Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1972131742', 'doi': 'https://doi.org/10.1016/j.devbrainres.2005.05.004', 'title': 'Developmental differences between cation-independent and cation-dependent mannose-6-phosphate receptors in rat brain at perinatal stages', 'display_name': 'Developmental differences between cation-independent and cation-dependent mannose-6-phosphate receptors in rat brain at perinatal stages', 'publication_year': 2005, 'publication_date': '2005-06-28', 'ids': {'openalex': 'https://openalex.org/W1972131742', 'doi': 'https://doi.org/10.1016/j.devbrainres.2005.05.004', 'mag': '1972131742', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15982751'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.devbrainres.2005.05.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S20757867', 'display_name': 'Developmental Brain Research', 'issn_l': '0165-3806', 'issn': ['0165-3806', '1872-6755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055997876', 'display_name': 'Patricia Silvia Romano', 'orcid': 'https://orcid.org/0000-0002-2843-1668'}, 'institutions': [{'id': 'https://openalex.org/I4210147606', 'display_name': 'Instituto de Histología y Embriología de Mendoza', 'ror': 'https://ror.org/04jpdpb33', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I15881080', 'https://openalex.org/I4210147606']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I15881080', 'display_name': 'National University of Cuyo', 'ror': 'https://ror.org/05sn8wf81', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I15881080']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'P.S. Romano', 'raw_affiliation_strings': ['Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina', 'institution_ids': ['https://openalex.org/I4210147606', 'https://openalex.org/I151201029', 'https://openalex.org/I15881080']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063889622', 'display_name': 'Lorena Carvelli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147606', 'display_name': 'Instituto de Histología y Embriología de Mendoza', 'ror': 'https://ror.org/04jpdpb33', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I15881080', 'https://openalex.org/I4210147606']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I15881080', 'display_name': 'National University of Cuyo', 'ror': 'https://ror.org/05sn8wf81', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I15881080']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'L. Carvelli', 'raw_affiliation_strings': ['Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina', 'institution_ids': ['https://openalex.org/I4210147606', 'https://openalex.org/I151201029', 'https://openalex.org/I15881080']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006100510', 'display_name': 'Ana Claudia López', 'orcid': 'https://orcid.org/0000-0002-7064-9652'}, 'institutions': [{'id': 'https://openalex.org/I4210147606', 'display_name': 'Instituto de Histología y Embriología de Mendoza', 'ror': 'https://ror.org/04jpdpb33', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I15881080', 'https://openalex.org/I4210147606']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I15881080', 'display_name': 'National University of Cuyo', 'ror': 'https://ror.org/05sn8wf81', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I15881080']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'A.C. López', 'raw_affiliation_strings': ['Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina', 'institution_ids': ['https://openalex.org/I4210147606', 'https://openalex.org/I151201029', 'https://openalex.org/I15881080']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008982948', 'display_name': 'Guillermo Jofré', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147606', 'display_name': 'Instituto de Histología y Embriología de Mendoza', 'ror': 'https://ror.org/04jpdpb33', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I15881080', 'https://openalex.org/I4210147606']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I15881080', 'display_name': 'National University of Cuyo', 'ror': 'https://ror.org/05sn8wf81', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I15881080']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'G. Jofré', 'raw_affiliation_strings': ['Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina', 'institution_ids': ['https://openalex.org/I4210147606', 'https://openalex.org/I151201029', 'https://openalex.org/I15881080']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086055039', 'display_name': 'T. Sartor', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210147606', 'display_name': 'Instituto de Histología y Embriología de Mendoza', 'ror': 'https://ror.org/04jpdpb33', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I15881080', 'https://openalex.org/I4210147606']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I15881080', 'display_name': 'National University of Cuyo', 'ror': 'https://ror.org/05sn8wf81', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I15881080']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'T. Sartor', 'raw_affiliation_strings': ['Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina', 'institution_ids': ['https://openalex.org/I4210147606', 'https://openalex.org/I151201029', 