The Relation of Leukotrienes to Liver Injury

Name: Work Video:
Duration: 3 min 30 s
Dietrich Keppler; Wolfgang Hagmann; S. Rapp; Claudio Denzlinger; Herbert K. Koch
{'id': 'https://openalex.org/W1971471687', 'doi': 'https://doi.org/10.1002/hep.1840050530', 'title': 'The Relation of Leukotrienes to Liver Injury', 'display_name': 'The Relation of Leukotrienes to Liver Injury', 'publication_year': 1985, 'publication_date': '1985-09-01', 'ids': {'openalex': 'https://openalex.org/W1971471687', 'doi': 'https://doi.org/10.1002/hep.1840050530', 'mag': '1971471687', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3897018'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/hep.1840050530', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.1840050530', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.1840050530', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002662351', 'display_name': 'Dietrich Keppler', 'orcid': 'https://orcid.org/0000-0003-2964-2333'}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Dietrich Keppler', 'raw_affiliation_strings': ['Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany'], 'affiliations': [{'raw_affiliation_string': 'Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057459313', 'display_name': 'Wolfgang Hagmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Wolfgang Hagmann', 'raw_affiliation_strings': ['Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany'], 'affiliations': [{'raw_affiliation_string': 'Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073127029', 'display_name': 'S. Rapp', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Stephan Rapp', 'raw_affiliation_strings': ['Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany'], 'affiliations': [{'raw_affiliation_string': 'Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062968394', 'display_name': 'Claudio Denzlinger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Claudio Denzlinger', 'raw_affiliation_strings': ['Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany'], 'affiliations': [{'raw_affiliation_string': 'Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110827131', 'display_name': 'Herbert K. Koch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Herbert K. Koch', 'raw_affiliation_strings': ['Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany'], 'affiliations': [{'raw_affiliation_string': 'Biochemisches Institut and Pathologisches Institut, University of Freiburg im Breisgau, D‐7800 Freiburg, West Germany', 'institution_ids': ['https://openalex.org/I161046081']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.732, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 211, 'citation_normalized_percentile': {'value': 0.723404, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '5', 'issue': '5', 'first_page': '883', 'last_page': '891'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9865, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9865, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11635', 'display_name': 'Poisoning and overdose treatments', 'score': 0.9779, 'subfield': {'id': 'https://openalex.org/subfields/2711', 'display_name': 'Emergency Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10875', 'display_name': 'Pesticide Exposure and Toxicity', 'score': 0.9728, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C25343380', 'wikidata': 'https://www.wikidata.org/wiki/Q277521', 'display_name': 'Relation (database)', 'level': 2, 'score': 0.46482307}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.44291085}, {'id': 'https://openalex.org/C74916050', 'wikidata': 'https://www.wikidata.org/wiki/Q841090', 'display_name': 'Classics', 'level': 1, 'score': 0.40778774}, {'id': 'https://openalex.org/C95457728', 'wikidata': 'https://www.wikidata.org/wiki/Q309', 'display_name': 'History', 'level': 0, 'score': 0.16814342}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C77088390', 'wikidata': 'https://www.wikidata.org/wiki/Q8513', 'display_name': 'Database', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D013189', 'descriptor_name': 'SRS-A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001646', 'descriptor_name': 'Bile', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D001646', 'descriptor_name': 'Bile', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056486', 'descriptor_name': 'Chemical and Drug Induced Liver Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002779', 'descriptor_name': 'Cholestasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002779', 'descriptor_name': 'Cholestasis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007728', 'descriptor_name': 'Kupffer Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007728', 'descriptor_name': 'Kupffer Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D008407', 'descriptor_name': 'Mast Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008407', 'descriptor_name': 'Mast Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008970', 'descriptor_name': 'Molecular Weight', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013189', 'descriptor_name': 'SRS-A', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D013189', 'descriptor_name': 'SRS-A', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D013189', 'descriptor_name': 'SRS-A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013189', 'descriptor_name': 