Abstract:textabstractIron transport in pregnancy is an active one-way process, from mother
to fetus.
Early in gestation fetal iron needs are low, and so is trans-placental
transport, but as erythropoiesis d...textabstractIron transport in pregnancy is an active one-way process, from mother
to fetus.
Early in gestation fetal iron needs are low, and so is trans-placental
transport, but as erythropoiesis develops, rising fetal iron needs are
met by trans-placental iron transport.
Apparently, the fetus is protected against iron toxicity as well as
against iron deficiency, the latter even if maternal iron stores are
depleted.
Fetectomy experiments in animals indicate that placental iron uptake
is an autonomous process, independent of the presence of a fetus.
The narrow and, in the course of pregnancy, enonnously changing difference
between iron deficiency and iron toxicity strongly suggests that
maternal-fetal iron transport needs to be regulated.
This thesis deals with some aspects of the regulation of placental
iron uptake. Cllapter 3 describes the development of a cell culture
model to study placental iron uptake. Cllapter 4 deals with characteristics
of transferrin receptors in these cells and chapter 5 describes
the regulation of transferrin receptor expression in nonnal hmnan
term trophoblast cells in vitro.
Finally, chapter 6 describes pregnancy-related changes of maternal
transferrin, the iron donor for the placenta.
In this chapter an animal model is used, the guinea-pig.Read More
Publication Year: 1989
Publication Date: 1989-12-06
Language: en
Type: article
Access and Citation
Cited By Count: 6
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