Publication Information

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5622, 5662, 5665, 5674, 5747, 5751, 5808], 'MDM2-MDMX': [20, 143, 693, 3710, 3893, 4013, 4047, 4065, 4120, 4919, 5666, 5781], 'complex': [21, 144, 4121, 4940], 'functions': [22, 145, 295, 351], 'as': [23, 39, 146, 162, 352, 1072, 1097, 1110, 1632, 2283, 2324, 2420, 2585, 2587, 2769, 3292, 3294, 3329, 3396, 3862, 4091, 4452, 5052, 5615], 'an': [24, 103, 147, 226, 353, 2391, 2472, 2873, 3200, 3886, 4012, 4854, 5105, 5638], 'integral': [25, 148], 'unit': [26, 149], 'targeting': [28, 151], 'for': [30, 153, 831, 923, 2179, 2242, 2275, 2364, 2390, 2533, 2642, 2993, 3061, 3138, 3334, 3379, 3968, 5537, 5805, 5812, 5824], 'degradation.': [31, 154, 5539], 'Here': [32, 155, 1848], 'we': [33, 57, 156, 180, 641, 1849, 2709, 2812, 2821, 2866, 2940, 2958, 3055, 3092, 3212, 3260, 3411, 3794, 3942, 4088, 4100, 4135, 4142, 4256, 4974, 4999, 5026, 5091, 5634, 5654], 'identify': [34, 157, 2559], 'small': [36, 159, 1063, 2789], 'protein': [37, 111, 160, 234, 313, 359, 820, 1018, 1156, 2039, 2350, 2628, 2683, 3081, 3220, 3443, 3510, 3834, 3964, 4445, 4508, 4605, 5739], '14-3-3': [38, 161, 925, 1025, 1060, 1080, 1162, 1172, 1862, 2552, 2690, 2712, 2729, 2786, 2805, 2825, 2847, 2864, 2878, 2893, 2935, 2948, 2995, 3001, 3005, 3029, 3342, 3356, 3380, 3679, 4396, 4977, 4990, 5003, 5191, 5612, 5625, 5641, 5658, 5692, 5708, 5728, 5765], 'a': [40, 53, 163, 176, 251, 264, 281, 374, 396, 918, 1092, 1161, 1861, 1999, 2540, 2554, 2565, 2578, 2588, 2652, 2711, 2728, 2799, 2868, 2895, 2907, 2971, 3043, 3089, 3187, 3311, 3330, 3484, 3540, 3678, 3997, 4030, 4092, 4102, 4210, 4317, 4330, 4443, 4453, 4621, 4984, 5053, 5125, 5681, 5727, 5755, 5764], 'binding': [41, 164, 473, 919, 1026, 1163, 1173, 1363, 1863, 2561, 2715, 2730, 2826, 2879, 2898, 2918, 2930, 2942, 2996, 3006, 3030, 3035, 3343, 3360, 3395, 3680, 3686, 3894, 4048, 4066, 4801, 4972, 5004, 5049, 5192, 5626, 5646, 5659, 5709, 5766], 'partner': [42, 165, 1089, 2899], 'of': [43, 66, 75, 80, 97, 166, 189, 198, 203, 220, 254, 277, 318, 338, 342, 361, 399, 410, 723, 906, 911, 1005, 1009, 1021, 1031, 1042, 1079, 1087, 1094, 1100, 1104, 1224, 1346, 1372, 1524, 1855, 1900, 1909, 1912, 1966, 1975, 2002, 2067, 2107, 2188, 2299, 2314, 2354, 2431, 2496, 2524, 2563, 2595, 2612, 2665, 2705, 2727, 2742, 2856, 2860, 2900, 2919, 2927, 2931, 2943, 3014, 3024, 3028, 3045, 3063, 3078, 3101, 3119, 3160, 3216, 3222, 3238, 3251, 3265, 3280, 3287, 3341, 3350, 3366, 3375, 3383, 3408, 3437, 3455, 3474, 3487, 3493, 3520, 3525, 3529, 3687, 3704, 3799, 3815, 3827, 3836, 3841, 3850, 3858, 3877, 3918, 3933, 3977, 3988, 4006, 4011, 4057, 4063, 4098, 4115, 4128, 4130, 4148, 4200, 4212, 4226, 4266, 4320, 4332, 4340, 4347, 4362, 4368, 4392, 4406, 4410, 4418, 4423, 4437, 4489, 4499, 4505, 4514, 4624, 4744, 4858, 4938, 4970, 4982, 5017, 5031, 5040, 5063, 5069, 5098, 5115, 5504, 5520, 5531, 5624, 5647, 5664, 5673, 5685, 5778], 'MDMX,': [44, 167, 401, 1525, 2564, 2768, 3113, 3211, 3217, 3410, 3838, 3948, 4173, 4207, 4393, 4803, 5051, 5715, 5769], 'which': [45, 107, 168, 230, 324, 927, 2965, 3057, 3478, 3691, 4022, 4161, 4267, 4302, 4382, 4750, 4804, 4928, 5716, 5770], 'binds': [46, 169, 333, 930, 5730], 'at': [47, 68, 170, 191, 698, 1237, 1364, 2253, 2361, 2530, 3065, 3196, 3476, 3675, 5081, 5789], 'C': [49, 172], 'terminus': [50, 173], '(Ser367)': [51, 174], 'phosphorylation-dependent': [54, 177, 2800], 'manner.': [55, 178, 2801, 5107], 'Importantly,': [56, 179, 1619, 4344], 'demonstrate': [58, 181, 2916, 3914], 'serine/threonine': [61, 184, 819, 1070, 3080, 4604], 'kinase': [62, 185, 821, 837, 2518, 3058, 3082, 3106, 3333, 4606], 'Akt': [63, 87, 100, 108, 186, 210, 223, 231, 822, 828, 1010, 1159, 1167, 1217, 1236, 1852, 1890, 1949, 2516, 3047, 3096, 3110, 3148, 3156, 3177, 3181, 3328, 3347, 3405, 3439, 3475, 3488, 3533, 3672, 3800, 3824, 3830, 3843, 3921, 3940, 3953, 3989, 4007, 4116, 4242, 4270, 4294, 4303, 4321, 4369, 4383, 4607, 4761, 5021, 5034, 5070, 5103, 5131, 5752, 5762], 'mediates': [64, 187, 4741], 'phosphorylation': [65, 71, 188, 194, 905, 915, 1157, 1351, 1509, 1633, 1866, 2858, 3062, 3100, 3159, 3250, 3263, 3308, 3320, 3374, 3473, 5016, 5493, 5519, 5530, 5619], 'MDMX': [67, 76, 98, 190, 199, 221, 466, 571, 579, 705, 1516, 1620, 1857, 1901, 2505, 2556, 2581, 2596, 2658, 2666, 2688, 2707, 2734, 2808, 2829, 2861, 2901, 2922, 2933, 2944, 3009, 3025, 3041, 3064, 3120, 3192, 3239, 3266, 3351, 3432, 3442, 3464, 3494, 3509, 3521, 3674, 3688, 3701, 3807, 3820, 3887, 3925, 3936, 3981, 4044, 4059, 4131, 4227, 4236, 4251, 4333, 4341, 4363, 4398, 4847, 4971, 5007, 5032, 5120, 5138, 5336, 5345, 5538, 5628, 5648, 5686, 5731], 'Ser367.': [69, 192, 3066], 'This': [70, 193, 1354, 2763, 2881, 4140, 4617], 'leads': [72, 195, 1023, 3683, 4619, 4941, 5660, 5771], 'to': [73, 196, 259, 291, 334, 356, 367, 370, 405, 474, 574, 584, 726, 931, 1014, 1024, 1034, 1068, 1350, 1625, 1636, 1642, 1893, 1905, 1931, 1938, 2576, 2608, 2624, 2681, 2767, 2807, 2815, 2832, 2845, 2872, 2887, 2889, 2915, 2934, 2945, 2963, 2969, 3007, 3036, 3072, 3244, 3255, 3269, 3314, 3346, 3355, 3417, 3448, 3462, 3482, 3497, 3537, 3684, 3689, 3811, 3823, 3871, 3896, 4001, 4035, 4043, 4045, 4117, 4144, 4228, 4238, 4273, 4292, 4313, 4366, 4371, 4447, 4620, 4852, 4922, 4942, 4994, 5044, 5050, 5057, 5059, 5124, 5143, 5186, 5190, 5339, 5512, 5552, 5607, 5627, 5649, 5661, 5691, 5735, 5772], 'stabilization': [74, 79, 96, 197, 202, 219, 1243, 3215, 3492, 3814, 3917, 4129, 4339, 4391, 4405, 4504, 4613, 4814, 5030, 5039, 5078, 5663, 5774, 5777], 'and': [77, 89, 113, 200, 212, 236, 284, 346, 366, 575, 662, 704, 729, 826, 932, 1027, 1170, 1368, 1902, 1914, 1916, 1934, 1936, 1941, 1951, 1957, 1961, 1970, 1979, 1991, 1995, 2076, 2087, 2100, 2115, 2122, 2139, 2165, 2177, 2181, 2197, 2204, 2245, 2278, 2303, 2316, 2367, 2383, 2397, 2414, 2464, 2528, 2548, 2619, 2635, 2640, 2659, 2689, 2913, 2956, 3173, 3527, 3546, 3553, 3682, 3707, 3935, 3949, 3963, 3980, 4037, 4110, 4171, 4195, 4250, 4260, 4276, 4309, 4408, 4494, 4520, 4614, 4788, 4800, 4935, 4945, 5179, 5498, 5525, 5546, 5621, 5732, 5775, 5786, 5802, 5807], 'consequent': [78, 201, 5776], 'MDM2.': [81, 91, 204, 214, 1227, 2670, 4497, 5779], 'Previous': [82, 205, 1511], 'studies': [83, 206, 1341, 1512, 3233, 3864, 4757, 4773, 5134], 'phosphorylates': [88, 211, 3673, 4608], 'stabilizes': [90, 213, 1517, 5023], 'Our': [92, 215, 1886, 3666, 5072, 5743], 'data': [93, 216, 3667, 3913, 4358, 4376, 5073, 5744], 'suggest': [94, 217, 3372, 