Publication Information

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3379, 3398, 3416, 3432, 3478, 3483, 3486, 3497, 3500], 'transformed': [25], 'cells.': [26, 994, 3276], 'Interactions': [27], 'between': [28, 1263, 3205], 'non-transformed': [31], 'create': [33], 'tumor': [35, 208, 255, 276, 351, 356, 380, 474, 522, 577, 619, 643, 849, 888, 984, 993, 1046, 1202, 1267, 1523, 1583, 1597, 1665, 1707, 1941, 1982, 2026, 2076, 2112, 2260, 2378, 2450, 2509, 2535, 2619, 2873, 2964, 2978, 2989], 'microenvironment': [36, 1268, 1498, 1880], '(TME).': [37], 'The': [38, 96, 234, 514, 1378, 1469, 1494, 1742, 2259, 2293, 2671, 2963, 3382], 'non-malignant': [39, 186, 244, 3039], 'TME': [43, 106, 194, 268, 347, 426, 593, 719, 756, 1154, 1476, 1501, 1915, 1998, 2128, 2336, 2555, 2576, 2609, 2636, 2805, 2846, 2956, 3043, 3075, 3131, 3135, 3150, 3191, 3204, 3280, 3292, 3325, 3417, 3433], 'have': [44, 107, 129, 251, 482, 660, 963, 1048, 1110, 1457, 1513, 1608, 1651, 2557, 2583, 2869, 2922, 3188, 3224], 'a': [45, 65, 82, 177, 386, 430, 487, 634, 639, 676, 721, 802, 812, 872, 894, 1010, 1181, 1186, 1351, 1363, 1448, 1531, 1560, 1609, 1646, 1931, 2075, 2223, 2352, 2437, 2490, 2514, 2628, 2640, 2655, 2807, 2929, 2939, 2969, 2977, 3002, 3125, 3189, 3225, 3238, 3267, 3351, 3369, 3442], 'dynamic': [46, 68, 2641], 'often': [48, 304, 519, 2068], 'tumor-promoting': [49, 803, 1957, 3227, 3447], 'function': [50, 552, 1505, 1679, 1980, 2272, 2586], 'at': [51, 176, 353, 730, 1521, 2070, 2948, 3108, 3182, 3485], 'all': [52, 1540, 2632], 'stages': [53], 'carcinogenesis': [55], '(Hanahan': [56], 'Coussens,': [58, 3033], '2012).': [59, 392, 436, 543, 693, 1468, 1553, 2463, 2502, 2962, 2993, 3116, 3365], 'Intercellular': [60], 'communication': [61, 2868], 'is': [62, 153, 315, 706, 757, 778, 1053, 1142, 1155, 1280, 1294, 1383, 1388, 1536, 1587, 1591, 1999, 2067, 2213, 2245, 2262, 2329, 2338, 2594, 2660, 2938, 3006, 3082, 3094, 3123, 3161, 3175, 3260, 3341, 3345, 3424, 3452, 3460], 'driven': [63], 'network': [69], 'cytokines,': [71], 'chemokines,': [72, 2683], 'growth': [73, 475, 559, 645, 1059, 1309, 1584, 1598, 1821, 1830, 1834, 1839, 1890, 1942, 2168, 2197, 2217, 2676, 2791], 'factors,': [74, 1822, 2677], 'inflammatory': [76, 135, 155, 1497, 1974, 2234, 2345, 3021], 'matrix': [78, 1628, 3392], 'remodeling': [79, 2008], 'enzymes': [80, 2009], 'against': [81, 675], 'background': [83], 'major': [85, 185, 1199, 1989], 'perturbations': [86], 'physical': [89, 2629], 'chemical': [91], 'properties': [92, 1900], 'tissue.': [95], 'evolution,': [97], 'structure': [98, 2270], 'activities': [100, 1080], 'in': [104, 126, 165, 192, 224, 291, 359, 424, 491, 497, 507, 591, 598, 622, 629, 717, 740, 762, 779, 784, 811, 856, 871, 893, 923, 929, 961, 966, 990, 1022, 1044, 1071, 1152, 1168, 1226, 1286, 1360, 1362, 1460, 1474, 1539, 1568, 1573, 1599, 1733, 1769, 1872, 1970, 1981, 2019, 2029, 2100, 2189, 2241, 2264, 2313, 2317, 2334, 2395, 2440, 2444, 2466, 2493, 2574, 2587, 2634, 2643, 2749, 2755, 2800, 2841, 2897, 2928, 2954, 3020, 3086, 3128, 3157, 3163, 3185, 3202, 3237, 3273, 3372, 3418], 'parallels': [109], 'with': [110, 133, 385, 429, 486, 595, 633, 759, 992, 1115, 1157, 1180, 1240, 1654, 2036, 2281, 2417, 2431, 2482, 2489, 2495, 2686, 2885], 'processes': [112, 158, 2819], 'wound': [114], 'healing': [115], 'inflammation,': [117, 468], 'such': [120, 441, 998, 1305, 1790, 1823, 2192, 2678, 3023, 3121, 3231], 'as': [121, 212, 214, 280, 282, 442, 490, 521, 621, 836, 938, 940, 999, 1129, 1306, 1320, 1350, 1385, 1530, 1713, 1715, 1791, 1824, 2176, 2193, 2327, 2370, 2513, 2651, 2679, 2847, 2909, 2911, 3024, 3122, 3232, 3465], 'macrophages': [122, 1067, 1264, 1446, 2546], 'also': [124, 259, 427, 483, 617, 865, 883, 981, 1127, 1318, 1432, 1747, 1774, 1897, 2124, 2165, 2470, 2599, 2638, 2673, 2787, 2877, 2967, 3176, 3282, 3294], 'found': [125, 191, 729, 989, 1473, 1515], 'cancers': [127, 509, 767, 1077, 1369, 2933, 3089, 3159, 3336], 'that': [128, 154, 189, 241, 348, 464, 1041, 1052, 1147, 1172, 1177, 1221, 1228, 1245, 1296, 1357, 1471, 1482, 1535, 1557, 1593, 1901, 2022, 2040, 2089, 2114, 2126, 2146, 2212, 2358, 