Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1972402575', 'doi': 'https://doi.org/10.1126/science.182.4113.720', 'title': 'Pentobarbital: Selective Depression of Excitatory Postsynaptic Potentials', 'display_name': 'Pentobarbital: Selective Depression of Excitatory Postsynaptic Potentials', 'publication_year': 1973, 'publication_date': '1973-11-16', 'ids': {'openalex': 'https://openalex.org/W1972402575', 'doi': 'https://doi.org/10.1126/science.182.4113.720', 'mag': '1972402575', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4356518'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.182.4113.720', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053055805', 'display_name': 'Jeffery L. Barker', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144228', 'display_name': 'Eunice Kennedy Shriver National Institute of Child Health and Human Development', 'ror': 'https://ror.org/04byxyr05', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210144228']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffery L. Barker', 'raw_affiliation_strings': ['National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014', 'institution_ids': ['https://openalex.org/I4210144228', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043160604', 'display_name': 'Harold Gainer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144228', 'display_name': 'Eunice Kennedy Shriver National Institute of Child Health and Human Development', 'ror': 'https://ror.org/04byxyr05', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210144228']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Harold Gainer', 'raw_affiliation_strings': ['National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014', 'institution_ids': ['https://openalex.org/I4210144228', 'https://openalex.org/I1299303238']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.109, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 115, 'citation_normalized_percentile': {'value': 0.826323, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '182', 'issue': '4113', 'first_page': '720', 'last_page': '722'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10436', 'display_name': 'Anesthesia and Sedation Management', 'score': 0.9856, 'subfield': {'id': 'https://openalex.org/subfields/2703', 'display_name': 'Anesthesiology and Pain Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10581', 'display_name': 'Neuronal Oscillations in Cortical Networks', 'score': 0.9829, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/postsynaptic-current', 'display_name': 'Postsynaptic Current', 'score': 0.53602284}, {'id': 'https://openalex.org/keywords/post-tetanic-potentiation', 'display_name': 'Post-tetanic potentiation', 'score': 0.535051}, {'id': 'https://openalex.org/keywords/synaptic-plasticity', 'display_name': 'Synaptic Plasticity', 'score': 0.507912}], 'concepts': [{'id': 'https://openalex.org/C112592302', 'wikidata': 'https://www.wikidata.org/wiki/Q1207387', 'display_name': 'Excitatory postsynaptic potential', 'level': 3, 'score': 0.956442}, {'id': 'https://openalex.org/C197341189', 'wikidata': 'https://www.wikidata.org/wiki/Q863533', 'display_name': 'Postsynaptic potential', 'level': 3, 'score': 0.8643489}, {'id': 'https://openalex.org/C17077164', 'wikidata': 'https://www.wikidata.org/wiki/Q1185869', 'display_name': 'Inhibitory postsynaptic potential', 'level': 2, 'score': 0.8110623}, {'id': 'https://openalex.org/C2776755955', 'wikidata': 'https://www.wikidata.org/wiki/Q409632', 'display_name': 'Pentobarbital', 'level': 2, 'score': 0.61278766}, {'id': 'https://openalex.org/C200170125', 'wikidata': 'https://www.wikidata.org/wiki/Q969316', 'display_name': 'Neurotransmission', 'level': 3, 'score': 0.5569512}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5391185}, {'id': 'https://openalex.org/C2910581834', 'wikidata': 'https://www.wikidata.org/wiki/Q1207387', 'display_name': 'Postsynaptic Current', 'level': 4, 'score': 0.53602284}, {'id': 'https://openalex.org/C118232355', 'wikidata': 'https://www.wikidata.org/wiki/Q7233588', 'display_name': 'Post-tetanic potentiation', 'level': 4, 'score': 0.535051}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.4874816}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.29191655}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26761952}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.13119587}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.118799776}], 'mesh': [{'descriptor_ui': 'D000200', 'descriptor_name': 'Action Potentials', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010424', 'descriptor_name': 'Pentobarbital', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D000109', 'descriptor_name': 'Acetylcholine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000200', 'descriptor_name': 