Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1972731985', 'doi': 'https://doi.org/10.1021/ja982415e', 'title': 'Relative Configuration and Conformation of Key In- termediates for Matrix Metalloproteinase Inhibitors as Determined by NMR-Based Restrained Simulated Annealing and Validated by X-ray Analysis', 'display_name': 'Relative Configuration and Conformation of Key In- termediates for Matrix Metalloproteinase Inhibitors as Determined by NMR-Based Restrained Simulated Annealing and Validated by X-ray Analysis', 'publication_year': 1998, 'publication_date': '1998-10-27', 'ids': {'openalex': 'https://openalex.org/W1972731985', 'doi': 'https://doi.org/10.1021/ja982415e', 'mag': '1972731985'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ja982415e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111155417', 'display_name': 'Journal of the American Chemical Society', 'issn_l': '0002-7863', 'issn': ['0002-7863', '1520-5126', '1943-2984'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007864658', 'display_name': 'Hans Matter', 'orcid': 'https://orcid.org/0000-0002-0249-6025'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hans Matter', 'raw_affiliation_strings': ['Hoechst Marion Roussel Core Research Functions & Chemical Research D-65926 Frankfurt am Main, Germany'], 'affiliations': [{'raw_affiliation_string': 'Hoechst Marion Roussel Core Research Functions & Chemical Research D-65926 Frankfurt am Main, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019216057', 'display_name': 'Martin Knauf', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Martin Knauf', 'raw_affiliation_strings': ['Hoechst Marion Roussel Core Research Functions & Chemical Research D-65926 Frankfurt am Main, Germany'], 'affiliations': [{'raw_affiliation_string': 'Hoechst Marion Roussel Core Research Functions & Chemical Research D-65926 Frankfurt am Main, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080338371', 'display_name': 'Wilfried Schwab', 'orcid': 'https://orcid.org/0000-0002-9753-3967'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Wilfried Schwab', 'raw_affiliation_strings': ['Hoechst Marion Roussel Core Research Functions & Chemical Research D-65926 Frankfurt am Main, Germany'], 'affiliations': [{'raw_affiliation_string': 'Hoechst Marion Roussel Core Research Functions & Chemical Research D-65926 Frankfurt am Main, Germany', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003653530', 'display_name': 'E. F. Paulus', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Erich F. Paulus', 'raw_affiliation_strings': ['Hoechst Marion Roussel Core Research Functions & Chemical Research D-65926 Frankfurt am Main, Germany'], 'affiliations': [{'raw_affiliation_string': 'Hoechst Marion Roussel Core Research Functions & Chemical Research D-65926 Frankfurt am Main, Germany', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.431, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.59619, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 81}, 'biblio': {'volume': '120', 'issue': '44', 'first_page': '11512', 'last_page': '11513'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10620', 'display_name': 'Role of Matrix Metalloproteinases in Cancer and Physiology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10620', 'display_name': 'Role of Matrix Metalloproteinases in Cancer and Physiology', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation in Health and Disease', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Calcineurin-NFAT Signaling in Transcriptional Regulation', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/matrix-metalloproteinases', 'display_name': 'Matrix Metalloproteinases', 