Title: Characterization of human lymphocyte subpopulations for cytotoxicity against tumor‐derived monolayer cultures
Abstract:Lymphocyte fractions of three healthy donors were tested for cytotoxicity in a 48-h assay on several tumor-derived lines. Analysis of surface markers indicated that a non-T non-B fraction comprising a...Lymphocyte fractions of three healthy donors were tested for cytotoxicity in a 48-h assay on several tumor-derived lines. Analysis of surface markers indicated that a non-T non-B fraction comprising about 50% Fc-receptor-positive cells was most potent. The cell yield in this fraction was on the average 6.5% of the non-fractionated population. Elimination of SIg positive cells did not influence the cytotoxic potential. Pure T cells isolated with E-rosetting subsequent to passage on nylon wool column had no or very low cytotoxicity. We had indications that cells without conventional markers —“null” cells—were also cytotoxic.Read More
Publication Year: 1977
Publication Date: 1977-04-15
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 55
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