3506, 4234, 4359, 4738, 4791], 'by': [99, 106, 222, 229, 323, 472, 916, 936, 1091, 1108, 1158, 1235, 1352, 1628, 1881, 1921, 1985, 2157, 2289, 2369, 2403, 2550, 2644, 3428, 3435, 3514, 3550, 3805, 3910, 3920, 3924, 3939, 4157, 4254, 4381, 4435, 4516, 4749, 4779, 5010, 5020, 5033, 5102, 5670], 'may': [101, 224, 3143, 5534, 5711, 5717], 'be': [102, 225, 406, 1626, 2970, 3144, 3483, 3872, 4853, 4923, 5045, 5509, 5535, 5605, 5712], 'alternative': [104, 227], 'mechanism': [105, 228, 4380, 4484, 4748], 'up-regulates': [109, 232], 'MDM2': [110, 233, 312, 325, 332, 350, 703, 1232, 1347, 1362, 1502, 1518, 1526, 1873, 2583, 2601, 2776, 3037, 3526, 3552, 3706, 3718, 3802, 3816, 3851, 3868, 3898, 3919, 3934, 3979, 4407, 4501, 4507, 4740, 4764, 4776, 4781, 4793, 4943, 5060, 5065, 5077, 5650], 'levels': [112, 235, 360, 372, 3444, 3465, 3511, 3835, 3849, 3869, 3965, 5121], 'exerts': [114, 237], 'its': [115, 238, 285, 475, 727, 836, 1012, 1032, 1242, 1898, 3694, 4385, 4450, 4518, 4612, 4798, 4813, 5048, 5086, 5773], 'oncogenic': [116, 239, 1907, 4386], 'effects': [117, 240, 4127, 4346], 'on': [118, 241, 1858, 2539, 2828, 3150, 3167, 3393, 3801, 3819, 4132, 4223, 5006, 5047, 5088, 5501, 5642, 5714, 5768], 'cells.': [122, 245], 'regulator': [253, 317, 409, 4493, 4857], 'cell': [255, 269, 273, 732, 824, 2373, 2399, 2572, 3544, 4934], 'proliferation.': [256, 827], 'In': [257, 1153, 2480, 2938, 4095, 4296, 4429, 4968, 5327], 'response': [258, 265, 376, 1349, 1635, 3243, 3268, 3312, 3447, 3496, 3822, 4365, 5123, 5142, 5488, 5551, 5567], 'cellular': [260, 294, 5705], 'stresses,': [261], 'elicits': [263, 4384], 'results': [267, 1028, 1355, 2782, 3302, 3371, 3692, 4233, 4736, 4762, 5035], 'cycle': [270], 'arrest': [271], 'death.': [274], 'activation': [276, 3436, 4947, 5114], 'occurs': [279], 'robust': [282], 'manner,': [283, 2811], 'proper': [286], 'regulation': [287, 1899], 'therefore': [289, 5784], 'maintain': [292, 357], 'normal': [293, 371], '(1Vogelstein': [296], 'B.': [297, 1487, 3652, 4564, 4720], 'Lane': [298, 5313, 5468], 'D.': [299, 380, 418, 542, 649, 735, 739, 741, 1278, 1317, 1329, 1408, 1557, 1648, 1774, 1824, 2048, 2330, 3592, 3727, 4074, 4536, 4581, 4660, 4885, 4889, 4955, 5283, 5438], 'Levine': [300], 'A.J.': [301, 520, 808, 3753, 4828], 'Nature.': [302, 892], '2000;': [303, 485, 2058, 3759, 4834], '408:': [304], '307-310Crossref': [305], 'PubMed': [306, 389, 461, 488, 528, 562, 606, 635, 657, 684, 769, 848, 868, 896, 955, 986, 998, 1055, 1121, 1136, 1148, 1185, 1200, 1212, 1262, 1292, 1311, 1335, 1392, 1422, 1441, 1473, 1496, 1545, 1565, 1590, 1614, 1668, 1691, 1724, 1742, 1766, 1804, 1843, 2061, 2339, 2758, 2986, 3576, 3606, 3638, 3661, 3735, 3767, 3789, 4082, 4470, 4550, 4573, 4592, 4644, 4674, 4706, 4729, 4842, 4879, 4908, 4963, 5172, 5221, 5239, 5263, 5302, 5322, 5376, 5394, 5418, 5457, 5477, 5596], 'Scopus': [307, 390, 462, 489, 529, 563, 607, 636, 658, 685, 770, 849, 869, 897, 956, 987, 999, 1056, 1122, 1137, 1149, 1186, 1201, 1213, 1263, 1293, 1312, 1336, 1393, 1423, 1442, 1474, 1497, 1546, 1566, 1591, 1615, 1669, 1692, 1725, 1743, 1767, 1805, 1844, 2062, 2340, 2759, 2987, 3577, 3607, 3639, 3662, 3736, 3768, 3790, 4083, 4471, 4551, 4574, 4593, 4645, 4675, 4707, 4730, 4843, 4880, 4909, 4964, 5173, 5222, 5240, 5264, 5303, 5323, 5377, 5395, 5419, 5458, 5478, 5597], '(5798)': [308], 'Google': [309, 392, 440, 464, 491, 531, 565, 609, 638, 660, 687, 772, 795, 816, 851, 871, 899, 958, 989, 1001, 1058, 1124, 1139, 1151, 1188, 1203, 1215, 1265, 1295, 1314, 1338, 1395, 1425, 1444, 1476, 1499, 1548, 1568, 1593, 1617, 1671, 1694, 1727, 1745, 1769, 1807, 1846, 2064, 2342, 2761, 2989, 3579, 3609, 3641, 3664, 3738, 3770, 3792, 4085, 4473, 4553, 4576, 4595, 4647, 4677, 4709, 4732, 4845, 4882, 4911, 4966, 5175, 5224, 5242, 5266, 5305, 5325, 5379, 5397, 5421, 5460, 5480, 5599], 'Scholar).': [310, 393, 465, 566, 639, 817, 900, 1002, 1059, 1152, 1216, 1339, 1500, 1618, 1847, 2065, 2343, 2762, 2990, 3665, 4474, 4596, 4733, 4846, 4912, 4967, 5176, 5326, 5481], 'one': [315, 4379], 'key': [316], 'activity.': [320, 1885, 3348, 3489, 3825, 4151, 4231, 4243, 4295, 5071, 5132, 5792], 'manner': [322, 3202, 3541], 'inhibits': [326], 'activity': [328, 412, 471, 588, 838, 1360, 1908, 3557, 4185, 4271, 4304, 4322, 4354, 4524, 4785, 5097], '2-fold.': [330], 'First,': [331], 'transactivation': [336, 476, 1366], 'domain': [337, 477, 1367, 1956, 2664, 4033, 4040], 'p53,': [339, 716, 4745], 'preventing': [340, 1040, 1882, 5671], 'transcription': [341, 912, 4454], 'downstream': [343, 4986], 'targets.': [344, 3053], 'Second,': [345], 'perhaps': [347], 'more': [348, 696, 1869, 3714, 5562, 5602, 5787], 'importantly,': [349], 'E3': [354, 586, 4495, 4783, 4807], 'ligase': [355, 587, 4496, 4784, 4808], 'low': [358], 'under': [363, 2096, 2109, 4241, 5522, 5693, 5703, 5740], 'non-stressed': [364], 'conditions': [365, 5695], 'return': [368], 'after': [373, 1519, 3423, 3451], 'damage': [375, 1638, 3258, 5487, 5566], 'resolved': [378, 2156, 2368, 2538], '(2Michael': [379], 'Oren': [381, 1305], 'M.': [382, 420, 505, 673, 743, 779, 1245, 1306, 1375, 1579, 1678, 1781, 1783, 1816, 3559, 3777, 4627, 4893, 5275, 5430], 'Semin.': [383, 841], 'Cancer': [384, 435, 652, 790, 811, 1560, 2007, 3730, 4077, 4958], 'Biol.': [385, 484, 552, 596, 625, 765, 844, 1282, 1412, 1463, 1492, 1535, 1604, 1658, 1720, 1839, 2057, 2335, 3596, 3628, 3657, 3757, 3779, 4540, 4569, 4664, 4696, 4725, 4832, 4904, 5217, 5298, 5372, 5453, 5592], '2003;': [386, 627, 681, 952, 995, 1052, 1118, 1182, 1587, 1660, 2336, 2755, 2983, 4467], '13:': [387], '49-58Crossref': [388], '(643)': [391], 'More': [394], 'recently,': [395], 'close': [397], 'homologue': [398, 4799], 'MDM2,': [400, 3947, 4036, 4609], 'has': [402, 580, 1218, 1622, 2041, 2966, 3479, 3534, 4598, 4849], 'been': [403, 582, 707, 1219, 1623, 2042, 2967, 3480, 3535, 4599, 4850, 5184], 'another': [407, 4137, 5736], '(3Finch': [413], 'R.A.': [414], 'Donoviel': [415], 'D.B.': [416, 1249, 1379, 1430, 3563, 4631], 'Potter': [417], 'Shi': [419], 'Fan': [421], 'A.': [422, 445, 494, 667, 669, 680, 754, 881, 971, 982, 1276, 1406, 1437, 1573, 1575, 1586, 1680, 1682, 1701, 1800, 1820, 1822, 3590, 4534, 4658, 4863, 4891, 4895, 5198, 5279, 5281, 5353, 5434, 5436, 5573], 'Freed': [423], 'D.D.': [424], 'Wang': [425], 'C.Y.': [426], 'Zambrowicz': [427], 'B.P.': [428, 1479, 3644, 4556, 4712], 'Ramirez-Solis': [429], 'R.': [430, 745, 777, 800, 944, 1270, 1302, 1400, 3584, 3741, 4528, 4652, 4816], 'Sands': [431], 'A.T.': [432], 