Publication Information

{'id': 'https://openalex.org/W1974167857', 'doi': 'https://doi.org/10.1038/bjc.2011.156', 'title': 'A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer', 'display_name': 'A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer', 'publication_year': 2011, 'publication_date': '2011-05-10', 'ids': {'openalex': 'https://openalex.org/W1974167857', 'doi': 'https://doi.org/10.1038/bjc.2011.156', 'mag': '1974167857', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21559012', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3111195'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/bjc.2011.156', 'pdf_url': 'https://www.nature.com/articles/bjc2011156.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.nature.com/articles/bjc2011156.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083373965', 'display_name': 'Pamela N. Münster', 'orcid': 'https://orcid.org/0000-0002-2074-0984'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P N Munster', 'raw_affiliation_strings': ['Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049096078', 'display_name': 'Kenneth T. Thurn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'K T Thurn', 'raw_affiliation_strings': ['Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079184666', 'display_name': 'Scott Thomas', 'orcid': 'https://orcid.org/0000-0002-5564-4271'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S Thomas', 'raw_affiliation_strings': ['Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081075208', 'display_name': 'Paromita Raha', 'orcid': 'https://orcid.org/0000-0002-6941-1495'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P Raha', 'raw_affiliation_strings': ['Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048044563', 'display_name': 'M. Lacevic', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M Lacevic', 'raw_affiliation_strings': ['H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA'], 'affiliations': [{'raw_affiliation_string': 'H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA', 'institution_ids': ['https://openalex.org/I3019308854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110561964', 'display_name': 'Alexandra Miller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A Miller', 'raw_affiliation_strings': ['Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000761973', 'display_name': 'Michelle Melisko', 'orcid': 'https://orcid.org/0000-0002-8729-4667'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M Melisko', 'raw_affiliation_strings': ['Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015970851', 'display_name': 'Roohi Ismail‐Khan', 'orcid': 'https://orcid.org/0000-0002-1301-6736'}, 'institutions': [{'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R Ismail-Khan', 'raw_affiliation_strings': ['H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA'], 'affiliations': [{'raw_affiliation_string': 'H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA', 'institution_ids': ['https://openalex.org/I3019308854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090188675', 'display_name': 'Hope S. Rugo', 'orcid': 'https://orcid.org/0000-0001-6710-4814'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'H Rugo', 'raw_affiliation_strings': ['Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006839105', 'display_name': 'Mark M. Moasser', 'orcid': 'https://orcid.org/0000-0003-4411-4336'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M Moasser', 'raw_affiliation_strings': ['Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.'], 'affiliations': [{'raw_affiliation_string': 'Division of Hematology and Oncology, University of California, San Francisco, 1600 Divisadero, Rm A719 Box 1711, San Francisco, CA 94143, USA.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111541235', 'display_name': 'Susan Minton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3019308854', 'display_name': 'Moffitt Cancer Center', 'ror': 'https://ror.org/01xf75524', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019308854']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S E Minton', 'raw_affiliation_strings': ['H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA'], 'affiliations': [{'raw_affiliation_string': 'H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA', 'institution_ids': ['https://openalex.org/I3019308854']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3790, 'currency': 'EUR', 'value_usd': 4690, 'provenance': 'doaj'}, 'apc_paid': {'value': 3790, 'currency': 'EUR', 'value_usd': 4690, 'provenance': 'doaj'}, 'fwci': 15.421, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 360, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '104', 'issue': '12', 'first_page': '1828', 