2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3

Name: Work Video:
Duration: 3 min 30 s
Hongzhen Hu; Qihai Gu; Chunbo Wang; Craig K. Colton; Jisen Tang; Mariko Kinoshita-Kawada; Lu‐Yuan Lee; Jackie D. Wood; Michael X. Zhu
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3634, 3717, 3754, 3793, 3865, 3912, 4132, 4186, 4317, 4500], 'transient': [1, 196, 391, 400], 'receptor': [2, 197, 392, 401, 541], 'potential': [3, 198, 393, 2368, 3466], '(TRP)': [4, 199, 394], 'superfamily': [5, 200, 441], 'contains': [6, 201], 'a': [7, 166, 179, 202, 361, 374, 447, 464, 1129, 1240, 1285, 1444, 1515, 1521, 1558, 1816, 2146, 2227, 2358, 2387, 2609, 2785, 2828, 2834, 2900, 2907, 2944, 2969, 2988, 3054, 3061, 3094, 3121, 3182, 3213, 3231, 3297, 3333, 3517, 3693, 3803, 4025, 4124, 4180, 4264, 4418, 4430, 4571, 4594, 4701], 'large': [8, 203, 448, 4125], 'number': [9, 204, 449, 1131, 1241, 1873, 2179, 3863], 'of': [10, 77, 104, 118, 124, 135, 165, 205, 272, 299, 313, 319, 330, 360, 426, 431, 436, 442, 446, 450, 811, 1132, 1242, 1288, 1471, 1486, 1491, 1561, 1634, 1698, 1716, 1728, 1745, 1755, 1819, 1911, 1999, 2067, 2078, 2085, 2184, 2316, 2325, 2351, 2369, 2407, 2476, 2538, 2569, 2576, 2584, 2600, 2661, 2666, 2672, 2679, 2734, 2739, 2766, 2816, 2830, 2836, 2839, 3003, 3072, 3233, 3286, 3357, 3364, 3485, 3490, 3552, 3584, 3682, 3712, 3720, 3816, 3821, 3850, 3892, 3915, 3949, 4016, 4019, 4041, 4110, 4237, 4244, 4253, 4258, 4286, 4319, 4328, 4335, 4396, 4411, 4421, 4479, 4494, 4503, 4545, 4553, 4560, 4566, 4579, 4646, 4650, 4746], 'proteins': [11, 206], 'encoding': [12, 207], 'cation': [13, 41, 208, 236, 443, 1518], 'permeable': [14, 209], 'channels': [15, 210, 444, 475, 533, 814, 1198, 1246, 1344, 1448, 1493, 1563, 1644, 3528, 3964], 'that': [16, 73, 134, 175, 211, 268, 329, 370, 454, 1708, 1762, 1795, 1806, 2903, 3304, 3349, 3695, 3699, 3852, 4011, 4243, 4276, 4292, 4312, 4327, 4538, 4589, 4630], 'are': [17, 60, 68, 212, 255, 263, 476, 534, 1124, 1191, 1703], 'further': [18, 213, 477], 'divided': [19, 214, 478], 'into': [20, 215, 479, 2173, 2628, 3109], 'TRPC': [21, 216, 483, 1243], '(canonical),': [22, 217, 484], 'TRPM': [23, 218, 485, 1245], '(melastatin),': [24, 219, 486], 'and': [25, 37, 58, 66, 86, 92, 106, 111, 127, 154, 158, 173, 185, 192, 220, 232, 253, 261, 281, 287, 301, 306, 322, 349, 353, 368, 380, 387, 487, 511, 542, 667, 750, 834, 916, 971, 1073, 1244, 1443, 1526, 1740, 1751, 1764, 1781, 1811, 1813, 1827, 1875, 1879, 1893, 1925, 1928, 1939, 1947, 1979, 2037, 2047, 2057, 2070, 2123, 2143, 2169, 2245, 2267, 2341, 2416, 2441, 2526, 2532, 2545, 2595, 2623, 2637, 2664, 2692, 2697, 2714, 2775, 2802, 2825, 2884, 2962, 2978, 3028, 3042, 3070, 3087, 3097, 3118, 3145, 3155, 3168, 3202, 3209, 3269, 3328, 3453, 3505, 3523, 3545, 3577, 3612, 3650, 3662, 3671, 3709, 3741, 3781, 3800, 3813, 3878, 3951, 4036, 4142, 4199, 4208, 4273, 4323, 4326, 4330, 4360, 4540, 4548, 4748], 'TRPV': [26, 32, 221, 227, 488, 1197, 1821], '(vanilloid)': [27, 222, 489], 'subfamilies.': [28, 223], 'Among': [29, 224], 'the': [30, 75, 102, 122, 163, 225, 270, 297, 317, 358, 459, 473, 812, 1489, 1632, 1700, 1713, 1717, 1726, 1746, 1753, 1912, 1951, 1987, 1992, 1997, 2009, 2013, 2022, 2052, 2073, 2076, 2086, 2128, 2174, 2197, 2205, 2248, 2278, 2293, 2314, 2317, 2323, 2326, 2334, 2342, 2383, 2392, 2401, 2432, 2437, 2444, 2477, 2484, 2570, 2574, 2579, 2582, 2585, 2587, 2601, 2633, 2640, 2644, 2650, 2670, 2673, 2680, 2700, 2963, 2980, 3021, 3034, 3038, 3045, 3240, 3243, 3251, 3291, 3323, 3350, 3355, 3358, 3420, 3486, 3499, 3506, 3543, 3546, 3550, 3553, 3585, 3680, 3710, 3713, 3766, 3809, 3814, 3831, 3844, 3858, 3881, 3893, 3903, 3925, 3928, 3936, 4007, 4037, 4155, 4162, 4215, 4226, 4231, 4234, 4256, 4268, 4274, 4280, 4283, 4355, 4368, 4376, 4379, 4394, 4409, 4422, 4433, 4457, 4477, 4492, 4541, 4551, 4558, 4563, 4567, 4580, 4601, 4604, 4616, 4722, 4732, 4744], 'six': [31, 226], 'members,': [33, 228], 'TRPV1,': [34, 84, 171, 229, 279, 366, 828, 1922, 2121, 3927], 'TRPV2,': [35, 85, 172, 230, 280, 367, 1924], 'TRPV3,': [36, 87, 231, 282, 1878], 'TRPV4': [38, 59, 233, 254, 1881], 'form': [39, 234, 3849], 'heat-activated': [40, 235], 'channels,': [42, 237], 'which': [43, 238, 1699, 3535, 4176, 4297, 4689], 'serve': [44, 177, 239, 372], 'diverse': [45, 240, 537], 'functions': [46, 241, 539], 'ranging': [47, 242], 'from': [48, 243, 1032, 1884, 1888, 2019, 2212, 2333, 2366, 2400, 2551, 2578, 2669, 2717, 2743, 2772, 3242, 3476, 4383, 4436, 4466, 4507], 'nociception': [49, 244], 'to': [50, 245, 470, 816, 1238, 1339, 1477, 1482, 1724, 1742, 1771, 2072, 2221, 2298, 2321, 2354, 2363, 2436, 2443, 2572, 2639, 2943, 3020, 3044, 3060, 3238, 3347, 3480, 3531, 3570, 3669, 3756, 3807, 4029, 4164, 4173, 4233, 4242, 4271, 4295, 4302, 4375, 4398, 4446, 4462, 4481, 4520, 4570, 4577, 4600, 4606, 4665, 4700, 4734], 'osmolality': [51, 246, 751], 'regulation.': [52, 247], 'Although': [53, 248, 1121, 4709], 'chemical': [54, 249, 3324, 4602], 'activators': [55, 250, 4544], 'for': [56, 64, 170, 182, 187, 251, 259, 365, 377, 382, 809, 824, 1128, 1473, 1583, 1829, 1868, 1920, 2034, 2094, 2452, 2559, 2753, 2781, 2849, 3124, 3165, 3722, 3768, 3833, 3846, 3924, 3958, 4371, 4425, 4460], 'TRPV1': [57, 130, 252, 325, 1133, 1741, 1776, 1870, 2168, 2453, 3673, 3684, 3723, 3770, 3779, 3782, 3817, 3834, 3851, 3963, 4020, 4103, 4128, 4336, 4464, 4546, 4617, 4647], 'well': [61, 132, 256, 327, 1024, 2074, 4240], 'documented,': [62, 257], 'those': [63, 258, 4311], 'TRPV2': [65, 260, 1810], 'TRPV3': [67, 138, 174, 262, 333, 369], 'lacking.': [69, 264], 'Here': [70, 265], 'we': [71, 266, 1736, 1804, 4662], 'show': [72, 267], 'in': [74, 95, 140, 269, 290, 335, 492, 536, 1531, 1778, 1782, 1944, 1955, 1961, 1996, 2064, 2082, 2127, 2140, 2156, 2164, 2191, 2204, 2247, 2277, 2420, 2426, 2431, 2495, 2535, 2567, 2597, 2694, 2699, 2726, 2784, 2821, 2827, 2852, 2899, 3033, 3085, 3099, 3113, 3120, 3127, 3130, 3152, 3159, 3181, 3250, 3275, 3296, 3419, 3516, 3679, 3706, 3761, 3802, 3827, 3837, 4100, 4127, 4255, 4339, 4342, 4347, 4393, 4408, 4432, 4476, 4491, 4596, 4743], 'absence': [76, 271, 3681, 4395, 4478], 'other': [78, 273, 1188, 1446, 2624, 3029, 4542, 4642], 'stimuli,': [79, 274], '2-aminoethoxydiphenyl': [80, 275, 404], 'borate': [81, 276, 