'Zhang': [433], 'N.': [434, 498, 1459, 3624, 3745, 4692, 4820], 'Res.': [436, 653, 791, 812, 1561, 2754, 3731, 4078, 4588, 4959], '2002;': [437, 554, 598, 860, 1145, 1209, 1259, 1308, 1389, 1465, 1537, 1688, 3573, 3630, 4641, 4698, 4905], '62:': [438], '3221-3225PubMed': [439], 'Scholar,': [441, 492, 532, 610, 773, 796, 852, 872, 959, 990, 1125, 1140, 1189, 1204, 1266, 1296, 1315, 1396, 1426, 1445, 1477, 1549, 1569, 1594, 1672, 1695, 1728, 1746, 1770, 1808, 3580, 3610, 3642, 3739, 3771, 4554, 4577, 4648, 4678, 4710, 4883, 5225, 5243, 5267, 5306, 5380, 5398, 5422, 5461], '4Parant': [442], 'J.': [443, 524, 534, 546, 551, 595, 624, 781, 783, 802, 840, 856, 889, 969, 1130, 1194, 1268, 1281, 1398, 1411, 1462, 1534, 1603, 1652, 1657, 1736, 1738, 1762, 2046, 2050, 3582, 3595, 3627, 3749, 3756, 3778, 4526, 4539, 4579, 4585, 4650, 4663, 4695, 4824, 4831, 4861, 5233, 5235, 5259, 5316, 5318, 5388, 5390, 5414, 5471, 5473], 'Chavez-Reyes': [444, 4862], 'Little': [446, 614, 3744, 4819, 4864], 'N.A.': [447, 615, 4865], 'Yan': [448, 4866], 'W.': [449, 514, 1483, 3648, 4560, 4716, 4867], 'Reinke': [450, 4868], 'V.': [451, 645, 1553, 3723, 4070, 4869, 4951], 'Jochemsen': [452, 521, 543, 622, 759, 809, 1683, 1716, 1790, 1833, 3754, 4829, 4870, 4890, 5160, 5213, 5292, 5368, 5447, 5588], 'A.G.': [453, 522, 544, 623, 760, 810, 1684, 1717, 1791, 1834, 3755, 4830, 4871, 5161, 5214, 5293, 5369, 5448, 5589], 'Lozano': [454, 547, 4872], 'G.': [455, 516, 548, 789, 1709, 4873, 5206, 5361, 5581], 'Nat.': [456, 1049, 1115, 1179, 1490, 2980, 3655, 4464, 4567, 4723, 4874], 'Genet.': [457, 4875], '2001;': [458, 813, 1438, 1493, 3658, 4570, 4726, 4876], '29:': [459, 4877], '92-95Crossref': [460, 4878], '(412)': [463, 4881], 'also': [467, 2885, 3213, 3853, 4327, 5110, 5183, 5542, 5677, 5724], 'suppresses': [468, 5130], 'transcriptional': [470, 1359, 1884, 4150, 4353, 4523, 5096, 5113], '(5Jackson': [478], 'M.W.': [479], 'Berberich': [480], 'S.J.': [481, 621], 'Mol.': [482, 763, 1718, 1837, 2055, 2333, 4902, 5162, 5215, 5296, 5370, 5451, 5590], 'Cell.': [483, 764, 859, 1719, 1838, 2056, 2334, 4903, 5163, 5216, 5297, 5371, 5452, 5591], '20:': [486, 2059], '1001-1007Crossref': [487], '(183)': [490], '6Shvarts': [493], 'Steegenga': [495], 'W.T.': [496], 'Riteco': [497], 'van': [499, 506, 509, 512, 517, 805, 3750, 4825], 'Laar': [500], 'T.': [501, 942, 1451, 1455, 3616, 3620, 4684, 4688], 'Dekker': [502], 'P.': [503, 613, 748, 752, 1319, 1777, 4463], 'Bazuine': [504], 'Ham': [507], 'R.C.': [508], 'der': [510, 518, 806, 3751, 4826], 'Houven': [511], 'Oordt': [513], 'Hateboer': [515], 'Eb': [519, 807, 3752, 4827], 'EMBO': [523, 1737, 1761, 5234, 5258, 5317, 5389, 5413, 5472], '1996;': [525], '15:': [526, 846], '5349-5357Crossref': [527], '(517)': [530], '7Gu': [533], 'Kawai': [535], 'H.': [536, 540, 643, 961, 967, 1048, 1114, 1178, 1551, 1646, 1650, 1760, 2328, 2979, 3721, 4068, 4949, 5155, 5257, 5412], 'Nie': [537], 'L.': [538, 1707, 1732, 5204, 5229, 5308, 5359, 5384, 5463, 5579], 'Kitao': [539, 1649], 'Wiederschain': [541, 648, 1556, 1647, 2329, 3726, 4073, 4954], 'Parant': [545], 'Yuan': [549, 650, 1558, 1655, 2053, 2331, 3728, 4075, 4956], 'Z.-M.': [550, 651, 1559, 1656, 2054, 2332, 3729, 4076, 4957], 'Chem.': [553, 597, 626, 1283, 1413, 1464, 1536, 1605, 1659, 3597, 3629, 3758, 3780, 4541, 4665, 4697, 4833], '277:': [555, 599, 1466, 1538, 3631, 4699], '19251-19254Abstract': [556], 'Full': [557, 559, 601, 603, 630, 632, 863, 865, 1287, 1289, 1417, 1419, 1468, 1470, 1540, 1542, 1609, 1611, 1663, 1665, 3601, 3603, 3633, 3635, 3762, 3764, 3784, 3786, 4545, 4547, 4669, 4671, 4701, 4703, 4837, 4839, 5167, 5169], 'Text': [558, 560, 602, 604, 631, 633, 864, 866, 1288, 1290, 1418, 1420, 1469, 1471, 1541, 1543, 1610, 1612, 1664, 1666, 3602, 3604, 3634, 3636, 3763, 3765, 3785, 3787, 4546, 4548, 4670, 4672, 4702, 4704, 4838, 4840, 5168, 5170], 'PDF': [561, 605, 634, 867, 1291, 1421, 1472, 1544, 1613, 1667, 3605, 3637, 3766, 3788, 4549, 4673, 4705, 4841, 5171], '(210)': [564], 'Studies': [567, 1228], 'can': [572, 4509], 'bind': [573, 1067, 2846, 2888, 3051, 5058, 5614], 'stabilize': [576, 3897, 4118], 'MDM2;': [577, 5041], 'however,': [578, 3141, 4771, 4797], 'not': [581, 1505, 2668, 2772, 2954, 2962, 2976, 3017, 3032, 3039, 3088, 3115, 3297, 3310, 3845, 5630, 5636, 5652, 5679, 5697], 'possess': [585], 'vivo': [590], '(8Badciong': [591, 1530], 'J.C.': [592, 762, 1531, 1828, 2747, 4901, 5287, 5442], 'Haas': [593, 1532], 'A.L.': [594, 1533], '49668-49675Abstract': [600, 1539], '(97)': [608, 1547], '9de': [611], 'Graaf': [612, 747, 1776], 'Ramos': [616, 3742, 4817], 'Y.F.': [617, 798, 3743, 4818], 'Meulmeester': [618, 736, 1704, 1778, 5201, 5356, 5576], 'E.': [619, 737, 877, 1705, 1779, 5147, 5202, 5357, 5577], 'Letteboer': [620], '278:': [628, 1661], '38315-38324Abstract': [629], '(122)': [637], 'Furthermore,': [640, 5025, 5611], '(10Kawai': [642, 3720, 4067, 4948], 'Lopez-Pajares': [644, 1552, 3722, 4069, 4950], 'Kim': [646, 1554, 3724, 4071, 4952], 'M.M.': [647, 1555, 3725, 4072, 4953, 5149], '2007;': [654, 1562, 3732, 3781, 4079, 4960], '67:': [655, 1563, 3733, 4080, 4961], '6026-6030Crossref': [656, 1564, 3734, 4081, 4962], '(114)': [659, 1567, 3737, 4084, 4965], 'Scholar)': [661, 688], 'others': [663, 4768], '(11Linares': [664], 'L.K.': [665, 1571], 'Hengstermann': [666, 1572], 'Ciechanover': [668, 1574], 'Muller': [670, 1576], 'S.': [671, 679, 750, 883, 885, 981, 992, 1321, 1323, 1436, 1449, 1577, 1585, 1699, 1703, 1785, 1799, 1818, 3614, 3747, 3775, 4583, 4682, 4822, 5196, 5200, 5277, 5351, 5355, 5432, 5571, 5575], 'Scheffner': [672, 1578, 3776], 'Proc.': [674, 976, 1431, 1580, 1794], 'Natl.': [675, 977, 1432, 1581, 1795], 'Acad.': [676, 978, 1433, 1582, 1796], 'Sci.': [677, 979, 1132, 1196, 1434, 1583, 1797], 'U.': [678, 787, 980, 1435, 1584, 1798], '100:': [682, 1588], '12009-12014Crossref': [683, 1589], '(280)': [686, 1592], 'heterocomplex': [694, 3711, 4920, 5782], 'efficient': [697, 5788], 'ubiquitylating': [699], 'p53.': [700, 4411], 'Of': [701, 3317], 'interest,': [702], 'found': [708, 2773], 'amplified': [709], 'certain': [711, 5506], 'cancers': [712], 'retain': [714, 4459], 'wild-type': [715, 3112, 3837, 4172, 4460], 'indicating': [717, 2891], 'these': [719, 2613, 4193, 4288, 4735, 5559], 'negative': [721, 4093, 4492, 4856], 'regulators': [722], 'contribute': [725], 'inactivation': [728, 1880, 4409, 4422, 4513, 4623, 4743], 'thus': [730, 1039, 3554], 'promote': [731, 1643], 'proliferation': [733], '(12Danovi': [734], 