2380, 2409, 2477, 2597, 2684, 2767, 2797, 2857, 2861, 2916, 3015, 3085, 3140, 3197, 3259, 3308, 3320, 3343, 3356, 3474, 3495], 'no': [130], 'known': [131, 835, 1128, 1319, 2326, 2369], 'association': [132, 2427], 'chronic': [134], 'conditions': [136, 2240], '(Grivennikov': [137], 'et': [138, 146, 170, 390, 434, 477, 501, 511, 541, 604, 608, 612, 651, 655, 687, 691, 769, 773, 795, 820, 825, 861, 879, 900, 935, 948, 1014, 1064, 1138, 1161, 1195, 1205, 1233, 1254, 1258, 1323, 1337, 1341, 1371, 1399, 1403, 1428, 1439, 1452, 1466, 1547, 1551, 1604, 1616, 1620, 1632, 1668, 1672, 1689, 1696, 1710, 1722, 1759, 1763, 1780, 1805, 1809, 1813, 1817, 1850, 1854, 1858, 1862, 1882, 1917, 1953, 1985, 2011, 2078, 2104, 2137, 2183, 2388, 2401, 2405, 2461, 2500, 2710, 2761, 2830, 2834, 2904, 2960, 2991, 3036, 3114, 3363, 3407, 3411], 'al.,': [139, 147, 171, 391, 435, 478, 502, 512, 542, 605, 609, 613, 652, 656, 688, 692, 770, 774, 796, 821, 826, 862, 880, 901, 936, 949, 1015, 1065, 1139, 1162, 1196, 1206, 1234, 1255, 1259, 1324, 1338, 1342, 1372, 1400, 1404, 1429, 1440, 1453, 1467, 1548, 1552, 1605, 1617, 1621, 1633, 1669, 1673, 1690, 1697, 1711, 1723, 1760, 1764, 1781, 1806, 1810, 1814, 1818, 1851, 1855, 1859, 1863, 1883, 1918, 1954, 1986, 2012, 2079, 2105, 2138, 2184, 2389, 2402, 2406, 2462, 2501, 2711, 2762, 2831, 2835, 2905, 2961, 2992, 3037, 3115, 3364, 3408, 3412], '2010;': [140, 653, 689, 822, 1134, 1256, 3030], 'Hanahan': [141, 3031], 'Weinberg,': [143], '2011;': [144, 649, 1136, 3409], 'Mantovani': [145, 1137], '2008).': [148, 172, 2733], 'One': [149], 'reason': [150], 'for': [151, 805, 1097, 1846, 2092, 2142, 2178, 2215, 2361, 2393, 2425, 2631, 2753, 2817, 2892, 2925, 3488, 3492, 3499], 'this': [152, 777, 1973], 'wound-healing': [157], 'activated': [160, 2774], 'downstream': [161], 'oncogenic': [163, 3154], 'mutations': [164, 3103], '(Mantovani': [169], 'This': [173, 1554, 3117], 'Cell': [174], 'Science': [175], 'Glance': [178], 'article': [179, 2705], 'will': [180, 220, 335, 1566, 2556], 'describe': [181], 'functions': [183, 1459], 'cell': [187, 305, 343, 439, 453, 625, 644, 752, 792, 1099, 1413, 1519, 1563, 1649, 1908, 2060, 2656, 2687, 3354], 'types': [188, 256, 600, 1909, 2874, 2899], 'most': [196, 332, 518, 1072, 3346], 'human': [197, 967, 1073, 1330, 1368, 1381, 1408, 1542, 2932, 3211, 3242], 'experimental': [199, 695, 1075], 'cancers;': [200, 626], 'immune': [205, 273, 550, 581, 668, 702, 854, 921, 1355, 1489, 1508, 1562, 1636, 1950, 2134, 2615, 3221, 3360, 3450, 3480], 'system,': [206, 274], 'vasculature': [209, 277, 2254, 2261, 2379, 2415, 2510], 'lymphatics,': [211, 279], 'well': [213, 281, 939, 1714, 2910], 'fibroblasts,': [215, 283], 'pericytes': [216, 284, 2208], 'adipocytes,': [218, 287], 'discuss': [221], 'their': [222, 249, 627, 1033, 1079, 1270, 1386, 1911, 2000, 2206, 2867, 3054, 3064, 3250, 3321], 'importance': [223, 3414], 'cancer': [225, 499, 602, 683, 697, 818, 859, 877, 1601, 1756, 2180, 2216, 2399, 2498, 2604, 2902, 3077, 3300, 3309, 3421, 3435], 'development,': [226], 'spread': [227, 2647], 'response': [229, 1273, 1490, 1734, 2616, 2975, 3361], 'treatment': [231, 262, 2880, 3422, 3436], '(see': [232], 'poster).': [233], 'common': [235, 739, 2851], 'features': [236, 2852], 'TMEs': [239, 1771, 2855], 'suggest': [240, 699, 2408, 2856], 'targeting': [242, 2858, 3290], 'cells,': [245, 266, 381, 404, 457, 681, 834, 980, 1645, 1793, 1799, 1972, 2235, 2368, 2592, 2777, 3099, 3318], 'or': [246, 455, 723, 841, 928, 1692, 1800, 2233, 2236, 2522, 2530, 2545, 2552, 2864, 2950, 3329, 3390, 3454, 3462], 'mediators': [247, 2132, 2865], 'communication,': [250], 'applications': [252, 2870], 'across': [253, 2871], 'different': [254, 341, 2872, 3109, 3138, 3183, 3190, 3206, 3429], 'could': [258, 2876, 3223, 3293], 'complement': [260, 2878], 'options.Apart': [263], 'from': [264, 1786, 1866, 2231, 2251, 2436, 3139], 'contains': [269, 2674], 'sometimes': [286, 3012], 'discussed': [290, 2848], 'detail': [292], 'below.': [293], 'These': [294, 1956], 'frequently': [297], 'distinguished': [298], 'cell-type-specific': [300], 'markers,': [301], 'surface': [306, 2688], 