1235], '(2APB)': [82, 277, 1236], 'activates': [83, 278], 'but': [88, 283, 3835, 3960], 'not': [89, 284, 3836, 3921, 3944, 3961, 4715], 'TRPV4,': [90, 285, 829], 'TRPV5,': [91, 286], 'TRPV6': [93, 288, 1929], 'expressed': [94, 139, 289, 334, 1732, 1777, 2144, 4099], 'HEK293': [96, 291, 1779, 1945, 1957, 2185, 2187, 3497, 4101, 4229], 'cells.': [97, 292, 2580, 3487], 'In': [98, 114, 143, 293, 309, 338, 1480, 1785, 3667, 4598, 4671], 'contrast,': [99, 294], '2APB': [100, 119, 153, 157, 295, 314, 348, 352, 1335, 1474, 1487, 1513, 1553, 1714, 1729, 1756, 1774, 1792, 1807, 2622, 3491, 3515, 3540, 3569, 3678, 3691, 3721, 3757, 3822, 4012, 4111, 4159, 4165, 4191, 4219, 4238, 4272, 4320, 4352, 4366, 4397, 4426, 4480, 4497, 4504, 4539, 4607, 4623, 4638, 4651, 4664, 4681, 4712, 4751], 'inhibits': [101, 296], 'activity': [103, 298, 1490, 3783, 4129], 'TRPC6': [105, 300, 1763, 1831, 2137, 2327, 3503, 3561, 3670], 'TRPM8': [107, 302, 1765, 3510, 3626], 'evoked': [108, 151, 303, 346, 3692, 4189, 4619, 4683], 'by': [109, 152, 190, 304, 347, 385, 1768, 1798, 1898, 1916, 1933, 2012, 2643, 3047, 3307, 3332, 3514, 3566, 3630, 3677, 3701, 3870, 3896, 3906, 3939, 3954, 4022, 4107, 4158, 4169, 4177, 4190, 4218, 4279, 4358, 4611, 4620, 4692, 4725], '1-oleolyl-2-acetyl-sn-glycerol': [110, 305, 2414], 'menthol,': [112, 307, 2413], 'respectively.': [113, 308, 3666], 'addition,': [115, 310], 'low': [116, 311, 1484, 1528, 1801, 2998, 4108, 4235, 4284], 'levels': [117, 312, 4257], 'strongly': [120, 315, 4167, 4314, 4353, 4741], 'potentiate': [121, 316], 'effect': [123, 318, 3914, 4183, 4318], 'capsaicin,': [125, 320, 2411, 3027, 3327, 3704], 'protons,': [126, 321, 4035], 'heat': [128, 136, 323, 331, 3942], 'on': [129, 137, 324, 332, 1640, 1730, 1757, 1906, 3492, 3917, 4184, 4321, 4332, 4652, 4658], 'as': [131, 133, 178, 326, 328, 373, 482, 841, 1023, 1025, 1284, 1557, 1834, 2106, 2145, 4152, 4212, 4239, 4241], 'Xenopus': [141, 336, 1783, 2165, 2695, 2732, 2744, 3762, 3774, 4343], 'oocytes.': [142, 337, 1784, 4344], 'dorsal': [144, 339, 415, 1787], 'root': [145, 340, 416, 1788], 'ganglia': [146, 341], 'neurons,': [147, 342, 1791], 'supra-additive': [148, 343], 'stimulations': [149, 344], 'were': [150, 345, 1637, 1766, 1796, 1882, 1930, 1953, 1959, 1989, 2024, 2062, 2092, 2125, 2154, 2171, 2189, 2202, 2210, 2275, 2331, 2344, 2372, 2379, 2418, 2429, 2481, 2498, 2550, 2589, 2626, 2682, 2703, 2708, 2724, 2741, 2751, 2769, 2823, 2844, 2897, 2957, 2965, 3001, 3031, 3051, 3080, 3091, 3248, 3330, 3417, 3439, 3448, 3474, 3512, 3563, 3594, 3628, 3637, 3725, 3776, 3795, 3868, 3956, 4195, 4337], 'capsaicin': [155, 350, 1035, 1799, 3883, 3909, 4044, 4115, 4245, 4287, 4303, 4329, 4372, 4416, 4660, 4728], 'or': [156, 351, 1030, 1800, 3315, 3840, 3941, 4114, 4246, 4288, 4304], 'acid.': [159, 354, 440, 4290], 'Our': [160, 355], 'data': [161, 356, 3447, 3473, 4009], 'suggest': [162, 357], 'existence': [164, 359], 'common': [167, 362, 1817], 'activation': [168, 363, 807, 3724, 4325, 4334], 'mechanism': [169, 364, 1470], 'may': [176, 371], 'therapeutic': [180, 375], 'target': [181, 376], 'pain': [183, 378], 'management': [184, 379], 'treatment': [186, 381], 'diseases': [188, 383], 'caused': [189, 384, 4123, 4417], 'hypersensitivity': [191, 386], 'temperature': [193, 388, 668, 2486, 3057, 3443], 'misregulation.': [194, 389], '1The': [395], 'abbreviations': [396], 'used': [397, 1737, 2451], 'are:': [398], 'TRP,': [399], 'potential;': [402], '2APB,': [403, 2408, 3026, 3311, 3897, 4296], 'borate;': [405], '4αPDD;': [406], '4α-phorbol': [407, 1074], '12,13-didecanoate;': [408], 'DMEM,': [409], "Dulbecco's": [410, 1962], 'minimal': [411, 1963], 'essential': [412, 1964], 'medium;': [413], 'DRG,': [414, 1890], 'ganglia;': [417], 'ECS,': [418], 'extracellular': [419, 2503, 3361, 4171], 'solution;': [420], 'OAG,': [421], '1-oleolyl-2-acetyl-sn-glycerol;': [422], 'TRPV,': [423], 'vanilloid': [424], 'subfamily': [425, 430, 435], 'TRP;': [427, 432, 437], 'TRPC,': [428], 'canonical': [429], 'TRPM,': [433], 'melastatin': [434], 'MES,': [438, 2472, 3018], '2-(N-morpholino)-ethanesulfonic': [439], 'consists': [445], 'recently': [451], 'identified': [452], 'molecules': [453], 'share': [455], 'sequence': [456, 471], 'homology': [457], 'with': [458, 1520, 1991, 2026, 2040, 2226, 2382, 2391, 2501, 2541, 2593, 2804, 2833, 2880, 2906, 2932, 2938, 3024, 3082, 3189, 3212, 3257, 3310, 3343, 3549, 3698, 3765, 3778, 3830, 3843, 4154, 4214, 4282, 4378, 4429, 4557, 4593, 4641, 4678], 'Drosophila': [460], 'protein': [461, 2113, 2149], 'named': [462], 'after': [463, 2196, 2313, 2357], 'phototransduction': [465], 'mutant': [466], 'called': [467], 'trp.': [468], 'According': [469], 'similarities,': [472], 'TRP': [474, 813, 1189, 1562, 1643, 1733, 1749, 3493], 'subfamilies,': [480], 'such': [481, 840, 4032], '(see': [490], 'reviews': [491], 'Refs.': [493], '1Clapham': [494], 'D.E.': [495, 924, 1200, 1217, 1248, 1265, 1565], 'Runnels': [496, 1201, 1249, 1566], 'L.W.': [497, 920, 1202, 1250, 1567], 'Strubing': [498, 1203, 1251, 1568], 'C.': [499, 513, 787, 851, 949, 1007, 1204, 1219, 1252, 1267, 1422, 1569, 3978], 'Nat.': [500, 794, 925, 1205, 1253, 1570], 'Rev.': [501, 1206, 1225, 1254, 1273, 1571], 'Neurosci.': [502, 1207, 1255, 1572, 1689], '2001;': [503, 963, 1208, 1256, 1351, 1362, 1500, 1573, 3998], '2:': [504, 798, 1209, 1257, 1574], '387-396Crossref': [505, 1210, 1258, 1575], 'PubMed': [506, 527, 569, 601, 636, 662, 685, 704, 745, 779, 800, 860, 890, 911, 931, 966, 995, 1018, 1052, 1068, 1116, 1151, 1183, 1211, 1229, 1259, 1277, 1308, 1330, 1365, 1387, 1412, 1438, 1464, 1503, 1548, 1576, 1602, 1627, 1660, 1675, 1693, 1862, 4001, 4061, 4093], 'Scopus': [507, 528, 570, 602, 637, 663, 686, 705, 746, 780, 801, 861, 891, 912, 932, 967, 996, 1019, 1053, 1069, 1117, 1152, 1184, 1212, 1230, 1260, 1278, 1309, 1331, 1366, 1388, 1413, 1439, 1465, 1504, 1549, 1577, 1603, 1628, 1661, 1676, 1694, 1863, 4002, 4062, 4094], '(982)': [508, 1213, 1261, 1578], 'Google': [509, 530, 572, 604, 639, 665, 688, 707, 748, 782, 803, 863, 893, 914, 934, 969, 998, 1021, 1055, 1071, 1119, 1154, 1186, 1214, 1232, 1262, 1280, 1311, 1333, 1354, 1368, 1390, 1415, 1441, 1467, 1506, 1551, 1579, 1605, 1630, 1663, 1678, 1696, 1865, 4004, 4064, 4096], 'Scholar': [510], '2Montell': [512], 