'Pasini': [738], 'Migliorini': [740, 1823, 5282, 5437], 'Capra': [742], 'Frenk': [744], 'de': [746, 1775], 'Francoz': [749], 'Gasparini': [751], 'Gobbi': [753, 4894], 'Helin': [755, 4896], 'K.': [756, 973, 1457, 1711, 1810, 1812, 3622, 4690, 4897, 5208, 5269, 5271, 5363, 5424, 5426, 5583], 'Pelicci': [757, 4898], 'P.G.': [758, 4899], 'Marine': [761, 1827, 4900, 5286, 5441], '2004;': [766, 845, 893, 983, 1133, 1197, 1284, 1332, 1414, 3598, 4542, 4666], '24:': [767, 5320, 5475], '5835-5843Crossref': [768], '(267)': [771], '13Riemenschneider': [774], 'M.J.': [775, 1600], 'Buschges': [776], 'Wolter': [778], 'Reifenberger': [780, 788], 'Bostrom': [782], 'Kraus': [784], 'J.A.': [785], 'Schlegel': [786], '1999;': [792, 1606], '59:': [793], '6091-6096PubMed': [794], '14Ramos': [797], 'Stad': [799], 'Attema': [801, 3748, 4823], 'Peltenburg': [803], 'L.T.': [804], '61:': [814], '1839-1842PubMed': [815], 'promotes': [823, 3543], 'survival': [825, 3545], 'responsible': [830, 3060], 'stimulating': [832], 'pro-survival': [833, 1007, 4603], 'signals': [834], 'through': [835, 1508, 1897, 4389, 4395, 4486, 5085, 5491], '(15Downward': [839], 'Cell': [842, 993, 1131, 1195, 1491, 2069, 2129, 2195, 2301, 3656, 4568, 4724], 'Dev.': [843], '177-182Crossref': [847], '(678)': [850], '16Brazil': [853], 'D.P.': [854, 1274, 1404, 3588, 4532, 4656], 'Park': [855], 'Hemmings': [857, 1279, 1409, 3593, 4537, 4661], 'B.A.': [858, 1280, 1410, 3594, 4538, 4662], '111:': [861], '293-303Abstract': [862], '(487)': [870], '17Wendel': [873], 'H.G.': [874], 'De': [875], 'Stanchina': [876], 'Fridman': [878], 'J.S.': [879], 'Malina': [880], 'Ray': [882], 'Kogan': [884], 'Cordon-Cardo': [886], 'C.': [887, 1730, 1830, 5151, 5227, 5289, 5382, 5444], 'Pelletier': [888], 'Lowe': [890], 'S.W.': [891], '428:': [894], '332-337Crossref': [895], '(843)': [898], 'One': [901, 4483], 'example': [902, 1004], 'pro-apoptotic': [908, 1017], 'Forkhead': [909], 'family': [910], 'factors.': [913], 'Following': [914], 'Akt,': [917, 4255], 'site': [920, 2827, 3076, 3137, 3198, 5005, 5767], 'generated': [922, 1920, 5009, 5713], 'protein,': [926, 2584], 'turn': [929], 'inactivates': [933], 'FOXO': [934], 'proteins': [935, 1061, 1065, 1090, 1112, 2615, 2699, 2787, 2791, 3049, 4930, 5613], 'promoting': [937], 'their': [938, 1088, 2796], 'nuclear': [939, 1344, 4615, 4765], 'export': [940], '(18Obsil': [941], 'Ghirlando': [943], 'Anderson': [945], 'D.E.': [946], 'Hickman': [947], 'A.B.': [948], 'Dyda': [949], 'F.': [950, 1327, 1674, 1676, 1686], 'Biochemistry.': [951], '42:': [953], '15264-15272Crossref': [954], '(84)': [957], '19You': [960], 'Jang': [962], 'Y.': [963, 1304, 1447, 1453, 1461, 1481, 1485, 1697, 1713, 1715, 1748, 1754, 1758, 1772, 1793, 1814, 1832, 1836, 3612, 3618, 3626, 3646, 3650, 4558, 4562, 4680, 4686, 4694, 4714, 4718, 5194, 5210, 5212, 5245, 5251, 5255, 5273, 5291, 5295, 5312, 5349, 5365, 5367, 5400, 5406, 5410, 5428, 5446, 5450, 5467, 5569, 5585, 5587], 'You-Ten': [964], 'A.I.': [965], 'Okada': [966], 'Liepa': [968], 'Wakeham': [970], 'Zaugg': [972], 'Mak': [974], 'T.W.': [975], '101:': [984], '14057-14062Crossref': [985], '(111)': [988], '20Basu': [991], 'Cycle.': [994], '2:': [996], '69-70Crossref': [997], '(2)': [1000], 'Another': [1003, 2494], 'function': [1008, 1086, 3538, 4387, 4451, 5623], 'ability': [1013, 1033, 4114, 4225], 'phosphorylate': [1015, 5187], 'Bad.': [1019], 'Phosphorylation': [1020, 3279], 'Bad': [1022], 'loss': [1030], 'induce': [1035, 2609], 'mitochondrial': [1036], 'membrane': [1037], 'permeability,': [1038], 'initiation': [1041], 'intrinsic': [1044], 'apoptotic': [1045], 'pathway': [1046, 3097, 3422, 3440, 5753], '(21Hermeking': [1047, 1113, 1177, 2978], 'Rev.': [1050, 1116, 1180, 2981, 4465], 'Cancer.': [1051, 1117, 1181, 2982, 4466], '3:': [1053, 1119, 1183, 1494, 2984, 3659, 4468, 4571, 4727], '931-943Crossref': [1054, 1120, 1184, 2985], '(372)': [1057, 1123, 1187, 2988], 'are': [1062, 1075, 1175, 2788, 3512, 3852, 3937, 4162, 4252, 5548, 5561], 'acidic': [1064, 2790], 'phosphorylated': [1069, 1234, 3052, 3111, 3195, 3241, 5140, 5549], 'residues': [1071, 2719], 'dimers.': [1073], 'There': [1074], 'seven': [1076], 'known': [1077], 'isoforms': [1078, 2949, 4991], 'humans.': [1082], 'They': [1083], 'modify': [1084], 'multitude': [1093], 'mechanisms': [1095], 'such': [1096, 1631], 'sequestration,': [1098], 'alteration': [1099, 1103, 2855], 'protein-protein': [1101], 'interactions,': [1102], 'enzymatic': [1105], 'activity,': [1106, 3941, 3990, 4134, 4214, 4809], 'functioning': [1109], 'adaptor': [1111], '22Dougherty': [1126, 1190], 'M.K.': [1127, 1191], 'Morrison': [1128, 1192], 'D.K.': [1129, 1193], '117:': [1134, 1198], '1875-1884Crossref': [1135, 1199], '(395)': [1138, 1202], '23Yaffe': [1141, 1205], 'M.B.': [1142, 1206, 2751], 'FEBS': [1143, 1207, 1330], 'Lett.': [1144, 1208, 1331], '513:': [1146, 1210], '53-57Crossref': [1147, 1211], '(555)': [1150, 1214], 'several': [1154], 'cases,': [1155, 4431, 4478, 5329], 'generates': [1160, 3677, 5763], 'site;': [1164, 1864], 'both': [1165, 3978, 4929, 5328, 5523], 'consensus': [1168, 3075], 'sequence': [1169, 1174, 2735, 2764, 3068, 3086], 'similar': [1176], 'implicated': [1220], 'down-regulation': [1223, 4361], 'via': [1226], 'different': [1238, 5513, 5704, 5720], 'sites,': [1239, 5620], 'resulting': [1240, 4441, 4610], '(24Ashcroft': [1244, 1374, 3558, 4626], 'Ludwig': [1246, 1376, 3560, 4628], 'R.L.': [1247, 1377, 3561, 4629], 'Woods': [1248, 1378, 3562, 4630], 'Copeland': [1250, 1380, 3564, 4632], 'T.D.': [1251, 1381, 3565, 4633], 'Weber': [1252, 1382, 3566, 4634], 'H.O.': [1253, 1383, 3567, 4635], 'MacRae': [1254, 1384, 3568, 4636], 'E.J.': [1255, 1385, 3569, 4637], 'Vousden': [1256, 1386, 3570, 4638], 'K.H.': [1257, 1387, 3571, 4639], 'Oncogene.': [1258, 1307, 1388, 1687, 3572, 4640], '21:': [1260, 1309, 1390, 1689, 3574, 4642], '1955-1962Crossref': [1261, 1391, 3575, 4643], '(163)': [1264, 1394, 3578, 4646], '25Feng': [1267, 1397, 3581, 4649], 'Tamaskovic': [1269, 1399, 3583, 4527, 4651], 'Yang': [1271, 1401, 3585, 4529, 4653], 'Z.': [1272, 1402, 1756, 3586, 4530, 4654, 5253, 5408], 'Brazil': [1273, 1403, 3587, 4531, 4655], 'Merlo': [1275, 1405, 3589, 4533, 4657], 'Hess': [1277, 1407, 3591, 4535, 4659], '279:': [1285, 1415, 3599, 4543, 4667], '35510-35517Abstract': [1286, 1416, 3600, 4544, 4668], '(222)': [1294, 1424, 3608, 4552, 4676], '26Gottlieb': [1297], 'T.M.': [1298], 'Leal': [1299], 'J.F.': [1300], 'Seger': [1301], 'Taya': [1303, 1712, 