Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1973391025', 'doi': 'https://doi.org/10.1002/jcb.20780', 'title': 'Functional role of VDR in the activation of p27<sup>Kip1</sup> by the VDR/Sp1 complex', 'display_name': 'Functional role of VDR in the activation of p27<sup>Kip1</sup> by the VDR/Sp1 complex', 'publication_year': 2006, 'publication_date': '2006-03-03', 'ids': {'openalex': 'https://openalex.org/W1973391025', 'doi': 'https://doi.org/10.1002/jcb.20780', 'mag': '1973391025', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16518840'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcb.20780', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004094689', 'display_name': 'Hsuen-Tsen Cheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142974352', 'display_name': 'National Sun Yat-sen University', 'ror': 'https://ror.org/00mjawt10', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I142974352']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Hsuen-Tsen Cheng', 'raw_affiliation_strings': ['Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.', 'institution_ids': ['https://openalex.org/I142974352']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100350604', 'display_name': 'Jingyi Chen', 'orcid': 'https://orcid.org/0000-0003-0361-4844'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jing-Yi Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065467808', 'display_name': 'Yu‐Chun Huang', 'orcid': 'https://orcid.org/0000-0002-8086-8998'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yu-Chun Huang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100830740', 'display_name': 'Hui‐Chiu Chang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hui-Chiu Chang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087031696', 'display_name': 'Wen‐Chun Hung', 'orcid': 'https://orcid.org/0000-0003-4860-5415'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wen-Chun Hung', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.616, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.894842, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '98', 'issue': '6', 'first_page': '1450', 'last_page': '1456'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D and Health Outcomes', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D and Health Outcomes', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Mechanisms of Estrogen Receptor Signaling', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chromatin-immunoprecipitation', 'display_name': 'Chromatin immunoprecipitation', 'score': 0.6425236}, {'id': 'https://openalex.org/keywords/sp1-transcription-factor', 'display_name': 'Sp1 transcription factor', 'score': 0.53652465}, {'id': 'https://openalex.org/keywords/vitamin-d', 'display_name': 'Vitamin D', 'score': 0.508867}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription (linguistics)', 'score': 0.47060546}], 'concepts': [{'id': 'https://openalex.org/C179639408', 'wikidata': 'https://www.wikidata.org/wiki/Q417057', 'display_name': 'Calcitriol receptor', 'level': 3, 'score': 0.99170786}, {'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.8795253}, {'id': 'https://openalex.org/C134320426', 'wikidata': 'https://www.wikidata.org/wiki/Q901026', 'display_name': 'Chromatin immunoprecipitation', 'level': 5, 'score': 0.6425236}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.5555492}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.5424985}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5377557}, {'id': 'https://openalex.org/C57467964', 'wikidata': 'https://www.wikidata.org/wiki/Q14888082', 'display_name': 'Sp1 transcription factor', 'level': 5, 'score': 0.53652465}, {'id': 'https://openalex.org/C33987129', 'wikidata': 'https://www.wikidata.org/wiki/Q13479514', 'display_name': 'DNA-binding domain', 'level': 4, 'score': 0.51107705}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.49597272}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.47060546}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.46627286}, {'id': 'https://openalex.org/C183978625', 'wikidata': 'https://www.wikidata.org/wiki/Q903596', 'display_name': 'Electrophoretic mobility shift assay', 'level': 4, 'score': 0.42628288}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3916186}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.37135416}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.25743294}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19978616}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002762', 'descriptor_name': 'Cholecalciferol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D050760', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p27', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050760', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p27', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018167', 'descriptor_name': 'Receptors, Calcitriol', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016329', 'descriptor_name': 'Sp1 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002762', 