Publication Information

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'https://openalex.org/W1954801073'], 'abstract_inverted_index': {'Transcription': [0, 228], 'factors': [1, 229], 'belonging': [2, 230], 'to': [3, 18, 79, 113, 187, 231, 246, 307, 341, 415, 502, 632, 663, 749, 819, 827, 968, 1016, 1340, 1360, 1777, 1832, 1923, 1986, 2160, 2210, 2286, 2321, 2325, 2339, 2367, 2414, 2496, 2977, 3031, 3091, 3105, 3117, 3207, 3278, 3344, 3403, 3450, 3458, 3468, 3473, 3499, 3541, 3547, 3714, 3734, 3873, 3971, 4007, 4205, 4220, 4244, 4260], 'the': [4, 36, 42, 54, 58, 106, 132, 137, 140, 162, 169, 193, 232, 264, 270, 282, 286, 334, 360, 365, 368, 390, 397, 421, 645, 664, 678, 1026, 1224, 1361, 1458, 1658, 1924, 1994, 2052, 2150, 2161, 2202, 2258, 2264, 2272, 2279, 2288, 2293, 2311, 2314, 2317, 2340, 2416, 2422, 2426, 2883, 2889, 3107, 3168, 3292, 3336, 3391, 3427, 3459, 3469, 3539, 3542, 3677, 3696, 3823, 3897, 3902, 3905, 3921, 4025, 4050, 4055, 4105, 4157, 4203, 4221, 4238, 4261], 'NF-κB': [5, 81, 103, 124, 177, 219, 233, 309, 331, 352, 405, 447, 459, 641, 708, 824, 982, 1017, 1078, 1090, 1114, 1341, 1455, 1480, 2369, 2375, 2460, 2472, 2522, 3202, 3245, 3269, 3288, 3313, 3354, 3399, 3433, 3446, 3682, 3706, 3722, 3735, 3914, 4070], 'family': [6, 56, 234, 284, 1363], 'regulate': [7, 235, 3088], 'inflammation': [8, 236], 'by': [9, 65, 130, 221, 237, 293, 358, 449, 463, 525, 647, 739, 760, 1018, 1080, 1342, 1440, 1485, 1511, 1598, 1615, 1938, 1965, 2074, 2200, 2330, 2355, 2379, 2393, 2433, 2447, 2476, 2583, 2593, 2708, 2743, 2834, 2914, 2960, 2964, 3044, 3057, 3079, 3099, 3129, 3174, 3212, 3222, 3679, 3723, 3739, 3767, 3835, 3840, 3850, 3915, 3957], 'inducing': [10, 238, 464], 'pro-inflammatory': [11, 109, 213, 239, 337, 441, 465, 529, 735, 1461, 3115, 3272, 3548, 3715], 'molecules': [12, 240, 466, 650], '(e.g.': [13, 20, 241, 248, 473, 531, 551], 'interleukin': [14, 242, 597], '(IL)-8)': [15, 243], 'in': [16, 41, 67, 92, 111, 153, 212, 244, 269, 295, 320, 339, 381, 440, 585, 644, 817, 825, 1442, 1463, 1933, 1971, 1989, 2058, 2193, 2421, 2467, 2760, 2775, 2831, 2975, 2979, 2991, 2995, 3029, 3049, 3053, 3076, 3113, 3133, 3152, 3163, 3205, 3215, 3247, 3275, 3317, 3334, 3357, 3361, 3397, 3401, 3448, 3471, 3497, 3521, 3544, 3617, 3712, 3773, 3787, 3805, 3827, 3852, 3871, 3879, 3969, 4005, 4039, 4086, 4121, 4166, 4214, 4242], 'response': [17, 112, 245, 340, 826, 2976, 3030, 3206, 3402, 3449, 3472, 3498, 3713, 3872, 3970, 4006, 4243], 'cytokines': [19, 247, 530], 'tumor': [21, 249, 598], 'necrosis': [22, 250, 479, 599], 'factor': [23, 251, 458, 600], '(TNF)': [24, 252], 'α,': [25, 253], 'IL-1)': [26, 254, 533], 'or': [27, 144, 255, 372, 829, 838, 1445, 1733, 1742, 1931, 1945, 1960, 2022, 2739, 2792, 2811, 2823, 2873, 2910, 2998, 3062, 3081, 3310, 3329, 3377, 3415, 3620, 3753, 3908, 3948, 4045, 4062, 4080, 4098, 4115, 4161, 4212], 'other': [28, 256, 1599], 'stimuli.': [29, 257, 3093, 3716], 'Several': [30, 258], 'negative': [31, 209, 259, 437, 1111, 1470, 3266], 'regulators': [32, 260, 1112], 'of': [33, 44, 53, 57, 71, 89, 108, 139, 156, 172, 195, 261, 272, 281, 285, 299, 317, 336, 367, 384, 400, 423, 496, 506, 594, 626, 636, 666, 680, 695, 699, 714, 752, 798, 823, 836, 848, 970, 1030, 1113, 1227, 1364, 1460, 1482, 1516, 1593, 1618, 1628, 1735, 1915, 1929, 1958, 1996, 2204, 2214, 2260, 2284, 2296, 2301, 2316, 2342, 2373, 2381, 2418, 2429, 2435, 2459, 2521, 2644, 2698, 2719, 2758, 2764, 2784, 2797, 2821, 2855, 2877, 2903, 2942, 2957, 2986, 3002, 3026, 3037, 3110, 3150, 3160, 3171, 3237, 3268, 3283, 3297, 3312, 3444, 3462, 3476, 3488, 3495, 3517, 3556, 3629, 3663, 3676, 3681, 3699, 3705, 3721, 3750, 3758, 3770, 3825, 3863, 3904, 3924, 3967, 3975, 4003, 4028, 4034, 4052, 4057, 4096, 4107, 4159, 4233, 4240], 'NF-κB,': [34, 262], 'including': [35, 263, 467, 528, 588, 670, 1115], 'ubiquitin-editing': [37, 265], 'enzyme': [38, 266, 609], 'A20,': [39, 267, 1116], 'participate': [40, 268], 'resolution': [43, 271], 'inflammatory': [45, 273, 461], 'responses.': [46, 274], 'We': [47, 275, 1349, 3119, 3233, 3348, 3842, 3891, 3918, 3955, 4102], 'report': [48, 276], 'that': [49, 98, 121, 158, 168, 182, 204, 216, 277, 326, 349, 386, 396, 410, 432, 444, 499, 629, 651, 688, 734, 744, 812, 850, 975, 1012, 1119, 1255, 1262, 1336, 1358, 1435, 1451, 1477, 1585, 1983, 2036, 2207, 2799, 2969, 3071, 3085, 3121, 3201, 3235, 3260, 3350, 3454, 3534, 3611, 3656, 3695, 3745, 3762, 3789, 3807, 3844, 3855, 3881, 3894, 3962, 3997, 4024, 4104, 4124, 4131, 4169, 4176, 4200, 4231, 4248], 'Cezanne,': [50, 278, 3390], 'a': [51, 154, 207, 279, 382, 435, 582, 682, 741, 756, 814, 844, 1074, 1117, 1258, 1353, 1468, 1583, 1844, 1980, 2532, 2696, 2935, 3137, 3184, 3265, 3330, 3358, 3506, 3949, 4178], 'member': [52, 280], 'A20': [55, 283, 1256, 1337, 1362], 'deubiquitinating': [59, 170, 287, 398, 1259, 1365, 3293, 3922, 4026], 'cysteine': [60, 164, 288, 392, 1260, 1660, 3294, 3339], 'proteases,': [61, 289], 'can': [62, 101, 184, 290, 329, 412, 689, 745, 1263, 1368, 1437, 3073, 3837], 'be': [63, 185, 291, 413, 746, 1438, 2322, 3074, 3838, 4258], 'induced': [64, 292, 1439, 2973, 3075], 'TNFα': [66, 294, 1108, 1441, 1496, 1507, 2513, 2652, 2895, 2978, 3032, 3038, 3080, 3175, 3208, 3366, 3404, 3479, 3500, 3632, 3771, 3836, 3851, 3874], 'cultured': [68, 296, 1443, 1789, 1895, 2774, 2993, 3077, 4215], 'cells.': [69, 94, 297, 322, 1447, 4041, 4216], 'Silencing': [70, 298, 3149], 'endogenous': [72, 99, 300, 327, 1452, 3111, 