1835, 5209, 5294, 5364, 5449, 5584], '1299-1303Crossref': [1310], '(379)': [1313], '27Milne': [1316], 'Kampanis': [1318], 'Nicol': [1320], 'Dias': [1322], 'Campbell': [1324], 'D.G.': [1325], 'Fuller-Pace': [1326], 'Meek': [1328], '577:': [1333], '270-276Crossref': [1334], '(37)': [1337], 'Other': [1340], 'translocation': [1345, 5684], 'Akt.': [1353, 1910, 2493, 3083, 3911, 3956, 4780, 5011], 'decreased': [1357, 4196, 5119], 'from': [1361, 2672, 2830, 5640], 'increases': [1369], 'ubiquitylation': [1371], '28Mayo': [1427], 'L.D.': [1428], 'Donner': [1429], '98:': [1439], '11598-11603Crossref': [1440], '(952)': [1443], '29Ogawara': [1446, 3611, 4679], 'Kishishita': [1448, 3613, 4681], 'Obata': [1450, 3615, 4683], 'Isazawa': [1452, 3617, 4685], 'Suzuki': [1454, 3619, 4687], 'Tanaka': [1456, 3621, 4689], 'Masuyama': [1458, 3623, 4691], 'Gotoh': [1460, 3625, 4693], '21843-21850Abstract': [1467, 3632, 4700], '(474)': [1475, 3640, 4708], '30Zhou': [1478, 3643, 4555, 4711], 'Liao': [1480, 3645, 4557, 4713], 'Xia': [1482, 3647, 4559, 4715], 'Zou': [1484, 3649, 4561, 4717], 'Spohn': [1486, 3651, 4563, 4719], 'Hung': [1488, 3653, 4565, 4721], 'M.C.': [1489, 3654, 4566, 4722], '973-982Crossref': [1495, 3660, 4572, 4728], '(785)': [1498, 3663, 4575, 4731], 'However,': [1501, 4475], 'stability,': [1503], 'regulated': [1506, 3513], 'solely': [1507], 'events.': [1510], 'multimerization;': [1520], 'absence': [1523], 'less': [1528], 'stable': [1529, 3715], '10Kawai': [1550], '11Linares': [1570], '31Sharp': [1595], 'D.A.': [1596], 'Kratowicz': [1597], 'S.A.': [1598], 'Sank': [1599], 'George': [1601], 'D.L.': [1602], '274:': [1607], '38189-38196Abstract': [1608], '(237)': [1616], 'degradation': [1621, 4519, 5672], 'triggered': [1627], 'post-translational': [1629], 'modifications': [1630], 'DNA': [1637, 2315, 3245, 3257, 3315, 5553], 'caspase': [1640], 'cleavage': [1641], 'apoptosis': [1644], '(32Kawai': [1645], 'Stuart': [1651], 'Tsai': [1653], 'K.K.': [1654], '45946-45953Abstract': [1662], '(144)': [1670, 1806], '33Gentiletti': [1673], 'Mancini': [1675], "D'Angelo": [1677], 'Sacchi': [1679], 'Pontecorvi': [1681], 'Moretti': [1685], '867-877Crossref': [1690], '(35)': [1693], '34Pereg': [1696], 'Lam': [1698, 5195, 5350, 5570], 'Teunisse': [1700, 1786, 1821, 5152, 5197, 5280, 5352, 5435, 5572], 'Biton': [1702, 1784, 5199, 5354, 5574], 'Mittelman': [1706, 5203, 5358, 5578], 'Buscemi': [1708, 5205, 5360, 5580], 'Okamoto': [1710, 5207, 5362, 5582], 'Shiloh': [1714, 1792, 1831, 5211, 5290, 5366, 5445, 5586], '2006;': [1721, 1739, 1763, 5218, 5236, 5260, 5373, 5391, 5415, 5593], '26:': [1722, 4590, 5219, 5374, 5594], '6819-6831Crossref': [1723, 5220, 5375, 5595], '(66)': [1726, 5223, 5378, 5598], '35Lebron': [1729, 5226, 5381], 'Chen': [1731, 1735, 2047, 5228, 5232, 5315, 5383, 5387, 5470], 'Gilkes': [1733, 5230, 5309, 5385, 5464], 'D.M.': [1734, 5231, 5310, 5386, 5465], '25:': [1740, 1764, 1841, 5237, 5261, 5300, 5392, 5416, 5455], '1196-1206Crossref': [1741, 5238, 5393], '(94)': [1744, 5241, 5396], '36Jin': [1747, 5244, 5399], 'Dai': [1749, 5246, 5401], 'M.S.': [1750, 5247, 5402], 'Lu': [1751, 1759, 5248, 5256, 5403, 5411], 'S.Z.': [1752, 5249, 5404], 'Xu': [1753, 5250, 5405], 'Luo': [1755, 5252, 5407], 'Zhao': [1757, 5254, 5409], '1207-1218Crossref': [1765, 5262, 5417], '(98)': [1768, 5265, 5420], '37Pereg': [1771], 'Shkedy': [1773], 'Edelson-Averbukh': [1780], 'Salek': [1782], 'A.F.': [1787, 5153], 'Lehmann': [1788], 'W.D.': [1789], '2005;': [1801, 1840, 5164, 5299, 5319, 5454, 5474], '102:': [1802], '5056-5061Crossref': [1803], '38Okamoto': [1809, 5268, 5423], 'Kashima': [1811, 5270, 5425], 'Pereg': [1813, 5272, 5427], 'Ishida': [1815, 5274, 5429], 'Yamazaki': [1817, 5276, 5431], 'Nota': [1819, 5278, 5433], 'Kitabayashi': [1825, 5284, 5439], 'I.': [1826, 5285, 5440], 'Prives': [1829, 5288, 5443], '9608-9620Crossref': [1842, 5301, 5456], '(104)': [1845, 5304, 5459], 'show': [1850, 4377, 5543], 'capable': [1854, 3407, 3703, 4062], 'phosphorylating': [1856], 'Ser367,': [1859, 3161, 3676, 5188], 'generating': [1860], 'this': [1865, 1876, 2678, 2810, 3197, 4432, 4753, 4939, 5042, 5609], 'renders': [1867], 'it': [1868, 2770, 4090, 4751, 5555, 5688, 5734], 'stable,': [1870], 'thereby': [1871, 1903, 2875], 'enhancing': [1872], 'stability.': [1874], 'Moreover,': [1875, 3883, 5090], 'translates': [1877], 'into': [1878, 2081, 2089, 4192, 4403], 'work': [1887], 'suggests': [1888, 3131], 'able': [1892], 'inactivate': [1895], 'contributes': [1904, 4237, 4370], 'Preparation': [1911, 2298], 'Plasmids': [1913, 1943, 2084], 'Proteins—pcDNA3-MDMX(S367A)': [1915], 'pcDNA3-MDMX(P369R)': [1917], 'mutants': [1918, 3808], 'were': [1919, 1963, 1982, 1998, 2079, 2085, 2094, 2111, 2118, 2124, 2131, 2155, 2172, 2211, 2235, 2268, 2287, 2306, 2322, 2346, 2359, 2375, 2401, 2406, 2469, 2485, 2507, 2537, 2631, 2638, 3809, 3958, 3966, 3982], 'two-step': [1922], 'site-directed': [1923, 2819], 'PCR': [1924], 'mutagenesis': [1925], 'utilizing': [1926, 3186], 'following': [1928, 2418], 'primers:': [1929], 'Ser367': [1930, 2814, 3070, 3133, 3237, 3252, 3281, 3307, 3376, 5018, 5497, 5521], 'Ala,': [1932], '5′-TGTCGA-AGAACCATTGCGGCTCCTGTCGTT': [1933], '3′-TCTAAC-GACAGGAGCCGCAATGGTTCTTCG;': [1935], 'Pro369': [1937], 'Arg,': [1939], '5′-ATTTCGGCTCGAGTCGTTAGA': [1940], '3′-TCTAACGAC-TCGAGCCGAAAT.': [1942], 'containing': [1944], 'constitutively': [1945, 2022, 2489, 2512, 3175, 3828, 3951], 'active,': [1946], 'myristoylated,': [1947], 'hemagglutinin-tagged': [1948, 1959], 'with': [1950, 2120, 2141, 2145, 2167, 2226, 2248, 2258, 2270, 2281, 2311, 2385, 2416, 2471, 2488, 2502, 2509, 2656, 2669, 2795, 2863, 3034, 3171, 3210, 3275, 3344, 3352, 3415, 3471, 3885, 3946, 3961, 4029, 4108, 4164, 4175, 4206, 4216, 4290, 4298, 4316, 4337, 4350, 5118, 5746], 'without': [1952], 'pleckstrin': [1954], 'homology': [1955], 'dominant-negative,': [1958], 'Akt(K179M)': [1960], 'Akt(T308A,S473A)': [1962], 'kind': [1964, 2000, 2429], 'gifts': [1965], 'Drs.': [1967, 5795], 'Ziv': [1968, 5796], 'Radisavljevic': [1969], 'Brendan': [1971, 5798], 'Manning': [1972], '(Harvard': [1973], 'School': [1974, 2187], 'Public': [1976, 2189], 'Health).': [1977], 'Difopein': [1978], '14-3-3ϵ': [1980], 'plasmids': [1981, 1997], 'kindly': [1983], 'provided': [1984], 'Dr.': [1986, 2003, 2432], 'Haian': [1987, 5800], 'Fu': [1988], '(Emory': [1989], 'University),': [1990], '14-3-3β,': [1992], '-γ,': [1993], '-ζ,': [1994], '-σ': [1996], 'gift': [2001, 2430], 'James': [2004, 5803], 