Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1970997423', 'doi': 'https://doi.org/10.1016/j.ceca.2011.03.010', 'title': 'Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases', 'display_name': 'Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases', 'publication_year': 2011, 'publication_date': '2011-07-05', 'ids': {'openalex': 'https://openalex.org/W1970997423', 'doi': 'https://doi.org/10.1016/j.ceca.2011.03.010', 'mag': '1970997423', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21724254'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ceca.2011.03.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80202938', 'display_name': 'Cell Calcium', 'issn_l': '0143-4160', 'issn': ['0143-4160', '1532-1991'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027544640', 'display_name': 'Emyr Lloyd‐Evans', 'orcid': 'https://orcid.org/0000-0002-3626-1611'}, 'institutions': [{'id': 'https://openalex.org/I79510175', 'display_name': 'Cardiff University', 'ror': 'https://ror.org/03kk7td41', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I79510175']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Emyr Lloyd-Evans', 'raw_affiliation_strings': ['School of Biosciences, Biomedical Sciences Building, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'School of Biosciences, Biomedical Sciences Building, Cardiff University, Museum Avenue, Cardiff CF10 3AX, United Kingdom.', 'institution_ids': ['https://openalex.org/I79510175']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5078895245', 'display_name': 'Frances M. Platt', 'orcid': 'https://orcid.org/0000-0001-7614-0403'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Frances M. Platt', 'raw_affiliation_strings': ['Department of Pharmacology; University of Oxford; Mansfield Road Oxford OX1 3QT United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology; University of Oxford; Mansfield Road Oxford OX1 3QT United Kingdom', 'institution_ids': ['https://openalex.org/I40120149']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3660, 'currency': 'USD', 'value_usd': 3660, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.374, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 129, 'citation_normalized_percentile': {'value': 0.981308, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '50', 'issue': '2', 'first_page': '200', 'last_page': '205'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13415', 'display_name': 'Lysosomal Calcium Signaling in Physiology and Pathology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13415', 'display_name': 'Lysosomal Calcium Signaling in Physiology and Pathology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lysosomal-storage-disease', 'display_name': 'Lysosomal storage disease', 'score': 0.768788}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.71824515}, {'id': 'https://openalex.org/keywords/mucolipidosis', 'display_name': 'Mucolipidosis', 'score': 0.62590086}, {'id': 'https://openalex.org/keywords/lysosomal-storage-diseases', 'display_name': 'Lysosomal Storage Diseases', 'score': 0.623239}, {'id': 'https://openalex.org/keywords/lysosomal-calcium-signaling', 'display_name': 'Lysosomal Calcium Signaling', 'score': 0.549397}, {'id': 'https://openalex.org/keywords/tfeb', 'display_name': 'TFEB', 'score': 0.47696173}, {'id': 'https://openalex.org/keywords/chédiak–higashi-syndrome', 'display_name': 'Chédiak–Higashi syndrome', 'score': 0.46744025}], 'concepts': [{'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.8858434}, {'id': 'https://openalex.org/C28005876', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytosis', 'level': 3, 'score': 0.8117553}, {'id': 'https://openalex.org/C2778264360', 'wikidata': 'https://www.wikidata.org/wiki/Q675010', 'display_name': 'Lysosomal storage disease', 'level': 3, 'score': 0.768788}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.71824515}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6832845}, {'id': 'https://openalex.org/C2780905385', 'wikidata': 'https://www.wikidata.org/wiki/Q1952032', 'display_name': 'Mucolipidosis', 'level': 3, 'score': 0.62590086}, {'id': 'https://openalex.org/C132647116', 'wikidata': 'https://www.wikidata.org/wiki/Q18032677', 'display_name': 'TFEB', 'level': 4, 'score': 0.47696173}, {'id': 'https://openalex.org/C2776070026', 'wikidata': 'https://www.wikidata.org/wiki/Q934034', 'display_name': 'Chédiak–Higashi syndrome', 'level': 2, 'score': 0.46744025}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45690978}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.35443395}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24606511}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21301964}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.115508586}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.09214485}], 'mesh': [{'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016464', 'descriptor_name': 'Lysosomal Storage Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002609', 'descriptor_name': 'Chediak-Higashi Syndrome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002609', 'descriptor_name': 'Chediak-Higashi Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002609', 'descriptor_name': 'Chediak-Higashi Syndrome', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016464', 'descriptor_name': 'Lysosomal Storage Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016464', 'descriptor_name': 'Lysosomal Storage Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009081', 'descriptor_name': 'Mucolipidoses', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009081', 'descriptor_name': 