3261], 'Cezanne': [73, 100, 122, 157, 173, 183, 205, 301, 328, 350, 385, 401, 411, 433, 1357, 1436, 1453, 1478, 1594, 1629, 1647, 1650, 1988, 2083, 2765, 2828, 2856, 2878, 2958, 2970, 2987, 3017, 3027, 3040, 3050, 3072, 3094, 3112, 3125, 3151, 3238, 3262, 3284, 3298, 3328, 3352, 3431, 3490, 3625, 3659, 3680, 3700, 3717, 3730, 3895, 3925, 3947, 3964, 3976, 3999, 4010, 4029, 4042, 4053, 4172, 4201, 4217, 4249], 'using': [74, 302, 1786, 1843, 1896, 1919, 1943, 1979, 2048, 2079, 2149, 2333, 2384, 2408, 2438, 2470, 2500, 2531, 2554, 2595, 2607, 2661, 2714, 2722, 2734, 2746, 2771, 2837, 2879, 2917, 2934, 3066, 3239, 3742, 3937, 4088], 'small': [75, 303, 603, 742], 'interfering': [76, 304, 482, 604], 'RNA': [77, 305, 605, 1973, 2100, 2297, 3103], 'led': [78, 306], 'elevated': [80, 308, 3848], 'luciferase': [82, 310, 2495, 2527, 2534], 'reporter': [83, 311, 2473, 2535, 3197], 'gene': [84, 312, 2196, 2266, 2283, 3198, 3308], 'activity': [85, 129, 171, 313, 357, 399, 1226, 2464, 2528, 2604, 3246, 3296, 3356, 3400, 3846, 3923, 4027], 'and': [86, 105, 127, 215, 314, 333, 355, 443, 471, 548, 580, 592, 673, 712, 763, 978, 1028, 1032, 1197, 1222, 1367, 1457, 1493, 1571, 1590, 1603, 1652, 1663, 1775, 1788, 1891, 1969, 2005, 2055, 2093, 2103, 2153, 2183, 2262, 2347, 2370, 2387, 2441, 2491, 2502, 2525, 2541, 2602, 2658, 2712, 2754, 2827, 2840, 2850, 2925, 2940, 3046, 3127, 3147, 3181, 3194, 3231, 3255, 3271, 3466, 3485, 3528, 3640, 3642, 3645, 3672, 3709, 3781, 3786, 3795, 3813, 3820, 3889, 3935, 3959, 3986, 3988, 3991, 4019, 4037, 4144, 4189, 4191, 4194], 'enhanced': [87, 315, 3024, 3167, 3211, 3244], 'expression': [88, 316, 1928, 1995, 2197, 2786, 2868, 2985, 3025, 3323, 3942, 4089], 'IL-8': [90, 318, 2088, 3161, 3172], 'transcripts': [91, 110, 319, 338, 1462, 2971, 3028, 3041, 3162, 3173], 'TNFα-treated': [93, 321, 1464, 3248], 'Thus': [95, 201, 323, 429, 1331, 3257, 4021], 'we': [96, 180, 202, 324, 408, 430, 1433, 1474, 3258, 3436, 3830, 4022, 4253], 'conclude': [97, 203, 325, 431, 3259, 3892, 4023], 'attenuate': [102, 330], 'activation': [104, 220, 332, 448, 679, 822, 983, 1029, 1079, 1456, 1484, 3204, 3270, 3711, 3834, 3870, 4071, 4239], 'induction': [107, 335, 1459, 3170], 'TNF': [114, 342, 601, 659], 'receptor': [115, 343, 602, 831], '(TNFR)': [116, 344, 661], 'signaling.': [117, 345, 4246], 'Overexpression': [118, 346, 3487], 'studies': [119, 347, 731, 3741], 'revealed': [120, 348, 733, 1450, 3200, 3453, 3761, 3996], 'suppressed': [123, 351, 3124, 3965, 4000, 4165], 'nuclear': [125, 353, 654, 710, 1092, 3442, 3493, 3518, 3612, 3649, 3707], 'translocation': [126, 354, 711, 3443], 'transcriptional': [128, 356, 2463, 3203, 3273, 3355, 3434, 3683, 3710], 'targeting': [131, 222, 359, 450, 1081, 1343, 1486], 'TNFR': [133, 361, 828, 1370, 2645, 2720, 2904, 3732, 3898, 4222, 4245], 'signaling': [134, 214, 224, 362, 442, 452, 668, 736, 818, 832, 840, 965, 1022, 1339, 1344, 1371, 1488, 3733, 3899], 'pathway': [135, 363, 3900], 'at': [136, 161, 364, 389, 1657, 2168, 2177, 3130, 3429, 3728, 3901], 'level': [138, 366, 3428, 3727, 3903], 'IκB': [141, 369, 606, 649, 1083, 3968], 'kinase': [142, 370, 607, 685, 686, 687, 2588], 'complex': [143, 371, 3907], 'upstream': [145, 373, 1481, 3909], 'from': [146, 374, 1267, 1622, 1637, 2278, 2581, 2591, 3538, 3654, 3910], 'it.': [147, 375], 'These': [148, 376], 'effects': [149, 377, 3015, 3036, 3304, 3931, 4051], 'were': [150, 378, 500, 630, 1574, 1580, 1604, 1613, 1635, 1744, 1784, 1830, 1894, 1962, 2032, 2037, 2040, 2072, 2166, 2191, 2208, 2431, 2487, 2509, 2552, 2648, 2706, 2730, 2741, 2779, 2816, 2829, 2865, 2891, 2912, 2932, 2972, 3042, 3315, 3615, 4084, 4119], 'not': [151, 379, 1596, 3220, 3652, 4013], 'observed': [152, 380, 2963, 3120, 3234, 3349, 3843, 3956, 4103], 'form': [155, 383, 847, 3333, 3394, 3509, 3952], 'was': [159, 387, 1497, 1508, 1586, 1917, 1936, 1976, 2101, 2146, 2198, 2255, 2276, 2304, 2328, 2377, 2406, 2465, 2529, 2579, 2589, 2605, 2769, 2860, 2988, 3209, 3219, 3395, 3651, 3736, 3764, 3802, 3847, 3876, 4164], 'mutated': [160, 388, 1656, 2795, 3343], 'catalytic': [163, 391, 1225, 1659, 3697], 'residue': [165, 393], '(Cys209),': [166, 394], 'indicating': [167, 395], 'is': [174, 402, 523, 642, 702, 737, 802, 979, 1257, 1984, 2310, 3299, 3531, 3536, 3606, 3686, 3926, 4030, 4235], 'essential': [175, 403, 980, 3687, 4031, 4067, 4236], 'for': [176, 226, 404, 454, 709, 981, 1085, 1091, 1346, 1490, 1840, 2009, 2062, 2082, 2171, 2180, 2186, 2257, 2263, 2274, 2281, 2335, 2504, 2516, 2655, 2804, 2898, 3023, 3287, 3301, 3502, 3525, 3550, 3688, 3703, 3928, 4032, 4227, 4237], 'regulation.': [178, 406], 'Finally,': [179, 407, 1473], 'demonstrate': [181, 409, 1434], 'recruited': [186, 414, 4259], 'activated': [188, 416, 4040], 'TNFRs': [189, 417], 'where': [190, 418, 800, 2308], 'it': [191, 217, 419, 445, 1332, 3020, 3086, 3439, 3801, 4256], 'suppresses': [192, 218, 420, 446, 1338, 1479, 4250], 'build-up': [194, 422, 4158], 'polyubiquitinated': [196, 424], 'RIP1': [197, 223, 425, 451, 837, 1487, 2858, 4226, 4234], 'signal': [198, 426, 1015], 'adapter': [199, 427], 'proteins.': [200, 428], 'forms': [206, 434, 1627, 1655, 2796, 2876], 'novel': [208, 436, 1354, 1469], 'feedback': [210, 438, 1471], 'loop': [211, 439], 'intermediaries': [225, 453, 669, 1345, 1489], 'deubiquitination.': [227, 455, 1491], 'The': [456, 2164, 2189, 2299, 2485, 2507, 2577, 2704, 2728, 2853, 2984, 3035, 3280], 'transcription': [457, 715], 'drives': [460], 