Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1971306169', 'doi': 'https://doi.org/10.1038/cmi.2014.60', 'title': 'HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts', 'display_name': 'HMGB1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts', 'publication_year': 2014, 'publication_date': '2014-08-25', 'ids': {'openalex': 'https://openalex.org/W1971306169', 'doi': 'https://doi.org/10.1038/cmi.2014.60', 'mag': '1971306169', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25152078', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4496537'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/cmi.2014.60', 'pdf_url': 'https://www.nature.com/articles/cmi201460.pdf', 'source': {'id': 'https://openalex.org/S19143454', 'display_name': 'Cellular and Molecular Immunology', 'issn_l': '1672-7681', 'issn': ['1672-7681', '2042-0226'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nature.com/articles/cmi201460.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101900083', 'display_name': 'Changchun Hou', 'orcid': 'https://orcid.org/0000-0001-6246-2241'}, 'institutions': [{'id': 'https://openalex.org/I4210126060', 'display_name': 'First Affiliated Hospital of GuangXi Medical University', 'ror': 'https://ror.org/030sc3x20', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126060']}, {'id': 'https://openalex.org/I160354086', 'display_name': 'Guangxi Medical University', 'ror': 'https://ror.org/03dveyr97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I160354086']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Changchun Hou', 'raw_affiliation_strings': ['The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China'], 'affiliations': [{'raw_affiliation_string': 'The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China', 'institution_ids': ['https://openalex.org/I4210126060', 'https://openalex.org/I160354086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067448001', 'display_name': 'Jinliang Kong', 'orcid': 'https://orcid.org/0000-0003-4065-7886'}, 'institutions': [{'id': 'https://openalex.org/I4210126060', 'display_name': 'First Affiliated Hospital of GuangXi Medical University', 'ror': 'https://ror.org/030sc3x20', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126060']}, {'id': 'https://openalex.org/I160354086', 'display_name': 'Guangxi Medical University', 'ror': 'https://ror.org/03dveyr97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I160354086']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jinliang Kong', 'raw_affiliation_strings': ['The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China'], 'affiliations': [{'raw_affiliation_string': 'The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China', 'institution_ids': ['https://openalex.org/I4210126060', 'https://openalex.org/I160354086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071728921', 'display_name': 'Yuejin Liang', 'orcid': 'https://orcid.org/0000-0002-9557-1847'}, 'institutions': [{'id': 'https://openalex.org/I160354086', 'display_name': 'Guangxi Medical University', 'ror': 'https://ror.org/03dveyr97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I160354086']}, {'id': 'https://openalex.org/I4210126060', 'display_name': 'First Affiliated Hospital of GuangXi Medical University', 'ror': 'https://ror.org/030sc3x20', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126060']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yue Liang', 'raw_affiliation_strings': ['The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China'], 'affiliations': [{'raw_affiliation_string': 'The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China', 'institution_ids': ['https://openalex.org/I160354086', 'https://openalex.org/I4210126060']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037740110', 'display_name': 'Hong Huang', 'orcid': 'https://orcid.org/0000-0003-3580-6453'}, 'institutions': [{'id': 'https://openalex.org/I4210126060', 'display_name': 'First Affiliated Hospital of GuangXi Medical University', 'ror': 'https://ror.org/030sc3x20', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126060']}, {'id': 'https://openalex.org/I160354086', 'display_name': 'Guangxi Medical University', 'ror': 'https://ror.org/03dveyr97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I160354086']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong Huang', 'raw_affiliation_strings': ['The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China'], 'affiliations': [{'raw_affiliation_string': 'The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China', 'institution_ids': ['https://openalex.org/I4210126060', 'https://openalex.org/I160354086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087449945', 'display_name': 'Huang Wen', 'orcid': 'https://orcid.org/0000-0002-6584-4998'}, 'institutions': [{'id': 'https://openalex.org/I4210126060', 'display_name': 'First Affiliated Hospital of GuangXi Medical University', 'ror': 'https://ror.org/030sc3x20', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126060']}, {'id': 'https://openalex.org/I160354086', 'display_name': 'Guangxi Medical University', 'ror': 'https://ror.org/03dveyr97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I160354086']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hanchun Wen', 'raw_affiliation_strings': ['The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China'], 'affiliations': [{'raw_affiliation_string': 'The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China', 'institution_ids': ['https://openalex.org/I4210126060', 