'Birnbaumer': [514, 558, 1320, 1592, 1849], 'L.': [515, 559, 728, 922, 1321, 1375, 1450, 1593, 1850], 'Flockerzi': [516, 1097], 'V.': [517, 1003, 1098], 'Cell.': [518, 560, 770, 986], '2002;': [519, 742, 928, 987, 1065, 1108, 1384, 1409, 1619, 1657, 1672], '108:': [520], '595-598Abstract': [521], 'Full': [522, 524, 564, 566, 596, 598, 631, 633, 774, 776, 990, 992, 1013, 1015, 1111, 1113, 1178, 1180, 1433, 1435, 1622, 1624, 1857, 1859, 4088, 4090], 'Text': [523, 525, 565, 567, 597, 599, 632, 634, 775, 777, 991, 993, 1014, 1016, 1112, 1114, 1179, 1181, 1434, 1436, 1623, 1625, 1858, 1860, 4089, 4091], 'PDF': [526, 568, 600, 635, 778, 994, 1017, 1115, 1182, 1437, 1626, 1861, 4092], '(736)': [529], 'Scholar).': [531, 1120, 1233, 1281, 1468, 1507, 1552, 1580, 1866, 4005, 4097], 'These': [532, 836, 4535], 'involved': [535], 'cellular': [538], 'including': [540], 'store-operated': [543, 1343, 1492], 'Ca2+': [544, 574, 1949, 1985, 2605], 'entry': [545], '(3Zhu': [546], 'X.': [547, 1840], 'Jiang': [548, 1843], 'M.': [549, 551, 670, 672, 674, 695, 712, 849, 1037, 1039, 1041, 1136, 1138, 1140, 1157, 1357, 1495, 1608, 1666, 1842, 1844, 1935, 1937, 3974, 3980, 3988, 4046, 4048, 4050, 4067], 'Peyton': [550, 1841], 'Boulay': [552], 'G.': [553, 710, 791, 855, 902, 1100, 1221, 1269, 1426, 1838], 'Hurst': [554, 1845], 'R.': [555, 653, 714, 785, 957, 983, 1458, 1652, 1846], 'Stefani': [556, 1847], 'E.': [557, 1848, 3972], '1996;': [561], '85:': [562], '661-671Abstract': [563], '(607)': [571], 'Scholar),': [573, 640, 666, 864, 915, 1022, 1056, 1072, 1187, 1334, 1391, 1416, 1442, 1631, 1697], 'transport': [575], '(4Peng': [576], 'J.B.': [577, 883, 1080], 'Chen': [578], 'X.Z.': [579], 'Berger': [580], 'U.V.': [581], 'Vassilev': [582], 'P.M.': [583], 'Tsukaguchi': [584], 'H.': [585, 896, 1078, 1165, 1683, 4075], 'Brown': [586], 'E.M.': [587], 'Hediger': [588], 'M.A.': [589, 757], 'J.': [590, 625, 656, 678, 722, 724, 726, 730, 740, 875, 885, 898, 900, 1045, 1090, 1096, 1105, 1144, 1302, 1360, 1383, 1407, 1427, 1454, 1498, 1616, 1655, 1669, 1685, 1688, 1851, 1940, 3976, 3984, 3996, 4054], 'Biol.': [591, 626, 796, 927, 1009, 1106, 1428, 1617, 1852], 'Chem.': [592, 627, 1107, 1429, 1618, 1853], '1999;': [593, 628, 701, 857], '274:': [594, 629], '22739-22746Abstract': [595], '(545)': [603], 'Scholar,': [605, 689, 708, 783, 894, 999, 1155, 1215, 1263, 1312, 1355, 1369, 1606, 1664, 1679, 4065], '5Hoenderop': [606], 'J.G.': [607, 1397, 1687], 'van': [608, 614, 618, 1317, 1589], 'der': [609], 'Kemp': [610], 'A.W.': [611], 'Hartog': [612], 'A.': [613, 655, 736, 763, 941, 977, 1654, 3970], 'de': [615], 'Graaf': [616], 'S.F.': [617], 'Os': [619], 'C.H.': [620], 'Willems': [621], 'P.H.': [622], 'Bindels': [623], 'R.J.': [624], '8375-8378Abstract': [630], '(531)': [638], 'trace': [641], 'metal': [642], 'detection': [643, 2324], '(6Monteilh-Zoller': [644], 'M.K.': [645, 1648], 'Hermosura': [646], 'M.C.': [647, 1646], 'Nadler': [648], 'M.J.': [649, 691, 869, 955, 1159, 1379, 4069], 'Scharenberg': [650, 960, 980, 1649], 'A.M.': [651, 759, 961, 981, 1650], 'Penner': [652, 956, 982, 1651], 'Fleig': [654, 940, 976, 1653], 'Gen.': [657, 1670], 'Physiol.': [658, 1361, 1499, 1656, 1671], '2003;': [659, 908, 1010, 1226, 1274, 1430, 1545], '121:': [660], '49-60Crossref': [661], '(450)': [664], '(7Caterina': [669, 1036, 1135, 4045], 'Schumacher': [671, 1038, 1137, 4047], 'Tominaga': [673, 694, 1040, 1139, 4049], 'Rosen': [675, 692, 1042, 1141, 1162, 4051, 4072], 'T.': [676, 845, 853, 904, 1001, 1005, 1043, 1142, 1293, 1295, 1299, 4052], 'Levine': [677, 1044, 1143, 4053], 'Julius': [679, 698, 1046, 1062, 1145, 1172, 1222, 1270, 4055, 4082], 'D.': [680, 699, 734, 867, 1047, 1063, 1082, 1146, 1173, 1223, 1271, 4056, 4083], 'Nature.': [681, 700, 741, 856, 907, 962, 1048, 1064, 1147, 4057], '1997;': [682, 1049, 1148, 1305, 1854, 4058], '389:': [683, 1050, 1149, 4059], '816-824Crossref': [684, 1051, 1150, 4060], '(7310)': [687, 1054, 1153, 4063], '8Caterina': [690], 'T.A.': [693, 1163, 4073], 'Brake': [696], 'A.J.': [697, 765, 951], '398:': [702], '436-441Crossref': [703], '(1292)': [706], '9Smith': [709], 'Gunthorpe': [711, 868], 'Kelsell': [713], 'Hayes': [715, 1087], 'P.': [716, 718, 720, 738, 947, 975, 1088, 1348, 3966], 'Reilly': [717], 'Facer': [719], 'Wright': [721], 'Jerman': [723, 870, 1083], 'Walhin': [725], 'Ooi': [727], 'Egerton': [729], 'Charles': [731], 'K.': [732, 789, 1167, 1301, 1323, 1595, 1681, 3982, 4077], 'Smart': [733, 1081, 1402], 'Randall': [735, 880], 'Anand': [737], 'Davis': [739, 882, 1079], '418:': [743], '186-190Crossref': [744], '(679)': [747], 'Scholar)': [749, 804], '(10Liedtke': [752], 'W.': [753, 1092], 'Choe': [754], 'Y.': [755, 1346, 1456], 'Marti-Renom': [756], 'Bell': [758], 'Denis': [760], 'C.S.': [761], 'Sali': [762], 'Hudspeth': [764], 'Friedman': [766], 'J.M.': [767], 'Heller': [768], 'S.': [769, 873, 1297, 3992], '2000;': [771, 797, 887, 1327, 1599], '103:': [772], '525-535Abstract': [773], '(1117)': [781], '11Strotmann': [784], 'Harteneck': [786, 850], 'Nunnenmacher': [788], 'Schultz': [790, 854, 1220, 1268], 'Plant': [792], 'T.D.': [793], 'Cell': [795, 926, 1825, 2182, 3281], '695-702Crossref': [799], '(818)': [802], 'sensations.': [805], 'mechanisms': [808], 'most': [810], 'remain': [815], 'be': [817, 1478], 'elucidated.': [818], 'Specific': [819], 'ligands': [820], 'have': [821], 'been': [822, 1555], 'found': [823, 1338, 3957], 'TRPC3,': [825], 'TRPC6,': [826, 1738, 2292], 'TRPC7,': [827], 'TRPM2,': [830], 'TRPM4,': [831], 'TRPM5,': [832], 'TRPM7,': [833], 'TRPM8.': [835], 'include': [837], 'endogenous': [838, 1642], 'substances,': [839], 'lipids': [842], '(diacylglycerol': [843], '(12Hofmann': [844], 'Obukhov': [846], 'A.G.': [847], 'Schaefer': [848], 'Gudermann': [852, 1004], '397:': [858], '259-263Crossref': [859], '(1285)': [862], 'anandamide': [865], '(13Smart': [866], 'J.C.': [871, 1084], 'Nasir': [872], 'Gray': [874], 'Muir': [876], 'A.I.': [877, 1171, 4081], 'Chambers': [878, 3969], 'J.K.': [879], 'A.D.': [881], 'Br.': [884, 3995], 'Pharmacol.': [886, 1224, 1272, 1350, 1544, 3997], '129:': [888], '227-230Crossref': [889], '(687)': [892], '14Watanabe': [895], 'Vriens': [897, 1089], 'Prenen': [899, 1095], 'Droogmans': [901, 1099], 'Voets': [903], 