'responses': [462, 3090, 3116, 3274], 'adhesion': [468], 'proteins,': [469], 'cytokines,': [470], 'chemokines': [472], 'IL-8)': [474], '2The': [475], 'abbreviations': [476], 'used': [477, 1970, 3102], 'are:ILinterleukinTNFtumor': [478], 'factorTNFRTNF': [480], 'receptorsiRNAsmall': [481], 'RNAIKKIκB': [483], 'kinaseE1ubiquitin-activating': [484], 'enzymeE2ubiquitin': [485], 'carrier': [486, 611], 'proteinE3ubiquitin-protein': [487], 'isopeptide': [488, 614], 'ligaseHAhemagglutininGFPgreen': [489], 'fluorescent': [490, 618], 'proteinHUVEChuman': [491], 'umbilical': [492, 621, 1779], 'vein': [493, 622, 1780], 'endothelial': [494, 623, 1446, 1781], 'cellCTnumber': [495], 'thermal': [497, 627, 2175, 2205], 'cycles': [498, 628, 2206], 'necessary': [501, 631, 2209], 'generate': [503, 633, 808, 2211], 'threshold': [504, 634, 2212], 'amounts': [505, 635, 1957, 2213], 'product.': [507, 637], '(1Hayden': [508, 534, 716, 1094], 'M.S.': [509, 535, 717, 1095], 'Ghosh': [510, 536, 718, 1096], 'S.': [511, 537, 719, 940, 1097, 1134, 1234, 1281, 1314, 1316, 1756, 1758, 2618], 'Genes': [512, 538, 720, 1098], 'Dev.': [513, 539, 721, 1099], '2004;': [514, 540, 722, 788, 956, 1054, 1100, 1297, 1323, 1765, 3597], '18:': [515, 541, 723, 1101], '2195-2224Crossref': [516, 542, 724, 1102], 'PubMed': [517, 543, 575, 725, 775, 791, 871, 903, 924, 959, 1003, 1062, 1103, 1139, 1169, 1192, 1217, 1247, 1300, 1326, 1391, 1427, 1687, 1723, 1768, 1822, 1884, 2138, 2249, 2638, 3600], 'Scopus': [518, 544, 576, 726, 776, 792, 872, 904, 925, 960, 1004, 1063, 1104, 1140, 1170, 1193, 1218, 1248, 1301, 1327, 1392, 1428, 1688, 1724, 1769, 1823, 1885, 2139, 2250, 2639, 3601], '(3380)': [519, 545, 727, 1105], 'Google': [520, 546, 578, 728, 778, 794, 874, 906, 927, 962, 1006, 1065, 1106, 1142, 1172, 1195, 1220, 1250, 1303, 1329, 1394, 1430, 1690, 1726, 1771, 1825, 1887, 2141, 2252, 2641, 3603], 'Scholar).': [521, 729, 795, 963, 1007, 1066, 1107, 1251, 1330, 1431, 1727, 1772, 1826, 1888, 2142, 2253, 2642, 3604], 'It': [522, 1008, 3530, 4224], 'regulated': [524, 738], 'diverse': [526], 'stimuli': [527, 3549], 'TNFα,': [532, 3972, 4008], 'Scholar)': [547, 579, 1221], 'mechanical': [549], 'forces': [550], 'shear': [552, 1834, 3004, 3010, 3082], 'stress)': [553], '(2Ganguli': [554], 'A.': [555, 885, 950, 1035, 1045, 1135, 1178, 1242, 1291, 1806, 1868, 2122, 2233], 'Persson': [556], 'L.': [557, 563, 877, 911, 938, 1049, 1279, 1804, 1866, 2120, 2231, 2622], 'Palmer': [558], 'I.R.': [559], 'Evans': [560, 1815, 1877, 2131, 2242], 'I.': [561], 'Yang': [562, 882], 'Smallwood': [564], 'R.': [565, 567, 946, 1156, 1162, 1287, 1383, 1411, 1679, 1707, 1810, 1872, 2126, 2237, 3587], 'Black': [566], 'Qwarnstrom': [568], 'E.E.': [569], 'Circ.': [570], 'Res.': [571], '2005;': [572, 772], '96:': [573], '626-634Crossref': [574], '(36)': [577], 'plays': [581], 'central': [583], 'role': [584, 816, 1076, 3109, 3824], 'numerous': [586], 'diseases': [587], 'atherosclerosis,': [589], 'rheumatoid': [590], 'arthritis,': [591], 'rejection': [593], 'transplanted': [595], 'organs.': [596], 'ubiquitin-activating': [608], 'ubiquitin': [610, 801, 852, 1265, 1347, 1732, 1736, 2791, 2798, 4097], 'protein': [612, 619, 684, 743, 974, 1118, 1355, 2715, 3051, 3128], 'ubiquitin-protein': [613], 'ligase': [615], 'hemagglutinin': [616], 'green': [617, 2155], 'human': [620, 1506, 1589], 'cell': [624, 1967], 'number': [625, 2203], 'In': [638, 4155], 'unstimulated': [639, 3164, 3463], 'cells,': [640, 1465, 3135], 'sequestered': [643], 'cytoplasm': [646, 3543], 'inhibitory': [648, 3303, 3930], 'bind': [652], 'its': [653, 2603, 3302, 3833, 3929], 'localization': [655, 2372, 3314, 3494, 3708], 'sequence.': [656], 'Signaling': [657, 1535], 'through': [658, 692, 755, 1070, 4077], 'receptors': [660], 'leads': [662, 967], 'recruitment': [665], 'several': [667, 1110], 'RIP1,': [671], 'TRAF2/5,': [672], 'NEMO': [674, 1174], '(IKKγ),': [675], 'which': [676, 701, 3335, 3430, 3685, 3729, 4065], 'control': [677, 2028, 3140, 3186, 3224, 3853], 'TAK1,': [681], 'mitogen-activated': [683], 'activate': [690], 'IKKs': [691], 'phosphorylation.': [693], 'Activation': [694, 3098], 'IKKβ': [696, 1033, 1228, 2587, 3826, 4241], 'triggers': [697], 'phosphorylation': [698, 3934, 4002, 4036], 'IκBα,': [700, 3829], 'subsequently': [703, 1605], 'destabilized,': [704], 'thus': [705, 1024, 1088, 1466, 2291, 3912], 'releasing': [706], 'free': [707], 'stimulation': [713, 3630, 3664], 'Recent': [730, 1252], 'have': [732, 1350, 1666], 'ubiquitin,': [740, 4100], 'covalently': [747], 'attached': [748], 'lysine': [750, 806], 'residues': [751, 1740, 2803, 4083], 'cellular': [753, 3089, 4058, 4108], 'proteins': [754, 765, 1084, 1269, 2768, 4059, 4109, 4207], 'chain': [757, 2806], 'reaction': [758], 'co-ordinated': [759], 'E1,': [761], 'E2,': [762], 'E3': [764], '(3Evans': [766], 'P.C.': [767, 1306, 1375, 1397, 1671, 1693, 1748, 1816, 1878, 2132, 2243], 'Exp.': [768], 'Rev.': [769], 'Mol.': [770, 1052], 'Med.': [771], '7:': [773], '1-19Crossref': [774], '(29)': [777], 'Scholar,': [779, 875, 907, 928, 1143, 1304, 1395, 1691], '4Sun': [780], 'L.J.': [781, 1039], 'Chen': [782, 892, 918, 1050], 'Z.J.': [783, 893, 1051], 'Curr.': [784], 'Opin.': [785], 'Cell': [786, 866, 1164, 1889, 2034], 'Biol.': [787, 867, 993, 1165, 1417, 1713, 2628], '16:': [789], '119-126Crossref': [790], '(375)': [793], 'Multiple': [796], 'rounds': [797], 'ubiquitination,': [799], 'itself': [803], 'ubiquitinated': [804, 2767], 'on': [805, 