'molecules.': [307], 'An': [308, 828, 2062, 2423], 'excellent': [309], 'summary': [310], 'some': [312, 326, 623, 661, 763, 1511, 2014, 2140], 'these': [314, 423, 906, 1246, 1297, 1681, 1700, 2109, 2467], 'given': [316], 'Joyce': [318], 'Pollard': [320], '(Joyce': [321], 'Pollard,': [323, 1086, 1092, 1106], '2009),': [324], 'commonly': [329], 'used': [330], 'informative': [333], 'markers': [334], 'detailed': [337], 'below.There': [338], 'T': [342, 368, 394, 400, 516, 527, 658, 715, 791, 978, 1412, 1518], 'populations': [344], 'within': [345, 3104], 'infiltrate': [349, 982], 'areas,': [352], 'invasive': [355, 732, 2072, 2496, 3269], 'margin': [357, 733], 'draining': [360, 741, 931], 'lymphoid': [361, 745, 926], 'organs.': [362], 'Among': [363], 'these,': [364], 'cytotoxic': [365, 567, 673, 790, 969], 'CD8+': [366, 393, 1411], 'memory': [367], '(CD8+CD45RO+),': [370], 'normally': [373], 'antigen': [374, 569, 1461], "'experienced'": [375], 'capable': [377], 'killing': [379], 'strongly': [383], 'associated': [384, 485, 758, 1156, 1179, 1653, 2207], 'good': [387, 431, 635, 722, 760, 1011], 'prognosis': [388, 432, 597, 761, 1012, 1159, 2419, 2433, 2492], '(Fridman': [389, 433, 476, 1063], 'supported': [397], 'CD4+': [399, 438, 515], 'helper': [401], '1': [402, 1841], '(TH1)': [403], 'characterized': [407, 533], 'production': [410, 555, 2527], 'cytokines': [413], 'interleukin-2': [414], '(IL-2)': [415], 'interferon': [417], 'gamma': [418], '(IFN-γ);': [419], 'high': [420, 2548], 'numbers': [421, 588, 1361], 'correlate': [428, 594], 'Other': [437, 2795], 'populations,': [440], 'TH2': [443, 495], 'producing': [445, 458], 'IL-4,': [446], 'IL-5': [447], 'IL-13,': [449], 'support': [451, 801, 1939, 2383], 'B': [452, 624, 751, 786, 806, 833, 838, 957], 'responses,': [454], 'TH17': [456, 505], 'IL-17A,': [459], 'IL-17F,': [460], 'IL-21': [461], 'IL-22': [463], 'favor': [465, 868], 'anti-microbial': [466], 'tissue': [467, 927, 2693], 'generally': [470], 'thought': [471, 1295, 1478], 'promote': [473, 1595, 1889, 2166], '2012),': [479, 847], 'although': [480, 1018], 'they': [481, 700, 916, 1006, 1019, 1222, 1392, 1484, 2031, 2598], 'been': [484, 1334, 1514, 1652, 1684, 2923, 3246], 'favorable': [488], 'outcome,': [489], 'case': [493], 'breast': [498, 764, 876, 1925, 2497, 3158], '(Yoon': [500], '2010)': [503], 'esophageal': [508], '(Lv': [510], '2011).': [513, 586, 881, 902, 1741, 2221, 2258, 2390, 2533, 2906, 3173, 3216], 'described': [520], 'promoting': [523], 'immunosuppressive': [526, 829], 'regulatory': [528, 837], '(Tregs),': [530], 'expression': [535, 1116, 1174, 1417], 'FOXP3': [537], 'CD25': [539], '(Hsieh': [540], 'Constitutive': [544], 'induced': [546, 1054, 2111, 3261], 'Tregs': [547, 590, 615, 1437], 'exert': [548, 701, 1032], 'an': [549, 1049, 1111, 1148, 1488, 1677, 1978, 2228, 2286, 2373, 2584, 2724, 3219, 3358], 'suppressive': [551, 620, 3449], 'through': [553, 566, 638, 1415, 1717, 2159, 2525], 'IL-10,': [557], 'transforming': [558, 1058], 'factor': [560, 1060, 1310, 1534, 1831, 1835, 1840, 1966, 2333], 'beta': [561, 1061], '(TGF-β)': [562, 1062], 'cell-mediated': [564], 'contact': [565, 991], 'T-lymphocyte': [568], '4': [570], '(CTLA4),': [571], 'inhibiting': [572], 'recognition': [573], 'clearance': [575, 886], 'system': [582, 3222, 3451], '(Campbell': [583], 'Koch,': [585], 'High': [587], 'worse': [596], '(Bates': [603], '2006;': [606, 1207, 1618], 'Curiel': [607], '2004;': [610, 1761, 2832], 'Hiraoka': [611], '2006).': [614, 1107, 1782, 1864], 'presence': [628, 712], "Hodgkin's": [630], 'Lymphoma': [631], 'correlates': [632, 2416], 'prognosis,': [636, 1188], 'presumably': [637], 'direct': [640], 'suppression': [641, 1637, 2135], '(Fozza': [646], 'Longinotti,': [648], 'Koreishi': [650], 'Tzankov': [654], '2008).