Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1973547087', 'doi': 'https://doi.org/10.1016/j.biocel.2008.07.019', 'title': 'Eph/ephrin signaling in epithelial development and homeostasis', 'display_name': 'Eph/ephrin signaling in epithelial development and homeostasis', 'publication_year': 2008, 'publication_date': '2008-08-10', 'ids': {'openalex': 'https://openalex.org/W1973547087', 'doi': 'https://doi.org/10.1016/j.biocel.2008.07.019', 'mag': '1973547087', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18761422', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3108796'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biocel.2008.07.019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183320690', 'display_name': 'The International Journal of Biochemistry & Cell Biology', 'issn_l': '1357-2725', 'issn': ['1357-2725', '1878-5875'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3108796?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020730562', 'display_name': 'Hui Miao', 'orcid': 'https://orcid.org/0000-0002-5446-1756'}, 'institutions': [{'id': 'https://openalex.org/I4210157264', 'display_name': 'MetroHealth Medical Center', 'ror': 'https://ror.org/05j4p5w63', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1299218025', 'https://openalex.org/I4210157264']}, {'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hui Miao', 'raw_affiliation_strings': ['Rammelkamp Center for Research, MetroHealth Medical Center, MetroHealth Campus, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, United States'], 'affiliations': [{'raw_affiliation_string': 'Rammelkamp Center for Research, MetroHealth Medical Center, MetroHealth Campus, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, United States', 'institution_ids': ['https://openalex.org/I4210157264', 'https://openalex.org/I58956616']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5044174487', 'display_name': 'Binghe Wang', 'orcid': 'https://orcid.org/0000-0002-2200-5270'}, 'institutions': [{'id': 'https://openalex.org/I4210157264', 'display_name': 'MetroHealth Medical Center', 'ror': 'https://ror.org/05j4p5w63', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1299218025', 'https://openalex.org/I4210157264']}, {'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Bingcheng Wang', 'raw_affiliation_strings': ['Rammelkamp Center for Research, MetroHealth Medical Center, MetroHealth Campus, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, United States'], 'affiliations': [{'raw_affiliation_string': 'Rammelkamp Center for Research, MetroHealth Medical Center, MetroHealth Campus, Case Western Reserve University School of Medicine, 2500 MetroHealth Drive, Cleveland, OH 44109, United States', 'institution_ids': ['https://openalex.org/I4210157264', 'https://openalex.org/I58956616']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5044174487'], 'corresponding_institution_ids': ['https://openalex.org/I4210157264', 'https://openalex.org/I58956616'], 'apc_list': {'value': 3650, 'currency': 'USD', 'value_usd': 3650, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.991, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 94, 'citation_normalized_percentile': {'value': 0.997658, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '41', 'issue': '4', 'first_page': '762', 'last_page': '770'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12061', 'display_name': 'Molecular Mechanisms of Axon Guidance', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12065', 'display_name': 'Role of Hippo Signaling Pathway in Mechanotransduction', 'score': 0.9753, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9629, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ephrin', 'display_name': 'Ephrin', 'score': 0.98341036}, {'id': 'https://openalex.org/keywords/eph-receptors', 'display_name': 'Eph receptors', 'score': 0.634138}, {'id': 'https://openalex.org/keywords/neural-development', 'display_name': 'Neural Development', 'score': 0.525111}, {'id': 'https://openalex.org/keywords/homeostasis', 'display_name': 'Homeostasis', 'score': 0.44331163}], 'concepts': [{'id': 'https://openalex.org/C19331615', 'wikidata': 'https://www.wikidata.org/wiki/Q423602', 'display_name': 'Erythropoietin-producing hepatocellular (Eph) receptor', 'level': 4, 'score': 0.9899768}, {'id': 'https://openalex.org/C170286479', 'wikidata': 'https://www.wikidata.org/wiki/Q24787399', 'display_name': 'Ephrin', 'level': 3, 'score': 0.98341036}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7595279}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.72436523}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4827139}, {'id': 'https://openalex.org/C63645605', 'wikidata': 'https://www.wikidata.org/wiki/Q103191', 'display_name': 'Homeostasis', 'level': 2, 'score': 0.44331163}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.41247886}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.3477666}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15729761}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D036342', 'descriptor_name': 'Ephrins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D036081', 'descriptor_name': 'Receptors, Eph Family', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036342', 'descriptor_name': 'Ephrins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D036342', 'descriptor_name': 'Ephrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004848', 'descriptor_name': 'Epithelium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004848', 'descriptor_name': 'Epithelium', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D004848', 'descriptor_name': 'Epithelium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036081', 'descriptor_name': 'Receptors, Eph Family', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D036081', 'descriptor_name': 'Receptors, Eph Family', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biocel.2008.07.019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183320690', 'display_name': 'The International Journal of Biochemistry & Cell Biology', 'issn_l': '1357-2725', 'issn': ['1357-2725', '1878-5875'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3108796', 'pdf_url': 'https://europepmc.org/articles/pmc3108796?