834, 2766, 2857, 3016, 3039, 3157, 3305, 3932, 4054], 'residues,': [807], 'isopeptide-linked': [809], 'branched': [810], 'chains': [811, 1014, 1068, 4075, 4118, 4163], 'play': [813, 1073], 'key': [815], 'NF-κB.': [820, 3306], 'Specifically,': [821], 'IL-1/Toll-like': [830], 'relies': [833], 'modification': [835, 4056], 'TRAF6': [839], 'intermediaries,': [841, 1023], 'respectively,': [842, 1947, 2845], 'with': [843, 1020, 1121, 1625, 1906, 1948, 2015, 2042, 2425, 2489, 2512, 2650, 2781, 2818, 2867, 2893, 3322, 3365, 3374, 3384, 3388, 3412, 3422, 3478, 3608, 3631, 3783, 3797, 3815, 3941, 4060, 4111, 4129, 4141, 4152, 4174, 4209], 'distinct': [845], 'structural': [846], 'polyubiquitin': [849, 2805], 'contains': [851], 'Lys63': [853, 1013, 2809], 'linkages': [854], '(5Wu': [855], 'C.J.': [856], 'Conze': [857], 'D.B.': [858, 3593], 'Li': [859, 1209], 'T.': [860, 1206, 2003], 'Srinivasula': [861], 'S.M.': [862], 'Ashwell': [863], 'J.D.': [864], 'Nat.': [865], '2006;': [868], '8:': [869], '398-406Crossref': [870], '(508)': [873], '6Deng': [876], 'Wang': [878, 986], 'C.': [879, 889, 891, 909, 944, 1212, 1285], 'Spencer': [880], 'E.': [881, 3585], 'L.Y.': [883], 'Braun': [884], 'You': [886], 'J.X.': [887], 'Slaughter': [888], 'Pickart': [890], 'Cell.': [894, 1053], '2000;': [895, 1184, 1244], '103:': [896], '351-361Abstract': [897], 'Full': [898, 900, 998, 1000, 1057, 1059, 1187, 1189, 1422, 1424, 1718, 1720, 2633, 2635], 'Text': [899, 901, 999, 1001, 1058, 1060, 1188, 1190, 1423, 1425, 1719, 1721, 2634, 2636], 'PDF': [902, 1002, 1061, 1191, 1426, 1722, 2637], '(1524)': [905], '7Wang': [908], 'Deng': [910, 1048], 'Hong': [912, 1042], 'M.': [913, 936, 1043, 1126, 1238, 1277, 1310, 1752, 1802, 1808, 1864, 1870, 2006, 2118, 2124, 2229, 2235, 3563], 'Akkaraju': [914], 'G.R.': [915], 'Inoue': [916], 'J.': [917, 992, 1163, 1322, 1379, 1387, 1416, 1675, 1683, 1712, 1764, 1794, 1818, 1856, 1880, 2110, 2134, 2221, 2245, 2624, 2627], 'Z.J.J.': [919], 'Nature.': [920, 955, 1296], '2001;': [921, 1214, 1388, 1684], '412:': [922], '346-351Crossref': [923], '(1651)': [926], '8Wertz': [929], 'I.E.': [930, 1271], "O'Rourke": [931, 1272], 'K.M.': [932, 1273], 'Zhou': [933, 1274], 'H.L.': [934, 1275, 1318, 1760], 'Eby': [935, 1276], 'Aravind': [937, 1278], 'Seshagiri': [939, 1280], 'Wu': [941, 1282], 'P.': [942, 1283], 'Wiesmann': [943, 1284], 'Baker': [945, 1286], 'Boone': [947, 1231, 1288], 'D.L.': [948, 1232, 1289], 'Ma': [949, 1241, 1290], 'Koonin': [951, 1292], 'E.V.': [952, 1293], 'Dixit': [953, 1294], 'V.M.': [954, 1295], '430:': [957, 1298], '694-699Crossref': [958, 1299], '(1477)': [961, 1302], 'Pro-inflammatory': [964, 2961, 3096], 'also': [966, 1072, 2861, 2989, 3243], 'Lys63-polyubiquitination': [969, 4232], 'NEMO,': [971], 'an': [972, 2471, 3240], 'adaptor': [973], 'binds': [976], 'IKK': [977, 1483, 2548, 3725, 3845, 3869, 3906, 4251], '(9Tang': [984], 'E.D.': [985], 'C.Y.': [987], 'Xiong': [988], 'Y.': [989, 1210], 'Guan': [990], 'K.L.': [991], 'Chem.': [994, 1418, 1714, 2629], '2003;': [995, 1419, 1715], '278:': [996, 1420, 1716], '37297-37305Abstract': [997], '(184)': [1005], 'has': [1009, 1333, 3341, 4202], 'been': [1010, 1334, 1667, 3342], 'suggested': [1011, 1335], 'interacting': [1019], 'TAB2': [1021], 'triggering': [1025], 'oligomerization': [1027], 'TAK1': [1031], '(10Kanayama': [1034], 'Seth': [1036], 'R.B.': [1037], 'Sun': [1038], 'Ea': [1040], 'C.K.': [1041], 'Shaito': [1044], 'Chiu': [1046], 'Y.H.': [1047], '15:': [1055, 1215], '535-548Abstract': [1056], '(703)': [1064], 'Polyubiquitin': [1067, 2826, 4074], 'linked': [1069, 4076], 'Lys48': [1071, 2812], 'vital': [1075], 'during': [1077, 4069], 'phosphorylated': [1082], 'proteasomal': [1086], 'degradation,': [1087], 'liberating': [1089], 'entry': [1093], 'induces': [1109], 'interacts': [1120], 'TRAFs': [1122], '(11Song': [1123], 'H.Y.': [1124], 'Rothe': [1125], 'Goeddel': [1127], 'D.V.': [1128], 'Proc.': [1129], 'Natl.': [1130], 'Acad.': [1131], 'Sci.': [1132], 'U.': [1133], '1996;': [1136], '93:': [1137], '6721-6725Crossref': [1138], '(376)': [1141], '12Heyninck': [1144], 'K.': [1145, 1381, 1407, 1677, 1703, 1798, 1860, 2114, 2225], 'Valck': [1146], 'De': [1147], 'D.': [1148, 1182, 3591], 'Berghe': [1149], 'Vanden': [1150], 'W.': [1151, 1154, 1158], 'Criekinge': [1152], 'Van': [1153], 'Contreras': [1155], 'Fiers': [1157], 'Haegeman': [1159], 'G.': [1160, 1180, 1513, 3571], 'Beyaert': [1161, 1382, 1410, 1678, 1706], '1999;': [1166], '145:': [1167], '1471-1482Crossref': [1168], '(255)': [1171], 'Scholar),': [1173, 1196], '(13Zhang': [1175], 'S.Q.': [1176], 'Kovalenko': [1177], 'Cantarella': [1179], 'Wallach': [1181], 'Immunity.': [1183], '12:': [1185], '301-311Abstract': [1186], '(393)': [1194], 'IKKα': [1198], '(14Zetoune': [1199], 'F.S.': [1200], 'Murthy': [1201], 'A.R.': [1202], 'Zhao': [1203], 'Z.H.': [1204], 'Hlaing': [1205], 'Zeidler': [1207], 'M.G.': [1208, 1403, 1699], 'Vincenz': [1211], 'Cytokine.': [1213], '282-298Crossref': [1216], '(38)': [1219], 'inhibits': [1223], '(15Lee': [1229], 'E.G.': [1230], 'Chai': [1233], 'Libby': [1235], 'S.L.': [1236], 'Chien': [1237], 'Lodolce': [1239], 'J.P.': [1240], 'Science.': [1243, 3596], '289:': [1245], '2350-2354Crossref': [1246], '(1200)': [1249], 'work': [1253], 'demonstrated': [1254, 3056], 'protease': [1261, 2699, 3295], 'cleave': [1264], 'monomers': [1266], 'modified': [1268, 1898, 4110, 4208], '(8Wertz': [1270], '16Evans': [1305], 'Ovaa': [1307, 1749], 