'DeCaprio': [2005, 5804], '(Dana-Farber': [2006], 'Institute).': [2008], 'GST': [2009, 2908], '2The': [2010], 'abbreviations': [2011], 'used': [2012, 2607, 2623, 3810, 4020, 4089], 'are:': [2013], 'GST,': [2014], 'glutathione': [2015], 'S-transferase;': [2016], 'RFD,': [2017, 2075], 'RING': [2018, 2662, 3888, 3905, 5054], 'finger': [2019, 2663], 'domain;': [2020], 'CA,': [2021], 'active;': [2023], 'DN,': [2024], 'dominant-negative;': [2025], 'KD,': [2026], 'kinase-dead;': [2027], 'IGF-1,': [2028], 'insulin-like': [2029], 'growth': [2030], 'factor': [2031], '1;': [2032], 'PI,': [2033], 'phosphatidylinositol;': [2034], 'E3,': [2035], 'ubiquitin-protein': [2036], 'isopeptide': [2037], 'ligase.': [2038], 'production': [2040], 'described': [2043, 2284, 2325], '(39Gu': [2045], 'Rosenblum': [2049], 'Rubin': [2051], 'R.M.': [2052], '1243-1253Crossref': [2060], '(53)': [2063], 'Generation': [2066], 'Inducible': [2068], 'Lines—Full-length': [2070], 'FLAG-MDMX,': [2071], 'full-length': [2072, 2579, 2657, 2932], 'FLAG-MDM2,': [2073], 'FLAG-MDMX': [2074, 2503, 3172], 'FLAG-MDM2': [2077], 'RFD': [2078, 2923, 3010, 4060], 'cloned': [2080], 'pcDNA4': [2082], '(Invitrogen).': [2083, 2092, 2297], 'linearized': [2086], 'transfected': [2088, 2307, 2487, 2501, 3274], '293-TREx': [2090, 2617], 'cells': [2091, 2123, 2206, 2234, 2263, 2484, 2498, 3169, 3273, 3414, 3945, 4194, 4289, 4311], 'Cells': [2093, 2321, 3957], 'put': [2095], 'Zeocin': [2097], '(Invitrogen)': [2098], 'selection,': [2099], 'positive': [2101], 'clones': [2102], 'expressed': [2104], 'insert': [2106], 'interest': [2108], 'tetracycline': [2110], 'chosen.': [2112], 'Immunoaffinity': [2113], 'Purification': [2114], 'Mass': [2116], 'Spectrometry—Cells': [2117], 'induced': [2119], 'tetracycline,': [2121], 'harvested': [2125, 2317], '24': [2126, 2318], 'h': [2127, 2244, 2319], 'post-induction.': [2128], 'lysates': [2130, 2154, 2374, 2400, 2510], 'prepared': [2132, 2376], '1%': [2134], 'Triton': [2135, 2379], 'X-100': [2136, 2380], 'lysis': [2137, 2381], 'buffer': [2138, 2382, 2520], 'incubated': [2140, 2360, 2384, 2508, 2529], 'preconjugated': [2142], 'agarose': [2143], 'beads': [2144, 2388], 'anti-FLAG': [2146, 2386, 2442, 2620], 'antibodies': [2147, 2419], '(Sigma).': [2148], 'After': [2149, 2352], 'boiling': [2150], 'Laemmli': [2152], 'buffer,': [2153, 2356], '12.5%': [2158], 'SDS-PAGE.': [2159, 2370, 2404], 'Gel': [2160, 2170], 'was': [2161, 2499, 2546, 2568, 2574, 2606, 2622, 2691, 2736, 2843, 2884, 2997, 3016, 3059, 3098, 3157, 3164, 3208, 3227, 3282, 3321, 3361, 3500, 3803, 3908, 4019, 4027, 4041, 4155, 5061, 5337, 5346, 5689], 'fixed': [2162], 'methanol': [2164], 'stained': [2166], 'Coomassie': [2168], 'Blue.': [2169], 'bands': [2171, 2637], 'excised,': [2173], 'washed': [2174], 'acetonitrile,': [2176], 'sent': [2178, 2641], 'digestion': [2180], 'tandem': [2182], 'mass': [2183, 2645, 2673], 'spectrometry': [2184, 2674], '(NIEHS': [2185], 'Harvard': [2186, 5809], 'Health': [2190, 5814], 'Proteomics': [2191, 5815], 'Facility,': [2192], 'Boston,': [2193], 'MA).': [2194], 'Culture': [2196, 2209], 'Transfection—293T,': [2198], '293-TREx,': [2199], 'H1299,': [2200], 'U2OS,': [2201, 4258], 'OVCA420,': [2202], 'LNCaP,': [2203, 4259], 'MCF7': [2205, 3413], '(American': [2207], 'Type': [2208], 'Collection)': [2210], 'maintained': [2212, 2236], 'minimal': [2214, 2239], 'essential': [2215, 2240, 4855], 'medium,': [2216, 2220], "Dulbecco's": [2217], 'modified': [2218], "Eagle's": [2219], 'RPMI': [2222], '1640': [2223], 'medium': [2224, 2241, 2267], 'supplemented': [2225], '10%': [2227, 2541], 'fetal': [2228], 'bovine': [2229], 'serum.': [2230], 'For': [2231, 2256, 2371], 'serum': [2232, 3424, 3452], 'starvation,': [2233], 'serum-free': [2238, 2266], '15–18': [2243], 'then': [2246, 2279, 3959, 4401], 'stimulated': [2247], 'human': [2249], 'recombinant': [2250, 2696], 'IGF-1': [2251, 2282, 3416, 3449, 3498], '(Sigma)': [2252, 2274, 2389], '10–50': [2254], 'ng/ml.': [2255], 'experiments': [2257, 3505], 'PI': [2260, 3385, 3420, 3457, 3516, 5126], '3-kinase': [2261, 3386, 3458, 5127], 'inhibitor,': [2262], 'grown': [2264], 'pretreated': [2269], '10': [2271, 2365, 2525], 'μm': [2272], 'LY294002': [2273, 3388, 3460, 4291, 4325, 4348], '30': [2276, 2531, 2534], 'min': [2277, 2366], 'treated': [2280, 3412, 3960, 4287], 'above.': [2285], 'Transfections': [2286], 'performed': [2288, 2906, 4156], 'calcium': [2290], 'phosphate': [2291], 'precipitation': [2292], 'Lipofectamine': [2295], 'method': [2296], 'Whole': [2300], 'Extracts': [2302], 'Immunoprecipitation': [2304, 2926], 'Analysis—Cells': [2305], '60-mm': [2309], 'plates': [2310], '1–5': [2312], 'μg': [2313], 'post-transfection.': [2320], 'lysed': [2323], '(40Kawai': [2327], '23:': [2337], '4939-4947Crossref': [2338], '(105)': [2341], 'Protein': [2344], 'concentrations': [2345], 'determined': [2347, 5000], 'using': [2348, 2633, 2695, 2738, 2911, 2999], 'Bio-Rad': [2349], 'assay.': [2351, 4139], 'addition': [2353, 3454], '5×Laemmli': [2355], 'samples': [2358], '95': [2362], '°C': [2363, 2532], 'immunoprecipitation,': [2372], '0.5%': [2378], 'M5': [2387], 'additional': [2392, 5492], '2': [2393], 'h.': [2394], 'Immune': [2395], 'complexes': [2396], 'whole': [2398], 'separated': [2402, 2632], 'Proteins': [2405, 2468], 'transferred': [2407], 'onto': [2408], 'nitrocellulose': [2409], 'membranes': [2410], '(Schleicher': [2411], '&': [2412], 'Schuell)': [2413], 'probed': [2415], 'indicated:': [2421], 'anti-MDMX': [2422, 2426], '(BL1258,': [2423], 'Bethyl': [2424], 'Laboratories),': [2425], 'pS367': [2427], '(a': [2428], 'Jiandong': [2433], 'Chen)': [2434], 'BL1563': [2436], 'where': [2437], 'noted,': [2438], 'anti-MDM2': [2439], '(Ab-1,': [2440], 'Oncogene),': [2441, 2447], 'M2': [2443], '(Sigma),': [2444], 'anti-p53': [2445], '(Ab-6,': [2446], 'anti-Akt': [2448, 2452], 'pS473': [2449], '(Cell': [2450, 2453], 'Signaling),': [2451, 2454], 'anti-pan-14-3-3β': [2455], '(Santa': [2456], 'Cruz': [2457, 2462], 'Biotechnology),': [2458, 2463], 'anti-p21': [2459], '(187,': [2460], 'Santa': [2461], 'anti-β-actin': [2465], '(AC-15,': [2466], 'Sigma).': [2467], 'visualized': [2470], 'enhanced': [2473, 3833, 5645], 'chemiluminescence': [2474], 'detection': [2475], 'system': [2476, 4000], '(PerkinElmer': [2477], 'Life': [2478], 'Sciences).': [2479], 'Vitro': [2481], 'Kinase': [2482], 'Assay—293T': [2483], 'transiently': [2486, 2500], 'active': [2490, 2513, 3176, 3532, 3829, 3952], 'dominant-negative': [2492, 2515, 3180, 3842], 