γδ': [657], 'lymphocytes': [659], 'characteristics': [662], 'innate': [664, 3376], 'rather': [665], 'than': [666, 2717], 'adaptive': [667], 'show': [671], 'potent': [672], 'activity': [674, 943], 'wide': [677, 2940], 'range': [678, 2353, 2941], 'including': [682], 'stem': [684, 1802], '(Gomes': [686], 'Hannani': [690], 'Although': [694, 2534], 'animal': [696], 'studies': [698, 1039, 1167, 1527], 'surveillance': [703], 'activity,': [704], 'it': [705, 3244, 3349], 'yet': [708], 'certain': [709], 'whether': [710, 3180], 'γδ': [714], 'reflects': [720], 'bad': [724], 'prognosis.B': [725], 'tumors,': [735, 1928], 'more': [738, 2757, 3226, 3268], 'lymph': [742, 932, 2565, 2568], 'nodes': [743], 'structures': [746, 2284], 'adjacent': [747], 'TME.': [750, 2315, 2670, 3381], 'infiltration': [753, 3374], 'into': [754, 1396, 1731, 1913, 2668, 3009, 3378], 'ovarian': [766], '(Coronella': [768], '2001;': [771], 'Milne': [772], '2009);': [775], 'however,': [776, 2347], 'contrast': [780], 'mouse': [782, 814, 873, 895, 1366, 1600, 1921, 2445, 2468, 3335], 'models,': [783], 'inhibit': [788, 884, 1410], 'tumor-specific': [789, 853], 'responses': [793, 855, 1520], '(Qin': [794], '1998).': [797], 'More': [798], 'recent': [799, 1526, 2081, 2438, 2703], 'data': [800], 'role': [804, 2642], 'immunoglobulin': [809], 'deposition': [810, 2727], 'genetic': [813, 2446], 'model': [815, 874, 896], 'skin': [817, 858], '(Andreu': [819, 947], 'de': [823], 'Visser': [824], '2005).': [827, 1016, 1919, 1955, 2274], 'population': [830, 1352], 'IL-10-producing': [832], '(Bregs)': [840], 'B10': [842], '(Mauri': [844], 'Bosma,': [846], 'increases': [848, 2319], 'burden': [850], 'inhibits': [852], 'inflammation-induced': [857], '(Schioppa': [860, 934], '2011),': [863, 937, 1712], 'appear': [866, 917, 1007], 'lung': [869, 1659], 'metastasis': [870, 1586, 3112], '(Olkhanud': [878], 'Bregs': [882, 911, 960], 'anti-CD20': [891], 'antibodies': [892, 2887, 3026], 'lymphoma': [898, 1170], '(Horikawa': [899], 'However,': [903, 1017], 'none': [904], 'effects': [907, 1611, 1958], 'due': [909], 'infiltrating': [912], 'TME;': [914], 'instead': [915], 'affect': [919, 2600], 'surrounding': [925, 2719], 'node': [933, 2569], 'modulate': [941], 'myeloid': [945, 1648, 2952], '2010).': [950, 1087, 1235, 1641, 1674, 1884, 1987, 2106], 'It': [951, 1293, 3081, 3174], 'remains': [952], 'established': [955], 'if': [956, 2542], 'particular': [962], 'similar': [964, 3126], 'roles': [965], 'cancers.Innate': [968], 'lymphocytes,': [970], 'natural': [971, 976], 'killer': [972, 977], '(NK)': [973], '(NKT)': [979], 'stroma,': [985], 'For': [995, 2275], 'cancers,': [997, 2015, 2141, 2649, 3207, 3243], 'colorectal,': [1000], 'gastric,': [1001], 'lung,': [1002], 'renal': [1003], 'liver,': [1005], 'predict': [1009], '(Tachibana': [1013], 'present': [1021, 2188, 2748], 'TME,': [1024, 2191, 2243, 2751], 'NK': [1025, 1042], 'might': [1027, 2511, 2838, 2966, 3281, 3395, 3437], 'able': [1030], 'tumor-killing': [1034], 'function.': [1035, 3067], 'A': [1036, 1125, 1326], 'number': [1037], 'reported': [1040], 'stroma': [1047, 2039], 'anergic': [1050], 'phenotype': [1051, 1114, 1271, 1332, 1387, 1450], 'cell-derived': [1057], '2012).Tumor-associated': [1066], '(TAMs)': [1068], 'abundant': [1070, 1768], 'murine': [1076, 1544, 3209], 'usually': [1082], 'pro-tumorigenic': [1083, 1610], '(Qian': [1084], 'According': [1088], 'Condeelis': [1090], 'TAMs': [1093, 1109, 1151, 1219, 1284, 1300, 1397, 2778], 'obligate': [1095], 'partners': [1096], 'migration,': [1100], 'invasion': [1101], 'metastases': [1103, 3137], '(Condeelis': [1104], 'Most': [1108], 'IL-10high,': [1112], 'IL-12low': [1113], 'mannose': [1119], 'receptor': [1120, 1123, 2458, 2487, 3388], 'scavenger': [1122], 'class': [1124], '(SR-A,': [1126], 'SCARA)': [1130], '(Biswas': [1131], 'Mantovani,': [1133, 1135, 3029], '2002).': [1140, 1163], 'There': [1141, 1590], 'pre-clinical': [1143, 2943], 'clinical': [1145, 1192, 1242, 2883, 2926, 2945, 3010, 3338], 'evidence': [1146, 1592, 2596, 3342], 'abundance': [1149], 'poor': [1158, 1187, 2418, 2432, 2491], '(Bingle': [1160], 'Additionally,': [1164], 'gene': [1165, 1933], 'array': [1166], 'follicular': [1169], 'demonstrate': [1171], 'genes': [1176], 'strong': [1182], "'macrophage'": [1183], 'signature': [1184], 'confers': [1185], 'independent': [1189], 'variables': [1193], '(Dave': [1194], '2004).Macrophages': [1197], 'contributors': [1200], 'angiogenesis': [1203, 1614, 2244, 2826], '(Lin': [1204], 