'score': 0.553867}, {'id': 'https://openalex.org/keywords/extracellular-matrix-remodeling', 'display_name': 'Extracellular Matrix Remodeling', 'score': 0.538158}, {'id': 'https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases', 'display_name': 'Tissue Inhibitors of Metalloproteinases', 'score': 0.530873}, {'id': 'https://openalex.org/keywords/matrix', 'display_name': 'Matrix (chemical analysis)', 'score': 0.42550498}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.962799}, {'id': 'https://openalex.org/C126980161', 'wikidata': 'https://www.wikidata.org/wiki/Q863783', 'display_name': 'Simulated annealing', 'level': 2, 'score': 0.54757464}, {'id': 'https://openalex.org/C26517878', 'wikidata': 'https://www.wikidata.org/wiki/Q228039', 'display_name': 'Key (lock)', 'level': 2, 'score': 0.5241673}, {'id': 'https://openalex.org/C2777855556', 'wikidata': 'https://www.wikidata.org/wiki/Q4339544', 'display_name': 'Annealing (glass)', 'level': 2, 'score': 0.49761298}, {'id': 'https://openalex.org/C109523444', 'wikidata': 'https://www.wikidata.org/wiki/Q424216', 'display_name': 'Matrix metalloproteinase', 'level': 2, 'score': 0.4532316}, {'id': 'https://openalex.org/C106487976', 'wikidata': 'https://www.wikidata.org/wiki/Q685816', 'display_name': 'Matrix (chemical analysis)', 'level': 2, 'score': 0.42550498}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.4066015}, {'id': 'https://openalex.org/C8010536', 'wikidata': 'https://www.wikidata.org/wiki/Q160398', 'display_name': 'Crystallography', 'level': 1, 'score': 0.36180198}, {'id': 'https://openalex.org/C147597530', 'wikidata': 'https://www.wikidata.org/wiki/Q369472', 'display_name': 'Computational chemistry', 'level': 1, 'score': 0.3489495}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.324188}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.12943408}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1268945}, {'id': 'https://openalex.org/C11413529', 'wikidata': 'https://www.wikidata.org/wiki/Q8366', 'display_name': 'Algorithm', 'level': 1, 'score': 0.09598628}, {'id': 'https://openalex.org/C97355855', 'wikidata': 'https://www.wikidata.org/wiki/Q11473', 'display_name': 'Thermodynamics', 'level': 1, 'score': 0.08441323}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ja982415e', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111155417', 'display_name': 'Journal of the American Chemical Society', 'issn_l': '0002-7863', 'issn': ['0002-7863', '1520-5126', '1943-2984'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/17', 'score': 0.44, 'display_name': 'Partnerships for the goals'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 8, 'referenced_works': ['https://openalex.org/W1967397350', 'https://openalex.org/W1985985383', 'https://openalex.org/W2004328696', 'https://openalex.org/W2026136850', 'https://openalex.org/W2037304739', 'https://openalex.org/W2059756210', 'https://openalex.org/W2949094981', 'https://openalex.org/W4313017660'], 'related_works': ['https://openalex.org/W640825770', 'https://openalex.org/W4386623055', 'https://openalex.org/W4238456428', 'https://openalex.org/W3031328390', 'https://openalex.org/W2602725667', 'https://openalex.org/W2292402945', 'https://openalex.org/W2155030722', 'https://openalex.org/W2081165140', 'https://openalex.org/W1997680731', 'https://openalex.org/W1494554257'], 'abstract_inverted_index': {'ADVERTISEMENT': [0], 'RETURN': [1], 'TO': [2], 'ISSUEPREVCommunicationNEXTRelative': [3], 'Configuration': [4], 'and': [5, 22, 32, 106, 111, 140, 184, 201, 217, 219], 'Conformation': [6], 'of': [7, 96, 131, 157], 'Key': [8], 'In-': [9], 'termediates': [10], 'for': [11, 189], 'Matrix': [12], 