'SRS-A', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/hep.1840050530', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.1840050530', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3897018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/hep.1840050530', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.1840050530', 'source': {'id': 'https://openalex.org/S156174673', 'display_name': 'Hepatology', 'issn_l': '0270-9139', 'issn': ['0270-9139', '1527-3350'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.51, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 95, 'referenced_works': ['https://openalex.org/W115374393', 'https://openalex.org/W1505976169', 'https://openalex.org/W1559121852', 'https://openalex.org/W1574332929', 'https://openalex.org/W1605053531', 'https://openalex.org/W1607010538', 'https://openalex.org/W16075687', 'https://openalex.org/W1649143309', 'https://openalex.org/W1684261677', 'https://openalex.org/W1769616531', 'https://openalex.org/W1966620372', 'https://openalex.org/W1970468741', 'https://openalex.org/W1973366892', 'https://openalex.org/W1974852622', 'https://openalex.org/W1977089571', 'https://openalex.org/W1979558578', 'https://openalex.org/W1983397523', 'https://openalex.org/W1987425357', 'https://openalex.org/W1988885639', 'https://openalex.org/W1993643873', 'https://openalex.org/W1993725936', 'https://openalex.org/W1994843637', 'https://openalex.org/W1999057730', 'https://openalex.org/W1999285629', 'https://openalex.org/W1999425237', 'https://openalex.org/W2004351423', 'https://openalex.org/W2004700610', 'https://openalex.org/W2005322998', 'https://openalex.org/W2005325254', 'https://openalex.org/W2011577549', 'https://openalex.org/W2011854272', 'https://openalex.org/W2015496429', 'https://openalex.org/W2017680205', 'https://openalex.org/W2022456234', 'https://openalex.org/W2022533979', 'https://openalex.org/W2022792869', 'https://openalex.org/W2023265161', 'https://openalex.org/W2027704731', 'https://openalex.org/W2030253110', 'https://openalex.org/W2031419185', 'https://openalex.org/W2032830404', 'https://openalex.org/W2033426097', 'https://openalex.org/W2036881146', 'https://openalex.org/W2037022310', 'https://openalex.org/W2043602216', 'https://openalex.org/W2048521817', 'https://openalex.org/W2049065283', 'https://openalex.org/W2056343330', 'https://openalex.org/W2061393907', 'https://openalex.org/W2064524249', 'https://openalex.org/W2065234246', 'https://openalex.org/W2066271854', 'https://openalex.org/W2066950125', 'https://openalex.org/W2067901510', 'https://openalex.org/W2069081720', 'https://openalex.org/W2072099683', 'https://openalex.org/W2075029445', 'https://openalex.org/W2075673909', 'https://openalex.org/W2080657937', 'https://openalex.org/W2085887833', 'https://openalex.org/W2088404151', 'https://openalex.org/W2091383827', 'https://openalex.org/W2092971835', 'https://openalex.org/W2094395704', 'https://openalex.org/W2097685656', 'https://openalex.org/W2132727601', 'https://openalex.org/W2137613075', 'https://openalex.org/W2141817909', 'https://openalex.org/W2162185150', 'https://openalex.org/W2168049797', 'https://openalex.org/W218365305', 'https://openalex.org/W2237532145', 'https://openalex.org/W2272409965', 'https://openalex.org/W2313196016', 'https://openalex.org/W2320958616', 'https://openalex.org/W2327878210', 'https://openalex.org/W2409845129', 'https://openalex.org/W2413045881', 'https://openalex.org/W2415050981', 'https://openalex.org/W2418159926', 'https://openalex.org/W2475198120', 'https://openalex.org/W2478284359', 'https://openalex.org/W2478529386', 'https://openalex.org/W2483235927', 'https://openalex.org/W2561468230', 'https://openalex.org/W28254441', 'https://openalex.org/W2889107333', 'https://openalex.org/W3103793334', 'https://openalex.org/W3145954235', 'https://openalex.org/W38003271', 'https://openalex.org/W4242755902', 'https://openalex.org/W4244271951', 'https://openalex.org/W52439888', 'https://openalex.org/W644769947', 'https://openalex.org/W95558536'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W4234874385', 'https://openalex.org/W2899084033', 'https://openalex.org/W2748952813', 'https://openalex.org/W2388988621', 'https://openalex.org/W2378782423', 'https://openalex.org/W2366623913', 'https://openalex.org/W2357797405', 'https://openalex.org/W2323648130', 'https://openalex.org/W2157140558'], 'abstract_inverted_index': {'HepatologyVolume': [0], '5,': [1], 'Issue': [2], '5': [3, 406], 'p.': [4], '883-891': [5, 2821], 'Special': [6], 'ArticleFree': [7], 'Access': [8], 'The': [9, 373, 786, 1530, 1794, 2129, 2304], 'relation': [10], 'of': [11, 30, 62, 85, 108, 133, 161, 193, 216, 239, 264, 303, 313, 326, 337, 358, 399, 417, 485, 508, 511, 531, 582, 597, 651, 680, 685, 713, 722, 767, 770, 777, 804, 811, 850, 898, 902, 928, 955, 995, 1020, 1047, 1053, 1084, 1153, 1200, 1217, 1238, 1281, 1291, 1307, 1333, 1351, 1375, 1424, 1430, 1437, 1448, 1463, 1508, 1532, 1556, 1564, 1586, 1605, 1618, 1640, 1662, 1734, 1765, 1768, 1774, 1797, 1849, 1878, 1881, 1885, 1905, 1932, 1936, 1939, 1958, 2004, 2014, 2036, 2043, 2065, 2087, 2113, 2131, 2142, 2165, 2172, 2196, 2231, 2237, 2244, 2265, 2293, 2324, 2368, 2434, 2454, 2485, 2527, 2532, 2554, 2593, 2611, 2664, 2674, 2700, 2711, 2720, 2745, 2764, 2771, 2795], 'leukotrienes': [12, 513, 533, 716, 805, 903, 957, 1021, 1085, 1155, 1334, 1425, 1533, 1557, 1798, 1880, 1931, 2088, 2132], 'to': [13, 287, 309, 