'Zumsteg': [1208], 'Christofori,': [1210], '2009).': [1211, 2763], 'Transcriptional': [1212], 'profiling': [1213], 'on': [1214, 2706, 2918, 3252, 3266, 3323], 'high-density': [1215], 'oligonucleotide': [1216], 'arrays': [1217], 'shows': [1220, 1244], 'highly': [1224], 'enriched': [1225], 'transcripts': [1227], 'encode': [1229], 'angiogenic': [1230, 2229, 2332, 2356, 2680, 2793, 3287], 'molecules': [1231], '(Ojalvo': [1232, 1253], 'Comparison': [1236], 'TAM': [1238], 'transcriptomes': [1239], 'available': [1241], 'databases': [1243], 'transcriptional': [1247], 'signatures': [1248, 3169], 'predictive': [1250], 'survival': [1252, 1892], 'Zabuawala': [1257], '2010).The': [1260], 'bidirectional': [1261], 'interaction': [1262], 'shapes': [1269], 'environmental': [1276], 'conditions.': [1277], 'Tumor': [1278], 'hypoxia': [1279, 2320, 3258], 'important,': [1281], 'because': [1282, 3256], 'accumulate': [1285], 'hypoxic': [1287, 1495, 2239], 'and/or': [1288], 'necrotic': [1289], 'areas': [1290, 1298], 'tumors.': [1292], 'attract': [1299], 'releasing': [1302, 2788], 'hypoxia-induced': [1303, 1328], 'chemoattractants,': [1304], 'vascular': [1307], 'endothelial': [1308, 1792, 2203, 2572], '(VEGF),': [1311], 'endothelins': [1312], 'endothelial-monocyte-activating': [1314], 'polypeptide': [1315], 'II': [1316], '(EMAP2,': [1317], 'AIMP1)': [1321], '(Murdoch': [1322], '2004).': [1325, 1405], 'distinct,': [1327], 'pro-angiogenic': [1329], 'macrophage': [1331], 'has': [1333, 1683, 1898, 1977, 2434, 2639, 3000, 3245], 'identified': [1335], '(Burke': [1336], '2002;': [1339, 1807, 1815, 1852, 1860], 'White': [1340], '2004).Myeloid-derived': [1343], 'suppressor': [1344], '(MDSCs)': [1346], 'currently': [1348], 'defined': [1349], 'inhibitory': [1354], 'increased': [1359, 2063, 2421, 2453, 2725], 'variety': [1364, 2930, 3239], '(Gabrilovich': [1370, 1465], '2012;': [1373, 1549, 3034], 'Sica': [1374], 'Bronte,': [1376], '2007).': [1377, 1765], 'characterization': [1379], 'MDSCs': [1382, 1409], 'difficult': [1384, 3247], 'quite': [1389], 'variable.': [1390], 'Indeed,': [1391, 2882], 'even': [1394], 'differentiate': [1395, 1730], '(Kusmartsev': [1398], '2005;': [1401], 'Kusmartsev': [1402], 'Murine': [1406], 'activation': [1414, 1694, 2097, 2459, 2483], 'nitric': [1419], 'oxide': [1420], 'synthase': [1421], '2': [1422], '(NOS2)': [1423], 'arginase': [1425], '(ARG1)': [1426], '(Bronte': [1427], '2003).': [1430], 'They': [1431], 'induce': [1433], 'development': [1435, 1757], '(Huang': [1438], '2006)': [1441, 1691], 'polarization': [1444], 'TAM-like': [1449], '(Sinha': [1451], '2007).Dendritic': [1454], '(DCs)': [1456], 'important': [1458, 1979, 2131, 2585, 3119, 3200], 'processing': [1462], 'presentation': [1464], 'DCs': [1470, 1512, 1545, 1558, 1572], 'defective,': [1481], 'is,': [1483], 'cannot': [1485], 'adequately': [1486], 'stimulate': [1487, 1902, 2202, 3295], 'tumor-associated': [1492, 1578], 'antigens.': [1493], 'further': [1502, 2475, 2782, 3296], 'impairs': [1503], 'DC': [1504], 'activate': [1507], 'function,': [1509], 'suppress': [1517], 'site.': [1524], 'Two': [1525], 'designate': [1528], 'ZBTB46': [1529], 'new': [1532, 2248, 3420, 3470], 'transcription': [1533, 1965], 'specifically': [1537], 'expressed': [1538], 'classical': [1541], '(Meredith': [1546], 'Satpathy': [1550], 'work': [1555], 'suggests': [1556], 'unique': [1561], 'lineage': [1564], 'help': [1567], 'our': [1569, 2995], 'understanding': [1570, 2996], 'TME.The': [1575], 'contribution': [1576, 1990], 'neutrophils': [1579, 1594, 1702], '(TANs)': [1580], 'primary': [1582, 1596, 2449, 3051, 3143], 'somewhat': [1588], 'controversial.': [1589], 'models': [1602, 1922, 2447], '(Pekarek': [1603], '1995)': [1606], 'enhancing': [1613, 1944], '(Nozawa': [1615], 'Shojaei': [1619], '2008),': [1622], 'increasing': [1623, 2982], 'degradation': [1624], 'extracellular': [1627], '(ECM)': [1629], '(De': [1630], 'Larco': [1631], '2004)': [1634], '(Youn': [1638], 'Gabrilovich,': [1640], 'Furthermore,': [1642], 'CD11b+': [1643], 'bone-marrow-derived': [1644], 'heterogeneous': [1647, 2280, 3102], 'population,': [1650], 'priming': [1655], 