Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1973173478', 'doi': 'https://doi.org/10.1111/j.1600-0609.2007.00838.x', 'title': 'A novel fibrinogen variant – Praha I: hypofibrinogenemia associated with <i><b>γ</b></i> Gly351Ser substitution', 'display_name': 'A novel fibrinogen variant – Praha I: hypofibrinogenemia associated with <i><b>γ</b></i> Gly351Ser substitution', 'publication_year': 2007, 'publication_date': '2007-02-27', 'ids': {'openalex': 'https://openalex.org/W1973173478', 'doi': 'https://doi.org/10.1111/j.1600-0609.2007.00838.x', 'mag': '1973173478', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17331136'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0609.2007.00838.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159715054', 'display_name': 'European Journal Of Haematology', 'issn_l': '0902-4441', 'issn': ['0902-4441', '1600-0609'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035769871', 'display_name': 'Roman Kotlín', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Roman Kotlín', 'raw_affiliation_strings': ['Institute of Hematology and Blood Transfusion, Praha, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology and Blood Transfusion, Praha, Czech Republic', 'institution_ids': ['https://openalex.org/I4210096318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065126645', 'display_name': 'Martina Chytilová', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Martina Chytilová', 'raw_affiliation_strings': ['Institute of Hematology and Blood Transfusion, Praha, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology and Blood Transfusion, Praha, Czech Republic', 'institution_ids': ['https://openalex.org/I4210096318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085743451', 'display_name': 'Jiřı́ Suttnar', 'orcid': 'https://orcid.org/0000-0003-4305-9718'}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Jiří Suttnar', 'raw_affiliation_strings': ['Institute of Hematology and Blood Transfusion, Praha, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology and Blood Transfusion, Praha, Czech Republic', 'institution_ids': ['https://openalex.org/I4210096318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076272782', 'display_name': 'Peter Salaj', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Peter Salaj', 'raw_affiliation_strings': ['Institute of Hematology and Blood Transfusion, Praha, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology and Blood Transfusion, Praha, Czech Republic', 'institution_ids': ['https://openalex.org/I4210096318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062934365', 'display_name': 'Tomáš Riedel', 'orcid': 'https://orcid.org/0000-0002-2971-6956'}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Tomáš Riedel', 'raw_affiliation_strings': ['Institute of Hematology and Blood Transfusion, Praha, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology and Blood Transfusion, Praha, Czech Republic', 'institution_ids': ['https://openalex.org/I4210096318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063648740', 'display_name': 'Jiří Šantrůček', 'orcid': 'https://orcid.org/0000-0003-0430-5795'}, 'institutions': [{'id': 'https://openalex.org/I9073902', 'display_name': 'University of Chemistry and Technology, Prague', 'ror': 'https://ror.org/05ggn0a85', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I9073902']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Jiří Šantrůček', 'raw_affiliation_strings': ['Department of Biochemistry and Microbiology, Institute of Chemical Technology, Praha, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Microbiology, Institute of Chemical Technology, Praha, Czech Republic', 'institution_ids': ['https://openalex.org/I9073902']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030288033', 'display_name': 'P Klener', 'orcid': 'https://orcid.org/0000-0003-3721-3926'}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Pavel Klener', 'raw_affiliation_strings': ['Institute of Hematology and Blood Transfusion, Praha, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology and Blood Transfusion, Praha, Czech Republic', 'institution_ids': ['https://openalex.org/I4210096318']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070518027', 'display_name': 'Jan E. Dyr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096318', 'display_name': 'Institute of Haematology and Blood Transfusion', 'ror': 'https://ror.org/00n6rde07', 'country_code': 'CZ', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096318']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Jan Evangelista Dyr', 'raw_affiliation_strings': ['Institute of Hematology and Blood Transfusion, Praha, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Institute of Hematology and Blood Transfusion, Praha, Czech Republic', 'institution_ids': ['https://openalex.org/I4210096318']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.817, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.764455, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '78', 'issue': '5', 'first_page': '410', 'last_page': '416'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11721', 'display_name': 'Blood properties and coagulation', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11721', 'display_name': 'Blood properties and coagulation', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hypofibrinogenemia', 'display_name': 'Hypofibrinogenemia', 'score': 0.9806838}, {'id': 'https://openalex.org/keywords/thrombin-time', 'display_name': 'Thrombin time', 'score': 0.59863025}], 'concepts': [{'id': 'https://openalex.org/C2910129229', 'wikidata': 'https://www.wikidata.org/wiki/Q56014077', 'display_name': 'Hypofibrinogenemia', 'level': 3, 'score': 0.9806838}, {'id': 'https://openalex.org/C2779036427', 