'set': [2495], '293T': [2497, 3168, 3944], 'plasmids.': [2504], 'immunoprecipitates': [2506], 'expressing': [2511], 'assay': [2519, 2910, 3107, 4018, 4154], 'presence': [2523, 2726, 3013, 3286, 3365, 3857, 3876, 3987, 4005, 4010, 4097, 4199, 5068], 'mm': [2526], '[γ-32P]ATP': [2527], 'min.': [2535], 'Samples': [2536], 'SDS-polyacrylamide': [2542], 'gel.': [2543], 'gel': [2545], 'dried': [2547], 'analyzed': [2549], 'autoradiography.': [2551], 'Is': [2553, 3042], 'Novel': [2555], 'Binding': [2557], 'Partner—To': [2558], 'novel': [2560], 'partners': [2562], 'proteomic': [2566], 'screen': [2567], 'performed.': [2569], 'An': [2570, 3103], 'inducible': [2571], 'line': [2573], 'utilized': [2575, 3996, 4136, 4257], 'express': [2577], 'FLAG-tagged': [2580, 2589, 2614, 2627], 'well': [2586, 3293], 'mini-protein': [2590], 'encoding': [2591], 'zinc': [2593, 2661], 'RFDs': [2594], '(amino': [2597, 2602], 'acids': [2598, 2603], '301–490)': [2599], '302–491).': [2604], 'Tetracycline': [2605], 'expression': [2611, 4056], 'cells,': [2618, 4160, 4262, 4300], 'antibody': [2621, 3189], 'purify': [2625], 'complexes.': [2629], 'Immunoprecipitates': [2630], 'SDS-PAGE,': [2634], 'unique': [2636, 2653], 'cut': [2639], 'identification': [2643], 'spectrometry.': [2646], 'As': [2647, 2834, 3426, 4179], 'Fig.': [2650, 2837, 4182], '1A,': [2651], 'band': [2654, 2679, 3125], 'associated': [2655], 'but': [2667, 2961, 3114, 3296], 'Results': [2671, 3522], 'analysis': [2675, 2704, 3185], 'revealed': [2676], 'corresponded': [2680], '14-3-3.': [2684], 'interaction': [2686], 'between': [2687], 'verified': [2692], 'vitro': [2694, 3105], 'GST-MDMX': [2697], 'fusion': [2698], '(Fig.': [2700, 2721, 2783, 2902, 2924, 2936, 3019, 3121, 3203, 3230, 3299, 3368, 3399, 3466, 3502, 3846, 3860, 3881, 3926, 3973, 4049, 4122, 4323, 4342, 4355], '1B).': [2701], 'Upon': [2702, 4996], 'careful': [2703], 'sequence,': [2708, 2777], 'identified': [2710, 4975], 'mode': [2713], '1': [2714], 'motif': [2716, 2731], '(RXXSXP)': [2717], '364–369': [2720], '1C,': [2722, 2784], 'underlined).': [2723, 2785], 'Additionally,': [2724, 3021, 3490], 'confirmed': [2737], 'Massachusetts': [2740], 'Institute': [2741], 'Technology': [2743], 'Scansite': [2744], 'program': [2745], '(41Obenauer': [2746], 'Cantley': [2748], 'L.C.': [2749], 'Yaffe': [2750], 'Nucleic': [2752, 4586], 'Acids': [2753, 4587], '31:': [2756], '3635-3641Crossref': [2757], '(1339)': [2760], 'specific': [2766, 2994, 3254, 3313, 5015], 'further': [2778, 3153, 4245, 4997], 'supporting': [2779, 3991], 'our': [2780, 4375, 5819], 'immunoprecipitation': [2781, 3163], 'typically': [2793], 'interact': [2794], 'ligands': [2797], 'To': [2802, 2849, 3152, 3247, 3401, 3928, 4124, 4244], 'investigate': [2803], 'whether': [2804, 3094, 3155, 3249, 3403, 3796, 3813, 3930, 4003, 4247], 'bound': [2806, 4993, 5690], 'subjected': [2813], 'point-directed': [2816], 'mutagenesis.': [2817], 'Using': [2818], 'PCR,': [2820], 'putative': [2824], 'serine': [2831], 'alanine.': [2833], '1D,': [2838], 'MDMX(S367A)': [2840, 3129, 3879], 'point': [2841, 3022], 'mutant': [2842, 2883, 3118, 3226, 3880, 3889, 3906, 4444, 5055], 'unable': [2844, 2886, 4446, 5056], 'proteins.': [2848, 4978], 'rule': [2850], 'out': [2851, 3166, 4449], 'possibility': [2853], 'status': [2859, 3264, 3340], 'interferes': [2862], 'binding,': [2865, 3357], 'conserved': [2869], 'proline': [2870], 'residue': [2871], 'arginine,': [2874], 'eliminating': [2876], 'motif.': [2880], 'MDMX(P369R)': [2882], '14-3-3,': [2890, 3690], 'bona': [2896], 'fide': [2897], '1D).': [2903], 'next': [2905, 3337, 3995], 'pulldown': [2909], 'GST-14-3-3β': [2912], 'GST-14-3-3ζ': [2914], 'direct': [2917], 'C-terminal': [2921], '1E).': [2925], 'Myc-14-3-3': [2928], 'showed': [2929, 3108], '1F).': [2937], 'total,': [2939], 'observed': [2941, 3018, 3126, 3214, 3283, 3362, 4101, 5517, 5637], 'four': [2947], '(β,': [2950], 'ϵ,': [2951], 'γ': [2952], '(data': [2953, 2975, 3038, 5651, 5696], 'shown),': [2955, 5653], 'ζ)': [2957], 'had': [2959, 4220], 'available,': [2960], '14-3-3σ,': [2964, 4983], 'target': [2973], 'gene': [2974, 4502], 'shown)': [2977], 'Further': [2991], 'evidence': [2992], 'competitive': [3002], 'inhibitor': [3003, 3387, 3459, 4315, 5128], 'difopein.': [3004], 'difopein': [3015], '1G).': [3020], 'mutations': [3023], 'disruption': [3027, 4937], 'did': [3031, 3397, 3844, 5678], 'interfere': [3033], 'shown).': [3040, 5698], 'Substrate': [3044], 'Kinase—14-3-3': [3048], 'normally': [3050], 'Therefore,': [3054], 'investigated': [3056, 3338], 'surrounding': [3069], 'appears': [3071, 3461, 4921, 5043], 'fit': [3073, 5745], 'RXRXXS': [3077], 'Although': [3084, 4734, 5633], 'perfect': [3090], 'match,': [3091], 'tested': [3093, 4992], 'mediating': [3099, 3158], 'MDMX.': [3102, 3151, 3335, 3806, 4201, 4995, 5024, 5089], 'S367A': [3117, 3224], '2A).': [3122], 'residual': [3124], 'lane': [3130], 'primary': [3136], 'Akt-mediated': [3139, 3319, 4338, 5657], 'phosphorylation;': [3140], 'there': [3142, 4208], 'other,': [3145], 'yet': [3146, 5631, 5737], 'uncharacterized': [3147], 'sites': [3149, 5494, 5507, 5533, 5560, 5710], 'assess': [3154, 4145], 'FLAG': [3162], 'carried': [3165], 'cotransfected': [3170, 3943], 'either': [3174, 3950, 4274], '(CA-Akt)': [3178], '(DN-Akt).': [3182], 'Western': [3183], 'blot': [3184], 'phospho-Ser367-specific': [3188], 'indicated': [3190, 3970], 'indeed': [3194], 'Akt-dependent': [3201, 4742], '2B).': [3204, 3231], 'Interestingly,': [3205, 3867], 'when': [3206, 4188, 5687], 'CA-Akt': [3207, 3276, 3288, 3353, 3859, 4176, 4203, 4217], 'coexpressed': [3209, 4028, 4205], 'whereas': [3218, 3358, 3839, 4767], 'level': [3221, 4147], 'phosphorylation-deficient': [3225], 'largely': [3228], 'unchanged': [3229, 3873], 'Recent': [3232, 5133], 'damage.': [3246, 3316], 'test': [3248, 3929], 'response,': [3259], 'compared': [3261, 4107, 4215], 'Adriamycin': [3270], 'treatment': [3271, 3450, 3499, 4326], 'DN-Akt.': [3278], 'vector': [3290, 4109], 'only,': [3291], 'Adriamycin,': [3295], 'KD-Akt': [3298, 4219], '2C).': [3300], 'These': [3301, 3370, 3468, 3504, 3912, 4232, 4357], 'suggest,': [3303], 'quite': [3304], 'interestingly,': [3305], 'note,': [3318], 'even': [3322], 'stronger': [3323], 'than': [3324, 3716, 5496], 'Adriamycin-induced': [3325], 'phosphorylation,': [3326, 5335, 5344], 'implicating': [3327], 'physiologically': [3331], 'relevant': [3332], 'respect': [3345], 'Cotransfection': [3349], 'led': [3354], 'no': [3359, 4221], 'DN-Akt': [3367, 