'https://openalex.org/I160354086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104230677', 'display_name': 'Xiaowen Zheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126060', 'display_name': 'First Affiliated Hospital of GuangXi Medical University', 'ror': 'https://ror.org/030sc3x20', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126060']}, {'id': 'https://openalex.org/I160354086', 'display_name': 'Guangxi Medical University', 'ror': 'https://ror.org/03dveyr97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I160354086']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaowen Zheng', 'raw_affiliation_strings': ['The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China'], 'affiliations': [{'raw_affiliation_string': 'The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China', 'institution_ids': ['https://openalex.org/I4210126060', 'https://openalex.org/I160354086']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046183787', 'display_name': 'Lihong Wu', 'orcid': 'https://orcid.org/0000-0002-4561-9400'}, 'institutions': [{'id': 'https://openalex.org/I4210126060', 'display_name': 'First Affiliated Hospital of GuangXi Medical University', 'ror': 'https://ror.org/030sc3x20', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126060']}, {'id': 'https://openalex.org/I160354086', 'display_name': 'Guangxi Medical University', 'ror': 'https://ror.org/03dveyr97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I160354086']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lihong Wu', 'raw_affiliation_strings': ['The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China'], 'affiliations': [{'raw_affiliation_string': 'The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China', 'institution_ids': ['https://openalex.org/I4210126060', 'https://openalex.org/I160354086']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101455395', 'display_name': 'Yiqiang Chen', 'orcid': 'https://orcid.org/0000-0001-6270-8600'}, 'institutions': [{'id': 'https://openalex.org/I4210126060', 'display_name': 'First Affiliated Hospital of GuangXi Medical University', 'ror': 'https://ror.org/030sc3x20', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126060']}, {'id': 'https://openalex.org/I160354086', 'display_name': 'Guangxi Medical University', 'ror': 'https://ror.org/03dveyr97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I160354086']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yiqiang Chen', 'raw_affiliation_strings': ['The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China'], 'affiliations': [{'raw_affiliation_string': 'The Institute of Respiratory Diseases, First Affiliated Hospital of Guangxi Medical University, Nanning, China', 'institution_ids': ['https://openalex.org/I4210126060', 'https://openalex.org/I160354086']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3690, 'currency': 'EUR', 'value_usd': 4790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.414, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 73, 'citation_normalized_percentile': {'value': 0.907165, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '12', 'issue': '4', 'first_page': '409', 'last_page': '423'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11142', 'display_name': 'Biochemistry of Diabetic Complications', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11142', 'display_name': 'Biochemistry of Diabetic Complications', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10143', 'display_name': 'Standardisation and Management of COPD', 'score': 0.9575, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hmgb1', 'display_name': 'HMGB1', 'score': 0.593989}, {'id': 'https://openalex.org/keywords/blocking-antibody', 'display_name': 'Blocking antibody', 'score': 0.51030535}], 'concepts': [{'id': 'https://openalex.org/C2780545709', 'wikidata': 'https://www.wikidata.org/wiki/Q21130552', 'display_name': 'HMGB1', 'level': 3, 'score': 0.8158246}, {'id': 'https://openalex.org/C2776946954', 'wikidata': 'https://www.wikidata.org/wiki/Q420291', 'display_name': 'Ovalbumin', 'level': 3, 'score': 0.76857615}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.6349444}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.6326681}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.5319082}, {'id': 'https://openalex.org/C141105273', 'wikidata': 'https://www.wikidata.org/wiki/Q79455', 'display_name': 'Immunoglobulin E', 'level': 3, 'score': 0.53170735}, {'id': 'https://openalex.org/C45121317', 'wikidata': 'https://www.wikidata.org/wiki/Q4927287', 'display_name': 'Blocking antibody', 'level': 3, 'score': 0.51030535}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5078476}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.42745227}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.4010004}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.24216855}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20738319}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.20615268}], 'mesh': [{'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002908', 'descriptor_name': 'Chronic Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D024243', 'descriptor_name': 'HMGB1 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007073', 'descriptor_name': 'Immunoglobulin E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007073', 'descriptor_name': 'Immunoglobulin E', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018836', 'descriptor_name': 'Inflammation