Title: Enzymes metabolizing ornithine-proline pathway in the rovine eye
Abstract: We studied bovine ocular tissues biochemically for the following enzyme activities related to ornithine metabolism: arginase, Δ1-pyrroline-5-carboxylate reductase, Δ1-pyrroline-5-carboxylate dehydrogenase and proline oxidase. Arginase activity was high in the retina and uvea; Δ1-pyrroline-5-carboxylate reductase activity was high in the lens, cornea and retina; Δ1-pyrroline-5-carboxylate dehydrogenase activity was high in the uvea but lower in the retina; and proline oxidase activity was negligible in all ocular tissues. It is possible that ornithine in the retina may be supplied from arginine, or from the uptake of ornithine itself, and converted into proline by the cooperative action of ornithine-ketoacid-transaminase and Δ1-pyrroline-5-carboxylate reductase.
Publication Year: 1982
Publication Date: 1982-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 9
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