Title: Target Organ Specificity For N-Heterocyclic Aromatics
Abstract:Abstract N-Heterocyclic aromatics are environmental carcinogenic pollutants. Of these compounds, 7H-dibenzo[c,g]carbazole (DBC) is a liver and skin carcinogen in the mouse by topical application and a...Abstract N-Heterocyclic aromatics are environmental carcinogenic pollutants. Of these compounds, 7H-dibenzo[c,g]carbazole (DBC) is a liver and skin carcinogen in the mouse by topical application and a lung carcinogen by IP injection, whereas dibenz[a,j]acridine (DBA) is a skin carcinogen by topical application. Using 32P-postlabeling techniques, it was found that DBC-DNA adduct 6 is the major adduct in the liver, consistent with the metabolism of DBC to the 3-OH-DBC; adducts 2 and 3 are major adducts in the skin and adduct 3 is the major adduct in the lung. On the other hand, DBA adduction is apparent only in the skin and is consistent with the initial metabolism to DBA-3, 4-dihydrodiol. These data indicate that the adduct pattern, as well as the proximate metabolites, are target organ specific; these data will have an impact on the development of biomarkers of the carcinogenic process.Read More
Publication Year: 1994
Publication Date: 1994-08-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 9
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