'H.': [1308, 1750, 1796, 1800, 1858, 1862, 2112, 2116, 2223, 2227], 'Hamon': [1309, 1751], 'Kilshaw': [1311, 1384, 1414, 1680, 1710, 1753], 'P.J.': [1312, 1385, 1415, 1681, 1711, 1754], 'Hamm': [1313, 1755], 'Bauer': [1315, 1757], 'Ploegh': [1317, 1759], 'Smith': [1319, 1398, 1694, 1761], 'T.S.': [1320, 1399, 1695, 1762], 'Biochem.': [1321, 1386, 1682, 1763], '378:': [1324, 1766], '727-734Crossref': [1325, 1767], '(197)': [1328, 1770], 'editing.': [1348], 'previously': [1351, 1669, 1746, 1792, 1854, 2108, 2219, 2614], 'described': [1352, 1668, 1745, 1791, 1853, 2107, 2218, 2613], 'called': [1356], 'belongs': [1359], 'enzymes': [1366], 'modulate': [1369], 'when': [1372], 'overexpressed': [1373, 3657], '(17Evans': [1374, 1670], 'Taylor': [1376, 1672], 'E.R.': [1377, 1673], 'Coadwell': [1378, 1674], 'Heyninck': [1380, 1406, 1676, 1702], '357:': [1389, 1685], '617-623Crossref': [1390, 1686], '(77)': [1393, 1689], '18Evans': [1396, 1692], 'Lai': [1400, 1696], 'M.J.': [1401, 1697], 'Williams': [1402, 1698], 'Burke': [1404, 1700], 'D.F.': [1405, 1701], 'Kreike': [1408, 1704], 'M.M.': [1409, 1705], 'Blundell': [1412, 1708], 'T.L.': [1413, 1709], '23180-23186Abstract': [1421, 1717], '(139)': [1429, 1725], 'Here': [1432], 'epithelial': [1444], 'Gene': [1448], 'silencing': [1449, 3236], 'attenuates': [1454], 'completing': [1467], 'loop.': [1472], 'provide': [1475], 'evidence': [1476], 'Reagents': [1492], 'Antibodies—Human': [1494], 'recombinant': [1495], 'obtained': [1498, 1575], 'commercially': [1499], '(R': [1500], '&': [1501], 'D,': [1502], 'Minneapolis,': [1503], 'MN).': [1504], 'Biotinylated': [1505], 'kindly': [1509], 'provided': [1510], 'Prof.': [1512], 'Cohen': [1514], '(University': [1515], 'Leicester).': [1517], 'Anti-RelA': [1518], '(p65)': [1519], '(sc372;': [1520], 'Santa': [1521, 1524, 1529], 'Cruz': [1522, 1530, 1549], 'Biotechnology,': [1523], 'Cruz,': [1525], 'CA),': [1526], 'anti-IκBα': [1527, 2439], '(sc-847;': [1528], 'Biotechnology),': [1531, 1550], 'anti-phosphoIκBα': [1532], 'Ser32/36': [1533], '(Cell': [1534], 'Technology),': [1536], 'anti-RIP': [1537, 1563], '(BD': [1538, 1552, 1558, 1564, 2598], 'Biosciences': [1539, 1553, 1559, 1565], 'Pharmingen,': [1540, 1554, 1560, 1566, 2599], 'Oxford,': [1541, 1555, 1561, 1567, 2600], 'UK),': [1542, 1556, 1562, 1568, 2601], 'anti-HA': [1543, 2838], '(Roche': [1544, 2701, 2725], 'Applied': [1545, 2702, 2726], 'Science),': [1546], 'anti-GFP': [1547, 2841], '(Santa': [1548], 'anti-IKKα': [1551], 'anti-IKKγ': [1557, 2596], 'anti-TNFR': [1569], '(Invitrogen),': [1570], 'anti-tubulin': [1572], '(Sigma)': [1573], 'commercially.': [1576], 'Rabbit': [1577], 'polyclonal': [1578], 'antibodies': [1579, 1612, 2345, 2352, 2386, 2391, 2440, 2445, 2597, 2753], 'raised': [1581], 'against': [1582], 'peptide': [1584], 'conserved': [1587], 'between': [1588, 2313, 2930], 'mouse': [1591], 'versions': [1592, 1734, 4095], 'but': [1595, 3166, 3218, 3800], 'encoded': [1597], 'mammalian': [1600, 2785], 'genes': [1601, 2259], '(C+YSNGYREPPEPDGWA-CONH2)': [1602], 'affinity': [1606], 'purified': [1607, 2590], '(Eurogentech,': [1608], 'Liege,': [1609], 'Belgium).': [1610], 'Anti-Cezanne': [1611], 'validated': [1614], 'Western': [1616, 2744, 2835, 2915, 3058, 3756, 3994], 'blotting': [1617, 2745, 2836, 2916, 3059, 3757, 3995], 'cytosolic': [1619, 2832, 3759], 'lysates': [1620, 2582, 2592, 2705, 2740, 2833, 2911, 3760], 'made': [1621], 'cells': [1623, 1782, 1893, 1916, 1935, 1940, 1954, 1991, 2332, 2383, 2437, 2469, 2486, 2508, 2551, 2647, 2773, 2864, 2890, 2981, 3078, 3165, 3217, 3249, 3276, 3319, 3363, 3465, 3523, 3545, 3619, 3621, 3655, 3744, 3775, 3788, 3806, 3854, 3880, 3938, 4087, 4123, 4130, 4168, 4175], 'transfected': [1624, 1941, 1953, 2041, 2780, 2866, 3320, 3522, 3939], 'epitope-tagged': [1626, 1646], '(supplemental': [1630], 'Fig.': [1631], 'S1).': [1632], 'Other': [1633], 'reagents': [1634], 'purchased': [1636], 'Sigma-Aldrich': [1638], 'unless': [1639], 'otherwise': [1640], 'stated.': [1641], 'Plasmids—Expression': [1642], 'vectors': [1643, 4090], 'encoding': [1644], 'HA': [1645], '(pHM6-Cezanne),': [1648], 'GFP-tagged': [1649], '(pEGFP-Cezanne)': [1651], 'enzymatically': [1653], 'inactive': [1654, 2875, 3332, 3393, 3508, 3624, 3951, 4180], '(pHM6-Cezanne': [1661], 'C209S': [1662, 3977, 4011], 'pEGFP-Cezanne': [1664, 2822, 2824], 'C209S)': [1665, 4183], 'Expression': [1728, 2959], 'plasmids': [1729, 2869, 3324, 3943], 'containing': [1730, 1737, 2788, 2793, 2870, 3325, 3622, 3944, 4091], 'HA-tagged': [1731, 2789], 'single': [1738, 2801, 4093], 'Lys': [1739, 2802, 4082, 4094], '(Lys48': [1741], 'Lys63)': [1743], '(16Evans': [1747], 'Endothelial': [1773], 'Cells': [1774], 'Exposure': [1776], 'Flow—Human': [1778], '(HUVEC)': [1783], 'collected': [1785], 'collagenase': [1787], 'as': [1790, 1852, 2106, 2217, 2306, 2610, 2612, 2906, 3055, 3264], '(19Partridge': [1793, 1855, 2109, 2220], 'Carlsen': [1795, 1857, 2111, 2222], 'Enesa': [1797, 1859, 2113, 2224], 'Chaudhury': [1799, 1861, 2115, 2226], 'Zakkar': [1801, 1863, 2117, 2228], 'Luong': [1803, 1865, 2119, 2230], 'Kinderlerer': [1805, 1867, 2121, 2232], 'Johns': [1807, 1869, 2123, 2234], 'Blomhoff': [1809, 1871, 2125, 2236], 'Mason': [1811, 1873, 2127, 2238], 'J.C.': [1812, 1874, 2128, 2239], 'Haskard': [1813, 1875, 2129, 2240], 'D.O.': [1814, 1876, 2130, 2241], 'FASEB': [1817, 1879, 2133, 2244], '2007;': [1819, 1881, 2135, 2246, 2630], '21:': [1820, 1882, 2136, 2247], '3553-3561Crossref': [1821, 