Title: Differential expression of neprilysin ?enkephalinase? mRNA transcripts in rat brain
Abstract: Neprilysin (NEP; EC 3.4.24.11), also referred to as neutral endopeptidase 24.11 or “enkephalinase”, regulates the concentration of extracellular enkephalins available for peptide receptor binding. We have examined the expression patterns of three NEP mRNA transcripts (type 1, type 2b and type 3) in rat brain tissue using non-isotopic in situ hybridization techniques. The results indicate that the different NEP transcripts are not uniformly expressed in brain, but show specific regional and cellular distributions. The type 1 and type 2b transcripts were most abundant and had a distribution reflecting neuronal localization. The type 3 mRNA was a rare transcript and was primarily localized to myelinated pathways of the central nervous system. Differential expression of NEP transcripts in a regional and cell specific manner may allow specific functions to be attributed to the various NEP mRNAs and thereby account for the differential regulation of expression of these mRNAs at the transcriptional level.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 2
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