Mediators', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053583', 'descriptor_name': 'Interleukin-1beta', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020780', 'descriptor_name': 'Matrix Metalloproteinase 9', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020780', 'descriptor_name': 'Matrix Metalloproteinase 9', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/cmi.2014.60', 'pdf_url': 'https://www.nature.com/articles/cmi201460.pdf', 'source': {'id': 'https://openalex.org/S19143454', 'display_name': 'Cellular and Molecular Immunology', 'issn_l': '1672-7681', 'issn': ['1672-7681', '2042-0226'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496537', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25152078', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/cmi.2014.60', 'pdf_url': 'https://www.nature.com/articles/cmi201460.pdf', 'source': {'id': 'https://openalex.org/S19143454', 'display_name': 'Cellular and Molecular Immunology', 'issn_l': '1672-7681', 'issn': ['1672-7681', '2042-0226'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W140429815', 'https://openalex.org/W1484450968', 'https://openalex.org/W1490007860', 'https://openalex.org/W1970801712', 'https://openalex.org/W1998812407', 'https://openalex.org/W2009797710', 'https://openalex.org/W2018653121', 'https://openalex.org/W2027926750', 'https://openalex.org/W2043424050', 'https://openalex.org/W2043926384', 'https://openalex.org/W2045404555', 'https://openalex.org/W2046661997', 'https://openalex.org/W2049038183', 'https://openalex.org/W2056560464', 'https://openalex.org/W2060763719', 'https://openalex.org/W2072353509', 'https://openalex.org/W2083419397', 'https://openalex.org/W2086243507', 'https://openalex.org/W2100592123', 'https://openalex.org/W2103224375', 'https://openalex.org/W2103276204', 'https://openalex.org/W2104386880', 'https://openalex.org/W2118295402', 'https://openalex.org/W2127203245', 'https://openalex.org/W2128426645', 'https://openalex.org/W2135374161', 'https://openalex.org/W2136005561', 'https://openalex.org/W2144541431', 'https://openalex.org/W2149240296', 'https://openalex.org/W2157820814', 'https://openalex.org/W2161361346', 'https://openalex.org/W2171028311', 'https://openalex.org/W2366630861', 'https://openalex.org/W2404708061', 'https://openalex.org/W9670700'], 'related_works': ['https://openalex.org/W4255399293', 'https://openalex.org/W3118313920', 'https://openalex.org/W284386456', 'https://openalex.org/W2286986362', 'https://openalex.org/W2079537492', 'https://openalex.org/W2009376119', 'https://openalex.org/W2002936791', 'https://openalex.org/W1968234338', 'https://openalex.org/W1964674919', 'https://openalex.org/W1611533949'], 'abstract_inverted_index': {'The': [0, 87], 'pro-inflammation': [1], 'factor': [2, 154, 163], 'high-mobility': [3], 'group': [4, 90], 'box': [5], 'protein': [6], '1': [7], '(HMGB1)': [8], 'has': [9], 'been': [10], 'implicated': [11], 'in': [12, 137], 'the': [13, 30, 120, 142, 147], 'pathogenesis': [14], 'of': [15, 25, 32, 94, 151], 'asthma.': [16], 'In': [17, 78], 'this': [18, 79], 'study,': [19], 'we': [20], 'used': [21], 'a': [22], 'murine': [23], 'model': [24], 'chronic': [26], 'asthma': [27], 'to': [28], 'evaluate': [29], 'effects': [31], 'HMGB1': [33, 82, 125, 171], 'on': [34, 60], 'airway': [35, 106, 175, 179], 'remodeling.': [36], 'Female': [37], 'BALB/c': [38], 'mice': [39], 'were': [40], 'randomly': [41], 'divided': [42], 'into': [43], 'four': [44], 'groups:': [45], 'control,': [46], 'ovalbumin': [47], '(OVA)': [48], 'asthmatic,': [49], 'OVA+isotype': [50], 'antibody': [51, 56, 89], 'and': [52, 63, 98, 101, 114, 131, 149, 159, 181, 186], 'OVA+anti-HMGB1': [53], 'antibody.': [54], 'Anti-HMGB1': [55], 'therapy': [57], 'was': [58, 64], 'started': [59], 'day': [61], '21': [62], 'administered': [65], 'three': [66], 'times': [67], 'per': [68], 'week': [69], 'for': [70], '6': [71], 'weeks': [72], 'before': [73], 'intranasal': [74], 'challenge': [75], 'with': [76, 119, 124, 141], 'OVA.': [77], 'mouse': [80], 'model,': [81], 'expression': [83, 136, 148], 'is': [84], 'significantly': [85, 145], 'elevated.': [86], 'anti-HMGB1': [88], 'exhibited': [91], 'decreased': [92], 'levels': [93], 'immunoglobulin': [95], 'E': [96], '(IgE)': [97], 'inflammatory': [99, 103], 'mediators': [100], 'reduced': [102], 'cell': [104], 'accumulation,': [105], 'hyperresponsiveness': [107], '(AHR),': [108], 'mucus': [109], 'synthesis,': [110], 'smooth': [111], 'muscle': [112, 133], 'thickness': [113], 'lung': [115, 183], 'collagen': [116, 129], 'content': [117], 'compared': [118], 'OVA': [121], 'groups.': [122], 'Treatment': [123, 140], 'increased': [126, 146], 'proliferation,': [127], 'migration,': [128], 'secretion': [130, 150], 'α-smooth': [132], 'actin': [134], '(SMA)': [135], 'MRC-5': [138], 'cells.': [139], 'HMGB1/IL-1β': [143], 'complex': [144], 'transforming': [152], 'growth': [153, 162], '(TGF-β1),': [155], 'matrix': [156], 'metalloproteinase': [157], '(MMP)-9': [158], 'vascular': [160], 'endothelial': [161], '(VEGF).': [164], 'Altogether,': [165], 'these': [166], 'results': [167], 'suggest': [168], 'that': [169], 'blocking': [170], 'activity': [172], 'may': [173], 'reverse': [174], 'remodeling': [176], 'by': [177], 'suppressing': [178], 'inflammation': [180], 'modulating': [182], 'fibroblast': [184], 'phenotype': [185], 'activation.': [187]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1971306169', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-09-10T15:23:57.067849', 'created_date': '2016-06-24'}