'https://openalex.org/I15881080']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103104387', 'display_name': 'Miguel A. Sosa', 'orcid': 'https://orcid.org/0000-0001-5579-5494'}, 'institutions': [{'id': 'https://openalex.org/I4210147606', 'display_name': 'Instituto de Histología y Embriología de Mendoza', 'ror': 'https://ror.org/04jpdpb33', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I15881080', 'https://openalex.org/I4210147606']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I15881080', 'display_name': 'National University of Cuyo', 'ror': 'https://ror.org/05sn8wf81', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I15881080']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'M.A. Sosa', 'raw_affiliation_strings': ['Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Casilla de Correo 56, Centro Universitario, Parque General San Martín, (5500) Mendoza, Argentina', 'institution_ids': ['https://openalex.org/I4210147606', 'https://openalex.org/I151201029', 'https://openalex.org/I15881080']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.398, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.611894, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '158', 'issue': '1-2', 'first_page': '23', 'last_page': '30'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9592, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9592, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders in Human Health and Disease', 'score': 0.9485, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.948, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mannose-6-phosphate', 'display_name': 'Mannose 6-phosphate', 'score': 0.8232224}, {'id': 'https://openalex.org/keywords/mannose-receptor', 'display_name': 'Mannose receptor', 'score': 0.62474793}, {'id': 'https://openalex.org/keywords/mannose-6-phosphate-receptor', 'display_name': 'Mannose 6-phosphate receptor', 'score': 0.44105226}, {'id': 'https://openalex.org/keywords/membrane-fusion', 'display_name': 'Membrane Fusion', 'score': 0.432652}], 'concepts': [{'id': 'https://openalex.org/C2778822930', 'wikidata': 'https://www.wikidata.org/wiki/Q259546', 'display_name': 'Mannose 6-phosphate', 'level': 4, 'score': 0.8232224}, {'id': 'https://openalex.org/C2775887612', 'wikidata': 'https://www.wikidata.org/wiki/Q10809118', 'display_name': 'Mannose', 'level': 2, 'score': 0.8076047}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.7462509}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.73553216}, {'id': 'https://openalex.org/C2776205754', 'wikidata': 'https://www.wikidata.org/wiki/Q6750945', 'display_name': 'Mannose receptor', 'level': 4, 'score': 0.62474793}, {'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.6014806}, {'id': 'https://openalex.org/C2777132085', 'wikidata': 'https://www.wikidata.org/wiki/Q46220103', 'display_name': 'Phosphate', 'level': 2, 'score': 0.4699799}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.45834374}, {'id': 'https://openalex.org/C120694314', 'wikidata': 'https://www.wikidata.org/wiki/Q6750941', 'display_name': 'Mannose 6-phosphate receptor', 'level': 4, 'score': 0.44105226}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40320423}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3979183}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.3852911}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37015092}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.34543598}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.1647175}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.102484256}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.06258455}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002412', 'descriptor_name': 'Cations', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D017527', 'descriptor_name': 'Receptor, IGF Type 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000367', 'descriptor_name': 'Age Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002412', 'descriptor_name': 'Cations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005966', 'descriptor_name': 'Glucuronidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005966', 'descriptor_name': 'Glucuronidase', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D005966', 'descriptor_name': 'Glucuronidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006868', 'descriptor_name': 'Hydrolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017527', 'descriptor_name': 'Receptor, IGF Type 2', 'qualifier_ui': 'Q000145', 'qualifier_name': 'classification', 'is_major_topic': False}, {'descriptor_ui': 'D017527', 'descriptor_name': 'Receptor, IGF Type 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017527', 'descriptor_name': 'Receptor, IGF Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013347', 'descriptor_name': 'Subcellular Fractions', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D013347', 'descriptor_name': 'Subcellular Fractions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.devbrainres.2005.05.