Title: Effects of Calcitonin in Paget's Disease and Polyostotic Fibrous Dysplasia
Abstract: The effects of porcine calcitonin, 4 or 8 MRC U/kg/day for 16 days, were investigated in 4 patients with Paget's disease, and in one patient with polyostotic fibrous dysplasia. Balances of calcium and phosphorus and urinary hydroxyproline were determined in all of the patients and balances of sodium and potassium were measured in 4 of them. Calcitonin lowered fecal calcium and produced net retention of calcium in all of the patients with Paget's disease. It decreased urinary calcium in 3 of them and urinary hydroxyproline in 2 of them. With calcitonin there was an increase in urinary phosphorus and a decrease in urinary hydroxyproline in the patient with polyostotic fibrous dysplasia. Calcitonin increased urinary sodium transiently in 3 patients and persistently in a patient with Paget's disease who had edema. The results suggest that calcitonin may be of therapeutic value in some patients with abnormalities in the metabolism of calcium or collagen.
Publication Year: 1970
Publication Date: 1970-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 67
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