'Nilius': [905, 1103], 'B.': [906, 1104], '424:': [909], '434-438Crossref': [910], '(823)': [913], 'phosphatidylinositol': [917], '4,5-bisphosphate': [918], '(15Runnels': [919], 'Yue': [921], 'Clapham': [923], '4:': [929], '329-336Crossref': [930], '(466)': [933], 'Scholar)),': [935, 970], 'nucleotides': [936], '(ADP-ribose': [937], '(16Perraud': [938], 'A.L.': [939, 979], 'Dunn': [942], 'C.A.': [943], 'Bagley': [944], 'L.A.': [945], 'Launay': [946], 'Schmitz': [948], 'Stokes': [950], 'Zhu': [952, 1839], 'Q.': [953], 'Bessman': [954], 'Kinet': [958, 984], 'J.P.': [959, 985], '411:': [964], '595-599Crossref': [965], '(772)': [968], 'calcium': [972], 'ions': [973], '(17Launay': [974], 'Perraud': [978], '109:': [988], '397-407Abstract': [989], '(568)': [997], '18Hofmann': [1000], 'Chubanov': [1002], 'Montell': [1006, 1218, 1266], 'Curr.': [1008], '13:': [1011], '1153-1158Abstract': [1012], '(332)': [1020], 'exogenous': [1026], 'materials': [1027], 'either': [1028], 'synthesized': [1029, 2709], 'extracted': [1031, 3092], 'plants,': [1033], 'e.g.': [1034], 'menthol': [1057], '(19McKemy': [1058], 'D.D.': [1059], 'Neuhausser': [1060], 'W.M.': [1061], '416:': [1066], '52-58Crossref': [1067], '(2066)': [1070], '12,13-didecanoate': [1075], '(4αPDD)': [1076], '(20Watanabe': [1077], 'Smith': [1085], 'G.D.': [1086], 'Cairns': [1091], 'Wissenbach': [1093], 'U.': [1094], 'Benham': [1101], 'C.D.': [1102], '277:': [1109, 1620], '13569-13577Abstract': [1110], '(506)': [1118], 'several': [1122], 'blockers': [1123], 'also': [1125, 1808, 3759, 3931, 4298, 4505, 4609, 4740], 'available,': [1126], 'except': [1127, 1582], 'limited': [1130], 'antagonists': [1134], '21Tominaga': [1156, 4066], 'Caterina': [1158, 4068], 'Malmberg': [1160, 4070], 'A.B.': [1161, 4071], 'Gilbert': [1164, 4074], 'Skinner': [1166, 4076], 'Raumann': [1168, 4078], 'B.E.': [1169, 4079], 'Basbaum': [1170, 4080], 'Neuron.': [1174, 4084], '1998;': [1175, 4085], '21:': [1176, 4086], '531-543Abstract': [1177, 4087], '(2644)': [1185, 4095], 'inhibitors': [1190], 'nonspecific.': [1192], 'Ruthenium': [1193, 2422], 'red': [1194, 2423, 3874, 4696], 'blocks': [1195], 'all': [1196, 2568], '(1Clapham': [1199, 1247, 1564], '22Clapham': [1216, 1264], '55:': [1227, 1275], '591-596Crossref': [1228, 1276], '(215)': [1231, 1279], '2-Aminoethoxydiphenyl': [1234], 'appears': [1237], 'block': [1239, 1341], 'First': [1282], 'reported': [1283], 'membrane-permeable': [1286], 'inhibitor': [1287, 1560], 'inositol': [1289], '1,4,5-trisphosphate': [1290], 'receptors': [1291], '(23Maruyama': [1292], 'Kanaji': [1294], 'Nakade': [1296], 'Kanno': [1298], 'Mikoshiba': [1300, 1322, 1594], 'Biochem.': [1303, 1408], '(Tokyo).': [1304], '122:': [1306], '498-505Crossref': [1307], '(786)': [1310], '24Ma': [1313], 'H.T.': [1314, 1586], 'Patterson': [1315, 1587], 'R.L.': [1316, 1588], 'Rossum': [1318, 1590], 'D.B.': [1319, 1591], 'Gill': [1324, 1596], 'D.L.': [1325, 1597], 'Science.': [1326, 1598], '287:': [1328, 1600], '1647-1651Crossref': [1329, 1601], '(534)': [1332, 1604], 'was': [1336, 1832, 1914, 2103, 2138, 2296, 2424, 2565, 2606, 2657, 2890, 2904, 2930, 3106, 3138, 3150, 3178, 3223, 3294, 3305, 3352, 3460, 3467, 3674, 3696, 3758, 3784, 3920, 3930, 4135, 4166, 4248, 4263, 4277, 4373, 4574, 4585, 4608, 4624, 4690, 4739], 'soon': [1337], 'directly': [1340], 'native': [1342, 1718, 4659], '(25Dobrydneva': [1345], 'Blackmore': [1347], 'Mol.': [1349, 1543], '60:': [1352], '541-552PubMed': [1353], '26Prakriya': [1356], 'Lewis': [1358, 1496, 1667], 'R.S.': [1359, 1497, 1668], '536:': [1363, 1501], '3-19Crossref': [1364, 1502], '(437)': [1367, 1505], '27Bootman': [1370], 'M.D.': [1371], 'Collins': [1372], 'T.J.': [1373], 'Mackenzie': [1374], 'Roderick': [1376], 'H.L.': [1377], 'Berridge': [1378], 'Peppiatt': [1380], 'C.M.': [1381], 'FASEB': [1382], '16:': [1385], '1145-1150Crossref': [1386], '(618)': [1389], 'sarco/endoplasmic': [1392], 'reticulum': [1393], 'Ca2+-ATPase': [1394], 'pumps': [1395], '(28Bilmen': [1396], 'Wootton': [1398], 'L.L.': [1399], 'Godfrey': [1400], 'R.E.': [1401], 'O.S.': [1403], 'Michelangeli': [1404], 'F.': [1405], 'Eur.': [1406], '269:': [1410], '3678-3687Crossref': [1411], '(98)': [1414], 'mitochondrial': [1417], 'permeability': [1418], 'transition': [1419], 'pore': [1420], '(29Chinopoulos': [1421], 'Starkov': [1423], 'A.A.': [1424], 'Fiskum': [1425], '278:': [1431], '27382-27389Abstract': [1432], '(119)': [1440], 'few': [1445], 'ion': [1447], '(30Lemonnier': [1449], 'Prevarskaya': [1451], 'N.': [1452, 3986], 'Mazurier': [1453], 'Shuba': [1455], 'Skryma': [1457], 'FEBS': [1459], 'Lett.': [1460], '2004;': [1461, 1690], '556:': [1462], '121-126Crossref': [1463], '(28)': [1466], 'action': [1472], 'is': [1475, 1706, 1722, 1815, 4013, 4024, 4104, 4591], 'likely': [1476], 'complex.': [1479], 'addition': [1481, 2077, 4599], 'inhibition,': [1483], 'concentrations': [1485, 2440, 2636, 3041, 4109], 'enhanced': [1488, 2110, 4610], '(26Prakriya': [1494], 'At': [1508, 2581, 3688, 4364, 4613], 'greater': [1509], 'than': [1510, 2736, 2818, 4310, 4629], '50': [1511, 1976, 1980, 2065, 2397, 2536, 2831, 3258], 'μm,': [1512], 'activated': [1514, 1775, 1809, 3676, 3905, 4106], 'Ca2+-permeable': [1516], 'nonselective': [1517], 'channel': [1519, 1524, 4259], '50-picosiemens': [1522], 'single': [1523], 'conductance': [1525, 3812], 'very': [1527, 3932, 4181], 'open': [1529], 'probability': [1530], 'rat': [1532, 1786, 1921, 1926, 3959, 4668], 'basophilic': [1533], 'leukemia': [1534], 'cells': [1535, 1780, 1946, 1958, 1988, 2080, 2091, 2188, 2274, 2378, 2494, 2588, 3046, 3241, 3293, 3794, 4673], '(31Braun': [1536], 'F.J.': [1537], 'Aziz': [1538], 'O.': [1539], 'Putney': [1540, 1613], 'Jr.,': [1541, 1614], 'J.W.': [1542, 1615], '63:': [1546], '1304-1311Crossref': [1547], '(47)': [1550], 'has': [1554], 'perceived': [1556], 'general': [1559], 'However,': [1581, 1770, 3880], 'TRPC3': [1584], '(24Ma': [1585], '32Trebak': [1607], 'Bird': [1609], 'G.S.': [1610], 'McKay': [1611], 'R.R.': [1612], '21617-21623Abstract': [1621], '(222)': [1629], 'effects': [1633, 1727, 1754, 4552, 4657], 'this': [1635, 4365], 'drug': [1636, 3483], 'often': [1638], 'examined': [1639, 1752], 'presumptive': [1641], '(33Hermosura': [1645], 