'Mucolipidoses', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009081', 'descriptor_name': 'Mucolipidoses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009249', 'descriptor_name': 'NADP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052556', 'descriptor_name': 'Niemann-Pick Disease, Type C', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D052556', 'descriptor_name': 'Niemann-Pick Disease, Type C', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D052556', 'descriptor_name': 'Niemann-Pick Disease, Type C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050053', 'descriptor_name': 'TRPM Cation Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050053', 'descriptor_name': 'TRPM Cation Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050051', 'descriptor_name': 'Transient Receptor Potential Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ceca.2011.03.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80202938', 'display_name': 'Cell Calcium', 'issn_l': '0143-4160', 'issn': ['0143-4160', '1532-1991'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21724254', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.67, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W146706964', 'https://openalex.org/W181645930', 'https://openalex.org/W1856333849', 'https://openalex.org/W1953311373', 'https://openalex.org/W1964549513', 'https://openalex.org/W1968704909', 'https://openalex.org/W1969515779', 'https://openalex.org/W1970849988', 'https://openalex.org/W1972080672', 'https://openalex.org/W1975420301', 'https://openalex.org/W1978678832', 'https://openalex.org/W1980390514', 'https://openalex.org/W1981707898', 'https://openalex.org/W1983421087', 'https://openalex.org/W1984065750', 'https://openalex.org/W1990708583', 'https://openalex.org/W1996140061', 'https://openalex.org/W1997112574', 'https://openalex.org/W2007066406', 'https://openalex.org/W2014039927', 'https://openalex.org/W2016983155', 'https://openalex.org/W2017011727', 'https://openalex.org/W2018387411', 'https://openalex.org/W2019363409', 'https://openalex.org/W2024571115', 'https://openalex.org/W2025102169', 'https://openalex.org/W2027542176', 'https://openalex.org/W2031790758', 'https://openalex.org/W2033808333', 'https://openalex.org/W2039187058', 'https://openalex.org/W2047813766', 'https://openalex.org/W2048557893', 'https://openalex.org/W2049900702', 'https://openalex.org/W2055467310', 'https://openalex.org/W2055672024', 'https://openalex.org/W2061347886', 'https://openalex.org/W2061436416', 'https://openalex.org/W2065368005', 'https://openalex.org/W2069159417', 'https://openalex.org/W2073679788', 'https://openalex.org/W2075461750', 'https://openalex.org/W2080489264', 'https://openalex.org/W2081196334', 'https://openalex.org/W2087933553', 'https://openalex.org/W2096330132', 'https://openalex.org/W2102714558', 'https://openalex.org/W2103989789', 'https://openalex.org/W2107766190', 'https://openalex.org/W2108629058', 'https://openalex.org/W2112045725', 'https://openalex.org/W2118597788', 'https://openalex.org/W2132320808', 'https://openalex.org/W2135224653', 'https://openalex.org/W2138786573', 'https://openalex.org/W2152750003', 'https://openalex.org/W2155239512', 'https://openalex.org/W2165500244', 'https://openalex.org/W2191787781', 'https://openalex.org/W2266799572', 'https://openalex.org/W2291704802'], 'related_works': ['https://openalex.org/W4385191034', 'https://openalex.org/W4306971719', 'https://openalex.org/W4304091936', 'https://openalex.org/W4243180838', 'https://openalex.org/W4237382727', 'https://openalex.org/W3173564820', 'https://openalex.org/W3114379697', 'https://openalex.org/W2809738004', 'https://openalex.org/W2153188271', 'https://openalex.org/W1970997423'], 'abstract_inverted_index': {'Disrupted': [0], 'cellular': [1], 'Ca2+': [2, 63, 69, 105, 122, 140], 'signaling': [3, 141], 'is': [4, 52, 87, 116], 'believed': [5, 117], 'to': [6, 57, 77, 101, 118], 'play': [7], 'a': [8, 11, 23, 88, 121, 129], 'role': [9, 137], 'in': [10, 32, 37, 73, 80, 112, 142], 'number': [12], 'of': [13, 25, 39, 90, 131, 138, 145, 148], 'human': [14, 55], 'diseases': [15, 19, 27], 'including': [16], 'lysosomal': [17, 33, 62, 68, 104, 139], 'storage': [18, 85], '(LSD).': [20], 'LSDs': [21], 'are': [22], 'group': [24, 147], '∼50': [26], 'caused': [28], 'predominantly': [29], 'by': [30], 'mutations': [31], 'proteins': [34], 'that': [35, 47, 86], 'result': [36], 'accumulation': [38], 'macromolecules': [40], 'within': [41], 'the': [42, 53, 78, 108, 132, 136, 143], 'lysosome.': [43], 'We': [44], 'recently': [45], 'reported': [46, 100], 'Niemann-Pick': [48], 'type': [49, 114], 'C': [50], '(NPC)': [51], 'first': [54], 'disease': [56], 'be': [58], 'associated': [59], 'with': [60], 'defective': [61, 66, 111], 'uptake': [64, 106], 'and': [65, 82], 'NAADP-mediated': [67], 'release.': [70], 'These': [71], 'defects': [72], 'NPC': [74], 'cells': [75, 97], 'leads': [76], 'disruption': [79], 'endocytosis': [81], 'subsequent': [83], 'lipid': [84], 'feature': [89], 'this': [91, 125, 146], 'disease.': [92], 'In': [93, 124], 'contrast,': [94], 'Chediak–Higashi': [95], 'Syndrome': [96], 'have': [98, 102], 'been': [99], 'enhanced': [103], 'whilst': [107], 'TRPML1': [109], 'protein': [110], 'mucolipidosis': [113], 'IV': [115], 'function': [119], 'as': [120], 'channel.': [123], 'review': [126], 'we': [127], 'provide': [128], 'summary': [130], 'current': [133], 'knowledge': [134], 'on': [135], 'pathogenesis': [144], 'diseases.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1970997423', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-24T09:55:27.227006', 'created_date': '2016-06-24'}