'last_page': '1835'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vorinostat', 'display_name': 'Vorinostat', 'score': 0.8291576}, {'id': 'https://openalex.org/keywords/aromatase-inhibitor', 'display_name': 'Aromatase inhibitor', 'score': 0.6057535}, {'id': 'https://openalex.org/keywords/histone-deacetylase-inhibitor', 'display_name': 'Histone deacetylase inhibitor', 'score': 0.5156235}], 'concepts': [{'id': 'https://openalex.org/C2776262904', 'wikidata': 'https://www.wikidata.org/wiki/Q905901', 'display_name': 'Vorinostat', 'level': 5, 'score': 0.8291576}, {'id': 'https://openalex.org/C2777176818', 'wikidata': 'https://www.wikidata.org/wiki/Q412178', 'display_name': 'Tamoxifen', 'level': 4, 'score': 0.7480695}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6271878}, {'id': 'https://openalex.org/C2778504769', 'wikidata': 'https://www.wikidata.org/wiki/Q3040305', 'display_name': 'Aromatase inhibitor', 'level': 5, 'score': 0.6057535}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.59806097}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5953393}, {'id': 'https://openalex.org/C2778305200', 'wikidata': 'https://www.wikidata.org/wiki/Q174378', 'display_name': 'Histone deacetylase', 'level': 4, 'score': 0.5368202}, {'id': 'https://openalex.org/C2776202225', 'wikidata': 'https://www.wikidata.org/wiki/Q3569101', 'display_name': 'Histone deacetylase inhibitor', 'level': 5, 'score': 0.5156235}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5108073}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4271106}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4191654}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34730902}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.32283717}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28950763}, {'id': 'https://openalex.org/C64927066', 'wikidata': 'https://www.wikidata.org/wiki/Q36293', 'display_name': 'Histone', 'level': 3, 'score': 0.17734039}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004965', 'descriptor_name': 'Estrogen Antagonists', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D006877', 'descriptor_name': 'Hydroxamic Acids', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013629', 'descriptor_name': 'Tamoxifen', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000107', 'descriptor_name': 'Acetylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D004965', 'descriptor_name': 'Estrogen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056464', 'descriptor_name': 'Histone Deacetylase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056464', 'descriptor_name': 'Histone Deacetylase 2', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D056572', 'descriptor_name': 'Histone Deacetylase Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006657', 'descriptor_name': 'Histones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006877', 'descriptor_name': 'Hydroxamic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006877', 'descriptor_name': 'Hydroxamic Acids', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006877', 'descriptor_name': 'Hydroxamic Acids', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013629', 'descriptor_name': 'Tamoxifen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013629', 'descriptor_name': 'Tamoxifen', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D013629', 'descriptor_name': 'Tamoxifen', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000077337', 'descriptor_name': 'Vorinostat', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/bjc.2011.156', 'pdf_url': 'https://www.nature.com/articles/bjc2011156.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3111195', 'pdf_url': 'https://europepmc.org/articles/pmc3111195?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/15q9v0qw', 'pdf_url': 'https://escholarship.org/content/qt15q9v0qw/qt15q9v0qw.pdf?t=qafqwd', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111195', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21559012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/bjc.2011.156', 'pdf_url': 'https://www.nature.com/articles/bjc2011156.pdf', 'source': {'id': 'https://openalex.org/S62966998', 'display_name': 'British Journal of Cancer', 'issn_l': '0007-0920', 'issn': ['0007-0920', '1532-1827'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.86, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1812576394', 'https://openalex.org/W1918073772', 'https://openalex.org/W1932574503', 'https://openalex.org/W1961026612', 'https://openalex.org/W1982403882', 'https://openalex.org/W1984458529', 'https://openalex.org/W1998957807', 'https://openalex.org/W2008500457', 'https://openalex.org/W2009012471', 