'Monteilh-Zoller': [1647], '539:': [1658], '445-458Crossref': [1659], '(166)': [1662], '34Prakriya': [1665], '119:': [1673], '487-507Crossref': [1674], '(269)': [1677], '35Tsuzuki': [1680], 'Xing': [1682], 'Ling': [1684], 'Gu': [1686], '24:': [1691], '762-771Crossref': [1692], '(109)': [1695], 'molecular': [1701], 'compositions': [1702], 'uncertain.': [1704], 'It': [1705], 'possible': [1707, 3482], 'an': [1709, 2109, 2283, 2299, 2502, 3847, 4014, 4684], 'unknown': [1710], 'subunit': [1711], 'confers': [1712], 'sensitivity': [1715], 'channels.': [1719, 1734, 1822, 3818, 4648], 'Therefore,': [1720, 4637], 'it': [1721, 3899, 4584, 4719], 'important': [1723], 'confirm': [1725], 'heterologously': [1731], 'Here,': [1735], 'TRPM8,': [1739, 1876, 3672], 'represent': [1743], 'each': [1744, 2050, 4554], 'three': [1747, 1820, 2591, 2631], 'major': [1748], 'subfamilies': [1750], 'their': [1758], 'activities.': [1759], 'We': [1760], 'confirmed': [1761, 1915], 'inhibited': [1767, 3513, 3902, 4691], '2APB.': [1769, 3633, 4412], 'our': [1772], 'surprise,': [1773], 'ganglion': [1789, 3105, 3136, 3148, 3176], '(DRG)': [1790], 'elicited': [1793, 3700, 3823, 3895, 3938, 4157, 4217, 4278], 'currents': [1794, 2343, 2964, 3511, 3548, 3562, 3627, 3825, 3867, 3919, 3937, 4156], 'potentiated': [1797, 4168, 4354], 'pH.': [1802], 'Finally,': [1803], 'showed': [1805], 'V3': [1812, 2170, 2698], 'therefore': [1814], 'activator': [1818, 4015], 'DNA': [1823, 1917, 1994, 2054], 'Constructs,': [1824], 'Culture,': [1826], 'Transfections—cDNA': [1828], 'murine': [1830, 1869, 1877, 1923, 2120, 2167], 'cloned': [1833], 'previously': [1835], 'described': [1836], '(36Boulay': [1837], '272:': [1855], '29672-29680Abstract': [1856], '(294)': [1864], 'cDNAs': [1867, 1913, 1919, 1952], '(GenBank™': [1871, 2177, 3861], 'accession': [1872, 2178, 3862], 'AY452083)': [1874], 'human': [1880, 1894, 3962], 'isolated': [1883], 'total': [1885, 2835], 'RNA': [1886], 'prepared': [1887], 'mouse': [1889, 1891, 3769, 3926], 'skin,': [1892], 'endothelial': [1895], 'cells,': [1896, 3498, 4102, 4230], 'respectively,': [1897, 4211], 'reverse': [1899], 'transcriptase-PCR': [1900], 'using': [1901, 2004, 2108, 2159, 2282, 2608, 2705, 2710, 2968, 2987, 3053, 3429, 3789], 'oligonucleotide': [1902], 'primers': [1903], 'designed': [1904], 'based': [1905], 'published': [1907], 'sequences.': [1908], 'correctness': [1910], 'sequencing.': [1918], 'TRPV5': [1927], 'kindly': [1931], 'provided': [1932, 2011], 'Drs.': [1934], 'Caterina,': [1936], 'Kanzaki,': [1938], 'Peng.': [1941], 'For': [1942, 1983, 2049, 2116, 2162, 2291, 2761, 4225], 'expression': [1943, 2114, 2130, 2163], 'intracellular': [1948, 1984, 2934, 3389], 'measurements,': [1950, 1986], 'subcloned': [1954, 2126, 2139, 2172], 'pcDNA3.': [1956], 'grown': [1960], 'medium': [1965, 2087, 2098], '(DMEM)': [1966], 'containing': [1967, 2230, 2251, 2302, 2506, 2787, 2910, 3290], '4.5': [1968], 'mg/ml': [1969, 2806], 'glucose,': [1970, 2266, 2469, 2521, 3382], '10%': [1971, 3190], 'heat-inactivated': [1972, 3192], 'fetal': [1973, 3193], 'bovine': [1974, 2523, 3194, 3235], 'serum,': [1975, 3195], 'units/ml': [1977, 2882, 3197], 'penicillin,': [1978, 3198], 'μg/ml': [1981, 2028, 2886, 3200, 3427], 'streptomycin.': [1982], 'transfected': [1990, 2491, 3496, 4228], 'desired': [1993, 2393, 2438, 2634, 3022, 3039], 'constructs': [1995], 'wells': [1998, 2023], '96-well': [2000, 2496], 'plates': [2001, 2497], 'without': [2002, 2045, 2088, 2097], 'preseeding': [2003], 'LipofectAMINE': [2005, 2058, 2160], '2000': [2006, 2059], '(Invitrogen)': [2007, 2069], 'following': [2008, 2206], 'protocol': [2010], 'manufacturer.': [2014], 'To': [2015], 'prevent': [2016, 2573], 'cell': [2017, 2118, 2200, 2280, 2319, 2402, 2445, 2479, 2929, 3221, 3351, 3422], 'loss': [2018], 'subsequent': [2020], 'washing,': [2021], 'treated': [2025], '20': [2027, 2881, 2885], 'polyornithine': [2029], '(molecular': [2030], 'weight': [2031], '>30,000;': [2032], 'Sigma)': [2033], '>15': [2035], 'min': [2036, 2783], 'rinsed': [2038], 'once': [2039, 2500], "Hanks'": [2041, 3160], 'balanced': [2042, 3161], 'salt': [2043, 3162], 'solution': [2044, 2229, 2250, 2295, 2301, 2385, 2450, 2504, 2786, 2889, 2909, 3036, 3065, 3255, 3362, 3390, 3806], 'Mg2+': [2046], 'Ca2+.': [2048], 'well,': [2051], 'plasmid': [2053], '(25': [2055], 'ng)': [2056], '(0.4': [2060], 'μl)': [2061], 'mixed': [2063], 'μl': [2066, 2084, 2537, 2599], 'OptiMEM': [2068], 'added': [2071, 4119], 'before': [2075, 2758], '120,000': [2079], 'suspended': [2081], '100': [2083, 2352, 2911, 2985, 3004, 3196, 3199, 3203, 3507, 3664, 4350, 4495, 4621, 4749], 'antibiotics.': [2089], 'incubated': [2093, 2534, 2845, 3119, 3164, 3271], '24–28': [2095], 'h': [2096, 3126], 'change.': [2099], 'transfection': [2101], 'efficiency': [2102], 'about': [2104, 2396, 4625], '70%': [2105], 'determined': [2107], 'green': [2111, 2147], 'fluorescence': [2112, 2613, 2656], 'vector.': [2115], 'whole': [2117, 2279, 2318, 2478, 3421], 'recordings,': [2119], 'V3,': [2122], 'M8': [2124], 'bicistronic': [2129], 'vector,': [2131], 'pIRES2-EGFP': [2132], '(Clontech,': [2133], 'Palo': [2134], 'Alto,': [2135], 'CA).': [2136, 2621, 3436], 'pEGFP-N1': [2141], '(Clontech)': [2142], 'fluorescent': [2148], 'fusion': [2150], 'protein.': [2151], 'transfections': [2153], 'performed': [2155, 2203, 2482, 2683, 3440], '35-mm': [2157, 2192], 'dishes': [2158, 2193], '2000.': [2161], 'oocytes,': [2166], 'pAGA3': [2175, 2701], 'vector': [2176, 2702], 'AY452085).': [2180], 'Whole': [2181, 2199, 3280], 'Recordings': [2183, 3416], 'Cells—Transfected': [2186], 'reseeded': [2190], '1': [2194, 2237, 2261, 2464, 2513, 2794, 2805, 2819, 2859, 2917, 3010, 3125, 3374, 3402, 3702, 3907], 'day': [2195], 'transfection.': [2198], 'recordings': [2201], 'day.': [2207], 'Recording': [2208, 3285], 'pipettes': [2209], 'pulled': [2211], 'micropipette': [2213], 'glass': [2214, 2935, 3267], '(World': [2215], 'Precision': [2216], 'Instruments': [2217, 2286], 'Inc,': [2218, 2287], 'Sarasota,': [2219], 'FL)': [2220], '2–4': [2222, 3786], 'MΩ': [2223], 'when': [2224, 4583], 'filled': [2225, 2937], 'pipette': [2228], '140': [2231, 2252, 2455, 2507], 'mm': [2232, 2235, 2238, 2241, 2253, 2256, 2259, 2262, 2265, 2269, 2304, 2309, 2456, 2459, 2462, 2465, 2468, 2471, 2508, 2511, 2514, 2517, 