 'https://openalex.org/C2776991684', 'wikidata': 'https://www.wikidata.org/wiki/Q190012', 'display_name': 'Adenosine', 'level': 2, 'score': 0.55334854}, {'id': 'https://openalex.org/C120069818', 'wikidata': 'https://www.wikidata.org/wiki/Q415496', 'display_name': 'Dopamine receptor', 'level': 3, 'score': 0.55276793}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.54803646}, {'id': 'https://openalex.org/C44208683', 'wikidata': 'https://www.wikidata.org/wiki/Q15335165', 'display_name': 'Dopamine receptor D2', 'level': 3, 'score': 0.5050805}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.49789405}, {'id': 'https://openalex.org/C2778491162', 'wikidata': 'https://www.wikidata.org/wiki/Q3063865', 'display_name': 'Adenosine A2A receptor', 'level': 5, 'score': 0.48850024}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4662069}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4251101}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.35269}, {'id': 'https://openalex.org/C67907053', 'wikidata': 'https://www.wikidata.org/wiki/Q356147', 'display_name': 'Adenosine receptor', 'level': 4, 'score': 0.29456443}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23831537}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.08074254}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.065785825}], 'mesh': [{'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004298', 'descriptor_name': 'Dopamine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017448', 'descriptor_name': 'Receptors, Dopamine D2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018047', 'descriptor_name': 'Receptors, Purinergic P1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001552', 'descriptor_name': 'Benzazepines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001552', 'descriptor_name': 'Benzazepines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003042', 'descriptor_name': 'Cocaine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004298', 'descriptor_name': 'Dopamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018492', 'descriptor_name': 'Dopamine Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018492', 'descriptor_name': 'Dopamine Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D065127', 'descriptor_name': 'Dopamine D2 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051937', 'descriptor_name': 'Dopamine and cAMP-Regulated Phosphoprotein 32', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054645', 'descriptor_name': 'Protein Phosphatase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011743', 'descriptor_name': 'Pyrimidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D043705', 'descriptor_name': 'Receptor, Adenosine A2A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017447', 'descriptor_name': 'Receptors, Dopamine D1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017447', 'descriptor_name': 'Receptors, Dopamine D1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017448', 'descriptor_name': 'Receptors, Dopamine D2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018047', 'descriptor_name': 'Receptors, Purinergic P1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012457', 'descriptor_name': 'Salicylamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012457', 'descriptor_name': 'Salicylamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.97.4.1856', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc26526', 'pdf_url': 'https://europepmc.org/articles/pmc26526?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC26526', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10677546', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc26526', 'pdf_url': 'https://europepmc.org/articles/pmc26526?