Publication Information

{'id': 'https://openalex.org/W1971950891', 'doi': 'https://doi.org/10.1002/mus.880050115', 'title': 'Treatment of ongoing experimental myasthenia gravis with short term high dose cyclophosphamide', 'display_name': 'Treatment of ongoing experimental myasthenia gravis with short term high dose cyclophosphamide', 'publication_year': 1982, 'publication_date': '1982-01-01', 'ids': {'openalex': 'https://openalex.org/W1971950891', 'doi': 'https://doi.org/10.1002/mus.880050115', 'mag': '1971950891', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6977088'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/mus.880050115', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S173274907', 'display_name': 'Muscle & Nerve', 'issn_l': '0148-639X', 'issn': ['0148-639X', '1097-4598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025781296', 'display_name': 'Alan Pestronk', 'orcid': 'https://orcid.org/0000-0002-8991-5770'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}, {'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan Pestronk', 'raw_affiliation_strings': ['Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948', 'https://openalex.org/I2799853436']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112223794', 'display_name': 'Daniel B. Drachman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel B. Drachman', 'raw_affiliation_strings': ['Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD.', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111675354', 'display_name': 'Robert N. Adams', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert N. Adams', 'raw_affiliation_strings': ['Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD.', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4530, 'currency': 'USD', 'value_usd': 4530, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.079, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.844508, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '5', 'issue': '1', 'first_page': '79', 'last_page': '84'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11271', 'display_name': 'Myasthenia Gravis and Thymoma', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11271', 'display_name': 'Myasthenia Gravis and Thymoma', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10150', 'display_name': 'Antifungal resistance and susceptibility', 'score': 0.934, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.905, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778105408', 'wikidata': 'https://www.wikidata.org/wiki/Q8285', 'display_name': 'Myasthenia gravis', 'level': 2, 'score': 0.95966756}, {'id': 'https://openalex.org/C2776755627', 'wikidata': 'https://www.wikidata.org/wiki/Q408524', 'display_name': 'Cyclophosphamide', 'level': 3, 'score': 0.85537916}, {'id': 'https://openalex.org/C80161118', 'wikidata': 'https://www.wikidata.org/wiki/Q408520', 'display_name': 'Acetylcholine receptor', 'level': 3, 'score': 0.7337858}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6955467}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.617877}, {'id': 'https://openalex.org/C2777240379', 'wikidata': 'https://www.wikidata.org/wiki/Q776995', 'display_name': 'Neuromuscular junction', 'level': 2, 'score': 0.5420024}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.48680493}, {'id': 'https://openalex.org/C2779075594', 'wikidata': 'https://www.wikidata.org/wiki/Q8084905', 'display_name': 'Autoimmune disease', 'level': 3, 'score': 0.4814955}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.43206528}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.31015748}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2721141}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.26608026}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1529626}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003520', 'descriptor_name': 'Cyclophosphamide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009157', 'descriptor_name': 'Myasthenia Gravis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D003520', 'descriptor_name': 'Cyclophosphamide', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D003520', 'descriptor_name': 'Cyclophosphamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009157', 'descriptor_name': 'Myasthenia Gravis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009157', 'descriptor_name': 'Myasthenia Gravis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011917', 'descriptor_name': 'Rats, Inbred Lew', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/mus.880050115', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S173274907', 'display_name': 'Muscle & Nerve', 'issn_l': '0148-639X', 'issn': ['0148-639X', '1097-4598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6977088', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.88, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 17, 'referenced_works': ['https://openalex.org/W1921745771', 'https://openalex.org/W1982150827', 'https://openalex.org/W2004630889', 'https://openalex.org/W2013292781', 'https://openalex.org/W2020736956', 'https://openalex.org/W2024990200', 'https://openalex.org/W2029769666', 'https://openalex.org/W2032883446', 'https://openalex.org/W2035909636', 'https://openalex.org/W2048046323', 'https://openalex.org/W2137937004', 'https://openalex.org/W2331112163', 'https://openalex.org/W2337135035', 'https://openalex.org/W2399457679', 'https://openalex.org/W4237377959', 'https://openalex.org/W4295682875', 'https://openalex.org/W5387557'], 'related_works': ['https://openalex.org/W4242664158', 'https://openalex.org/W4233150862', 'https://openalex.org/W2775018575', 'https://openalex.org/W2417178085', 'https://openalex.org/W2161256203', 'https://openalex.org/W2103815723', 'https://openalex.org/W2035919986', 'https://openalex.org/W2004458579', 'https://openalex.org/W1999552103', 'https://openalex.org/W1953864717'], 'abstract_inverted_index': {'We': [0], 'have': [1], 'treated': [2, 105], 'animals': [3, 106], 'with': [4, 120], 'an': [5, 88, 132], 'ongoing': [6], 'autoimmune': [7, 10, 148], 'disease,': [8], 'experimental': [9], 'myasthenia': [11, 144], 'gravis': [12, 145], '(EAMG),': [13], 'using': [14], 'a': [15, 26, 61], 'strategy': [16], 'designed': [17], 'to': [18, 91], 'eliminate': [19], 'the': [20, 43, 47, 49, 71, 78, 92, 102, 109], 'antibody-producing': [21], 'cells.': [22], 'During': [23], 'well-established': [24], 'EAMG,': [25], 'single': [27], 'high': [28, 129], 'dose': [29], 'of': [30, 35, 46, 66, 127, 131], 'cyclophosphamide': [31], 'was': [32, 94], 'given': [33], 'because': [34], 'its': [36], 'known': [37], 'effectiveness': [38], 'against': [39, 69], 'B-lymphocytes.': [40], 'To': [41], 'counteract': [42], 'lethal': [44], 'effects': [45], 'drug,': [48, 134], 'rats': [50], 'were': [51], '"rescued"': [52], 'by': [53, 87], 'bone': [54], 'marrow': [55], 'cell': [56], 'transplantation.': [57], 'This': [58, 124], 'treatment': [59, 98, 125], 'produced': [60, 99], 'rapid': [62], 'and': [63, 77, 146], 'sustained': [64], 'fall': [65], 'antibody': [67], 'titers': [68], 'both': [70], 'immunizing': [72], 'antigen': [73], '(Torpedo': [74], 'acetylcholine': [75, 81, 114], 'receptor)': [76], 'autoantigen': [79], '(rat': [80], 'receptor).': [82], 'Immunologic': [83], 'memory,': [84], 'as': [85, 112, 136], 'measured': [86], 'anamnestic': [89], 'response': [90], 'antigen,': [93], 'partially': [95], 'suppressed.': [96], 'Cyclophosphamide': [97], 'improvement': [100], 'in': [101], 'neuromuscular': [103, 117], 'defect:': [104], 'had,': [107], 'on': [108], 'average,': [110], 'twice': [111], 'many': [113], 'receptors': [115], 'at': [116], 'junctions': [118], 'compared': [119], 'untreated': [121], 'EAMG': [122], 'animals.': [123], 'method': [126], 'short-term': [128], 'doses': [130], 'immunosuppressive': [133], 'such': [135], 'cyclophosphamide,': [137], 'may': [138], 'eventually': [139], 'prove': [140], 'useful': [141], 'for': [142], 'human': [143], 'other': [147], 'diseases.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1971950891', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-15T15:29:47.637917', 'created_date': '2016-06-24'}