Title: MANDELIC ACID IN THE TREATMENT OF INFECTIONS OF THE URINARY TRACT
Abstract: In recent years the treatment of infections of the urinary tract has taken on a more scientific aspect. The older empirical methods which were efficacious in alleviating symptoms have been supplanted by newer forms of treatment which have a logical and predetermined basis and the value of which has been proved. Since Shohl and Janney<sup>1</sup>demonstrated that the growth of Escherichia coli was inhibited in urine at a<i>p</i><sub>H</sub>of 4.6 to 5.0, the question of combating infection of the urine has come steadily to the foreground. Clark<sup>2</sup>in 1931, searching for a means of acidifying the urine, used the ketogenic diet. Early observations soon revealed that a secondary factor was needed besides high acidity if bacillary infections of the urinary tract were to be eradicated. Fuller<sup>3</sup>proved this secondary factor to be beta-hydroxybutyric acid. Helmholz and Osterberg 4 have definitely shown that a certain concentration of this acid, which is an end product of the ketogenic diet, is needed along with a certain pH of urine if negative cultures of urine are to be obtained.
Publication Year: 1936
Publication Date: 1936-11-28
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 12
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