'descriptor_name': 'Cholecalciferol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016384', 'descriptor_name': 'Consensus Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050760', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor p27', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018167', 'descriptor_name': 'Receptors, Calcitriol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018167', 'descriptor_name': 'Receptors, Calcitriol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016329', 'descriptor_name': 'Sp1 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcb.20780', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16518840', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.6, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1537480087', 'https://openalex.org/W1549100704', 'https://openalex.org/W1566472466', 'https://openalex.org/W1596659824', 'https://openalex.org/W1972431145', 'https://openalex.org/W1994869819', 'https://openalex.org/W2000846615', 'https://openalex.org/W2000930609', 'https://openalex.org/W2002340616', 'https://openalex.org/W2005744028', 'https://openalex.org/W2009139525', 'https://openalex.org/W2013034768', 'https://openalex.org/W2013256342', 'https://openalex.org/W2020952430', 'https://openalex.org/W2025827828', 'https://openalex.org/W2034064102', 'https://openalex.org/W2054630945', 'https://openalex.org/W2054917615', 'https://openalex.org/W2079706694', 'https://openalex.org/W2081501399', 'https://openalex.org/W2096654038', 'https://openalex.org/W2105024913', 'https://openalex.org/W2110788986', 'https://openalex.org/W2124941872', 'https://openalex.org/W2138153315', 'https://openalex.org/W2156264518', 'https://openalex.org/W2161352669', 'https://openalex.org/W2170919347', 'https://openalex.org/W4230079732'], 'related_works': ['https://openalex.org/W3170675108', 'https://openalex.org/W2597607848', 'https://openalex.org/W2417995734', 'https://openalex.org/W2413146854', 'https://openalex.org/W2345139751', 'https://openalex.org/W2049631972', 'https://openalex.org/W2045861459', 'https://openalex.org/W2036417383', 'https://openalex.org/W1993575212', 'https://openalex.org/W1965399867'], 'abstract_inverted_index': {'Abstract': [0], 'Our': [1], 'previous': [2, 84], 'study': [3], 'demonstrate': [4], 'that': [5, 88, 135, 186, 202, 222], 'vitamin': [6, 13, 73, 107, 161], 'D': [7, 14, 74, 108, 162], '3': [8, 15, 75, 109, 163], 'induces': [9], 'the': [10, 28, 33, 49, 53, 62, 70, 119, 145, 150, 155, 174, 208, 226, 230], 'binding': [11, 152], 'of': [12, 52, 66, 72, 90, 103, 122, 141, 168, 204, 210, 229], 'receptor': [16], '(VDR)': [17], 'to': [18, 144, 149, 194, 233], 'Sp1': [19, 29, 38, 151], 'transcription': [20, 50], 'factor': [21], 'and': [22, 37, 68, 115, 138, 178, 188, 213], 'stimulates': [23], 'p27': [24, 77, 111, 156, 195], 'Kip1': [25, 78, 112, 157, 196], 'expression': [26, 89, 121], 'via': [27], 'consensus': [30], 'sequences': [31], 'in': [32, 93, 154, 159, 198], 'promoter.': [34], 'Both': [35], 'VDR': [36, 67, 92, 142, 177, 187, 223], 'are': [39], 'transcriptional': [40], 'activators,': [41], 'it': [42], 'is': [43], 'unclear': [44], 'which': [45, 98], 'protein': [46, 116], 'functions': [47, 224], 'as': [48, 225], 'component': [51, 228], 'VDR/Sp1': [54, 231], 'complex.': [55], 'To': [56], 'address': [57], 'this': [58], 'issue,': [59], 'we': [60, 86], 'constructed': [61], 'AF‐2': [63, 123, 169, 190, 205], 'deletion': [64, 124, 139, 167, 191, 203], 'mutant': [65, 125, 140, 192], 'tested': [69], 'effect': [71], 'on': [76], 'expression.': [79, 117, 236], 'In': [80], 'consistent': [81], 'with': [82, 215], 'our': [83, 219], 'results,': [85], 'found': [87, 201], 'wild‐type': [91, 137], 'SW620': [94], 'colon': [95], 'cancer': [96], 'cells,': [97], 'expressed': [99], 'very': [100], 'low': [101], 'level': [102], 'endogenous': [104], 'VDR,': [105], 'increased': [106], '‐stimulated': [110], 'promoter': [113, 158, 197], 'activity': [114], 'On': [118], 'contrary,': [120], 'had': [126], 'little': [127], 'effect.': [128], 'DNA': [129, 146], 'affinity': [130], 'precipitation': [131], 'assay': [132, 183], '(DAPA)': [133], 'showed': [134], 'both': [136], 'bound': [143, 193], 'probe': [147], 'corresponding': [148], 'site': [153], 'a': [160], '‐dependent': [164], 'manner': [165], 'indicating': [166], 'domain': [170, 206], 'does': [171], 'not': [172], 'affect': [173], 'interaction': [175, 209], 'between': [176], 'Sp1.': [179], 'Chromatin': [180], 'immunoprecipitation': [181], '(CHIP)': [182], 'also': [184], 'confirmed': [185], 'its': [189], 'vivo.': [199], 'We': [200], 'abolished': [207], 'coactivators': [211], 'SRC‐1': [212], 'DRIP205': [214], 'VDR.': [216], 'Taken': [217], 'together,': [218], 'results': [220], 'suggest': [221], 'transactivation': [227], 'complex': [232], 'trigger': [234], 'gene': [235], '©': [237], '2006': [238], 'Wiley‐Liss,': [239], 'Inc.': [240]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1973391025', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-09-13T08:54:35.815151', 'created_date': '2016-06-24'}