'Metalloproteinase': [13], 'Inhibitors': [14], 'as': [15], 'Determined': [16], 'by': [17, 24, 138], 'NMR-Based': [18], 'Restrained': [19], 'Simulated': [20], 'Annealing': [21], 'Validated': [23], 'X-ray': [25], 'AnalysisHans': [26], 'Matter,': [27], 'Martin': [28], 'Knauf,': [29], 'Wilfried': [30], 'Schwab,': [31], 'Erich': [33], 'F.': [34], 'PaulusView': [35], 'Author': [36], 'Information': [37, 231, 233], 'Hoechst': [38], 'Marion': [39], 'Roussel': [40], 'Core': [41], 'Research': [42, 46], 'Functions': [43], '&': [44], 'Chemical': [45, 83], 'D-65926': [47], 'Frankfurt': [48], 'am': [49], 'Main,': [50], 'Germany': [51], 'Cite': [52], 'this:': [53], 'J.': [54], 'Am.': [55], 'Chem.': [56], 'Soc.': [57], '1998,': [58], '120,': [59], '44,': [60], '11512–11513Publication': [61], 'Date': [62], '(Web):October': [63], '27,': [64], '1998Publication': [65], 'History': [66], 'Received9': [67], 'July': [68], '1998Revised8': [69], 'September': [70], '1998Published': [71, 74], 'online27': [72], 'October': [73], 'inissue': [75], '1': [76], 'November': [77, 102], '1998https://pubs.acs.org/doi/10.1021/ja982415ehttps://doi.org/10.1021/ja982415erapid-communicationACS': [78], 'PublicationsCopyright': [79], '©': [80], '1998': [81], 'American': [82], 'SocietyRequest': [84], 'reuse': [85], 'permissionsArticle': [86], 'Views184Altmetric-Citations13LEARN': [87], 'ABOUT': [88], 'THESE': [89], 'METRICSArticle': [90], 'Views': [91], 'are': [92, 115, 128], 'the': [93, 124, 129, 158, 169, 182, 185, 190, 197, 203], 'COUNTER-compliant': [94], 'sum': [95], 'full': [97], 'text': [98], 'article': [99, 163], 'downloads': [100], 'since': [101], '2008': [103], '(both': [104], 'PDF': [105], 'HTML)': [107], 'across': [108], 'all': [109], 'institutions': [110], 'individuals.': [112], 'These': [113], 'metrics': [114], 'regularly': [116], 'updated': [117, 141], 'to': [118, 123], 'reflect': [119], 'usage': [120], 'leading': [121], 'up': [122], 'last': [125], 'few': [126], 'days.Citations': [127], 'number': [130], 'other': [132], 'articles': [133], 'citing': [134], 'this': [135], 'article,': [136], 'calculated': [137], 'Crossref': [139, 147], 'daily.': [142], 'Find': [143, 193], 'more': [144, 194], 'information': [145, 195], 'about': [146, 181], 'citation': [148], 'counts.The': [149], 'Altmetric': [150, 198], 'Attention': [151, 199], 'Score': [152, 200], 'is': [153, 205], 'a': [154, 161, 174], 'quantitative': [155], 'measure': [156], 'attention': [159], 'that': [160], 'research': [162], 'has': [164], 'received': [165], 'online.': [166], 'Clicking': [167], 'on': [168, 196], 'donut': [170], 'icon': [171], 'will': [172], 'load': [173], 'page': [175], 'at': [176], 'altmetric.com': [177], 'with': [178, 213], 'additional': [179], 'details': [180], 'score': [183, 204], 'social': [186], 'media': [187], 'presence': [188], 'given': [191], 'article.': [192], 'how': [202], 'calculated.': [206], 'Share': [207, 222], 'Add': [208], 'toView': [209], 'InAdd': [210], 'Full': [211], 'Text': [212], 'ReferenceAdd': [214], 'Description': [215], 'ExportRISCitationCitation': [216], 'abstractCitation': [218], 'referencesMore': [220], 'Options': [221], 'onFacebookTwitterWechatLinked': [223], 'InRedditEmail': [224], 'Other': [225], 'access': [226], 'optionsGet': [227], 'e-AlertscloseSupporting': [228], 'Info': [229], '(1)»Supporting': [230], 'Supporting': [232], 'SUBJECTS:Chemical': [234], 'structure,Chirality,Conformation,Molecular': [235], 'structure,Solution': [236], 'structures': [237], 'Get': [238], 'e-Alerts': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1972731985', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-20T00:46:14.792386', 'created_date': '2016-06-24'}