332, 655, 939, 1117, 1372, 1803, 2280, 2482, 2621], 'liver': [14, 557, 1218, 1668, 2243, 2274, 2679, 2766], 'injury': [15], 'Dietrich': [16, 21, 147, 152], 'Keppler': [17, 22, 148, 153, 528, 547, 952, 2499], 'M.D.,': [18, 149], 'Corresponding': [19, 150], 'Author': [20, 151], 'M.D.': [23, 154], 'Biochemisches': [24, 56, 79, 102, 127, 155, 187, 210, 233, 258], 'Institut': [25, 38, 57, 80, 103, 128, 156, 169, 188, 211, 234, 259], 'and': [26, 58, 81, 104, 129, 157, 189, 212, 235, 260, 301, 305, 317, 324, 343, 362, 397, 414, 428, 440, 454, 483, 534, 556, 615, 631, 678, 711, 749, 764, 789, 905, 912, 1000, 1061, 1066, 1087, 1178, 1184, 1313, 1368, 1398, 1402, 1443, 1567, 1611, 1638, 1647, 1669, 1701, 1713, 1771, 1801, 1807, 1825, 1832, 1860, 1983, 2008, 2039, 2062, 2067, 2085, 2089, 2106, 2115, 2135, 2210, 2246, 2269, 2296, 2307, 2395, 2478, 2613, 2668, 2798], 'Pathologisches': [27, 59, 82, 105, 130, 158, 190, 213, 236, 261], 'Institut,': [28, 60, 83, 106, 131, 159, 191, 214, 237, 262], 'University': [29, 61, 84, 107, 132, 160, 192, 215, 238, 263], 'Freiburg': [31, 63, 86, 109, 134, 162, 194, 217, 240, 265], 'im': [32, 64, 87, 110, 135, 163, 195, 218, 241, 266], 'Breisgau,': [33, 65, 88, 111, 136, 164, 196, 219, 242, 267], 'D-7800': [34, 43, 66, 89, 112, 137, 165, 174, 197, 220, 243, 268], 'Freiburg,': [35, 44, 67, 90, 113, 138, 166, 175, 198, 221, 244, 269], 'West': [36, 45, 68, 91, 114, 139, 167, 176, 199, 222, 245, 270], 'GermanyBiochemisches': [37, 168], 'der': [39, 170], 'Universität,': [40, 171], 'Hermann-Herder-Str.': [41, 172], '7,': [42, 173], 'Germany===Search': [46, 177], 'for': [47, 70, 93, 116, 141, 178, 201, 224, 247, 272, 815, 931, 1278, 1433, 1445, 1986, 2717], 'more': [48, 71, 94, 117, 142, 179, 202, 225, 248, 273], 'papers': [49, 72, 95, 118, 143, 180, 203, 226, 249, 274], 'by': [50, 73, 96, 119, 144, 181, 204, 227, 250, 275, 514, 659, 717, 745, 774, 806, 854, 934, 1484, 1538, 1559, 1643, 1665, 1827, 1914, 1964, 2018, 2046, 2109, 2327, 2371, 2589, 2677, 2804], 'this': [51, 74, 97, 120, 145, 182, 205, 228, 251, 276, 338], 'authorWolfgang': [52, 183], 'Hagmann,': [53, 184], 'Wolfgang': [54, 185], 'Hagmann': [55, 186, 524, 551, 948, 971, 1722, 2497], 'GermanySearch': [69, 92, 115, 140, 200, 223, 246, 271], 'authorStephan': [75, 206], 'Rapp,': [76, 207], 'Stephan': [77, 208], 'Rapp': [78, 209, 969, 1726], 'authorClaudio': [98, 229], 'Denzlinger,': [99, 230], 'Claudio': [100, 231], 'Denzlinger': [101, 232, 526, 950, 967, 1724], 'authorHerbert': [121, 252], 'K.': [122, 125, 253, 256, 1213], 'Koch,': [123, 254], 'Herbert': [124, 255], 'Koch': [126, 257], 'author': [146, 277], 'First': [278], 'published:': [279], 'September/October': [280], '1985': [281, 982, 1413, 1751], 'https://doi.org/10.1002/hep.1840050530Citations:': [282], '173AboutPDF': [283], 'ToolsRequest': [284], 'permissionExport': [285], 'citationAdd': [286], 'favoritesTrack': [288], 'citation': [289], 'ShareShare': [290], 'Give': [291], 'accessShare': [292, 295], 'full': [293], 'text': [294], 'full-text': [296, 311, 335], 'accessPlease': [297], 'review': [298], 'our': [299], 'Terms': [300, 323], 'Conditions': [302, 325], 'Use': [304], 'check': [306], 'box': [307], 'below': [308, 331], 'share': [310, 333], 'version': [312, 336], 'article.I': [314], 'have': [315], 'read': [316], 'accept': [318], 'the': [319, 329, 441, 490, 509, 595, 681, 768, 875, 1279, 1336, 1379, 1407, 1427, 1434, 1446, 1512, 1735, 1743, 1808, 1879, 2012, 2110, 2140, 2175, 2242, 2328, 2399, 2489, 2530, 2559, 2587, 2590, 2609, 2630, 2672, 2698, 2701, 2712, 2718, 2743, 2769, 2772], 'Wiley': [320, 2216], 'Online': [321], 'Library': [322], 'UseShareable': [327], 'LinkUse': [328], 'link': [330], 'a': [334, 349, 690, 833, 1051, 1235, 1289, 1431, 1606, 1666, 1940, 1965, 2411], 'article': [339], 'with': [340, 900, 1028, 1182, 1615, 1699, 2174, 2198, 2618], 'your': [341], 'friends': [342], 'colleagues.': [344], 'Learn': [345], 'more.Copy': [346], 'URL': [347], 'Share': [348], 'linkShare': [350], 'onEmailFacebookTwitterLinkedInRedditWechat': [351], 'References': [352], '1': [353], 'Samuelsson': [354], 'B.': [355, 2364], 'Leukotrienes:': [356, 451, 467], 'mediators': [357, 977, 2144], 'immediate': [359], 'hypersensitivity': [360, 2147], 'reactions': [361, 2148], 'inflammation.': [363, 1239], 'Science': [364, 914, 981], '1983;': [365, 390, 520, 587, 730, 1191, 1208, 1265, 1492, 1815, 1838, 1945, 1971, 1991, 2153, 2403, 2419, 2441, 2520], '220:': [366, 639], '568–575.': [367], '2': [368], 'Lewis': [369, 1755, 1788, 1873], 'RA,': [370, 1756, 1789, 1874], 'Austen': [371, 801, 1759], 'KF.': [372, 802], 'biologically': [374], 'active': [375], 'leukotrienes.': [376, 400, 418, 1850], 'J': [377, 470, 492, 606, 637, 818, 859, 941, 1068, 1121, 1189, 1240, 1341, 1470, 1589, 1674, 1812, 1835, 1943, 2022, 2180, 2462, 2633, 2652, 2779, 2811], 'Clin': [378, 942, 1069, 2023, 2181, 2463, 2634, 2780], 'Invest': [379, 943, 1070, 2024, 2250, 2464, 2635, 2781], '1984;': [380, 403, 445, 474, 543, 638, 666, 698, 753, 820, 839, 861, 885, 915, 944, 1123, 1142, 1164, 1295, 1320, 1383, 1456, 1473, 2025, 2052, 2094, 2121, 2183, 2339, 2355, 2382, 2465, 2493, 2540, 2563, 2636, 2813], '73:': [381], '889–897.': [382], '3': [383], 'Hammarström': [384, 480, 986, 1496, 1977], 'S.': [385, 481, 1151], 'Leukotrienes.': [386], 'Ann': [387], 'Rev': [388, 402, 835], 'Biochem': [389, 605, 636, 696, 837, 1261, 1488, 