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S20757867', 'display_name': 'Developmental Brain Research', 'issn_l': '0165-3806', 'issn': ['0165-3806', '1872-6755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15982751', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 68, 'referenced_works': ['https://openalex.org/W125445627', 'https://openalex.org/W1496231783', 'https://openalex.org/W1544577728', 'https://openalex.org/W1552727119', 'https://openalex.org/W1567768297', 'https://openalex.org/W158017865', 'https://openalex.org/W1596979305', 'https://openalex.org/W1617969468', 'https://openalex.org/W1717541169', 'https://openalex.org/W172453087', 'https://openalex.org/W1775749144', 'https://openalex.org/W1797007315', 'https://openalex.org/W1820732010', 'https://openalex.org/W1965293509', 'https://openalex.org/W1965784244', 'https://openalex.org/W1966908061', 'https://openalex.org/W1968646067', 'https://openalex.org/W1971939987', 'https://openalex.org/W1973584991', 'https://openalex.org/W1975522141', 'https://openalex.org/W1978538506', 'https://openalex.org/W1980408578', 'https://openalex.org/W1986100321', 'https://openalex.org/W1990862055', 'https://openalex.org/W1993356072', 'https://openalex.org/W2001639671', 'https://openalex.org/W2004473236', 'https://openalex.org/W2006068317', 'https://openalex.org/W2009928329', 'https://openalex.org/W2020850810', 'https://openalex.org/W2021721582', 'https://openalex.org/W2031997272', 'https://openalex.org/W2040180944', 'https://openalex.org/W2041166963', 'https://openalex.org/W2041229020', 'https://openalex.org/W2042195196', 'https://openalex.org/W2045823022', 'https://openalex.org/W2046453156', 'https://openalex.org/W2053113288', 'https://openalex.org/W2058858640', 'https://openalex.org/W2073246440', 'https://openalex.org/W2074501368', 'https://openalex.org/W2083270783', 'https://openalex.org/W2083652796', 'https://openalex.org/W2085787620', 'https://openalex.org/W2088606198', 'https://openalex.org/W2095017414', 'https://openalex.org/W2103049426', 'https://openalex.org/W2105256463', 'https://openalex.org/W2105408661', 'https://openalex.org/W2112222544', 'https://openalex.org/W2127619125', 'https://openalex.org/W2131380785', 'https://openalex.org/W2140984295', 'https://openalex.org/W2145518958', 'https://openalex.org/W2147218892', 'https://openalex.org/W2158681568', 'https://openalex.org/W2166004416', 'https://openalex.org/W2316958623', 'https://openalex.org/W2328647730', 'https://openalex.org/W2345426411', 'https://openalex.org/W2474303973', 'https://openalex.org/W4234664852', 'https://openalex.org/W4239201415', 'https://openalex.org/W4242488005', 'https://openalex.org/W4245090902', 'https://openalex.org/W4250313948', 'https://openalex.org/W4295202935'], 'related_works': ['https://openalex.org/W4389750119', 'https://openalex.org/W2468125839', 'https://openalex.org/W2132855664', 'https://openalex.org/W2075267760', 'https://openalex.org/W2053061893', 'https://openalex.org/W1994117019', 'https://openalex.org/W1980427216', 'https://openalex.org/W1972131742', 'https://openalex.org/W195644537', 'https://openalex.org/W1808900192'], 'abstract_inverted_index': {'Mannose-6-phosphate': [0], 'receptors': [1, 150], '(MPRs)': [2], 'play': [3, 151], 'a': [4, 152], 'role': [5, 46, 154], 'in': [6, 26, 47, 62, 103, 126, 155, 165], 'the': [7, 32, 48, 52, 72, 83, 87, 104, 110, 119], 'selective': [8], 'transport': [9], 'of': [10, 21, 28, 57, 74, 90, 122, 132], 'macromolecules': [11], 'bearing': [12], 'mannose-6-phosphate': [13, 37], 'residue': [14], 'to': [15, 42, 80, 97], 'lysosomes.': [16], 'To': [17], 'date,': [18], 'two': [19], 'types': [20], 'MPRs': [22, 59], 'have': [23], 'been': [24], 'described': [25], 'most': [27], 'cells': [29], 'and': [30, 35, 54, 92, 106, 113, 130], 'tissues:': [31], 'cation-dependent': [33], '(CD-MPR)': [34], 'cation-independent': [36], 'receptor': [38], '(CI-MPR).': [39], 'In': [40], 'order': [41], 'elucidate': [43], 'their': [44], 'possible': [45], 'central': [49], 'nervous': [50], 'system,': [51], 'expression': [53, 73, 120, 131], 'binding': [55], 'properties': [56], 'both': [58, 123, 149], 'were': [60], 'studied': [61], 'rat': [63, 156], 'brain': [64, 157], 'along': [65], 'perinatal': [66, 159], 'development.': [67], 'It': [68], 'was': [69], 'observed': [70], 'that': [71, 148], 'CI-MPR': [75, 143], 'decreases': [76], 'progressively': [77], 'from': [78], 'fetuses': [79], 'adults,': [81], 'while': [82], 'CD-MPR': [84, 140, 162], 'increases': [85], 'around': [86], '10th': [88], 'day': [89], 'birth,': [91], 'maintains': [93], 'these': [94], 'values': [95, 108], 'up': [96], 'adulthood.': [98], 'Binding': [99], 'assays': [100], 'showed': [101], 'differences': [102], 'Bmax': [105], 'KD': [107], 'between': [109], 'ages': [111], 'studied,': [112], 'they': [114], 'did': [115], 'not': [116], 'correlate': [117], 'with': [118, 139, 142], 'levels': [121], 'MPRs.': [124], 'Variations': [125], 'lysosomal': [127], 'enzyme': [128], 'activities': [129], 'phosphomannosylated': [133], 'ligands': [134], 'during': [135, 158], 'development': [136], 'correlated': [137], 'more': [138], 'than': [141], 'expression.': [144], 'These': [145], 'results': [146], 'suggest': [147], 'different': [153], 'development,': [160], 'being': [161], 'mostly': [163], 'involved': [164], 'lysosome': [166], 'maturation.': [167]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1972131742', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-17T14:54:08.824826', 'created_date': '2016-06-24'}