'premetastatic': [1658], 'enhanced': [1661, 2471], 'seeding': [1662], 'circulating': [1664], '(Erler': [1667], '2009;': [1670, 1811, 1856], 'Yan': [1671], 'By': [1675], 'contrast,': [1676], 'antitumor': [1678], 'observed': [1685], 'following': [1686], 'immunological': [1687], '(Hicks': [1688], 'cytokine': [1693, 3387], '(Colombo': [1695], '1992).': [1698], 'Under': [1699], 'conditions,': [1701], 'actively': [1704, 2152], 'eliminate': [1705], 'disseminated': [1706], '(Granot': [1709], 'indirectly': [1716], 'inhibition': [1718, 1962], 'TGF-β': [1720, 1865], '(Fridlender': [1721], '2009).When': [1724], 'tissues': [1725, 2721], 'injured,': [1727], 'residential': [1728], 'fibroblasts': [1729, 1777, 1867, 1992], 'myofibroblasts': [1732, 1745], 'paracrine': [1736], 'signals': [1737], '(Li': [1738], 'Wang,': [1740], 'induction': [1743], 'cause': [1748], 'organ': [1749], 'fibrosis,': [1750], 'enhances': [1752], 'risk': [1754], '(Desmoulière': [1758], 'Radisky': [1762], 'Myofibroblasts': [1766], 'called': [1775], 'cancer-associated': [1776], '(CAFs)': [1778], '(Sugimoto': [1779], 'CAFs': [1783, 1929, 2016, 2066, 2729], 'derive': [1785], 'multiple': [1787], 'resident': [1788], 'precursors,': [1789], 'smooth': [1794], 'muscle': [1795], 'myoepithelial': [1798], 'mesenchymal': [1801], '(Brittan': [1804, 1849], 'Spaeth': [1808, 1853], 'Tomasek': [1812, 1857], 'Willis': [1816, 1861], '2006).CAFs': [1819], 'secrete': [1820, 2547], 'EGF': [1826], 'family': [1827, 2809], 'members': [1828], 'hepatocyte': [1829], '(HGF),': [1832], 'fibroblast': [1833, 2094, 2096], '(FGFs)': [1836], 'insulin-like': [1838], '(IGF1),': [1842], 'mitogenic': [1845], 'induces': [1868], 'epithelial–mesenchymal': [1869], 'transition': [1870], '(EMT)': [1871], 'contributes': [1876, 1936], 'immune-suppressive': [1879], '(Erez': [1881, 1984, 2010, 2077], 'Fibroblast-produced': [1885], 'CXCL12': [1886], 'chemokine': [1887, 3385], 'chemoattractant': [1899], 'migration': [1904], 'stromal': [1907, 1971, 2367, 3167], 'progenitors': [1912], '(Orimo': [1916, 1952], 'In': [1920, 3217, 3277, 3334], 'skin,': [1924], 'pancreatic': [1927], 'express': [1930], 'pro-inflammatory': [1932], 'signature,': [1934], 'neovascularisation': [1945], 'recruitment': [1948, 2155], 'abolished': [1960], 'upon': [1961], 'NF-κB,': [1967], 'suggesting': [1968], 'that,': [1969], 'signaling': [1975, 2920], 'pathway': [1976], 'progression': [1983, 2602, 3078], 'Another': [1988], 'composition': [1995, 2843, 3147], 'secretion': [2001, 2161], 'ECM': [2003, 2007, 2624, 2659, 2672, 2708, 2726, 2769, 2965], 'components': [2004], '2010).In': [2013, 2139], 'arranged': [2018], 'fibrovascular': [2020], 'cores': [2021], 'branch': [2023], 'throughout': [2024], 'mass,': [2027], 'whereas': [2028], 'others,': [2030], 'surround': [2032], 'dense': [2037], 'desmoplastic': [2038], 'occupy': [2042], 'majority': [2044], 'space': [2047], 'thus': [2049], 'restrict': [2050], 'ability': [2052], 'anti-cancer': [2054], 'drugs': [2055, 2986], 'reach': [2057, 3441], 'target.': [2061], 'density': [2064], 'seen': [2069], 'front': [2073], '2010).A': [2080], 'study': [2082], 'investigated': [2083], 'impact': [2085, 2917, 3251], 'deleting': [2087], 'positive': [2091], 'marker': [2095], 'protein-α': [2098], '(FAP)': [2099], 'tumor-bearing': [2101], 'mice': [2102], '(Kraman': [2103, 2136], 'Depletion': [2107], 'necrosis': [2113], 'was': [2115], 'mediated': [2116], 'IFN-γ': [2118], 'TNF-α,': [2120], 'authors': [2123, 2474], 'showed': [2125, 2476], 'FAP-positive': [2127], 'instance': [2143], 'intra-abdominal': [2144], 'tumors': [2145, 2349, 3052, 3092, 3106, 3181], 'metastasize': [2147], 'omentum,': [2150], 'adipocytes': [2151], 'aid': [2153], 'adipokines': [2163], 'providing': [2173], 'fatty': [2174], 'acids': [2175], 'fuel': [2177], '(Nieman': [2182], '2011).Many': [2185], 'soluble': [2186], 'factors': [2187, 2198, 2357, 2681], 'VEGFs,': [2194], 'FGFs,': [2195], 'platelet-derived': [2196], '(PDGFs)': [2199], 'chemokines': [2201, 2789], 'during': [2209, 3076, 3434], 'neovascularization': [2211], 'needed': [2214], '(Carmeliet': [2218, 2255, 2363, 2934], 'Jain,': [2220, 2257, 