1514, 1623, 1649, 1673, 1967, 2051, 2117, 2152, 2437, 2685], '52:': [391], '355–377.': [392], '4': [393], 'Piper': [394, 1301, 1324], 'PJ.': [395], 'Formation': [396, 849], 'actions': [398], 'Physiol': [401, 836, 2812], '64:': [404], '744–776.': [405], 'Hedqvist': [407], 'P,': [408, 647, 1128, 1952], 'Dahlén': [409, 869, 1389, 1844], 'S-E,': [410, 870, 1390, 1845], 'Björk': [411], 'J.': [412], 'Pulmonary': [413], 'cardiovascular': [415, 442], 'pharmacology': [416], 'In:': [419, 559, 780, 1338, 1705, 1851, 2205, 2298], 'F': [420, 1852], 'Berti,': [421, 1853], 'G': [422, 1854], 'Folco,': [423, 1855], 'GP': [424, 1856], 'Velo,': [425, 1857], 'eds.': [426, 566, 785, 1345, 1710, 1858, 2303], 'Leukotrienes': [427, 439, 555, 873, 975, 1395, 1730, 1859, 2209], 'prostacyclin.': [429, 1861], 'New': [430, 1715, 1862], 'York:': [431, 1716, 1863], 'Plenum': [432, 1864], 'Press,': [433, 793, 1355, 1718, 1865, 2311], '1983:': [434, 1866, 2219], '81–105.': [435], '6': [436], 'Feuerstein': [437], 'G.': [438, 2660], 'system.': [443, 879], 'Prostaglandins': [444, 1141, 1163, 1207, 1294, 1750, 2075, 2093, 2354], '27:': [446], '781–802.': [447], '7': [448], 'Ford-Hutchinson': [449, 1148, 1229], 'AW.': [450], 'their': [452, 535, 812], 'formation': [453, 744, 1563, 2461], 'role': [455, 1773], 'as': [456, 633, 976, 1050, 1731, 1912], 'inflammatory': [457], 'mediators.': [458], 'Fed': [459], 'Proc': [460, 725, 880, 1346, 1451, 1571, 1777, 1887, 2334], '1985;': [461, 963, 1007, 1035, 1223, 1545, 2076, 2755], '44:': [462], '25–29.': [463], '8': [464], 'Goldyne': [465], 'ME.': [466], 'clinical': [468], 'significance.': [469], 'Am': [471, 2810], 'Acad': [472, 727, 882, 1453, 1573, 1779, 1889, 2336], 'Dermatol': [473], '10:': [475, 2404, 2687], '659–668.': [476], '9': [477], 'Appelgren': [478], 'LE,': [479], 'Distribution': [482], 'metabolism': [484, 712, 830, 1483, 1507, 1531, 1639, 1712, 1796, 2107, 2141], '3H-labeled': [486], 'leukotriene': [487, 652, 656, 682, 723, 743, 851, 996, 1109, 1136, 1201, 1283, 1309, 1311, 1376, 1438, 1449, 1464, 1509, 1565, 1641, 1740, 1769, 1906, 1987, 2166, 2294, 2486], 'C3': [488, 1510, 1642], 'in': [489, 538, 568, 602, 831, 874, 907, 958, 978, 998, 1022, 1058, 1063, 1089, 1114, 1138, 1156, 1180, 1315, 1335, 1378, 1406, 1505, 1511, 1534, 1747, 2149, 2168, 2241, 2273, 2398, 2457, 2488, 2529, 2535, 2558, 2579, 2586, 2629, 2671, 2703, 2708, 2751, 2775], 'mouse.': [491], 'Biol': [493, 1471, 1590, 1813, 1836], 'Chem': [494, 1472, 1591, 1814, 1837, 2683], '1982;': [495, 607, 1576, 1592, 1653, 1692, 1918, 2507, 2727], '257:': [496, 1593], '531–535.': [497], '10': [498], 'Uehara': [499, 1631], 'N,': [500, 1632], 'Ormstad': [501, 1629], 'K,': [502, 894, 991, 1499, 1630, 2223, 2227], 'Örning': [503, 988, 1500], 'L,': [504, 989, 1250, 1270, 1501, 1870], 'et': [505, 553, 648, 708, 740, 871, 895, 925, 973, 992, 1017, 1081, 1106, 1133, 1174, 1275, 1330, 1365, 1393, 1502, 1528, 1602, 1635, 1728, 1761, 1792, 1875, 1902, 1928, 1955, 2001, 2193, 2228, 2261, 2321, 2350, 2429, 2451, 2475, 2550, 2573, 2738, 2792], 'al.': [506, 554, 649, 709, 741, 872, 896, 926, 974, 993, 1018, 1082, 1107, 1134, 1175, 1276, 1331, 1366, 1394, 1503, 1529, 1603, 1636, 1729, 1762, 1793, 1876, 1903, 1929, 1956, 2002, 2194, 2229, 2262, 2322, 2351, 2430, 2452, 2476, 2551, 2574, 2739, 2793], 'Characteristics': [507], 'uptake': [510], 'cysteine-containing': [512], 'isolated': [515, 1292, 1644], 'hepatocytes.': [516], 'Biochim': [517, 620, 1542, 2379], 'Biophys': [518, 621, 697, 1262, 1489, 1515, 1543, 1624, 1650, 1968, 2118, 2380, 2438], 'Acta': [519, 622, 1544, 2284, 2381], '732:': [521], '69–74.': [522], '11': [523], 'W,': [525, 552, 949, 972, 1525, 1723, 1901, 2498, 2549], 'C,': [527, 550, 951, 968, 1043, 1362, 1725, 2000, 2450, 2472], 'D.': [529, 953, 2500], 'Role': [530, 2453, 2526], 'peptide': [532, 956], 'hepatobiliary': [536, 1745], 'elimination': [537], 'endotoxin': [539, 959, 2232, 2504], 'action.': [540, 2297], 'Circ': [541, 1381, 2401, 2491], 'Shock': [542, 2402], '14:': [544, 2637], '223–235.': [545], '12': [546], 'D,': [548, 1950, 2512], 'Forsthove': [549], 'injury.': [558], 'L': [560], 'Bianchi,': [561], 'W': [562, 1339], 'Gerok,': [563], 'H': [564], 'Popper,': [565], 'Trends': [567], 'hepatology.': [569], 'Lancaster:': [570], 'MTP': [571], 'Press': [572], 'Limited,': [573], '1985:': [574], '137–145.': [575], '13': [576], 'Blackwell': [577], 'GJ,': [578], 'Flower': [579, 2346], 'RJ.': [580], 'Inhibition': [581, 2323], 'phospholipase.': [583], 'Br': [584], 'Med': [585, 1122, 1190, 2519], 'Bull': [586], '39:': [588, 1321], '260–264.': [589], '14': [590], 'Irvine': [591], 'RF.': [592], 'How': [593], 'is': [594, 1742], 'level': [596], 'free': [598], 'arachidonic': [599, 778, 1048, 2044], 'acid': [600, 829, 1049, 1620, 1703, 1737, 2045, 2238, 2715], 'controlled': [601], 'mammalian': [603], 'cells?': [604], '204:': [608], '3–16.': [609], '15': [610, 1036], 'Michell': [611], 'RH.': [612], 'Inositol': [613, 629], 'phospholipids': [614], 'cell': [616, 1259, 2275], 'surface': [617], 'receptor': [618, 814, 1432], 'function.': [619, 1714], '1975;': [623, 1675], '415:': [624], '81–147.': [625], '16': [626], 'Berridge': [627], 'MJ.': [628, 2525], 'trisphosphate': [630], 'diacylglycerol': [632], 'second': [634], 'messengers.': [635], '345–360.': [640], '17': [641], 'Mannervik': [642], 'B,': [643, 1478, 2190], 'Jensson': [644], 'H,': [645, 