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.66}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1502843806', 'https://openalex.org/W1519847602', 'https://openalex.org/W1521659744', 'https://openalex.org/W1603297402', 'https://openalex.org/W1643311486', 'https://openalex.org/W1647678806', 'https://openalex.org/W1928303249', 'https://openalex.org/W1977233750', 'https://openalex.org/W1977533543', 'https://openalex.org/W1978559289', 'https://openalex.org/W1982686544', 'https://openalex.org/W1986782732', 'https://openalex.org/W1991603311', 'https://openalex.org/W1999116988', 'https://openalex.org/W2002933217', 'https://openalex.org/W2005657014', 'https://openalex.org/W2009449932', 'https://openalex.org/W2015623933', 'https://openalex.org/W2018289835', 'https://openalex.org/W2020174502', 'https://openalex.org/W2034588648', 'https://openalex.org/W2042991737', 'https://openalex.org/W2053650795', 'https://openalex.org/W2073561633', 'https://openalex.org/W2077172541', 'https://openalex.org/W2089588917', 'https://openalex.org/W2101108802', 'https://openalex.org/W2119384581', 'https://openalex.org/W2122836762', 'https://openalex.org/W2122873971', 'https://openalex.org/W2122956388', 'https://openalex.org/W2123986548', 'https://openalex.org/W2146439993', 'https://openalex.org/W2149614104', 'https://openalex.org/W2157867342', 'https://openalex.org/W2169542395', 'https://openalex.org/W4297983381'], 'related_works': ['https://openalex.org/W3311311', 'https://openalex.org/W2896569647', 'https://openalex.org/W2253990439', 'https://openalex.org/W2061828239', 'https://openalex.org/W2046827837', 'https://openalex.org/W2043514528', 'https://openalex.org/W2042726027', 'https://openalex.org/W2017955683', 'https://openalex.org/W1997196479', 'https://openalex.org/W1968408848'], 'abstract_inverted_index': {'Dopamine': [0], 'D': [1, 5, 83, 147, 216, 219, 246], '1': [2, 148, 217], ',': [3, 7, 26, 195, 218, 221], 'dopamine': [4, 245], '2': [6, 84, 220, 247], 'and': [8, 40, 154, 157, 222], 'adenosine': [9, 103, 234], 'A': [10, 64, 104, 112, 126, 223], '2A': [11, 105, 127, 224], 'receptors': [12, 31], 'are': [13, 210], 'highly': [14], 'expressed': [15], 'in': [16, 24, 61, 67, 75, 94, 96, 117, 137, 182, 193, 239, 249], 'striatal': [17], 'medium-sized': [18], 'spiny': [19], 'neurons.': [20], 'We': [21], 'have': [22], 'examined,': [23], 'vivo': [25, 194, 250], 'the': [27, 33, 38, 68, 82, 98, 102, 124, 146, 180, 196, 205, 230, 233, 240], 'influence': [28], 'of': [29, 35, 37, 43, 53, 70, 72, 81, 198, 200, 207, 215, 242], 'these': [30], 'on': [32], 'state': [34, 69, 197], 'phosphorylation': [36, 71, 139, 199], 'dopamine-': [39], 'cAMP-regulated': [41], 'phosphoprotein': [42], '32': [44], 'kDa': [45], '(DARPP-32).': [46], 'DARPP-32': [47, 73, 138, 183, 201], 'is': [48], 'a': [49, 237], 'potent': [50], 'endogenous': [51], 'inhibitor': [52], 'protein': [54, 208], 'phosphatase-1,': [55], 'which': [56, 97], 'plays': [57, 236], 'an': [58], 'obligatory': [59], 'role': [60, 238], 'dopaminergic': [62], 'transmission.': [63], 'dose-dependent': [65], 'increase': [66, 136, 181], 'occurred': [74], 'mouse': [76], 'striatum': [77], 'after': [78], 'systemic': [79], 'administration': [80], 'receptor': [85, 106, 128, 149], 'antagonist': [86, 129, 150], 'eticlopride': [87], '(0.1–2.0': [88], 'mg/kg).': [89, 133, 172, 188], 'This': [90], 'effect': [91], 'was': [92, 107, 114, 140], 'abolished': [93, 179], 'mice': [95, 118], 'gene': [99], 'coding': [100], 'for': [101], 'disrupted': [108], 'by': [109, 143, 160, 185, 203, 212], 'homologous': [110], 'recombination.': [111], 'reduction': [113], 'also': [115, 141, 228], 'observed': [116], 'that': [119, 232], 'had': [120], 'been': [121], 'pretreated': [122], 'with': [123, 145, 163], 'selective': [125], 'SCH': [130, 151, 164, 169, 173, 177], '58261': [131, 170], '(10': [132, 171], 'The': [134, 189, 226], 'eticlopride-induced': [135], 'decreased': [142], 'pretreatment': [144, 162], '23390': [152, 165], '(0.125': [153], '0.25': [155], 'mg/kg)': [156, 167], 'completely': [158], 'reversed': [159], 'combined': [161], '(0.25': [166], 'plus': [168], '23390,': [174], 'but': [175], 'not': [176], '58261,': [178], 'caused': [184], 'cocaine': [186], '(15': [187], 'results': [190, 227], 'indicate': [191], 'that,': [192], 'and,': [202], 'implication,': [204], 'activity': [206], 'phosphatase-1': [209], 'regulated': [211], 'tonic': [213], 'activation': [214], 'receptors.': [225], 'underscore': [229], 'fact': [231], 'system': [235], 'generation': [241], 'responses': [243], 'to': [244], 'antagonists': [248], '.': [251]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1974462651', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2025-01-11T17:45:24.948600', 'created_date': '2016-06-24'}