'https://openalex.org/W2010710786', 'https://openalex.org/W2025220605', 'https://openalex.org/W2025412384', 'https://openalex.org/W2046316599', 'https://openalex.org/W2054576779', 'https://openalex.org/W2070221969', 'https://openalex.org/W2071115015', 'https://openalex.org/W2081036615', 'https://openalex.org/W2100531260', 'https://openalex.org/W2102620699', 'https://openalex.org/W2105835610', 'https://openalex.org/W2107040737', 'https://openalex.org/W2110081110', 'https://openalex.org/W2135619784', 'https://openalex.org/W2136103407', 'https://openalex.org/W2139248078', 'https://openalex.org/W2154488022', 'https://openalex.org/W2155508219', 'https://openalex.org/W2157917711', 'https://openalex.org/W2158038535', 'https://openalex.org/W2158734599', 'https://openalex.org/W2171141282', 'https://openalex.org/W2171185186', 'https://openalex.org/W2508460892', 'https://openalex.org/W2974232217'], 'related_works': ['https://openalex.org/W4235617113', 'https://openalex.org/W4200528065', 'https://openalex.org/W3151757475', 'https://openalex.org/W2380036341', 'https://openalex.org/W2345149559', 'https://openalex.org/W2112330867', 'https://openalex.org/W2043322963', 'https://openalex.org/W1513102126', 'https://openalex.org/W1483077634', 'https://openalex.org/W1043690502'], 'abstract_inverted_index': {'Histone': [0, 69, 155], 'deacetylases': [1], '(HDACs)': [2], 'are': [3], 'crucial': [4], 'components': [5], 'of': [6, 55, 60, 167, 203], 'the': [7, 133, 201], 'oestrogen': [8], 'receptor': [9], '(ER)': [10], 'transcriptional': [11], 'complex.': [12], 'Preclinically,': [13], 'HDAC': [14], 'inhibitors': [15], 'can': [16], 'reverse': [17], 'tamoxifen/aromatase': [18], 'inhibitor': [19], 'resistance': [20], 'in': [21, 30, 74, 126, 178], 'hormone': [22, 180], 'receptor-positive': [23], 'breast': [24, 44], 'cancer.': [25], 'This': [26], 'concept': [27], 'was': [28, 130, 143, 149], 'examined': [29], 'a': [31, 189, 196], 'phase': [32], 'II': [33], 'combination': [34, 166], 'trial': [35], 'with': [36, 41, 52, 163], 'correlative': [37], 'end': [38], 'points.': [39], 'Patients': [40], 'ER-positive': [42], 'metastatic': [43], 'cancer': [45], 'progressing': [46], 'on': [47], 'endocrine': [48], 'therapy': [49], 'were': [50, 79, 91], 'treated': [51], '400': [53], 'mg': [54, 65], 'vorinostat': [56, 168], 'daily': [57], 'for': [58, 200], '3': [59], '4': [61], 'weeks': [62], 'and': [63, 71, 111, 132, 157, 169, 174, 192], '20': [64], 'tamoxifen': [66, 170], 'daily,': [67], 'continuously.': [68], 'acetylation': [70], 'HDAC2': [72, 160, 186], 'expression': [73, 187], 'peripheral': [75], 'blood': [76], 'mononuclear': [77], 'cells': [78], 'also': [80], 'evaluated.': [81], 'In': [82], 'all,': [83], '43': [84], 'patients': [85], '(median': [86], 'age': [87], '56': [88], 'years': [89], '(31–71))': [90], 'treated,': [92], '25': [93], '(58%)': [94], 'received': [95], 'prior': [96, 103], 'adjuvant': [97], 'tamoxifen,': [98], '29': [99], '(67%)': [100], 'failed': [101], 'one': [102], 'chemotherapy': [104], 'regimen,': [105], '42': [106], '(98%)': [107], 'progressed': [108], 'after': [109, 114], 'one,': [110], '23': [112], '(54%)': [113], 'two': [115], 'aromatase': [116], 'inhibitors.': [117], 'The': [118, 145, 165], 'objective': [119], 'response': [120, 147], 'rate': [121, 136], 'by': [122], 'Response': [123], 'Evaluation': [124], 'Criteria': [125], 'Solid': [127], 'Tumours': [128], 'criteria': [129], '19%': [131], 'clinical': [134], 'benefit': [135], '(response': [137], 'or': [138], 'stable': [139], 'disease': [140], '>24': [141], 'weeks)': [142], '40%.': [144], 'median': [146], 'duration': [148], '10.3': [150], 'months': [151], '(confidence': [152], 'interval:': [153], '8.1–12.4).': [154], 'hyperacetylation': [156, 194], 'higher': [158], 'baseline': [159], 'levels': [161], 'correlated': [162], 'response.': [164], 'is': [171, 188, 195], 'well': [172], 'tolerated': [173], 'exhibits': [175], 'encouraging': [176], 'activity': [177], 'reversing': [179], 'resistance.': [181], 'Correlative': [182], 'studies': [183], 'suggest': [184], 'that': [185], 'predictive': [190], 'marker': [191, 199], 'histone': [193], 'useful': [197], 'pharmacodynamic': [198], 'efficacy': [202], 'this': [204], 'combination.': [205]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1974167857', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 31}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 24}, {'year': 2018, 'cited_by_count': 22}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 29}, {'year': 2015, 'cited_by_count': 36}, {'year': 2014, 'cited_by_count': 41}, {'year': 2013, 'cited_by_count': 37}, {'year': 2012, 'cited_by_count': 39}], 'updated_date': '2024-12-14T07:35:26.867484', 'created_date': '2016-06-24'}