2520, 2528, 2789, 2792, 2795, 2798, 2820, 2857, 2860, 2863, 2866, 2869, 2872, 2875, 2912, 2915, 2918, 2921, 2924, 3005, 3008, 3011, 3014, 3017, 3157, 3366, 3369, 3372, 3375, 3378, 3381, 3384, 3393, 3397, 3400, 3403, 3406, 3409, 3412], 'CsCl,': [2233], '0.6': [2234], 'MgCl2,': [2236, 2263, 2466, 2515, 2796, 2919, 3012, 3376, 3407], 'EGTA,': [2239, 2922, 3015, 3410], '10': [2240, 2264, 2268, 2308, 2467, 2470, 2519, 3380, 3383, 3408, 3411, 3854, 4704], 'Hepes,': [2242, 2270, 2310, 2529, 2799, 2925, 3385, 3413], 'pH': [2243, 2271, 2311, 2473, 2530, 2800, 2877, 2926, 2999, 3023, 3386, 3414, 4174, 4193, 4221, 4467, 4482, 4518, 4531], '7.20,': [2244], 'placed': [2246, 2395, 2596, 2898, 3098, 3112, 3801], 'bath': [2249, 2294, 2384, 2908, 3035], 'NaCl,': [2254, 2305, 2457, 2509, 2790, 2858, 2913, 3006, 3367, 3401], '5': [2255, 2347, 2458, 2510, 2797, 2837, 2923, 3016, 3143, 3166, 3173, 3451], 'KCl,': [2257, 2460, 2512, 2793, 2861, 2916, 3009, 3370, 3398], '2': [2258, 2461, 2542, 2756, 2791, 3320, 3456, 4449], 'CaCl2,': [2260, 2463, 2518, 2864, 3373, 3404], '7.40.': [2272], 'Isolated': [2273], 'voltage-clamped': [2276], 'mode': [2281], 'EPC9': [2284], '(HEKA': [2285], 'Southboro,': [2288], 'MA)': [2289], 'amplifier.': [2290], 'changed': [2297, 2891, 4382, 4465], 'external': [2300, 2434, 3805], '160': [2303], '7.2': [2306], 'mmN-methyl-d-glucamine,': [2307], '7.4,': [2312, 2531, 2801], 'establishment': [2315], 'configuration': [2320, 3425], 'facilitate': [2322], 'currents.': [2328], 'Voltage': [2329, 2349, 2894], 'commands': [2330], 'made': [2332, 2419, 3002, 3052, 3418], 'Pulse+Pulse': [2335], 'Fit': [2336], 'program': [2337], '(version': [2338], '8.53,': [2339], 'HEKA),': [2340], 'recorded': [2345, 2967], 'at': [2346, 2483, 2556, 2630, 2649, 2659, 2675, 2684, 2754, 2778, 2846, 2959, 2979, 2984, 3037, 3132, 3277, 3319, 3441, 3450, 3455, 3462, 3469, 3574, 3581, 3599, 3617, 3660, 3730, 3746, 3797, 3857, 3886, 3934, 4139, 4146, 4192, 4206, 4220, 4517, 4530, 4632, 4675], 'kHz.': [2348, 3457], 'ramps': [2350], 'ms': [2353], '+100': [2355, 3575, 3618, 3747, 4140, 4207], 'mV': [2356, 2365, 2371, 3576, 3583, 3601, 3619, 3732, 3748, 3799, 4141, 4148, 4677], 'brief': [2359], '(20': [2360], 'ms)': [2361], 'step': [2362], '-100': [2364, 3582, 3600, 3661, 3731, 4147, 4209], 'holding': [2367], '0': [2370, 3538], 'applied': [2373, 2442, 3043, 4586, 4663], 'every': [2374], '0.5': [2375, 3405], 's.': [2376], 'continuously': [2380, 2966], 'perfused': [2381, 2905, 3306], 'through': [2386, 2446, 3230], 'gravity-driven': [2388], 'multioutlet': [2389], 'device': [2390], 'outlet': [2394], 'μm': [2398, 2543, 3204, 3508, 3568, 3598, 3616, 3632, 3641, 3654, 3703, 3729, 3745, 3872, 3888, 3908, 4351, 4362, 4387, 4402, 4415, 4440, 4450, 4496, 4511, 4524, 4622, 4694, 4705, 4711, 4727, 4750], 'away': [2399], 'being': [2403, 2759, 3556], 'recorded.': [2404], 'Stock': [2405], 'solutions': [2406, 2435, 2571, 3000], 'N-arachidonyl': [2409], 'dopamine,': [2410], 'capsazepine,': [2412, 3312, 3885], '(OAG),': [2415], 'resiniferatoxin': [2417], 'Me2SO.': [2421], 'dissolved': [2425, 2725, 3032], 'water.': [2427], 'Drugs': [2428], 'diluted': [2430, 2627], 'appropriate': [2433], 'final': [2439, 2635, 3040], 'perfusion.': [2447, 3048], 'acidic': [2449], 'contained': [2454, 3391], '6.50.': [2474], 'All': [2475, 2678], 'experiments': [2480, 2681, 3438], 'room': [2485, 3442], '(20–24': [2487, 3444], '°C).': [2488, 3279, 3445], 'Intracellular': [2489, 2604], 'Ca2+Measurements—Transiently': [2490], 'HEK': [2492], '293': [2493], 'washed': [2499, 2590], '(ECS)': [2505], '1.8': [2516, 3371, 3735], '0.1%': [2522], 'serum': [2524, 3236], 'albumin,': [2525], '15': [2527], 'then': [2533, 3179, 3270], 'ECS': [2539, 2594, 2629], 'supplemented': [2540, 2803, 2879, 3188, 3256], 'fluo4/AM': [2544], '0.05%': [2546, 3153], 'Pluronic': [2547], 'F-127': [2548], '(both': [2549], 'Molecular': [2552, 2618], 'Probes,': [2553], 'Eugene,': [2554], 'OR)': [2555], '37': [2557, 3133, 3278], '°C': [2558, 2686, 2780, 2848, 4634], '60': [2560], 'min.': [2561], 'Probenecid': [2562], '(2': [2563], 'mm)': [2564], 'included': [2566], 'leakage': [2575], 'fluo4': [2577, 2655], 'end': [2583], 'incubation,': [2586], 'times': [2592, 2632, 4627], '80': [2598], 'same': [2602, 2981], 'solution.': [2603, 3103], 'measured': [2607, 3785], 'fluid': [2610], 'handling': [2611], 'integrated': [2612, 2645], 'plate': [2614, 2642, 2674], 'reader': [2615], '(Flex': [2616], 'Station;': [2617], 'Devices,': [2619], 'Sunnyvale,': [2620], 'drugs': [2625, 3030, 4122], 'delivered': [2638, 3331], 'sample': [2641], 'robotic': [2646], 'eight-channel': [2647], 'pipettor': [2648], 'preprogrammed': [2651], 'time': [2652, 2982], 'points.': [2653], 'read': [2658], 'excitation': [2660], '494': [2662], 'nm': [2663, 2668], 'emission': [2665], '525': [2667], 'bottom': [2671], '0.67': [2676], 'Hz.': [2677], '32': [2685, 4143], 'unless': [2687], 'indicated': [2688], 'otherwise.': [2689], 'cRNA': [2690, 3767, 3832, 3845], 'Synthesis': [2691], 'Expression': [2693], 'Oocytes—TRPV1': [2696], 'linearized': [2704], 'HindIII.': [2706], 'cRNAs': [2707, 2723], 'mMessage': [2711], 'mMachine': [2712], 'reagents': [2713], 'protocols': [2715], 'obtained': [2716, 4631], 'Ambion': [2718], '(Austin,': [2719], 'TX).': [2720], 'resulting': [2722], 'diethylpyrocarbonate-treated': [2727], 'H2O.': [2728], 'Sexually': [2729], 'mature': [2730], 'female': [2731], 'laevis': [2733], 'older': [2735], '2.5': [2737, 2914, 3007, 3597], 'years': [2738], 'age': [2740], 'purchased': [2742], 'I,': [2745], 'Inc.': [2746], '(Dexter,': [2747], 'MI).': [2748], 'frogs': [2750, 2774], 'quarantined': [2752], 'least': [2755], 'weeks': [2757], 'used.': [2760], 'oocyte': [2762], 'isolation,': [2763], 'small': [2764, 3214, 3298, 4182], 'pieces': [2765], 'ovarian': [2767], 'lobe': [2768], 'dissected': [2770], 'out': [2771], 'anesthetized': [2773, 3081], 'shaken': [2776], 'gently': [2777, 3210], '19': [2779, 2847], '90': [2782], '82.5': [2788], 'collagenase': [2807], '(Worthington': [2808], 'Biochem,': [2809], 'Lakewood,': [2810], 'NJ).': [2811], 'Denuded,': [2812], 'healthy': [2813], 'looking': [2814], 'oocytes': [2815, 2843, 2896, 2956, 3763, 3775, 3828, 3839, 3841], 'more': [2817, 3558, 4308, 4340], 'diameter': [2822], 