'wikidata': 'https://www.wikidata.org/wiki/Q381899', 'display_name': 'Fibrinogen', 'level': 2, 'score': 0.88055515}, {'id': 'https://openalex.org/C54173615', 'wikidata': 'https://www.wikidata.org/wiki/Q27205', 'display_name': 'Fibrin', 'level': 2, 'score': 0.8253438}, {'id': 'https://openalex.org/C2778382381', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Coagulation', 'level': 2, 'score': 0.6576748}, {'id': 'https://openalex.org/C2780077467', 'wikidata': 'https://www.wikidata.org/wiki/Q2520736', 'display_name': 'Thrombin time', 'level': 4, 'score': 0.59863025}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5021863}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4321165}, {'id': 'https://openalex.org/C148898269', 'wikidata': 'https://www.wikidata.org/wiki/Q1108792', 'display_name': 'Kinetics', 'level': 2, 'score': 0.4208427}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.37247068}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.35011148}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3136053}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29473293}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25044435}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.22468644}, {'id': 'https://openalex.org/C2778261982', 'wikidata': 'https://www.wikidata.org/wiki/Q1755136', 'display_name': 'Partial thromboplastin time', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005998', 'descriptor_name': 'Glycine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001769', 'descriptor_name': 'Blood', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005998', 'descriptor_name': 'Glycine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008855', 'descriptor_name': 'Microscopy, Electron, Scanning', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019032', 'descriptor_name': 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0609.2007.00838.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159715054', 'display_name': 'European Journal Of Haematology', 'issn_l': '0902-4441', 'issn': ['0902-4441', '1600-0609'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17331136', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1516145269', 'https://openalex.org/W1526685564', 'https://openalex.org/W1576775161', 'https://openalex.org/W1582175547', 'https://openalex.org/W1822374386', 'https://openalex.org/W1971798285', 'https://openalex.org/W1973933191', 'https://openalex.org/W1977588695', 'https://openalex.org/W1978039741', 'https://openalex.org/W1982528013', 'https://openalex.org/W2007997648', 'https://openalex.org/W2019499077', 'https://openalex.org/W2025358191', 'https://openalex.org/W2047841570', 'https://openalex.org/W2078594804', 'https://openalex.org/W2097081828', 'https://openalex.org/W2100837269', 'https://openalex.org/W2113403117', 'https://openalex.org/W2120487268', 'https://openalex.org/W2144123218', 'https://openalex.org/W2145823747', 'https://openalex.org/W55148677'], 'related_works': ['https://openalex.org/W621194568', 'https://openalex.org/W3044923030', 'https://openalex.org/W3036624957', 'https://openalex.org/W2945127487', 'https://openalex.org/W2412734302', 'https://openalex.org/W2408782384', 'https://openalex.org/W2395336416', 'https://openalex.org/W2082498220', 'https://openalex.org/W1972585653', 'https://openalex.org/W1526846685'], 'abstract_inverted_index': {'Abstract': [0], 'Objectives:': [1], 'A': [2, 153], '25‐yr‐old': [3], 'man': [4], 'from': [5, 73], 'Prague': [6], 'had': [7, 30], 'abnormal': [8], 'bleeding': [9], 'after': [10], 'several': [11], 'surgical': [12], 'operations': [13], 'with': [14, 48], 'low': [15, 32], 'fibrinogen': [16, 33, 53, 85, 101], 'level': [17, 54], 'and': [18, 23, 41, 55, 90, 144, 165], 'hypofibrinogenemia': [19, 156], 'was': [20, 76, 111, 159, 166], 'suspected.': [21], 'Patients': [22], 'methods:': [24], 'The': [25, 108], 'patient,': [26], '25': [27], 'yr‐old': [28], 'male': [29], 'a': [31], 'concentration': [34], 'as': [35, 137, 139], 'determined': [36], 'by': [37, 120, 161], 'the': [38, 63, 74, 106, 118, 133], 'thrombin': [39], 'time': [40, 124], 'immunoturbidimetrical': [42], 'method.': [43], 'His': [44], '48‐yr‐old': [45], 'mother': [46], 'presented': [47], 'normal': [49, 52], 'coagulation': [50, 163], 'tests,': [51], 'reported': [56], 'no': [57], 'history': [58], 'of': [59, 82, 125, 132, 141, 155], 'bleeding.': [60], 'To': [61], 'identify': [62], 'genetic': [64], 'mutation': [65, 104], 'responsible': [66], 'for': [67], 'this': [68], 'hypofibrinogen,': [69], 'genomic': [70], 'DNA': [71, 97], 'extracted': [72], 'blood': [75], 'analyzed.': [77], 'Fibrin': [78], 'polymerization': [79, 146], 'measurement,': [80, 87], 'kinetics': [81, 140], 'fibrinopeptide': [83, 142], 'release,': [84], 'clottability': [86], 'mass': [88, 127], 'spectroscopy,': [89], 'scanning': [91], 'electron': [92, 130], 'microscopy': [93], 'were': [94, 147], 'performed.': [95], 'Results:': [96], 'sequencing': [98], 'showed': [99], 'heterogeneous': [100], 'γ': [102, 157], 'G351S': [103, 158], 'in': [105], 'propositus.': [107], 'mutant': [109], 'chain': [110], 'found': [112, 148, 160], 'not': [113], 'to': [114, 117, 149], 'be': [115, 150], 'expressed': [116], 'circulation': [119], 'matrix‐assisted': [121], 'laser': [122], 'desorption/ionization': [123], 'flight': [126], 'spectrometry.': [128], 'Scanning': [129], 'micrographs': [131], "patient's": [134], 'fibrin': [135, 145], 'clot': [136], 'well': [138], 'release': [143], 'normal.': [151], 'Conclusion:': [152], 'case': [154], 'routine': [162], 'testing': [164], 'genetically': [167], 'identified.': [168]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1973173478', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2025-01-05T09:10:55.840873', 'created_date': '2016-06-24'}