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108796', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18761422', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3108796', 'pdf_url': 'https://europepmc.org/articles/pmc3108796?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 83, 'referenced_works': ['https://openalex.org/W1521637208', 'https://openalex.org/W1523948508', 'https://openalex.org/W1524233852', 'https://openalex.org/W1560267422', 'https://openalex.org/W1584018958', 'https://openalex.org/W1594867935', 'https://openalex.org/W1744742580', 'https://openalex.org/W1768148184', 'https://openalex.org/W1904463995', 'https://openalex.org/W1947640509', 'https://openalex.org/W1973619153', 'https://openalex.org/W1973881587', 'https://openalex.org/W1978105135', 'https://openalex.org/W1980556333', 'https://openalex.org/W1988521127', 'https://openalex.org/W1988654710', 'https://openalex.org/W1992187858', 'https://openalex.org/W1995773697', 'https://openalex.org/W1996131261', 'https://openalex.org/W1996912527', 'https://openalex.org/W1998255137', 'https://openalex.org/W2000814069', 'https://openalex.org/W2005423313', 'https://openalex.org/W2006360922', 'https://openalex.org/W2010040980', 'https://openalex.org/W2012468813', 'https://openalex.org/W2013429578', 'https://openalex.org/W2014705520', 'https://openalex.org/W2016701198', 'https://openalex.org/W2028766433', 'https://openalex.org/W2029487310', 'https://openalex.org/W2043562994', 'https://openalex.org/W2047039640', 'https://openalex.org/W2047694154', 'https://openalex.org/W2054376706', 'https://openalex.org/W2063759377', 'https://openalex.org/W2067526109', 'https://openalex.org/W2067818732', 'https://openalex.org/W2074179903', 'https://openalex.org/W2080627387', 'https://openalex.org/W2082390023', 'https://openalex.org/W2085787432', 'https://openalex.org/W2090466657', 'https://openalex.org/W2092136345', 'https://openalex.org/W2093842873', 'https://openalex.org/W2098327185', 'https://openalex.org/W2099129395', 'https://openalex.org/W2099240520', 'https://openalex.org/W2101635479', 'https://openalex.org/W2103966995', 'https://openalex.org/W2105622034', 'https://openalex.org/W2107464678', 'https://openalex.org/W2108613636', 'https://openalex.org/W2111724542', 'https://openalex.org/W2113611763', 'https://openalex.org/W2116399625', 'https://openalex.org/W2123467604', 'https://openalex.org/W2124521784', 'https://openalex.org/W2128749739', 'https://openalex.org/W2129444165', 'https://openalex.org/W2133196171', 'https://openalex.org/W2134792095', 'https://openalex.org/W2137525036', 'https://openalex.org/W2137530154', 'https://openalex.org/W2140551998', 'https://openalex.org/W2142190178', 'https://openalex.org/W2142941757', 'https://openalex.org/W2143955067', 'https://openalex.org/W2146597600', 'https://openalex.org/W2147136456', 'https://openalex.org/W2147654683', 'https://openalex.org/W2155008209', 'https://openalex.org/W2155306309', 'https://openalex.org/W2157726561', 'https://openalex.org/W2162544707', 'https://openalex.org/W2163169815', 'https://openalex.org/W2167316581', 'https://openalex.org/W2179038141', 'https://openalex.org/W2265998384', 'https://openalex.org/W2288255362', 'https://openalex.org/W28936388', 'https://openalex.org/W299507476', 'https://openalex.org/W4230112911'], 'related_works': ['https://openalex.org/W401185121', 'https://openalex.org/W3016571216', 'https://openalex.org/W2604596303', 'https://openalex.org/W2370154876', 'https://openalex.org/W2269834552', 'https://openalex.org/W2096043623', 'https://openalex.org/W2005006136', 'https://openalex.org/W1992187858', 'https://openalex.org/W1973547087', 'https://openalex.org/W1498522783'], 'abstract_inverted_index': {'Eph': [0, 71], 'receptors': [1, 72], 'and': [2, 17, 30, 38, 73, 98, 113, 120, 138], 'ephrin': [3, 75], 'ligands': [4, 76], 'are': [5, 32, 49, 61, 78], 'widely': [6], 'expressed': [7, 79], 'during': [8], 'embryonic': [9], 'development': [10, 40, 137], 'with': [11], 'well-defined': [12], 'functions': [13, 45, 58], 'in': [14, 36, 80, 89, 108, 123, 133], 'directing': [15], 'neuronal': [16], 'vascular': [18], 'network': [19], 'formation.': [20], 'Over': [21], 'the': [22, 65, 70], 'last': [23], 'decade,': [24], 'evidence': [25, 122], 'has': [26], 'mounted': [27], 'that': [28, 77, 126], 'Ephs': [29, 95], 'ephrins': [31, 97], 'also': [33, 87], 'actively': [34], 'involved': [35], 'prenatal': [37], 'postnatal': [39], 'of': [41, 59, 69, 130], 'epithelial': [42, 90, 110, 135], 'tissues.': [43], 'Their': [44], 'beyond': [46], 'developmental': [47], 'settings': [48], 'starting': [50], 'to': [51, 64], 'be': [52], 'recognized': [53], 'as': [54], 'well.': [55], 'The': [56, 92], 'diverse': [57], 'Eph/ephrin': [60, 131], 'largely': [62], 'related': [63], 'complementary': [66], 'expression': [67, 85], 'pattern': [68, 86], 'corresponding': [74], 'adjacent': [81], 'compartments,': [82], 'although': [83], 'overlapping': [84], 'exists': [88], 'tissue.': [91], 'interconnection': [93], 'between': [94], 'or': [96], 'classical': [99], 'cell': [100, 136], 'junctional': [101], 'molecules': [102], 'suggests': [103], 'they': [104], 'may': [105], 'function': [106], 'coordinately': [107], 'maintaining': [109], 'structural': [111], 'integrity': [112], 'homeostasis.': [114], 'This': [115], 'review': [116], 'will': [117], 'highlight': [118], 'cellular': [119], 'molecular': [121], 'current': [124], 'literature': [125], 'support': [127], 'a': [128], 'role': [129], 'systems': [132], 'regulating': [134], 'physiology.': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1973547087', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-24T09:51:38.600205', 'created_date': '2016-06-24'}