Publication Information

{'id': 'https://openalex.org/W1973313721', 'doi': 'https://doi.org/10.1074/jbc.272.15.9907', 'title': '5′-Flanking Sequences in Thyroid Hormone Response Element Half-sites Determine the Requirement of Retinoid X Receptor for Receptor-mediated Gene Expression', 'display_name': '5′-Flanking Sequences in Thyroid Hormone Response Element Half-sites Determine the Requirement of Retinoid X Receptor for Receptor-mediated Gene Expression', 'publication_year': 1997, 'publication_date': '1997-04-01', 'ids': {'openalex': 'https://openalex.org/W1973313721', 'doi': 'https://doi.org/10.1074/jbc.272.15.9907', 'mag': '1973313721', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9092529'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.272.15.9907', 'pdf_url': 'http://www.jbc.org/article/S0021925818408332/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925818408332/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5044286863', 'display_name': 'David P. 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{'volume': '272', 'issue': '15', 'first_page': '9907', 'last_page': '9914'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 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270, 306, 330, 341, 373, 385, 415, 460, 472, 508], 'receptors': [2, 85, 159, 259, 342, 416], 'are': [3, 160, 260, 417], 'ligand-inducible': [4, 261], 'transcription': [5, 262], 'factors': [6, 263], 'that': [7, 31, 45, 71, 139, 209, 229, 264, 288, 302, 328, 396, 466, 486], 'can': [8, 265], 'potentially': [9, 266], 'interact': [10, 267], 'with': [11, 20, 268, 277], 'thyroid': [12, 48, 72, 83, 115, 127, 157, 202, 214, 250, 269, 305, 329, 340, 372, 384, 414, 459, 471, 507], 'response': [14, 74, 99, 150, 168, 187, 216, 241, 271, 331, 356, 407, 425, 444, 473, 498], 'elements': [15, 75, 100, 151, 169, 272, 332, 357, 408, 426], 'as': [16, 273], 'homodimers': [17, 274], 'or': [18, 275], 'heterodimers': [19, 276], 'the': [21, 32, 46, 55, 93, 109, 137, 140, 193, 198, 210, 213, 219, 240, 245, 248, 278, 289, 303, 312, 350, 366, 394, 397, 450, 455, 467, 470, 476, 497, 502, 505], 'retinoid': [22, 94, 110, 141, 194, 279, 351, 367, 398, 451], 'X': [23, 95, 111, 142, 195, 280, 352, 368, 399, 452], 'receptor.': [24, 96, 281, 353], 'It': [25, 282], 'has': [26, 283], 'generally': [27, 284], 'been': [28, 285], 'felt,': [29, 286], 'however,': [30, 190, 287, 447], 'heterodimer': [33, 290], 'is': [34, 53, 61, 144, 179, 291, 310, 318, 401, 436], 'responsible': [35, 292], 'for': [36, 146, 181, 223, 235, 293, 403, 438, 480, 492], 'induction': [37, 294], 'of': [38, 77, 92, 102, 153, 175, 192, 212, 247, 295, 334, 349, 359, 410, 432, 449, 469, 504], 'gene': [39, 89, 118, 130, 147, 164, 183, 224, 236, 296, 346, 375, 387, 404, 421, 440, 481, 493], 'expression.': [40, 119, 297, 376], 'We': [41, 298], 'have': [42, 125, 299, 382], 'demonstrated': [43, 300], 'previously': [44, 301], 'optimal': [47, 78, 171, 304, 335, 428], 'receptor': [50, 112, 143, 177, 196, 200, 221, 252, 307, 369, 400, 434, 453, 457, 478, 509], 'binding': [51, 308], 'sequence': [52, 309], 'not': [54, 311], 'consensus': [56, 313], 'hexamer': [57, 314], 'half-site': [58, 315], 'AGGTCA': [59, 316], 'but': [60, 317], 'an': [62, 319], 'octamer,': [63, 320], 'AGGTCA.': [64, 321], 'Based': [65, 322], 'upon': [66, 239, 323, 496], 'these': [67, 206, 324, 463], 'findings,': [68, 325], 'we': [69, 124, 326, 381], 'hypothesize': [70, 327], 'composed': [76, 101, 152, 333, 358, 409], 'half-sites': [79, 104, 336, 361], '(TAAGGTCA)': [80, 337], 'will': [81, 107, 338, 364], 'bind': [82, 339], 'readily': [86, 343], 'and': [87, 244, 344, 501], 'activate': [88, 163, 345, 420], 'expression': [90, 131, 148, 165, 347, 388, 405, 422], 'independently': [91, 348], 'In': [97, 354], 'contrast,': [98, 355], 'suboptimal': [103, 154, 360, 411], '(e.g.': [105, 362], 'GCAGGTCA)': [106, 363], 'require': [108, 365], 'to': [113, 162, 370, 419], 'facilitate': [114, 371], 'receptor-mediated': [117, 129, 374, 386], 'To': [120, 377], 'test': [121, 378], 'this': [122, 379], 'hypothesis,': [123, 380], 'reconstituted': [126, 383], 'in': [132, 389], 'yeast.': [133, 390], 'Our': [134, 391], 'studies': [135, 227, 392, 484], 'confirm': [136, 393], 'hypothesis': [138, 395], 'required': [145, 180, 234, 402, 437, 491], 'from': [149, 167, 185, 406, 424, 442], 'half-sites,': [155, 412], 'whereas': [156, 413], 'sufficient': [161, 418], 'maximally': [166, 423], 'containing': [170, 427], 'half-sites.': [172, 429], 'Furthermore,': [173, 430], 'coexpression': [174, 191, 431, 448], 'steroid': [176, 199, 433, 456], 'coactivator-1': [178, 435], 'ligand-dependent': [182, 439], 'activation': [184, 237, 441, 494], 'single': [186, 443], 'elements.': [188, 445], 'Surprisingly,': [189, 446], 'decreases': [197, 454], 'coactivator-1-dependent': [201, 458], 'induction.': [204, 461], 'Overall': [205, 462], 'data': [207, 464], 'demonstrate': [208, 465], 'architecture': [211, 243, 468, 500], 'element': [217, 242, 474, 499], 'dictates': [218, 475], 'nuclear': [220, 477], 'requirements': [222, 479], 'activation.': [225, 482], 'The': [226, 483], 'suggest': [228, 485], 'different': [230, 487], 'coactivators': [231, 488], 'may': [232, 489], 'be': [233, 490], 'depending': [238, 495], 'nature': [246, 503], 'bound': [249, 506], 'complex': [253, 510], '(homo-': [254, 511], 'versus': [255, 512], 'heterodimer).': [256, 513]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1973313721', 'counts_by_year': [{'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T19:00:50.499296', 'created_date': '2016-06-24'}