'Action Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000613', 'descriptor_name': 'Aminobutyrates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000613', 'descriptor_name': 'Aminobutyrates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003400', 'descriptor_name': 'Astacoidea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003864', 'descriptor_name': 'Depression, Chemical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004298', 'descriptor_name': 'Dopamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004298', 'descriptor_name': 'Dopamine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018691', 'descriptor_name': 'Excitatory Amino Acid Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005971', 'descriptor_name': 'Glutamates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005971', 'descriptor_name': 'Glutamates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008974', 'descriptor_name': 'Mollusca', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008121', 'descriptor_name': 'Nephropidae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009467', 'descriptor_name': 'Neuromuscular Depolarizing Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009467', 'descriptor_name': 'Neuromuscular Depolarizing Agents', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010424', 'descriptor_name': 'Pentobarbital', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012908', 'descriptor_name': 'Snails', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013569', 'descriptor_name': 'Synapses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009435', 'descriptor_name': 'Synaptic Transmission', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.182.4113.720', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4356518', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1876934550', 'https://openalex.org/W1933200125', 'https://openalex.org/W1976561710', 'https://openalex.org/W1979361323', 'https://openalex.org/W1984519987', 'https://openalex.org/W1991372004', 'https://openalex.org/W1991416239', 'https://openalex.org/W1992896127', 'https://openalex.org/W2001766383', 'https://openalex.org/W2009384667', 'https://openalex.org/W2011198767', 'https://openalex.org/W2024403974', 'https://openalex.org/W2030845649', 'https://openalex.org/W2039534866', 'https://openalex.org/W2053589038', 'https://openalex.org/W2063754185', 'https://openalex.org/W2068174368', 'https://openalex.org/W2085549887', 'https://openalex.org/W2086062850', 'https://openalex.org/W2087035274', 'https://openalex.org/W2090673969', 'https://openalex.org/W2094026739', 'https://openalex.org/W2109023602', 'https://openalex.org/W2271112592', 'https://openalex.org/W2301339089', 'https://openalex.org/W2333695061', 'https://openalex.org/W2399792522', 'https://openalex.org/W2401059362', 'https://openalex.org/W2412682547', 'https://openalex.org/W2414587550', 'https://openalex.org/W2414693601'], 'related_works': ['https://openalex.org/W4256298323', 'https://openalex.org/W4241474375', 'https://openalex.org/W4236455514', 'https://openalex.org/W2066065685', 'https://openalex.org/W2064319342', 'https://openalex.org/W2057776649', 'https://openalex.org/W2046705055', 'https://openalex.org/W2031969484', 'https://openalex.org/W2007600010', 'https://openalex.org/W1974249396'], 'abstract_inverted_index': {'The': [0, 74], 'effects': [1], 'of': [2, 16, 55, 92], 'pentobarbital': [3], '(Nembutal)': [4], 'on': [5], 'synaptic': [6, 94], 'transmission': [7], 'and': [8, 22, 29, 45, 72, 79], 'postsynaptic': [9, 27, 31, 41, 47, 56], 'potentials': [10, 28, 42], 'were': [11], 'studied': [12], 'by': [13], 'the': [14], 'use': [15], 'several': [17], 'invertebrate': [18], 'preparations.': [19], 'Pentobarbital': [20], 'selectively': [21], 'reversibly': [23], 'depressed': [24], 'both': [25], 'excitatory': [26, 35, 57, 93], 'sodium-dependent': [30], 'responses': [32, 48], 'to': [33, 49, 88], 'putative': [34, 50], 'transmitters': [36], 'without': [37], 'affecting': [38], 'either': [39], 'inhibitory': [40], 'or': [43], 'chloride-': [44], 'potassium-dependent': [46], 'transmitters.': [51], 'A': [52], 'selective': [53, 90], 'depression': [54, 81, 91], 'events': [58], 'was': [59], 'also': [60], 'observed': [61, 82], 'with': [62], 'other': [63], 'central': [64, 78], 'nervous': [65], 'system': [66], 'depressants': [67], '(ethanol,': [68], 'chloroform,': [69], 'chloralose,': [70], 'diphenylhydantoin,': [71], 'urethane).': [73], 'results': [75], 'suggest': [76], 'that': [77], 'peripheral': [80], 'during': [83], 'general': [84], 'anesthesia': [85], 'is': [86], 'due': [87], 'a': [89], 'events.': [95]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1972402575', 'counts_by_year': [], 'updated_date': '2024-09-15T17:23:39.735064', 'created_date': '2016-06-24'}