Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1971852532', 'doi': 'https://doi.org/10.1111/j.1365-2826.2005.01275.x', 'title': 'Inhibition by Lipopolysaccharide of Naloxone‐Induced Luteinising Hormone Secretion Is Accompanied by Increases in Corticotropin‐Releasing Factor Immunoreactivity in Hypothalamic Paraventricular Neurones in Female Rats', 'display_name': 'Inhibition by Lipopolysaccharide of Naloxone‐Induced Luteinising Hormone Secretion Is Accompanied by Increases in Corticotropin‐Releasing Factor Immunoreactivity in Hypothalamic Paraventricular Neurones in Female Rats', 'publication_year': 2005, 'publication_date': '2005-02-01', 'ids': {'openalex': 'https://openalex.org/W1971852532', 'doi': 'https://doi.org/10.1111/j.1365-2826.2005.01275.x', 'mag': '1971852532', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15796756'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2826.2005.01275.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100175869', 'display_name': 'Journal of Neuroendocrinology', 'issn_l': '0953-8194', 'issn': ['0953-8194', '1365-2826'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086263307', 'display_name': 'D. He', 'orcid': 'https://orcid.org/0000-0002-0697-918X'}, 'institutions': [{'id': 'https://openalex.org/I163917720', 'display_name': 'St. Marianna University School of Medicine', 'ror': 'https://ror.org/043axf581', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I163917720']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'D. He', 'raw_affiliation_strings': ['Department of Physiology, St Mariana University School of Medicine, Kawasaki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, St Mariana University School of Medicine, Kawasaki, Japan.', 'institution_ids': ['https://openalex.org/I163917720']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017825564', 'display_name': 'Tatsuo Akema', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I163917720', 'display_name': 'St. Marianna University School of Medicine', 'ror': 'https://ror.org/043axf581', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I163917720']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'T. Akema', 'raw_affiliation_strings': ['Department of Physiology, St Mariana University School of Medicine, Kawasaki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, St Mariana University School of Medicine, Kawasaki, Japan.', 'institution_ids': ['https://openalex.org/I163917720']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4120, 'currency': 'USD', 'value_usd': 4120, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.334, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.425296, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 74, 'max': 76}, 'biblio': {'volume': '17', 'issue': '2', 'first_page': '67', 'last_page': '72'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10529', 'display_name': 'Stress Responses and Cortisol', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10529', 'display_name': 'Stress Responses and Cortisol', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2802', 'display_name': 'Behavioral Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10960', 'display_name': 'Hypothalamic control of reproductive hormones', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11541', 'display_name': 'Neuroendocrine regulation and behavior', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/corticotropin-releasing-hormone', 'display_name': 'Corticotropin-releasing hormone', 'score': 0.5230875}], 'concepts': [{'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.9204204}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.91839886}, {'id': 'https://openalex.org/C2778750930', 'wikidata': 'https://www.wikidata.org/wiki/Q4540629', 'display_name': '(+)-Naloxone', 'level': 4, 'score': 0.6864004}, {'id': 'https://openalex.org/C2777003273', 'wikidata': 'https://www.wikidata.org/wiki/Q164386', 'display_name': 'Hypothalamus', 'level': 2, 'score': 0.5532399}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.54645264}, {'id': 'https://openalex.org/C2778458438', 'wikidata': 'https://www.wikidata.org/wiki/Q386664', 'display_name': 'Corticotropin-releasing hormone', 'level': 3, 'score': 0.5230875}, {'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.5098478}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32557017}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.32445526}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.17607948}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.16466552}], 'mesh': [{'descriptor_ui': 'D003346', 'descriptor_name': 'Corticotropin-Releasing Hormone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007986', 'descriptor_name': 'Luteinizing Hormone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010286', 'descriptor_name': 'Paraventricular Hypothalamic Nucleus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003346', 'descriptor_name': 'Corticotropin-Releasing Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003346', 'descriptor_name': 'Corticotropin-Releasing Hormone', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D004347', 'descriptor_name': 'Drug Interactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007986', 'descriptor_name': 'Luteinizing Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009270', 'descriptor_name': 'Naloxone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010286', 'descriptor_name': 'Paraventricular Hypothalamic Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010286', 'descriptor_name': 'Paraventricular Hypothalamic Nucleus', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D010286', 'descriptor_name': 'Paraventricular Hypothalamic Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2826.2005.01275.