1883, 2137, 2248], '(115)': [1824, 1886, 2140, 2251], 'Confluent': [1827], 'HUVEC': [1828, 2992, 3022, 3054, 3153], 'cultures': [1829, 2035, 2815, 4146], 'exposed': [1831, 3277, 3546], 'high': [1833, 2584], '(12': [1835, 3006], 'dynes/cm2)': [1836], 'unidirectional': [1837], 'laminar': [1838, 3003], 'flow': [1839, 1846], '16': [1841, 2505, 2517], 'h': [1842, 2064, 2518, 3628, 3662], 'parallel-plate': [1845], 'chamber': [1847], '(Cytodyne,': [1848], 'La': [1849], 'Jolla,': [1850], 'CA)': [1851], 'Lines': [1890], 'Transfection—HEK293': [1892], "Dulbecco's": [1897], "Eagle's": [1899], 'medium,': [1900], '10%': [1901, 2560, 2684], 'fetal': [1902], 'calf': [1903], 'serum,': [1904], 'supplemented': [1905], '100': [1907], 'U/ml': [1908], 'penicillin': [1909], 'G/100': [1910], 'μg/ml': [1911], 'streptomycin.': [1912], 'Transient': [1913], 'transfection': [1914, 2498], 'achieved': [1918, 1937], 'Lipofectamine': [1920, 2049, 2501, 2880], '(Invitrogen)': [1921, 2050, 2881], 'according': [1922, 2159], "manufacturer's": [1925, 2053, 2162, 2884], 'instructions.': [1926, 2163], 'Stable': [1927], 'GFP': [1930, 1959, 3754, 3791, 4134], 'GFP-Cezanne': [1932, 1961, 3752, 3809, 3883, 4127], 'HEK293': [1934, 1990, 2468, 2772, 2863, 2980, 3216, 3318, 3362, 3464, 3743, 4122, 4167], 'culturing': [1939], 'transiently': [1942, 3321, 3940], 'pEGFP': [1944], 'pEGFP-Cezanne,': [1946], 'neomycin.': [1949], 'After': [1950, 2886], '4': [1951, 3639, 3782, 3987], 'weeks,': [1952], 'expressing': [1955], 'similar': [1956, 3748], 'selected': [1963], 'further': [1964, 3738], 'fluorescence-activated': [1966], 'sorting': [1968], 'experiments.': [1972], 'Interference—RNA': [1974], 'interference': [1975, 3104], 'carried': [1977, 2147], 'out': [1978, 2148], 'specific': [1981, 2747, 2918], 'siRNA': [1982, 2013, 2043, 3123, 3214, 3242], 'known': [1985], 'silence': [1987], 'without': [1992], 'altering': [1993], 'related': [1997], 'molecules.': [1998], '3H.': [1999], 'Tran,': [2000], 'F.': [2001], 'Hamada,': [2002], 'Schwarz-Romand,': [2004], 'Bienz,': [2007], 'submitted': [2008], 'publication.': [2010], 'Cezanne-specific': [2011, 3122, 3213], 'double-stranded': [2012], 'oligonucleotides': [2014], '3′-dTdT': [2016], '(Cez': [2017], '5′-GAATCTATCTGCCTTTGGA-3′;': [2018], 'Dharmacon,': [2019], 'Chicago,': [2020], 'IL)': [2021], 'nontargeting': [2023, 3138], 'scrambled': [2024, 3139, 3185, 3223], 'controls': [2025], '(Silencer': [2026], 'Negative': [2027], '1': [2029, 2678, 2819, 3484, 4188], 'siRNA;': [2030], 'Ambion)': [2031], 'synthesized.': [2033], '80-90%': [2038], 'confluent': [2039], '(final': [2044], 'concentration,': [2045], '10': [2046, 2181, 2336, 2689], 'nm)': [2047], 'following': [2051, 2882, 3626, 3660, 3860], 'instructions': [2054], 'then': [2056, 2510, 2659, 2731], 'incubated': [2057, 2167, 2503], 'complete': [2059], 'growth': [2060], 'medium': [2061], '48': [2063, 2887], 'before': [2065, 2174, 2519, 2717, 2901], 'analysis.': [2066], 'Comparative': [2067], 'Real': [2068, 2143], 'Time': [2069], 'PCR—Transcript': [2070], 'levels': [2071, 3001, 3052, 3159, 3516, 3614, 4106], 'quantified': [2073], 'comparative': [2075, 2965], 'real': [2076, 2966], 'time': [2077, 2144, 2967], 'PCR': [2078, 2145, 2968], 'gene-specific': [2080], 'primers': [2081], '(sense,': [2084, 2089, 2095], '5′-ACAATGTCCGATTGGCCAGT-3′;': [2085], 'antisense,': [2086, 2091, 2097], '5′-ACAGTGGGATCCACTTCACATTC-3′),': [2087], '5′-TGCCAAGGAGTGCTAAAG-3′;': [2090], '5′-CTCCACAACCCTCTGCAC-3′),': [2092], 'β-actin': [2094, 2275], '5′-CTGGAACGGTGAAGGTGACA-3′;': [2096], '5′-AAGGGACTTCCTGTAACAATGCA-3′).': [2098], 'Total': [2099], 'extracted': [2102], 'reverse': [2104], 'transcribed': [2105], 'iCycler': [2151], 'system': [2152], 'SYBR': [2154], 'master': [2156], 'mix': [2157], '(Bio-Rad)': [2158], 'reactions': [2165, 2190], '95': [2169, 2178], '°C': [2170, 2179, 2185], '3': [2172, 2571, 2574, 3230, 3254, 3780, 3985, 4193], 'min': [2173, 2337, 3475, 3769, 3862], 'cycling': [2176], 's': [2182], '56': [2184], '45': [2187], 's.': [2188], 'performed': [2192, 2329, 2407, 3316], 'triplicate.': [2194], 'Relative': [2195], 'calculated': [2199, 2256, 2305], 'comparing': [2201], 'product': [2215], '(CT)': [2216], 'CT': [2254, 2273, 2280], 'interest': [2261, 2285], 'housekeeping': [2265], 'β-actin.': [2267], 'For': [2268], 'each': [2269, 2282, 2302], 'cDNA': [2270, 2319], 'sample,': [2271], 'subtracted': [2277], 'give': [2287], 'parameter': [2289], 'DCT,': [2290], 'normalizing': [2292], 'initial': [2294], 'amount': [2295, 2300], 'used.': [2298], 'target': [2303], '2-DDCT,': [2307], 'DDCT': [2309], 'difference': [2312], 'DCT': [2315], 'two': [2318], 'samples': [2320, 2931], 'compared.': [2323], 'Immunostaining': [2324, 2366, 3452], 'Detect': [2326, 2368], 'Cezanne—Immunostaining': [2327], 'fixing': [2331], 'methanol': [2334], 'prior': [2338], 'application': [2341], 'rabbit': [2343], 'anti-Cezanne': [2344, 3067], '(1:50)': [2346], 'goat': [2348], 'anti-rabbit': [2349], 'Alexafluor488-conjugated': [2350], 'secondary': [2351, 2390, 2444, 2752, 2848, 2923], '(1:500)': [2353], 'followed': [2354, 2392, 2446], 'laser': [2356, 2394, 2448], 'scanning': [2357, 2395, 2449], 'confocal': [2358, 2396, 2450, 3960], 'microscopy': [2359, 2397, 2451, 3961], '(LSM': [2360, 2398, 2452], '510': [2361, 2399], 'META;': [2362, 2400, 2454], 'Zeiss,': [2363, 2401, 2455], 'Oberkochen,': [2364, 2402, 2456], 'Germany).': [2365, 2403, 2457], 'IκB—Intracellular': [2371], 