'selected': [2824], 'injected': [2826, 2842, 3764, 3777, 3829, 3842], 'volume': [2829, 3299], 'nl/cell': [2832], 'ng': [2838], 'cRNA.': [2840], '2–5': [2850], 'days': [2851, 3787], 'sterile': [2853], "Barth's": [2854], 'saline': [2855], '(88': [2856], '0.41': [2862], '0.33': [2865, 3377], 'Ca(NO3)2,': [2867], '0.82': [2868], 'MgSO4,': [2870], '2.4': [2871], 'NaHCO3,': [2873], '7.5': [2874, 4519], 'Tris-HCl,': [2876], '7.6,': [2878], 'penicillin': [2883], 'streptomycin).': [2887], 'daily.': [2892], 'Two-electrode': [2893], 'Clamp—The': [2895], '50-μl': [2901], 'chamber': [2902, 3123, 3303], '1.5': [2920, 3013, 3751], '7.4.': [2927, 3387], 'impaled': [2931], 'two': [2933, 4543], 'electrodes': [2936], '3': [2939, 3871, 4693], 'm': [2940], 'KCl': [2941], 'connected': [2942, 3059], 'TEV-700': [2945], 'two-electrode': [2946, 3790], 'voltage': [2947], 'clamp': [2948], 'work': [2949], 'station': [2950], '(Warner': [2951, 3067], 'Instruments,': [2952, 3340, 3433], 'Hamden,': [2953], 'CT).': [2954], 'clamped': [2958], '-40': [2960, 3798], 'mV,': [2961, 3665, 4210], 'chart': [2970], 'recorder': [2971], '(Astro': [2972], 'Med,': [2973], 'Inc.,': [2974], 'West': [2975], 'Warwick,': [2976], 'RI)': [2977], 'digitized': [2983], 'Hz': [2986], 'PowerLab': [2989], 'Data': [2990], 'Acquisition': [2991], 'System': [2992], '(ADInstruments,': [2993], 'Colorado': [2994], 'Springs,': [2995], 'CO).': [2996], 'adjusted': [3019], 'NaOH.': [3025], 'Temperature': [3049], 'changes': [3050], 'CL-100': [3055], 'Bipolar': [3056], 'controller': [3058], 'SC-20': [3062], 'dual': [3063], 'in-line': [3064], 'heater/cooler': [3066], 'Instruments).': [3068], 'Isolation': [3069], 'Culture': [3071], 'Rat': [3073], 'DRG': [3074, 3089, 3287, 4653, 4669], 'Neurons—Male': [3075], 'Sprague-Dawley': [3076], 'rats': [3077], '(150–220': [3078], 'g)': [3079], '4%': [3083], 'halothane': [3084], 'air': [3086, 3131, 3276], 'decapitated.': [3088], '(T1–T10)': [3090], 'under': [3093], 'dissecting': [3095], 'microscope': [3096], 'ice-cold': [3100], "DMEM/Ham's": [3101, 3184, 3253], 'F-12': [3102, 3185, 3187, 3254], 'Each': [3104], 'desheathed,': [3107], 'cut': [3108], '∼10': [3110], 'pieces,': [3111], '0.125%': [3114], 'type': [3115], 'IV': [3116], 'collagenase,': [3117], 'humidified': [3122], '5%': [3128], 'CO2': [3129, 3274], '°C.': [3134], 'suspension': [3137, 3222], 'centrifuged': [3139, 3169, 3224], '(150': [3140, 3170], '×': [3141, 3171, 3226], 'g,': [3142, 3172, 3227], 'min)': [3144, 3229], 'supernatant-aspirated.': [3146], 'pellet': [3149, 3177], 'resuspended': [3151, 3180, 3249], 'trypsin': [3154], '0.53': [3156], 'EDTA': [3158], 'solution,': [3163], 'min,': [3167], 'min).': [3174], 'modified': [3183, 3252], "(DMEM/Ham's": [3186], '(v/v)': [3191], 'streptomycin,': [3201], 'MEM': [3205], 'nonessential': [3206], 'amino': [3207, 3855], 'acids)': [3208], 'triturated': [3211], 'bore': [3215], 'fire-polished': [3216], 'Pasteur': [3217], 'pipette.': [3218], 'dispersed': [3220], '(500': [3225], '8': [3228, 3399], 'layer': [3232], '15%': [3234], 'albumin': [3237], 'separate': [3239], 'myelin': [3244], 'debris.': [3245], 'pellets': [3247], 'ng/ml': [3259], '2.5S': [3260], 'nerve': [3261], 'growth': [3262], 'factor,': [3263], 'plated': [3264], 'onto': [3265], 'poly-l-lysine-coated': [3266], 'coverslips,': [3268], 'overnight': [3272], '(5%': [3273], 'Perforated': [3282], 'Patch': [3283], 'Clamp': [3284], 'Neurons—The': [3288], 'coverslip': [3289], 'attached': [3292], 'centered': [3295], '(0.2': [3300], 'ml)': [3301], 'perfusion': [3302, 3335], 'gravity': [3308], 'feed': [3309], 'ruthenium': [3313, 3873, 4695], 'red,': [3314], 'vehicle': [3316], '(extracellular': [3317], 'solution)': [3318], 'ml/min,': [3321], 'whereas': [3322], 'stimulants': [3325], '(2APB,': [3326], 'acid)': [3329, 4549], 'pressure-driven': [3334], 'system': [3336], '(ALA-VM8;': [3337], 'ALA': [3338], 'Scientific': [3339], 'Westbury,': [3341], 'NY),': [3342], 'its': [3344, 4656], 'tip': [3345], 'positioned': [3346], 'ensure': [3348], 'fully': [3353], 'within': [3354], 'stream': [3356], 'perfusate.': [3359], 'consisted': [3363], '136': [3365], '5.4': [3368], 'NaH2PO4,': [3379], '92': [3392], 'potassium': [3394], 'gluconate,': [3395], '40': [3396, 4614], '7.2.': [3415], 'perforated': [3423, 4679], 'patch': [3424], '(100': [3426, 4112], 'gramicidin)': [3428], 'Axopatch': [3430], '200B/pCLAMP9': [3431], '(Axon': [3432], 'Union': [3434], 'City,': [3435], 'acquired': [3449], 'kHz': [3452], 'filtered': [3454], 'Series': [3458], 'resistance': [3459], 'compensated': [3461], '∼80%.': [3463], 'membrane': [3465], 'held': [3468, 3796, 4674], '-70': [3470, 4676], 'mV.': [3471, 3539], 'collected': [3475], 'only': [3477, 3826, 3889], 'one': [3478], 'cell/dish': [3479], 'avoid': [3481], 'contamination': [3484], 'Differential': [3488], 'Effects': [3489], 'Channels—In': [3494], 'transiently': [3495, 4227], 'OAG': [3500], '(10': [3501], 'μm)-evoked': [3502], 'currents,': [3504, 3534], 'menthol-elicited': [3509], 'dose-dependent': [3518], 'manner': [3519], '(Fig.': [3520, 3686, 3771, 3875, 3910, 4130, 4223, 4315, 4427, 4498, 4533, 4635, 4687, 4697, 4707, 4729], '1,': [3521], 'A': [3522, 3877], 'B).': [3524], 'When': [3525, 4098, 4118], 'activated,': [3526], 'both': [3527, 3542, 3705], 'gave': [3529], 'rise': [3530], 'outwardly': [3532], 'rectifying': [3533], 'reversed': [3536], 'near': [3537], 'blocked': [3541, 3565, 3890], 'inward': [3544, 3554, 3824, 4685], 'outward': [3547], 'blockage': [3551], 'current': [3555, 3694, 3707, 4216, 4618, 4686, 4723], 'slightly': [3557], 'effective.': [3559], 'incompletely': [3564], '300': [3567, 3631], '47.6': [3571], '±': [3572, 3579, 3596, 3607, 3614, 3623, 3639, 3645, 3652, 3658, 3727, 3736, 3743, 3752, 4137, 4144, 4197, 4201, 4385, 4391, 4400, 4406, 4438, 4444, 4448, 4454, 4469, 4474, 4484, 4489, 4509, 4515, 4522, 4528], '6.7%': [3573], '35.4': [3578], '4.3%': [3580], 'control': [3586], 'response': [3587, 3755, 3894, 3904, 4163, 4232, 4270, 4356, 4605, 4733], '(n': [3588, 4149, 4203], '=': [3589, 3605, 3610, 3621, 3643, 3648, 3656, 3734, 3739, 3750, 4150, 4204, 4389, 4404, 4442, 4452, 4472, 4487, 4513, 4526], '5).': [3590], 'IC50': [3592, 3635], 'values': [3593, 3636, 3719], '10.4': [3595], '(Hill': [3602], 'coefficient,': [3603], 