1147, 2256, 2641, 2643], 'Alin': [646], 'Transformation': [650], 'A4': [653], 'methylester': [654], 'C4': [657, 683, 904, 997, 1177, 1202, 1377, 1907, 2487], 'monomethylester': [658], 'cytosolic': [660], 'rat': [661, 686, 855, 876, 936, 999, 1608, 1645, 1667, 1687, 2234, 2588, 2724, 2765, 2796], 'glutathione': [662, 693, 1700], 'transferases.': [663], 'FEBS': [664, 751, 961, 1916, 1989], 'Lett': [665, 752, 962, 1917, 1990], '175:': [667], '289–293.': [668], '18': [669], 'Bach': [670], 'MK,': [671], 'Brashler': [672], 'JR,': [673, 2101, 2360], 'Morton': [674], 'DR': [675], 'Jr.': [676], 'Solubilization': [677], 'characterization': [679], 'synthetase': [684], 'basophil': [687], 'leukemia': [688], 'cells:': [689], 'novel,': [691], 'particulate': [692, 816, 1607], 'S-transferase.': [694], 'Arch': [695, 1411, 1622], '230:': [699], '455–465.': [700], '19': [701], 'Weller': [702], 'PF,': [703], 'Lee': [704, 1786, 1995], 'CW,': [705, 1787], 'Foster': [706], 'DW,': [707, 760], 'Generation': [710], '5-lipoxygenase': [714, 2015, 2091], 'pathway': [715, 2016], 'human': [718, 747, 771, 807, 1157, 1204, 1256, 1317, 1441, 1909, 2020, 2752], 'eosinophils:': [719], 'predominant': [720], 'production': [721, 1137, 1824], 'C4.': [724, 1988], 'Natl': [726, 881, 1452, 1572, 1778, 1888, 2335], 'Sci': [728, 883, 1454, 1574, 1780, 1890, 2337], 'USA': [729, 884, 1455, 1575, 1781, 1891, 2338], '80:': [731], '7626–7630.': [732], '20': [733], 'Verhagen': [734], 'J,': [735, 1527, 2547], 'Bruynzeel': [736], 'PLB,': [737], 'Koedam': [738], 'JA,': [739, 866, 1976], 'Specific': [742], 'purified': [746, 1560], 'eosinophils': [748], 'neutrophils.': [750, 1834, 2021], '168:': [754], '23–28.': [755], '21': [756], 'Payan': [757], 'DG,': [758], 'Goldman': [759], 'Goetzl': [761, 1044, 1979, 2161], 'EJ.': [762, 1980, 2162], 'Biochemical': [763], 'cellular': [765], 'characteristics': [766], 'regulation': [769], 'leukocyte': [772, 1055], 'function': [773, 2534, 2628], 'lipoxygenase': [775, 2066, 2212, 2330, 2455], 'products': [776, 2017, 2069, 2456], 'acid.': [779], 'LW': [781, 2299], 'Chakrin,': [782, 2300], 'DM': [783, 2301], 'Bailey,': [784, 2302], 'leukotrienes,': [787, 2037, 2305, 2372], 'chemistry': [788, 2306], 'biology.': [790, 2308], 'Orlando:': [791, 2309], 'Academic': [792, 2310], '1984:': [794, 1356, 2312], '231–245.': [795], '22': [796], 'Williams': [797], 'JD,': [798], 'Czop': [799], 'JK,': [800], 'Release': [803, 1904], 'monocytes': [808], 'on': [809, 1288, 1440, 2011, 2233, 2576, 2608, 2626, 2697], 'stimulation': [810], 'phagocytic': [813], 'activators.': [817], 'Immunol': [819, 1944, 2182], '132:': [821], '3034–3040.': [822], '23': [823], 'Ruzicka': [824], 'T,': [825, 846, 868, 2424, 2572, 2787, 2791], 'Printz': [826], 'MP.': [827], 'Arachidonic': [828], 'skin;': [832], 'review.': [834], 'Pharmacol': [838, 860, 1242, 1412, 1691], '100:': [840], '121–160.': [841], '24': [842], 'Dembinska-Kieć': [843], 'A,': [844, 2225], 'Simmet': [845], 'Peskar': [847], 'BA.': [848], 'C4-like': [852], 'material': [853], 'brain': [856], 'tissue.': [857], 'Eur': [858, 2632], '99:': [862], '57–62.': [863], '25': [864], 'Lindgren': [865, 1975], 'Hökfelt': [867], 'central': [877], 'nervous': [878], '81:': [886, 1457, 2340], '6212–6216.': [887], '26': [888], 'Moskowitz': [889], 'MA,': [890, 2158], 'Kiwak': [891], 'KF,': [892, 1360, 1760, 2470], 'Hekimian': [893], 'Synthesis': [897], 'compounds': [899], 'properties': [901], 'D4': [906, 1179, 1397, 1566, 2167], 'gerbil': [908], 'brains': [909], 'after': [910, 1111], 'ischemia': [911], 'reperfusion.': [913], '224:': [916], '886–889.': [917], '27': [918], 'Perez': [919], 'HD,': [920], 'Roll': [921], 'FJ,': [922], 'Bissell': [923], 'DM,': [924], 'Production': [927, 954, 1152], 'chemotactic': [929, 1056], 'activity': [930, 2707, 2802], 'polymorphonuclear': [932, 1054, 1468, 1910], 'leukocytes': [933], 'cultured': [935], 'hepatocytes': [937], 'exposed': [938], 'ethanol.': [940], '74:': [945, 2026, 2466], '1350–1357.': [946], '28': [947], 'shock.': [960], '180:': [964], '309–313.': [965], '29': [966], 'S,': [970, 987, 1012, 1497, 1634, 1727, 1978, 2032, 2320, 2428, 2604], 'tissue': [979, 1062, 2138, 2325], 'trauma.': [980], '(in': [983, 1037, 1414, 1752], 'press).': [984, 1038, 1415, 1753], '30': [985], 'Bernström': [990, 1498], 'Metabolism': [994], 'man.': [1001], 'Adv': [1002, 1031], 'Prostaglandin': [1003, 1032], 'Thromboxane': [1004, 1033], 'Leukotriene': [1005, 1176, 1233, 1253, 1481, 1823, 2104, 2501], 'Res': [1006, 1034, 1263, 1382, 1490, 1516, 1651, 1969, 2119, 2439, 2492], '15:': [1008], '185–188.': [1009], '31': [1010], 'Kitamura': [1011], 'Ishihara': [1013], 'Y,': [1014, 1016, 1927, 2568], 'Uchida': [1015], 'Measurement': [1019], 'peripheral': [1023], 'venous': [1024], 'blood': [1025, 1535], 'from': [1026, 1091, 1203, 1286, 1467, 1686, 1908, 1961, 2137, 2414, 2616, 2723, 2806], 'patients': [1027, 1115, 2173, 2617, 2675], 'bronchial': [1029], 'asthma.': [1030], '32': [1039], 'Klickstein': [1040], 'LB,': [1041], 'Shapleigh': [1042], 'E.': [1045, 1847], 'Lipoxygenation': [1046], 'source': [1052, 2744], 'factors': [1057, 2615], 'synovial': [1059], 'fluid': [1060, 1159, 2171], 'rheumatoid': [1064], 'arthritis': [1065], 'spondyloarthritis.': [1067], '1980;': [1071, 1243, 2251], '66:': [1072], '1166–1170.': [1073], '33': [1074], 'Cromwell': [1075, 1131], 'O,': [1076, 1132], 'Walport': [1077], 'MJ,': [1078], 