'RelA': [2374, 2419, 3445, 3455, 3496, 3519, 3535, 3613, 3650, 3689], 'subunits': [2376, 3447], 'assessed': [2378, 2530, 2606, 2770, 2990, 3737, 3831, 4254], 'immunostaining': [2380, 2434, 3063, 3958], 'paraformaldehyde-fixed': [2382, 2436], 'anti-RelA': [2385], 'Alexafluor': [2388, 2442], '568-conjugated': [2389, 2443], 'Image': [2404], 'analysis': [2405, 2941], 'Velocity': [2409], 'software': [2410], '(Improvision,': [2411], 'Coventry,': [2412], 'UK)': [2413], 'calculate': [2415], 'ratio': [2417], 'present': [2420], 'nucleus': [2423, 3470, 3540], 'compared': [2424, 4128, 4173], 'cytoplasm.': [2427], 'Levels': [2428], 'IκBα': [2430, 3763, 3933, 4004, 4035], 'measured': [2432, 2466], '5105': [2453], 'Assay': [2458, 2757], 'Transcriptional': [2461], 'Activity—NF-κB': [2462], '(pGL2)': [2474], 'supplied': [2475], 'Dr.': [2477], 'Martin': [2478], 'Turner': [2479], '(The': [2480], 'Babraham': [2481], 'Institute,': [2482], 'Cambridge,': [2483], 'UK).': [2484], 'co-transfected': [2488, 2817], 'pNF-luc': [2490], 'pRL-TK': [2492], '(encoding': [2493], 'Renilla': [2494, 2526], 'normalize': [2497], 'efficiency)': [2499], 'h.': [2506], 'treated': [2511, 2649, 2892], '(10': [2514], 'ng/ml)': [2515, 2654, 2897], 'measurement': [2520], 'activity.': [2523], 'Firefly': [2524], 'dual': [2533], 'assay': [2536], 'kit': [2537], '(Promega,': [2538], 'Madison,': [2539], 'WI)': [2540], 'luminescence': [2542], 'counter': [2543], '(Top-count': [2544], 'Microplate': [2545], 'Scintillation;': [2546], 'Packard).': [2547], 'Kinase': [2549], 'Assay—Cultured': [2550], 'lysed': [2553, 2660], '50': [2555, 2662], 'mm': [2556, 2563, 2572, 2575, 2663, 2668, 2676, 2679, 2682, 2687], 'Tris-HCl,': [2557], 'pH': [2558, 2665], '7.5,': [2559], 'glycerol,': [2561, 2685], '250': [2562], 'NaCl,': [2564, 2669], '1%': [2565, 2670], 'Triton': [2566], 'X-100,': [2567], '0.5%': [2568, 2672], 'Nonidet': [2569, 2673], 'P-40,': [2570, 2674], 'EGTA,': [2573, 2680], 'EDTA.': [2576], 'debris': [2578], 'removed': [2580], 'speed': [2585, 2710], 'centrifugation.': [2586], 'immunoprecipitation': [2594], 'glutathione': [2608], 'S-transferase-IκBα': [2609], 'substrate': [2611], '(20Alford': [2615], 'K.A.': [2616], 'Glennie': [2617], 'Turrell': [2619], 'B.R.': [2620], 'Rawlinson': [2621], 'Saklatvala': [2623], 'Dean': [2625], 'J.L.E.': [2626], '282:': [2631], '6232-6241Abstract': [2632], '(105)': [2640], 'Precipitation': [2643], 'Complexes—HEK293': [2646], 'biotinylated': [2651, 2894], '(200': [2653, 2896], 'varying': [2656, 2899], 'durations': [2657, 2900], 'Tris,': [2664], '7.6,': [2666], '137': [2667], 'Triton-X100,': [2671], '1.5': [2675], 'MgCl2': [2677], '5': [2681, 3411, 3421, 3527, 3671, 3990, 4018], 'EDTA,': [2683], '0.1': [2686], 'Na3VO4,': [2688], 'μm': [2690], 'N-ethylmaleimide,': [2691], '20': [2692], 'nm': [2693], 'MG132': [2694], 'plus': [2695], 'mixture': [2697], 'inhibitors': [2700], 'Science).': [2703, 2727], 'clarified': [2707], 'low': [2709], 'centrifugation': [2711], 'precleared': [2713], 'G-Sepharose': [2716], 'precipitation': [2718, 2902], 'complexes': [2721, 2905], 'streptavidin-coated': [2723], 'beads': [2724, 2729], 'washed': [2732], 'extensively': [2733], 'lysis': [2735], 'buffer.': [2736], 'Precipitated': [2737, 2908], 'material': [2738, 2909], 'analyzed': [2742, 2913, 2933], 'primary': [2748, 2843, 2919], 'antibodies,': [2749, 2844, 2849, 2920, 2924], 'horseradish': [2750, 2846, 2921], 'peroxidase-conjugated': [2751, 2847, 2922], 'chemiluminescent': [2755, 2851, 2926], 'detection.': [2756, 2852, 2927], 'Deubiquitination': [2759], 'Cultured': [2761], 'Cells—The': [2762], 'effect': [2763, 2854, 3143, 3156, 3190, 3512, 3980], '60-mm': [2776], 'dishes.': [2777], 'They': [2778], '0.5': [2782], 'μg': [2783, 2820], 'vector': [2787], 'wild-type': [2790, 2872, 3327, 3351, 3389, 3489, 3658, 3946, 3963, 3998, 4099, 4171], 'HA-tagged,': [2794], 'contained': [2800], 'assembly': [2807], 'i.e.': [2808], 'only': [2810], 'only.': [2813], 'Some': [2814], 'C209S.': [2825], 'detected': [2830], '(1:1000)': [2839, 2842], 'ubiquitination': [2859], 'measured.': [2862], 'either': [2871, 2994, 3326, 3751, 3945, 4112, 4210], 'catalytically': [2874, 3331, 3392, 3507, 3623, 3950, 4179], 'recommendations.': [2885], 'h,': [2888], 'above.': [2907], 'Statistics—The': [2928], 'differences': [2929], 'paired': [2936], "Student's": [2937], 't': [2938], 'test': [2939], 'variance': [2943], '(*,': [2944], 'p': [2945, 2949, 2953], '<': [2946, 2950, 2954], '0.05;': [2947], '**,': [2948], '0.01;': [2951], '***,': [2952], '0.001).': [2955], 'Regulation': [2956], 'Stimuli—We': [2962], 'rapidly': [2974], '(Fig.': [2982, 3033, 3060, 3064, 3144, 3176, 3226, 3250, 3367, 3405, 3480, 3513, 3633, 3665, 3776, 3865, 3884, 3981, 4014, 4072, 4136, 4147, 4184], '1A).': [2983], 'static': [2996], 'conditions': [2997], 'under': [2999], 'physiological': [3000], 'stress': [3005, 3011, 3083], 'dynes/cm2).': [3007], 'Interestingly,': [3008], 'although': [3009], 'had': [3012, 3141, 3154, 3188, 3510, 3978], 'relatively': [3013], 'modest': [3014], 'mRNA': [3018, 3126], 'levels,': [3019], 'primed': [3021], '1B).': [3034], 'paralleled': [3043], 'rapid': [3045], 'sustained': [3047], 'increases': [3048], '1C)': [3061], '1D)': [3065], 'antibodies.': [3068], 'Our': [3069], 'observation': [3070, 3610], 'suggests': [3084], 'may': [3087], 'these': [3092, 4197], 'Limits': [3095], 'Cellular': [3097, 4047], 'Suppressing': [3100], 'NF-κB—We': [3101], 'assess': [3106], 'potential': [3108], 