2365, 2936], 'When': [2222], 'quiescent': [2224], 'blood': [2225, 2277, 2306, 2385, 3458], 'vessel': [2226, 2288, 2560], 'senses': [2227], 'signal': [2230], 'owing': [2237, 2722], 'stimulated': [2246], 'vessels': [2249, 2278, 2297, 2386, 2566, 2579], 'sprout': [2250], 'existing': [2253, 2539], 'abnormal': [2263], 'almost': [2265], 'every': [2266], 'aspect': [2267], 'its': [2269, 2663, 2694, 3302, 3446, 3456], '(Jain,': [2273], 'example,': [2276, 2754], 'chaotic': [2282, 3457], 'branching': [2283], 'uneven': [2287], 'lumen,': [2289], 'leaky.': [2292], 'leakiness': [2294], 'raises': [2298, 3118], 'interstitial': [2300], 'fluid': [2301], 'pressure': [2302], 'causing': [2303], 'unevenness': [2304], 'flow,': [2307], 'oxygenation,': [2308], 'nutrient': [2309], 'drug': [2311], 'distribution': [2312], 'This,': [2316], 'turn,': [2318], 'facilitates': [2322], 'metastasis.': [2323], 'VEGF': [2324, 2362, 2919, 3229, 3263], '(also': [2325], 'VEGFA)': [2328], 'predominant': [2331], 'produced': [2339], 'both': [2341, 3087, 3164, 3208], 'leukocytes;': [2346], 'advanced': [2348, 2901, 3241], 'produce': [2351, 3285], 'substitute': [2360], '2011).Perivascular': [2366], 'pericytes,': [2371], 'integral': [2374], 'component': [2375], 'provide': [2381], 'structural': [2382], '(Armulik': [2387], 'Clinical': [2391], 'studies,': [2392], 'example': [2394], 'bladder': [2396], 'colorectal': [2398], "(O'Keeffe": [2400], '2008;': [2403], 'Yonenaga': [2404], '2005),': [2407], 'low': [2410, 2478], 'pericyte': [2411, 2429, 2442, 2479, 2505], 'coverage': [2412, 2430, 2480, 2506], 'metastases.': [2422], 'explanation': [2424], 'come': [2435], 'study,': [2439], 'depletion': [2443, 2465], 'suppressed': [2448], 'growth,': [2451], 'hypoxia,': [2454], 'EMT': [2455], 'MET': [2457, 2486], '(Cooke': [2460, 2499], 'Pericyte': [2464], 'experiments': [2469], 'metastasis,': [2472, 2825], 'coupled': [2481], 'correlated': [2488], 'women': [2494], 'Hence': [2503], "'normal'": [2504], 'act': [2512], 'key': [2515, 2661, 2675], 'negative': [2516], 'regulator': [2517], 'metastases.Tumors': [2519], 'drive': [2520], 'lymphangiogenesis': [2521], 'lymphatic': [2523, 2540, 2559, 2578], 'hyperplasia': [2524], 'VEGFC': [2529, 2551], 'VEGFD': [2531], '(Alitalo,': [2532], 'invade': [2538], 'vessels,': [2541], 'levels': [2549], 'VEGFD,': [2553], 'extensive': [2558], 'sprouting,': [2561], 'enlargement': [2562], 'collecting': [2564], 'lymphangiogenesis.': [2570], 'Lymphatic': [2571], 'formed': [2580, 3496], 'them': [2582], 'dissemination': [2589], 'there': [2593, 2837, 3057, 3093, 3124, 3160, 3198, 3340], 'emerging': [2595], 'mechanically': [2606], 'modulating': [2607], 'altering': [2612], 'host': [2614], '(Swartz': [2620], 'Lund,': [2622], '2012).The': [2623, 3038, 3413], 'provides': [2625], 'only': [2627], 'scaffold': [2630], 'evolution': [2645, 3072, 3096, 3297], 'especially': [2650, 2971], 'adhesion': [2653], 'movement': [2664], 'out': [2665], 'interact': [2685], 'receptors': [2689], 'give': [2691], 'each': [2692], 'tensile': [2695], 'compressive': [2697], 'strength': [2698], 'elasticity': [2700], '[see': [2701], 'poster': [2704, 3501], '(Frantz': [2709], '2010)].': [2712], 'Tumors': [2713], 'typically': [2715], 'stiffer': [2716], 'normal': [2720], '(Weigelt': [2730], 'Bissell,': [2732], 'Collagen': [2734], 'elastin': [2736], 'fibers': [2737], 'reorientated': [2739], 'cross-linked': [2741], 'lysyl': [2743], 'oxidase': [2744], '(LOX)': [2745], 'transglutaminase': [2747], 'resulting,': [2752], 'larger,': [2756], 'rigid': [2758], 'fibrils': [2759], '(Levental': [2760], 'Matrix': [2764], 'metalloproteases': [2765], '(MMPs)': [2766], 'degrade': [2768], 'proteins': [2770], 'secreted': [2772], 'CAFs.': [2780], 'MMPs': [2781], 'remodel': [2783], 'ECM,': [2785], 'thereby': [2786, 2823], 'factors.': [2794, 3288], 'proteases': [2796], 'upregulated': [2799], 'include': [2806], 'large': [2808], 'cysteine': [2811], 'proteases,': [2812], 'cathepsins.': [2814], 'Cathepsin': [2815], 'L,': [2816], 'instance,': [2818, 2893], 'activates': [2821], 'heparanase,': [2822], 'aiding': [2824], 'inflammation': [2828, 2999], '(Edovitsky': [2829], 