3398], '2D).': [3369, 3400], 'required': [3378, 5536], 'binding.': [3381, 4397], 'Addition': [3382], 'elicited': [3389], 'same': [3391], 'effect': [3392, 3798, 4222, 5087, 5639], 'MDMX/14-3-3': [3394], 'determine': [3402, 3812, 4002, 4046, 4125, 4246], 'endogenous': [3404, 3431, 3508, 4248], 'stabilizing': [3409, 3551, 3705, 5064], 'activate': [3418], '3-kinase/Akt': [3421, 3517], 'starvation.': [3425], 'suggested': [3427], 'previous': [3429, 3863, 3992], 'experiments,': [3430], 'stabilized': [3434, 3909, 4778, 5785], 'because': [3441], 'increase': [3445, 4104], 'starvation;': [3453], 'diminish': [3463], '3A).': [3467], 'observations': [3469], 'correlate': [3470], 'Ser473,': [3477], 'good': [3485], 'indicator': [3486], 'dose-dependent': [3501], '3B).': [3503], 'pathway.': [3518, 4428, 5757], 'Stabilization': [3519, 3524], 'Down-regulation': [3528], 'Activity—Constitutively': [3531], 'proliferation,': [3547], 'part': [3549, 5084], 'down-regulating': [3555], 'support': [3668, 5074], 'hypothesis': [3670, 5749], 'site,': [3681], 'subsequent': [3695, 5038], 'stabilization.': [3696], 'Given': [3697], 'findings': [3699], 'inherently': [3713, 4795], 'homocomplex': [3719], '45Stad': [3740], 'Grivell': [3746, 4821], '275:': [3760, 4835], '28039-28044Abstract': [3761, 4836], '(119)': [3769, 4844], '46Singh': [3772], 'R.K.': [3773], 'Iyappan': [3774], '282:': [3782], '10901-10907Abstract': [3783], '(54)': [3791], 'Scholar),': [3793, 5600], 'asked': [3795], 'mediated': [3804, 3923, 5019, 5080, 5490], 'dependent': [3818, 5046], 'Overexpression': [3826], 'resulted': [3831, 4328], 'overexpression': [3840, 4284], '4A).': [3847, 3882, 3927], 'increased': [3854, 3984, 4008, 4187, 4351], '4A),': [3861], 'shown.': [3866], 'appear': [3870], 'coexpression': [3884], '(C463A)': [3890], 'disrupts': [3892], 'failed': [3895], 'levels,': [3899, 4335], 'despite': [3900], 'fact': [3902], 'itself': [3907, 4848], 'half-lives': [3932, 3976], 'extended': [3938], 'kinase-dead': [3955], 'cycloheximide,': [3962], 'tracked': [3967], 'time': [3971, 4141], 'points': [3972], '4B).': [3974, 4050, 4123], 'dramatically': [3983], 'result.': [3993], 'mammalian': [3998], 'two-hybrid': [3999], 'complex.': [4014, 5675], 'A': [4015, 4152, 4412], 'luciferase': [4016, 4153, 4184], 'reporter': [4017, 4024, 4138, 4168], 'plasmid,': [4025, 4169], 'pGal4-Luc,': [4026], 'Gal4': [4031], 'DNA-binding': [4032], 'fused': [4034, 4042], 'VP16-activation': [4039], 'reported': [4053, 4600], 'disrupting': [4064], 'Scholar);': [4086], 'therefore,': [4087], 'control.': [4094], 'CA-Akt,': [4099], '2-fold': [4103], 'signal': [4106], 'KD-Akt,': [4111], 'suggesting': [4112, 5528], 'chose': [4143], 'cotransfecting': [4158], 'H1299': [4159], 'p53-deficient,': [4163], 'p53-specific': [4166], 'pG13-Luc': [4167], 'Myc-p53,': [4170], 'along': [4174], 'KD-Akt.': [4178], '4C,': [4183], 'introduced': [4191], 'When': [4202], 'reduction': [4211], 'alone;': [4218], 'suppress': [4229], 'suppression': [4240, 4367], 'affected': [4253], 'OVCA420': [4261, 4310], 'latter': [4264], 'two': [4265, 5618], 'elevated': [4269], 'due': [4272], 'phosphatase': [4275], 'tensin': [4277], 'homolog': [4278], '(PTEN)': [4279], 'deficiency': [4280], '(LNCaP)': [4281], 'Her-2': [4283], '(OVCA420).': [4285], 'block': [4293], 'contrast': [4297], 'U2OS': [4299], 'relatively': [4306], 'low,': [4307], 'LNCaP': [4308], 'responded': [4312], 'significant': [4318], 'decrease': [4319, 4331], '4D).': [4324, 4343, 4356], 'steady-state': [4334], 'consistent': [4336], 'correlated': [4349], 'activation.': [4373], 'Together,': [4374], 'potentially': [4394], 'stability': [4399], 'translated': [4402], 'fundamental': [4413], 'process': [4414], 'development': [4417], 'cancer': [4419], 'some': [4430, 4457, 4789], 'achieved': [4434], 'mutation': [4436], 'TP53': [4439], 'gene,': [4440], 'carry': [4448], 'factor,': [4455], 'although': [4456, 5601], 'tumors': [4458], '(47Chene': [4462], '102-109Crossref': [4469], '(559)': [4472], 'those': [4477], 'inactivated.': [4482], 'up-regulation': [4488], 'Amplifications': [4498], 'result': [4510, 5718], 'increasing': [4517], 'inhibiting': [4521], '(25Feng': [4525], '48Momand': [4578], 'Jung': [4580], 'Wilczynski': [4582], 'Niland': [4584], '1998;': [4589], '3453-3459Crossref': [4591], '(819)': [4594], 'It': [4597, 5012, 5482, 5699, 5722], 'translocation.': [4616], 'eventually': [4618], 'functional': [4622], 'strongly': [4737], 'exact': [4747], 'does': [4752], 'remains': [4754], 'unclear.': [4755], 'Some': [4756], 'translocation,': [4766], 'do': [4769], 'not;': [4770], 'indicate': [4774], 'possesses': [4782], 'toward': [4786], 'itself,': [4787], 'reports': [4790, 5541], 'unstable;': [4796], 'partner,': [4802], 'lacks': [4805], 'involved': [4811], '(45Stad': [4815], '(4Parant': [4860], '42Migliorini': [4884], 'Denchi': [4886], 'E.L.': [4887], 'Danovi': [4888], 'Capillo': [4892], '22:': [4906], '5527-5538Crossref': [4907], '(261)': [4910], 'recently': [4916], 'predominant': [4925], 'form': [4926], 'exist': [4931], 'destabilization': [4944], 'pursuit': [4969], 'partners,': [4973], 'With': [4979], 'exception': [4981], 'target,': [4987], 'other': [4989, 5495, 5532, 5707], 'investigation,': [4998], 'incapable': [5062], 'Akt-induced': [5076], 'least': [5082], 'suppressed': [5101], 'MDMX-dependent': [5106], 'demonstrated': [5111], 'correlates': [5117], 'DNA-damaging': [5144, 5526], 'agents': [5145], '(43Meulmeester': [5146], 'Maurice': [5148], 'Boutell': [5150], 'Ovaa': [5154], 'Abraham': [5156], 'T.E.': [5157], 'Dirks': [5158], 'R.W.': [5159], '18:': [5165], '565-576Abstract': [5166], '(217)': [5174], 'Chk1': [5178], 'Chk2': [5180], 'kinases': [5181], 'leading': [5189, 5511], '(34Pereg': [5193, 5348, 5568], '44Chen': [5307, 5462], 'Pan': [5311, 5466], 'W.S.': [5314, 5469], '3411-3422Crossref': [5321, 5476], '(198)': [5324, 5479], 'outcome': [5331], 'differed:': [5332], 'Chk1-mediated': [5334], 'translocated': [5338], 'cytoplasm;': [5341], 'Chk2-mediated': [5343], 'degraded': [5347], 'possible': [5484, 5557, 5701, 5725], 'that,': [5499], 'depending': [5500], 'type': [5503], 'damage,': [5505], 'will': [5508, 5604], 'modified,': [5510], 'outcomes.': [5514, 5721], 'growth-promoting': [5524, 5694, 5741], 'conditions,': [5527, 5706], 'Indeed,': [5540], 'Ser403': [5545], 'Ser342': [5547], 'damage;': [5554], 'important': [5563], 'investigations': [5603], 'necessary': [5606], 'address': [5608], 'issue.': [5610], 'dimers': [5616], 'requiring': 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