'regulating': [3114], 'TNFα.': [3118, 3279, 3451], 'least': [3131], '70%': [3132], 'culture': [3134], 'whereas': [3136, 3183, 3505, 3973, 4009], 'no': [3142, 3155, 3189, 3511, 3979], '2,': [3145], 'A': [3146], 'B).': [3148], 'basal': [3158], 'subsequent': [3169], '2C,': [3177], 'compare': [3178, 3228, 3252, 3371, 3381, 3409, 3419, 3482, 3515, 3637, 3669, 3778, 3886, 3983, 4016, 4138, 4149, 4186], 'treatments': [3179, 3192, 3229, 3253, 3483, 3526, 3638, 3643, 3670, 3779, 3793, 3811, 3816, 3887, 3984, 3989, 4017, 4139, 4142, 4150, 4153, 4187, 4192], '2': [3180, 3193, 3627, 3661, 4190], '6),': [3182], 'sequence': [3187], '(compare': [3191, 3792, 3810], '4).': [3195, 3232, 3486, 4195], 'Similarly,': [3196, 3993], 'assays': [3199, 3311], 'significantly': [3210, 3491, 3877], 'altered': [3221], 'sequences': [3225], '2D,': [3227, 3251], 'alternative': [3241], '5).': [3256, 4073], 'functions': [3263], 'regulator': [3267], 'Deubiquitinating': [3281], 'Activity': [3282], 'Is': [3285, 4218], 'Essential': [3286], 'Suppression—We': [3289], 'determined': [3290, 3919], 'whether': [3291, 3438, 3832, 3920, 4255], 'required': [3300, 3702, 3927], 'Reporter': [3307], 'experiments': [3309], 'active': [3337], 'site': [3338], '(Cys209)': [3340], 'serine': [3345], '(Cezanne': [3346, 3953, 4182], 'C209S).': [3347, 3954], 'reduced': [3353, 3492, 3616, 3878, 4120], 'dose-dependent': [3359], 'manner': [3360], 'stimulated': [3364], '3A,': [3368, 3406], 'upper': [3369, 3407], 'panel,': [3370, 3380, 3408, 3418, 3636, 3668], 'bars': [3372, 3382], '3-5': [3373, 3383], 'bar': [3375, 3385, 3410, 3413, 3420, 3423], '2)': [3376], 'IL-1': [3378, 3416], '(lower': [3379, 3417], '2).': [3386], 'Compared': [3387], 'ineffective': [3396], 'reducing': [3398], '8)': [3414], '8).': [3424, 3821], 'To': [3425], 'understand': [3426], 'regulates': [3432], 'activity,': [3435, 3684], 'investigated': [3437], 'could': [3440, 4257], 'inhibit': [3441], 'localized': [3456], 'predominantly': [3457], 'cytoplasmic': [3460], 'compartment': [3461], 'translocated': [3467], '15': [3474, 3503, 3861], 'treatment': [3477, 3501, 3772, 3784, 3798, 3864, 3875], '3B,': [3481, 3514, 3634, 3666], 'min,': [3504], '(red)': [3520], '(green)': [3524], '6).': [3529, 3992, 4020], 'well': [3532], 'established': [3533], 'exported': [3537, 3653], 'prolonged': [3551], 'periods': [3552], 'via': [3553], 'NF-κB-dependent': [3554], 'resynthesis': [3555], 'IκBs': [3557], '(21Nelson': [3558], 'D.E.': [3559], 'Ihekwaba': [3560], 'A.E.C.': [3561], 'Elliott': [3562], 'Johnson': [3564], 'J.R.': [3565], 'Gibney': [3566], 'C.A.': [3567, 3575], 'Foreman': [3568], 'B.E.': [3569], 'Nelson': [3570], 'See': [3572], 'V.': [3573], 'Horton': [3574], 'Spiller': [3576], 'D.G.': [3577], 'Edwards': [3578], 'S.W.': [3579], 'McDowell': [3580], 'H.P.': [3581], 'Unitt': [3582], 'J.F.': [3583], 'Sullivan': [3584], 'Grimley': [3586], 'Benson': [3588], 'N.': [3589], 'Broomhead': [3590], 'Kell': [3592], 'White': [3594], 'M.R.H.': [3595], '306:': [3598], '704-708Crossref': [3599], '(985)': [3602], 'This': [3605], 'consistent': [3607], 'our': [3609, 3692], 'untransfected': [3618, 3774, 4145], 'lower': [3635, 3667], '7': [3641, 3794], '6': [3644], '9).': [3646], 'However,': [3647], 'residual': [3648], '8),': [3673], 'possibly': [3674], 'because': [3675], 'suppression': [3678, 3704, 4033], 'export.': [3690], 'Collectively,': [3691, 4196], 'data': [3693, 4198], 'indicate': [3694], 'properties': [3698], 'are': [3701, 4066], 'Suppresses': [3718], 'Nuclear': [3719], 'Translocation': [3720], 'Inhibiting': [3724], 'Activity—The': [3726], 'modulates': [3731], 'biochemical': [3740], 'stably': [3746, 4125, 4132], 'expressed': [3747, 3790, 3808, 3856, 3882, 4126, 4133, 4170, 4177], 'quantities': [3749], 'alone.': [3755], 'entirely': [3765], 'degraded': [3766], '15-30': [3768], '4A,': [3777], '1)': [3785], '8': [3796, 3888], '5),': [3799], 'largely': [3803], 'preserved': [3804], '11': [3812], '12': [3814], '3,': [3817], '4,': [3818], '7,': [3819], 'Given': [3822, 4247], 'phosphorylating': [3828], 'modulated': [3839], 'Cezanne.': [3841], 'sharply': [3849], 'GFP,': [3857], 'occurring': [3858], 'maximally': [3859], '4B).': [3866], 'By': [3867], 'comparison,': [3868], '4B,': [3885], '3).': [3890], 'therefore': [3893], 'targets': [3896], 'it,': [3911], 'suppressing': [3913], 'stabilizing': [3916], 'IκBα.': [3917], 'degradation': [3936, 3966, 4038], 'overexpression': [3974], '4C,': [3982], 'Ser': [4001], 'did': [4012], '4D,': [4015], 'Deubiquitinates': [4043], 'Lys48-': [4044], 'Lys63-polyubiquitinated': [4046], 'Proteins—We': [4048], 'examined': [4049], 'Lys63-': [4061, 4160, 4211], 'Lys48-polyubiquitin': [4063, 4162, 4213], 'chains,': [4064], 'processes': [4068], 'Lys48,': [4078], 'Lys63,': [4079], 'multiple': [4081], 'generated': [4085], 'mutated,': [4092], 'respectively.': [4101], 'Lys48-,': [4113], 'Lys63-,': [4114], 'mixed': [4116], 'Lys-polyubiquitin': [4117], 'alone': [4135], '5A,': [4137, 4148], '7-9': [4140, 4151], '4-8)': [4143], '1-3).': [4154], 'addition,': [4156], 'version': [4181], '5B,': [4185], 'imply': [4199], 'capacity': [4204], 'deubiquitinate': [4206], 'Recruited': [4219], 'Where': [4223], 'Targets': [4225], 'Deubiquitination—Recent': [4228], 'reports': [4229], 'suggest': [4230], 'activation,': [4252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1972266008', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-12-14T07:43:48.816719', 'created_date': '2016-06-24'}