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202], 'Cohesin': [15, 27], 'also': [17, 37, 215], 'important': [18], 'chromosome': [20, 197], 'condensation,': [21], 'DNA': [22], 'repair,': [23], 'and': [24, 34, 40, 48, 89, 94, 101, 129, 138, 145, 156, 169, 187, 196, 206, 234], 'gene': [25], 'expression.': [26], 'comprised': [29], 'Scc3,': [31], 'Mcd1,': [32, 124], 'Smc1,': [33], 'Smc3.': [35], 'Scc3': [36, 70, 105, 113, 131, 159, 219], 'binds': [38, 149], 'Pds5': [39, 137], 'Wpl1,': [41], 'cohesin-associated': [42], 'proteins': [43], 'that': [44, 184, 218, 238], 'regulate': [45], 'cohesin': [46, 52, 62, 95, 125, 135, 151, 165, 180, 224, 239], 'function,': [47], 'to': [49, 57, 97, 107, 127, 133, 167, 178, 211, 226], 'the': [50, 81, 119, 134, 146, 150, 179, 190], 'Scc2/4': [51], 'loader.': [53], 'We': [54, 182], 'mutagenized': [55], 'SCC3': [56], 'elucidate': [58], 'its': [59], 'role': [60, 163], 'in': [61, 80, 91, 142, 164], 'function.': [63], 'A': [64], '5': [65], 'amino': [66], 'acid': [67], 'insertion': [68], 'after': [69], 'residue': [71, 78], 'I358,': [72], 'or': [73], 'a': [74, 161, 172], 'missense': [75], 'mutation': [76], 'D373': [79, 102], 'adjacent': [82], 'stromalin': [83], 'conservative': [84], 'domain': [85], '(SCD)': [86], 'induce': [87], 'inviability': [88], 'defects': [90], 'both': [92], 'cohesion': [93, 170], 'binding': [96, 106, 123, 132, 166, 177], 'chromosomes.': [98], 'I358': [100, 117, 143], 'mutants': [103, 236], 'abrogate': [104], 'Mcd1.': [108, 212], 'These': [109, 213], 'results': [110], 'define': [111], 'an': [112], 'region': [114], 'extending': [115], 'from': [116, 175], 'through': [118], 'SCD': [120, 191], 'required': [121, 245], 'localization': [126], 'chromosomes': [128, 168], 'loader,': [136], 'Wpl1': [139], 'are': [140, 192], 'unaffected': [141], 'mutant': [144], 'loader': [147, 176], 'still': [148], 'core': [152], 'trimer': [153], '(Mcd1,': [154], 'Smc1': [155], 'Smc3).': [157], 'Thus,': [158], 'plays': [160], 'critical': [162, 193], 'at': [171, 241], 'step': [173], 'distinct': [174, 221], 'trimer.': [181], 'show': [183], 'residues': [185], 'Y371': [186, 233], 'K372': [188, 235], 'within': [189], 'viability': [195], 'condensation': [198], 'but': [199], 'dispensable': [200], 'However,': [203], 'scc3': [204, 207], 'Y371A': [205], 'K372A': [208], 'bind': [209], 'normally': [210], 'alleles': [214], 'provide': [216], 'evidence': [217], 'has': [220, 240], 'mechanisms': [222], 'loading': [225], 'different': [227], 'loci.': [228], 'cohesion-competence,': [230], 'condensation-incompetence': [231], 'suggests': [237], 'least': [242], 'one': [243], 'activity': [244], 'specifically': [246], 'condensation.': [248]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1973752471', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-09-09T04:33:42.178993', 'created_date': '2016-06-24'}