Title: Blood and lymph transport of DDT after oral and parenteral administration to anaesthetised rats
Abstract: The distribution of DDT between blood and lymph following intraduodenal (i.d.) and parenteral administration of a soybean ow emulsion was investigated in anaesthetised rats. In addition, the effect of ‘pre-loading’ the animal with chylomicrons on this distribution was examined. Following i.d. administration of DDT in a soybean emulsion 19.37 ± 4.13% S.E. of the dose was transported in the lymph over 11 h. Blood levels from these lymph collected animals were low but very variable; possible explanations for this unexpected behaviour are discussed. When blood alone was sampled, following i.d. administration, the higher blood levels obtained indicate redistribution of DDT from lymph to blood. Following i.v. administration similar blood profiles were obtained with and without lymphatic cannulation. Low levels of DDT were detected in the lymph indicating poor, but not insignificant, distribution from blood to lymph. Preloading the animal with chylomicrons caused a slight, but not statistically significant, increase in the cumulative percentage dose transported in the lymph.
Publication Year: 1991
Publication Date: 1991-07-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 12
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