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S100175869', 'display_name': 'Journal of Neuroendocrinology', 'issn_l': '0953-8194', 'issn': ['0953-8194', '1365-2826'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15796756', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.72}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1606525067', 'https://openalex.org/W1975004575', 'https://openalex.org/W1984982968', 'https://openalex.org/W1988357762', 'https://openalex.org/W1989930625', 'https://openalex.org/W1992096020', 'https://openalex.org/W1994554622', 'https://openalex.org/W1997663624', 'https://openalex.org/W2001517653', 'https://openalex.org/W2003414096', 'https://openalex.org/W2003851346', 'https://openalex.org/W2005730675', 'https://openalex.org/W2009577814', 'https://openalex.org/W2018822787', 'https://openalex.org/W2022460131', 'https://openalex.org/W2022861187', 'https://openalex.org/W2029720858', 'https://openalex.org/W2030989982', 'https://openalex.org/W2031511472', 'https://openalex.org/W2036118884', 'https://openalex.org/W2041671212', 'https://openalex.org/W2047610987', 'https://openalex.org/W2057238209', 'https://openalex.org/W2060770504', 'https://openalex.org/W2063028128', 'https://openalex.org/W2066134103', 'https://openalex.org/W2073220227', 'https://openalex.org/W2080575722', 'https://openalex.org/W2083674897', 'https://openalex.org/W2087733361', 'https://openalex.org/W2097414936', 'https://openalex.org/W2111201023', 'https://openalex.org/W2114689251', 'https://openalex.org/W2126792672', 'https://openalex.org/W2142650429', 'https://openalex.org/W2168469772', 'https://openalex.org/W2419461630', 'https://openalex.org/W4232173740', 'https://openalex.org/W4242471615', 'https://openalex.org/W4252947737'], 'related_works': ['https://openalex.org/W4224115270', 'https://openalex.org/W2436675439', 'https://openalex.org/W2361969180', 'https://openalex.org/W2358350851', 'https://openalex.org/W2087562989', 'https://openalex.org/W2065284647', 'https://openalex.org/W2040198728', 'https://openalex.org/W2036495427', 'https://openalex.org/W1991344898', 'https://openalex.org/W1859472238'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1], 'have': [2], 'recently': [3], 'reported': [4], 'that': [5, 140, 175], 'lipopolysaccharide': [6], '(LPS),': [7], 'a': [8, 97, 153], 'bacterial': [9], 'endotoxin,': [10], 'inhibits': [11, 187], 'steroid‐induced': [12], 'as': [13, 15], 'well': [14], 'naloxone‐induced': [16, 164], 'luteinising': [17], 'hormone': [18], '(LH)': [19], 'secretion': [20, 189], 'in': [21, 38, 106, 128, 141, 181, 185], 'ovariectomised': [22], 'oestrogen‐primed': [23], 'rats.': [24], 'In': [25, 90, 152], 'the': [26, 39, 81, 107, 111, 131, 145, 168], 'present': [27], 'study,': [28], 'we': [29], 'examined': [30, 88], 'whether': [31], 'corticotropin‐releasing': [32], 'factor': [33], '(CRF)': [34], 'may': [35], 'be': [36], 'involved': [37], 'LPS‐induced': [40], 'inhibition': [41], 'of': [42, 54, 65, 77, 100, 110, 133, 147, 159, 170, 179], 'LH': [43, 79, 121, 165, 188], 'secretion.': [44], 'Unanaesthetised': [45], 'rats': [46, 92], 'were': [47, 73, 83, 104], 'treated': [48], 'with': [49], 'an': [50, 62, 156], 'intravenous': [51], '(i.v.)': [52], 'injection': [53, 64, 158], 'LPS': [55, 176], '(10': [56], 'µg)': [57], 'or': [58], 'saline,': [59], 'followed': [60], 'by': [61], 'i.v.': [63], 'naloxone': [66, 117, 148], '(20': [67], 'mg/kg).': [68], 'After': [69], 'sequential': [70], 'blood': [71], 'samples': [72], 'collected': [74], 'for': [75], 'determination': [76], 'serum': [78, 120], 'concentrations,': [80], 'brains': [82], 'fixed': [84], 'and': [85, 116, 144], 'CRF‐immunoreactivity': [86], 'was': [87, 136, 149], 'histochemically.': [89], 'control': [91, 142], 'receiving': [93], 'saline': [94], 'injections,': [95], 'only': [96], 'small': [98], 'number': [99, 132], 'CRF‐immunoreactive': [101], '(ir)': [102], 'cells': [103, 135], 'found': [105], 'parvocellular': [108], 'portion': [109], 'hypothalamic': [112], 'paraventricular': [113], 'nucleus': [114], '(PVN),': [115], 'significantly': [118, 137], 'increased': [119], 'concentrations': [122], 'within': [123], '10': [124], 'min.': [125], 'By': [126], 'contrast,': [127], 'LPS‐treated': [129], 'rats,': [130, 143], 'CRF‐ir': [134], 'greater': [138], 'than': [139], 'effect': [146, 169], 'completely': [150], 'abolished.': [151], 'separate': [154], 'experiment,': [155], 'intracerebroventricular': [157], '5': [160], 'µg': [161], 'CRF': [162, 180], 'inhibited': [163], 'release,': [166], 'mimicking': [167], 'LPS.': [171], 'These': [172], 'results': [173], 'suggest': [174], 'stimulates': [177], 'production': [178], 'PVN': [182], 'neurones,': [183], 'which': [184], 'turn': [186], 'without': [190], 'opioidergic': [191], 'mediation.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1971852532', 'counts_by_year': [], 'updated_date': '2024-12-14T07:45:48.515773', 'created_date': '2016-06-24'}