'nh': [3604], '1.0': [3606], '0.3,': [3608], 'n': [3609, 3647, 3738], '5)': [3611, 3649], '13.9': [3613], '2.3': [3615], '(nh': [3620, 3642, 3655, 3733, 3749, 4388, 4403, 4441, 4451, 4471, 4486, 4512, 4525], '1.1': [3622], '0.2).': [3624, 3753], 'abolished': [3629, 3869], '7.7': [3638], '2.2': [3640], '0.9': [3644], '0.2,': [3646], '11.6': [3651], '1.2': [3653, 3657, 4405], '0.2)': [3659], '+': [3663], 'contrast': [3668], 'dose-dependently': [3675, 4682], 'any': [3683, 4717], 'agonists': [3685], '1C).': [3687], '0.3–1.0': [3689], 'mm,': [3690], 'comparable': [3697], 'amplitudes': [3708], 'shape': [3711], 'current-voltage': [3714], '(I/V)': [3715], 'curves.': [3716], 'EC50': [3718, 4380, 4434, 4458, 4501], '197': [3726], '13': [3728, 4439], '0.1,': [3737], '6)': [3740, 4205], '130': [3742], '17': [3744], 'detected': [3760], '2).': [3772, 3911], 'Defoliculated': [3773], 'cRNA,': [3780], 'later': [3788], 'voltage-clamp': [3791], 'techniques.': [3792], 'Ca2+-free': [3804], 'minimize': [3808], 'Ca2+-activated': [3810], 'Cl-': [3811], 'inactivation': [3815], 'Bath': [3819], 'application': [3820], 'uninjected': [3838], 'inactive': [3848], 'lacks': [3853], 'acids': [3856], 'N': [3859], 'terminus': [3860], 'AY452084).': [3864], '2APB-evoked': [3866, 4333], '2,': [3876], 'C).': [3879], 'competitive': [3882], 'antagonist,': [3884], '30': [3887, 4710, 4747], '∼30%': [3891], 'although': [3898], 'almost': [3900], 'completely': [3901], 'weak': [3913, 3933, 4170, 4289, 4300, 4735], 'capsazepine': [3916, 3955, 4706], '2APB-induced': [3918], 'unexpected': [3922], 'because': [3923, 4252], 'antagonist': [3929], 'inhibiting': [3935], 'acid': [3940, 4331, 4736], '(data': [3943], 'shown).': [3945], 'Similarly': [3946], 'poor': [3947], 'inhibitions': [3948], 'acid-': [3950], 'heat-induced': [3952], 'responses': [3953, 4301], '(37McIntyre': [3965], 'McLatchie': [3967], 'L.M.': [3968], 'Phillips': [3971], 'Clarke': [3973], 'Savidge': [3975], 'Toms': [3977], 'Peacock': [3979], 'Shah': [3981], 'Winter': [3983], 'Weerasakera': [3985], 'Webb': [3987], 'Rang': [3989], 'H.P.': [3990], 'Bevan': [3991], 'James': [3993], 'I.F.': [3994], '132:': [3999], '1084-1094Crossref': [4000], '(178)': [4003], 'Together,': [4006], 'above': [4008], 'demonstrate': [4010], 'TRPV1.': [4017, 4185], 'Potentiation': [4018], 'Responses': [4021], '2APB—TRPV1': [4023], 'polymodal': [4026], 'sensor': [4027], 'responsive': [4028], 'multiple': [4030], 'stimuli': [4031], 'as,': [4033], 'heat,': [4034], 'principal': [4038], 'pungent': [4039], 'ingredient': [4040], 'chili': [4042], 'peppers,': [4043], 'partially': [4105], 'μm)': [4113], '(0.3': [4116], 'μm).': [4117], 'together,': [4120], 'these': [4121], 'increase': [4126, 4134, 4275], '3A).': [4131], 'average': [4133, 4187], '9.0': [4136], '2.0-fold': [4138], '11-fold': [4145], '7)': [4151], 'compared': [4153, 4213], 'alone.': [4160], 'Similarly,': [4161, 4731], 'acidification': [4172], '6.5,': [4175], 'itself': [4178], 'had': [4179, 4299], 'increases': [4188], '6.5': [4194, 4532], '25.0': [4196], '6.0-': [4198], '21.0': [4200], '8.0-fold': [4202], '7.4': [4222], '3B).': [4224], 'concentration': [4236], 'protons': [4247, 4461], 'quite': [4249], 'variable,': [4250], 'presumably': [4251], 'differences': [4254], 'expression.': [4260], 'Noticeably,': [4261], 'there': [4262], 'negative': [4265], 'association': [4266], 'between': [4267], 'initial': [4269], 'co-application': [4281], 'level': [4285], 'Cells': [4291], 'responded': [4293, 4313], 'weakly': [4294], 'acid,': [4305], 'typically': [4306, 4575], 'displayed': [4307], 'potentiation': [4309], '3C).': [4316], 'capsaicin-': [4322], 'acid-induced': [4324], 'studied': [4338], 'detail': [4341], 'As': [4345], 'shown': [4346], 'Fig.': [4348], '4A,': [4349], 'induced': [4357, 4724], '0.1': [4359], '0.3': [4361, 4414, 4726], 'capsaicin.': [4363], 'concentration,': [4367], 'dose-response': [4369, 4423, 4568], 'curve': [4370, 4424, 4569], 'shifted': [4374], 'left': [4377, 4419], 'value': [4381, 4435, 4459, 4502, 4582], '1.34': [4384], '0.12': [4386], '2.0': [4390], '0.3)': [4392, 4407], '0.35': [4399], '0.08': [4401], 'presence': [4410, 4493, 4559, 4745], 'Inversely,': [4413], 'shift': [4420], '4B)': [4428], 'decrease': [4431, 4595], '315': [4437], '2.27': [4443], '0.24)': [4445], '34': [4447], '0.92': [4453], '0.05).': [4455], 'Likewise,': [4456], 'activate': [4463, 4716], '5.220': [4468], '0.001': [4470], '1.37': [4473], '0.02)': [4475], '6.036': [4483], '0.005': [4485], '1.00': [4488], '0.01)': [4490], '4C).': [4499], 'decreased': [4506, 4576], '322.0': [4508], '0.8': [4510], '3.10': [4514], '0.04)': [4516], '159.1': [4521], '5.9': [4523], '1.60': [4527], '0.10)': [4529], '4D).': [4534], 'results': [4536], 'indicate': [4537], '(capsaicin': [4547], 'sensitized': [4550], 'other.': [4555], 'Interestingly,': [4556], 'another': [4561], 'stimulus,': [4562], 'Hill': [4564], 'coefficient': [4565], 'given': [4572], 'ligand': [4573], 'half': [4578], 'original': [4581], 'alone,': [4587], 'suggesting': [4588], 'sensitization': [4590], 'accompanied': [4592], 'cooperativity.': [4597], 'activators,': [4603], 'heat.': [4612], '°C,': [4615], 'nine': [4626], 'larger': [4628], '22': [4633], '4E).': [4636], 'acts': [4639], 'synergistically': [4640], 'known': [4643], 'activating': [4644], 'factors': [4645], 'Effect': [4649], 'Neurons—To': [4654], 'examine': [4655], 'receptors,': [4661], 'acutely': [4666], 'cultured': [4667], 'neurons.': [4670], 'capsaicin-sensitive': [4672], 'patches,': [4680], '5A),': [4688], '5B)': [4698], 'and,': [4699], 'lesser': [4702], 'extent,': [4703], '5C).': [4708], 'alone': [4713], 'did': [4714], 'current,': [4718], 'significantly': [4720], 'increased': [4721, 4742], '6A).': [4730], '(pH': [4737], '6.5)': [4738]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1970629236', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 20}, {'year': 2021, 'cited_by_count': 26}, {'year': 2020, 'cited_by_count': 25}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 21}, {'year': 2015, 'cited_by_count': 23}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 34}, {'year': 2012, 'cited_by_count': 29}], 'updated_date': '2024-12-24T16:05:41.038625', 'created_date': '2016-06-24'}
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