'Morris': [1079, 2102], 'HR.': [1080, 2103], 'Identification': [1083], 'D': [1086], 'B': [1088], 'sputum': [1090], 'cystic': [1092], 'fibrosis': [1093], 'patients.': [1094], 'Lancet': [1095], '1981;': [1096, 1518, 1782, 1892, 2597], '2:': [1097], '164–165.': [1098], '34': [1099], 'Creticos': [1100], 'PS,': [1101], 'Peters': [1102], 'SP,': [1103], 'Adkinson': [1104], 'NF,': [1105, 1173], 'Peptide': [1108], 'release': [1110, 1960], 'antigen': [1112, 1161], 'challenge': [1113], 'sensitive': [1116, 1982], 'ragweed.': [1118], 'N': [1119, 1187], 'Engl': [1120, 1188], '310:': [1124], '1626–1630.': [1125], '35': [1126], 'Fitzharris': [1127], 'Shaw': [1129], 'RJ,': [1130, 2347], 'Allergen-induced': [1135], 'allergic': [1139, 2581], 'rhinitis.': [1140], '28:': [1143, 1165, 1296, 2095, 2356, 2598, 2728], '636.': [1144], '36': [1145], 'Bisgaard': [1146], 'AW,': [1149, 1230], 'Charleson': [1150], 'peptido-lipid': [1154], 'tear': [1158], 'following': [1160], 'challenge.': [1162], '620–622.': [1166], '37': [1167], 'Stenmark': [1168], 'KR,': [1169], 'James': [1170], 'SL,': [1171, 2446], 'Voelkel': [1172], 'neonates': [1181], 'hypoxemia': [1183], 'pulmonary': [1185, 2169, 2459], 'hypertension.': [1186], '309:': [1192], '77–80.': [1193], '38': [1194], 'Saad': [1195], 'MH,': [1196], 'Burka': [1197], 'JF.': [1198, 1304], 'Isolation': [1199], 'seminal': [1205], 'fluid.': [1206], '26:': [1209], '943–954.': [1210], '39': [1211], 'Decker': [1212], 'Eicosanoids,': [1214], 'signal': [1215], 'molecules': [1216], 'cells.': [1219, 1648], 'Sem': [1220], 'Liver': [1221, 2740], 'Dis': [1222], '5:': [1224, 2756], '175–190.': [1225], '40': [1226], 'Smith': [1227], 'MJH,': [1228], 'Bray': [1231], 'MA.': [1232], 'B:': [1234], 'potential': [1236], 'mediator': [1237], 'Pharm': [1241], '32:': [1244], '517–518.': [1245], '41': [1246], 'Rola-Pleszczynski': [1247], 'M,': [1248, 1523, 2192, 2258, 2345, 2362, 2426, 2789], 'Gagnon': [1249], 'Sirois': [1251], 'P.': [1252], 'B4': [1254, 1439, 1465, 1482, 1805], 'augments': [1255], 'natural': [1257], 'cytotoxic': [1258], 'activity.': [1260], 'Commun': [1264, 1491, 1517, 1652, 1970, 2120, 2440], '113:': [1266], '531–537.': [1267], '42': [1268], 'Feniuk': [1269], 'Kennedy': [1271], 'I,': [1272], 'Whelan': [1273], 'CJ,': [1274], 'Evidence': [1277], 'existence': [1280], 'multiple': [1282], '(LT)': [1284], 'receptors': [1285], 'studies': [1287], 'range': [1290], 'tissues.': [1293], '675.': [1297], '43': [1298], 'Barnes': [1299], 'NC,': [1300], 'PJ,': [1302, 1325], 'Costello': [1303], 'Comparative': [1305], 'effects': [1306], 'inhaled': [1308], 'C4,': [1310, 1396, 1799], 'D4,': [1312, 1800], 'histamine': [1314], 'normal': [1316, 2245], 'subjects.': [1318], 'Thorax': [1319], '500–504.': [1322], '44': [1323], 'Stanton': [1326], 'AWB,': [1327], 'McLeod': [1328], 'LJ,': [1329], 'Actions': [1332], 'circulation.': [1337], 'Paton,': [1340], 'Mitchell,': [1342], 'P': [1343], 'Turner,': [1344], 'IUPHAR': [1347], '9th': [1348], 'International': [1349], 'Congress': [1350], 'Pharmacology.': [1352], 'London:': [1353], 'Macmillan': [1354], '63–67.': [1357], '45': [1358], 'Badr': [1359, 2469], 'Baylis': [1361, 2471], 'Pfeffer': [1363, 2473], 'JM,': [1364, 1392, 1758, 2474], 'Renal': [1367, 2477], 'systemic': [1369, 2479], 'hemodynamic': [1370, 2480], 'responses': [1371, 2481], 'intravenous': [1373, 2483], 'infusions': [1374], 'rat.': [1380, 2400, 2490, 2631], '54:': [1384, 2494], '492–499.': [1385, 2495], '46': [1386], 'Hua': [1387], 'X-Y,': [1388], 'Lundberg': [1391], 'E4': [1399, 1741, 1802], 'cause': [1400], 'widespread': [1401], 'extensive': [1403], 'plasma': [1404, 1536, 2741], 'extravasation': [1405], 'guinea': [1408], 'pig.': [1409], "Naunyn-Schmiedeberg's": [1410], '47': [1416], 'Clancy': [1417, 2125], 'RM,': [1418, 1658, 2126], 'Dahinden': [1419], 'CA,': [1420], 'Hugli': [1421, 2127], 'TE.': [1422, 2034, 2128], 'Oxidation': [1423], 'at': [1426], 'ω-end:': [1428], 'demonstration': [1429], '20-hydroxy': [1435], 'derivative': [1436], 'neutrophils': [1442], 'implications': [1444], 'analysis': [1447, 2086, 2236], 'receptors.': [1450], '5729–5733.': [1458], '48': [1459], 'Powell': [1460], 'WS.': [1461], 'Properties': [1462], '20-hydroxylase': [1466], 'leukocytes.': [1469], '259:': [1474], '3082–3089.': [1475], '49': [1476], 'Bösterling': [1477, 2363], 'Trudell': [1479, 2359], 'JR.': [1480], 'hepatic': [1485, 2282, 2537, 2713, 2797], 'cytochrome': [1486], 'P-450.': [1487], '114:': [1493], '850–854.': [1494], '50': [1495], 'Rapid': [1504], 'vivo': [1506], 'monkey.': [1513], '101:': [1519], '1109–1115.': [1520], '51': [1521], 'Köller': [1522], 'Schönfeld': [1524], 'Knöller': [1526], 'studied': [1537], 'high-performance': [1539, 2047], 'liquid': [1540, 2048], 'chromatography.': [1541, 2049], '833:': [1546], '128–134.': [1547], '52': [1548], 'Anderson': [1549], 'ME,': [1550, 2733], 'Allison': [1551], 'RD,': [1552, 2545], 'Meister': [1553], 'A.': [1554, 2762], 'Interconversion': [1555], 'catalyzed': [1558], 'γ-glutamyltranspeptidase:': [1561], 'concomitant': [1562], 'γ-glutamyl': [1568], 'amino': [1569], 'acids.': [1570], '79:': [1577], '1088–1091.': [1578], '53': [1579], 'Kozak': [1580], 'EM,': [1581], 'Tate': [1582], 'SS.': [1583], 'Glutathione-degrading': [1584], 'enzymes': [1585, 1617], 'microvillus': [1587], 'membranes.': [1588], '6322–6327.': [1594], '54': [1595], 'Hughey': [1596], 'RP,': [1597], 'Rankin': [1598], 