'Lerner': [2833], '2011).Although': [2836], 'heterogeneity': [2840, 3127, 3162], 'above,': [2849], 'present,': [2863], 'options.': [2881], 'trials': [2884], 'anti-CTLA4': [2886], 'immunotherapy': [2890], 'approaches,': [2891], 'being': [2895, 3007], 'conducted': [2896], 'several': [2898, 3428], '(Mellman': [2903], 'Angiogenesis': [2907], 'inhibitors,': [2908, 3230], 'multi-targeted': [2912], 'tyrosine': [2913], 'kinase': [2914], 'inhibitors': [2915, 3394], 'pathways,': [2921], 'approved': [2924], 'use': [2927], '2011).There': [2937], 'approaches': [2946], 'aimed': [2947], 'eliminating': [2949], 'reprogramming': [2951], '(reviewed': [2957], 'Gabrilovich': [2959], 'target,': [2970], 'increase': [2973, 3371, 3397], 'chemotherapy': [2980, 3310, 3344, 3367, 3405], 'access': [2984], '(Provenzano': [2990], 'Finally,': [2994], 'cancer-related': [2998], 'reached': [3001], 'point': [3003], 'where': [3004, 3445], 'knowledge': [3005], 'translated': [3008], 'trials,': [3011, 3339], 'using': [3013], 'agents': [3014], 'already': [3017], 'under': [3018], 'investigation': [3019], 'diseases,': [3022], 'therapeutic': [3025], '(Balkwill': [3027], 'Swartz': [3035], 'comprise': [3045], '>50%': [3046], 'mass': [3049], 'metastases,': [3055], 'still': [3059, 3177], 'unanswered': [3061], 'questions': [3062], 'regarding': [3063], 'biology': [3065], 'We': [3068], 'know': [3069, 3196], 'little': [3070], 'about': [3071], 'treatment.': [3080, 3333], 'now': [3083, 3306, 3425], 'clear': [3084, 3179], 'hematological': [3088], 'solid': [3091], 'Darwinian': [3095], 'leading': [3100], 'single': [3105], 'sites': [3110, 3184], '(Yap': [3113], 'questions,': [3120], 'constituents?': [3132], 'Is': [3133], 'matched': [3142], 'tumors?': [3144], 'Can': [3145], 'modulated': [3152], 'mutations?': [3155], 'Certainly': [3156], 'gene-expression': [3168], '(Bertos': [3170], 'Park,': [3172, 3215], 'body': [3187], 'composition,': [3192], 'we': [3194], 'do': [3195, 3313], 'differences': [3201], '(e.g.': [3212], 'Bertos': [3213], 'addition,': [3218, 3278], 'aging': [3220], 'phenotype.Although': [3228], 'bevacizumab,': [3233], 'extend': [3234], 'disease-free': [3235], 'interval': [3236], 'determine': [3249], 'overall': [3253], 'survival,': [3254], 'mainly': [3255], 'blockade': [3264], 'switches': [3265], 'metastatic': [3271], 'program': [3272], 'evolve': [3283], 'Hence,': [3289], 'resistance': [3303], 'treatment.We': [3305], 'recognize': [3307], 'radiotherapy': [3312], 'target': [3316], 'actions': [3322], 'contribute': [3326], 'success': [3328], 'failure': [3330], 'successful': [3347], 'when': [3348], 'causes': [3350], 'form': [3352], 'death': [3355], 'stimulates': [3357, 3368], 'anti-tumor': [3359], '(Galluzzi': [3362], 'Conversely,': [3366], 'rapid': [3370], 'damaged': [3380], 'addition': [3383], 'antagonists,': [3389], 'metalloprotease': [3393], 'therefore': [3396], 'effectiveness': [3399], 'toxicity': [3401], 'profile': [3402], 'traditional': [3404], '(DeNardo': [3406], 'Nakasone': [3410], 'designing': [3419], 'regimes': [3423], 'apparent.': [3426], 'Targeting': [3427], 'aspects': [3430], 'allow': [3438], 'us': [3439], "'tipping": [3443], "point'": [3444], 'disabled': [3453], 'reprogrammed,': [3455], 'supply': [3459], 'normalized': [3461], 'destroyed,': [3463, 3469], 'antigens': [3471], 'uncovered': [3473], 'recognized': [3476], 'reawakened': [3479], 'system.We': [3481], 'thank': [3482], 'staff': [3484], 'Centre': [3487], 'Cancer': [3489], 'Inflammation': [3491], 'fruitful': [3493], 'discussions': [3494], 'basis': [3498], 'illustration.': [3502]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1972825083', 'counts_by_year': [{'year': 2024, 'cited_by_count': 133}, {'year': 2023, 'cited_by_count': 200}, {'year': 2022, 'cited_by_count': 235}, {'year': 2021, 'cited_by_count': 289}, {'year': 2020, 'cited_by_count': 239}, {'year': 2019, 'cited_by_count': 171}, {'year': 2018, 'cited_by_count': 141}, {'year': 2017, 'cited_by_count': 101}, {'year': 2016, 'cited_by_count': 62}, {'year': 2015, 'cited_by_count': 25}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-07T13:56:34.784776', 'created_date': '2016-06-24'}