Bromobenzene Metabolism and Hepatic Necrosis

Name: Work Video:
Duration: 3 min 30 s
Description: Treatment of rats with Phenobarbital stimulates the metabolism of bromobenzene and potentiates the hepatic necrosis elicited by the hydrocarbon. In contrast, administration of SKF 525-A or of piperonyl butoxide blocks bromobenzene metabolism and prevents the damage to the liver. These results indicate that the hepatotoxic effect of bromobenzene is mediated by a metabolite.
Watson D. Reid; B.G.B. Christie; G. Krishna; J. Mitchell; J. P. Moskowitz; B.B. Brodie
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