'RB,': [1599], 'Elce': [1600, 1659], 'JS,': [1601], 'Specificity': [1604], 'renal': [1609, 2533], 'peptidase': [1610], 'its': [1612], 'localization': [1613], 'along': [1614], 'other': [1616, 2040, 2090, 2211], 'mercapturic': [1619, 1702, 1736], 'synthesis.': [1621], '1978;': [1625, 2286], '186:': [1626], '211–217.': [1627], '55': [1628], 'Orrenius': [1633], 'Uptake': [1637], 'organs': [1646], '104:': [1654], '1434–1440.': [1655], '56': [1656], 'Green': [1657], 'JS.': [1660], 'Acetylation': [1661], 'S-substituted': [1663], 'cysteines': [1664], 'kidney': [1670, 1688], 'microsomal': [1671], 'N-acetyltransferase.': [1672], '147:': [1676], '283–289.': [1677], '57': [1678], 'Duffel': [1679], 'MW,': [1680], 'Jakoby': [1681], 'WB.': [1682], 'Cysteine': [1683], 'S-conjugate': [1684], 'N-acetyl-transferase': [1685], 'microsomes.': [1689], 'Molec': [1690], '21:': [1693], '444–448.': [1694], '58': [1695], 'Chasseaud': [1696], 'LF.': [1697], 'Conjugation': [1698], 'excretion.': [1704], 'IM': [1706], 'Arias,': [1707], 'WB': [1708], 'Jakoby,': [1709], 'Glutathione:': [1711], 'Raven': [1717], '1976:': [1719], '77–114.': [1720], '59': [1721], 'endogenous': [1732], 'substrates': [1733], 'pathway:': [1738], 'N-acetylated': [1739], 'major': [1744], 'metabolite': [1746], 'endotoxinshocked': [1748], 'rats.': [1749, 2248], '60': [1754], 'Drazen': [1757], 'Contractile': [1763], 'activities': [1764], 'structural': [1766], 'analogs': [1767], 'C': [1770], 'D:': [1772], 'polar': [1775], 'substituents.': [1776], '78:': [1783, 1893], '4579–4583.': [1784], '61': [1785], 'Tauber': [1790], 'AI,': [1791], 'myeloperoxidase-dependent': [1795], '6-trans-leukotriene': [1804], 'diastereoisomers': [1806], 'subclass-specific': [1809], 'S-diastereoisomeric': [1810], 'sulfoxides.': [1811], '258:': [1816, 1839], '15004–15010.': [1817], '62': [1818], 'Henderson': [1819], 'WR,': [1820], 'Klebanoff': [1821], 'SJ.': [1822], 'inactivation': [1826], 'normal,': [1828], 'chronic': [1829], 'granulomatous': [1830], 'disease': [1831], 'myeloperoxidase-deficient': [1833], '13522–13527.': [1840], '63': [1841], 'Hansson': [1842], 'G,': [1843, 2658], 'Granström': [1846], 'Assay': [1848], '65–80.': [1867], '64': [1868], 'Levine': [1869], 'Morgan': [1871], 'R,': [1872, 2691, 2693], 'Radioimmunoassay': [1877], 'slow': [1882, 1933], 'reacting': [1883, 1934], 'substance': [1884, 1935], 'anaphylaxis.': [1886], '7692–7696.': [1894], '65': [1895], 'Aehringhaus': [1896], 'U,': [1897], 'Wölbling': [1898], 'RH,': [1899], 'König': [1900], 'leucocytes': [1911], 'determined': [1913], 'radioimmunoassay.': [1915, 1942, 1966, 2116], '146:': [1919], '111–114.': [1920], '66': [1921], 'Hayes': [1922], 'EC,': [1923], 'Lombardo': [1924], 'DL,': [1925], 'Girard': [1926], 'Measuring': [1930], 'anaphylaxis:': [1937, 2202], 'development': [1938], 'specific': [1941, 1984], '131:': [1946], '429–433.': [1947], '67': [1948], 'Aharony': [1949], 'Dobson': [1951], 'Bernstein': [1953], 'PR,': [1954], 'Determination': [1957], 'SRS-A': [1959], 'guinea-pig': [1962], 'lungs': [1963], '117:': [1972], '574–579.': [1973], '68': [1974], 'A': [1981], 'radioimmunoassay': [1985], '152:': [1992], '83–88.': [1993], '69': [1994], 'TH,': [1996], 'Mencia-Huerta': [1997], 'J-M,': [1998], 'Shih': [1999], 'Effects': [2003], 'exogenous': [2005], 'arachidonic,': [2006], 'eicosapentaenoic': [2007], 'docosahexaenoic': [2009], 'acids': [2010], 'generation': [2013], 'ionophore-activated': [2019], '1922–1933.': [2027], '70': [2028], 'Henke': [2029], 'DC,': [2030], 'Kouzan': [2031], 'Eling': [2033], 'Analysis': [2035], 'prostaglandins,': [2038], 'oxygenated': [2041], 'metabolites': [2042], 'Anal': [2050, 2151], '140:': [2053], '87–94.': [2054], '71': [2055], 'Pickett': [2056], 'WC,': [2057], 'Douglas': [2058], 'MB.': [2059], 'Automated': [2060], 'extraction': [2061, 2130], 'HPLC': [2063, 2114], 'resolution': [2064], 'cyclooxygenase': [2068], 'utilizing': [2070], 'high': [2071, 2746], 'pressure': [2072], 'column': [2073], 'switching.': [2074], '29:': [2077], '83–90.': [2078], '72': [2079], 'Murphy': [2080, 2187], 'RC.': [2081], 'Mass': [2082], 'spectrometric': [2083], 'quantitation': [2084], 'metabolites.': [2092], '597–601.': [2096], '73': [2097], 'Beaubien': [2098], 'BC,': [2099], 'Tippins': [2100], 'biosynthesis': [2105], 'detected': [2108], 'combined': [2111], 'use': [2112], '125:': [2122], '97–104.': [2123], '74': [2124], '(LTC4,': [2133], 'LTD4': [2134], 'LTE4)': [2136], 'fluids:': [2139], 'these': [2143], 'during': [2145, 2201, 2393], 'IgE-dependent': [2146], 'lung.': [2150], '133:': [2154], '30–39.': [2155], '75': [2156], 'Matthay': [2157], 'Eschenbacher': [2159], 'WL,': [2160], 'Elevated': [2163], 'concentrations': [2164], 'edema': [2170], 'adult': [2176], 'respiratory': [2177], 'distress': [2178], 'syndrome.': [2179, 2561], '4:': [2184], '479–483.': [2185], '76': [2186], 'RC,': [2188], 'Hoffer': [2189], 'Palmer': [2191], 'Localization': [2195], 'cells': [2197], 'leukotriene-like': [2199], 'immunoreactivity': [2200], 'preliminary': [2203], 'observations.': [2204], 'PJ': [2206], 'Piper,': [2207], 'ed.': [2208], 'products.': [2213], 'Chichester:': [2214], 'John': [2215], '&': [2217], 'Sons,': [2218], '70–77.': [2220], '77': [2221], 'Hirata': [2222, 2348], 'Kaneko': [2224], 'Ogawa': [2226], 'Effect': [2230], 'liver,': [2235], 'phosphatase': [2239, 2667, 2706, 2722, 2750, 2801], 'isoenzymes': [2240], 'endotoxin-treated': [2247], 'Lab': [2249], '43:': [2252], '165–171.': [2253], '78': [2254], 'Liehr': [2255], 'Grün': [2257], 'Seelig': [2259], 'H-P,': [2260], 'Synergistic': [2263], 'action': [2264], 'hepatocyte': [2266, 2369], 'membrane': [2267], 'defect': [2268], 'activated': [2270, 2594], 'complement': [2271], 'system': [2272], 'death;': [2276], 'an': [2277], 'experimental': [2278], 'approach': [2279], 'fulminant': [2281], 'failure.': [2283], 'Hepato-Gastroenterol': [2285], '25:': [2287], '105–110.': [2288], '79': [2289], 'Back': [2290], 'MK.': [2291], 'Inhibitors': [2292], 'synthesis': [2295, 2556], '163–194.': [2313], '80': [2314], 'Higgs': [2315], 'GA,': [2316], 'Mugridge': [2317], 'KG,': [2318], 'Moncada': [2319], 'damage': [2326], 'arachidonate': [2329, 2435], 'inhibitor': [2331], 'BW': [2332], '755C.': [2333], '2890–2892.': [2341], '81': [2342], 'Di': [2343], 'Rosa': [2344], 'F,': [2349, 2570], 'Antiphospholipase': [2352], 'proteins.': [2353], '441–442.': [2357], '82': [2358], 'Bendix': [2361], 'Hypoxia': [2365], 'potentiates': [2366], 'killing': [2367], 'monolayers': [2370], 'hydroperoxyeicosatetraenoic': [2373], 'acids,': [2374], 'or': [2375, 2623], 'calcium': [2376], 'ionophore': [2377], 'A23187.': [2378], '803:': [2383], '338–341.': [2384], '83': [2385], 'Fitch': [2386], 'KA,': [2387], 'Rink': [2388], 'RD.': [2389], 'Hepatic': [2390], 'oxygen': [2391], 'supply': [2392], 'early': [2394], 'late': [2396], 'sepsis': [2397], '51–59.': [2405], '84': [2406], 'Conn': [2407], 'HO.': [2408], 'Cyanidanol:': [2409], 'will': [2410], 'hepatotrophic': [2412], 'drug': [2413], 'Europe': [2415], 'go': [2416], 'West?': [2417], 'Hepatology': [2418, 2754], '3:': [2420], '121–123.': [2421], '85': [2422], 'Yoshimoto': [2423], 'Furukawa': [2425], 'Yamamoto': [2427], 'Flavonoids:': [2431], 'potent': [2432], 'inhibitors': [2433], '5-lipoxygenase.': [2436], '116:': [2442], '612–618.': [2443], '86': [2444], 'Kunkel': [2445], 'Chensue': [2447], 'SW,': [2448], 'Mouton': [2449], 'murine': [2458], 'granuloma': [2460], '514–524.': [2467], '87': [2468], 'infusion': [2484], '88': [2496], 'antagonists': [2502], 'prevent': [2503], 'lethality.': [2505], 'Naturwiss': [2506], '69:': [2508], '594–595.': [2509], '89': [2510], 'Mirouze': [2511], 'Michel': [2513], 'H.': [2514, 2645], 'Le': [2515], 'syndrome': [2516], 'hépato-rénal.': [2517], 'Presse': [2518], '12:': [2521], '36–40.': [2522], '90': [2523], 'Dunn': [2524], 'eicosanoids': [2528], 'control': [2531], 'severe': [2536], 'disease.': [2538], 'Gastroenterology': [2539, 2562], '87:': [2541, 2564], '1392–1395.': [2542], '91': [2543], 'Zipser': [2544], 'Kronborg': [2546], 'Rector': [2548], 'Therapeutic': [2552], 'trial': [2553], 'thromboxane': [2555], 'inhibition': [2557], 'hepatorenal': [2560], '1228–1232.': [2565], '92': [2566], 'Mizoguchi': [2567], 'Ohnishi': [2569], 'Monna': [2571], 'Studies': [2575, 2607, 2696], 'intrahepatic': [2577], 'cholestasis': [2578, 2619], 'drug-induced': [2580], 'hepatitis:': [2582], 'Intrahepatic': [2583], 'chole-stasis': [2584], 'induced': [2585], 'culture': [2591], 'supernatant': [2592], 'lymphocytes.': [2595], 'Hepato-Gastroenterology': [2596], '147–150.': [2599], '93': [2600], 'Marbet': [2601], 'UA,': [2602], 'Shefer': [2603], 'Leevy': [2605], 'CM.': [2606], 'influence': [2610], 'immunological': [2612], 'serological': [2614], 'due': [2620], 'alcoholic': [2622], 'viral': [2624], 'hepatitis': [2625], 'biliary': [2627], '346–353.': [2638], '94': [2639], 'Eppinger': [2640], 'Kaunitz': [2642], 'Popper': [2644], 'Die': [2646], 'seröse': [2647], 'Entzündung;': [2648], 'eine': [2649], 'Permeabilitäts-Pathologie.': [2650], 'Wien:': [2651], 'Springer,': [2653], '1935:': [2654], '1–272.': [2655], '95': [2656], 'Idéo': [2657], 'Ronchi': [2659], 'Sephadex': [2661], 'gel': [2662], 'filtration': [2663], 'γ-glutamyl-transpep-tidase,': [2665], 'alkaline': [2666, 2705, 2721, 2749, 2767, 2800], 'leucine': [2669], 'amino-peptidase': [2670], 'serum': [2673, 2704, 2773], 'affected': [2676], 'various': [2678], 'diseases.': [2680], 'Z': [2681], 'Klin': [2682, 2684], '1972;': [2686], '211–214.': [2688], '96': [2689], 'Schlaeger': [2690], 'Haux': [2692], 'Kattermann': [2694], 'R.': [2695], 'mechanism': [2699, 2770], 'increase': [2702], 'cholestasis:': [2709], 'significance': [2710], 'bile': [2714, 2776, 2805, 2807], 'concentration': [2716], 'leakage': [2719], 'liver.': [2725], 'Enzyme': [2726], '3–13.': [2729], '97': [2730], 'De': [2731], 'Broe': [2732], 'Roels': [2734], 'FY': [2735], 'Nouwen': [2736], 'EJ,': [2737], 'membrane:': [2742], 'molecular': [2747], 'weight': [2748], 'serum.': [2753], '118–128.': [2757], '98': [2758], 'Kaplan': [2759], 'MM,': [2760], 'Righetti': [2761], 'Induction': [2763, 2794], 'phosphatase:': [2768], 'elevation': [2774], 'duct': [2777], 'obstruction.': [2778], '1970;': [2782], '49:': [2783], '508–516.': [2784], '99': [2785], 'Komoda': [2786], 'Kumegawa': [2788], 'Yajima': [2790], 'intestinal': [2799], 'produced': [2803], 'duct-ligated': [2808], 'animals.': [2809], '246:': [2814], 'G393–400.': [2815], 'Citing': [2816], 'Literature': [2817], 'Volume5,': [2818], 'Issue5September/October': [2819], '1985Pages': [2820], 'ReferencesRelatedInformation': [2822]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1971471687', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-09T03:42:23.824507', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
