Publication Information

{'id': 'https://openalex.org/W1970533648', 'doi': 'https://doi.org/10.1074/jbc.271.35.21193', 'title': 'Identification of Residues in the Translocation Pathway of EmrE, a Multidrug Antiporter from Escherichia coli', 'display_name': 'Identification of Residues in the Translocation Pathway of EmrE, a Multidrug Antiporter from Escherichia coli', 'publication_year': 1996, 'publication_date': '1996-08-01', 'ids': {'openalex': 'https://openalex.org/W1970533648', 'doi': 'https://doi.org/10.1074/jbc.271.35.21193', 'mag': '1970533648', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8702890'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.271.35.21193', 'pdf_url': 'http://www.jbc.org/article/S002192581974633X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 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'https://openalex.org/W2087941147', 'https://openalex.org/W2097878215', 'https://openalex.org/W2102131116', 'https://openalex.org/W2103697287', 'https://openalex.org/W2153360089', 'https://openalex.org/W2162097287', 'https://openalex.org/W2167131009', 'https://openalex.org/W2195565602', 'https://openalex.org/W231981629', 'https://openalex.org/W4256209751', 'https://openalex.org/W935389632'], 'related_works': ['https://openalex.org/W4297251098', 'https://openalex.org/W3208158820', 'https://openalex.org/W2727878429', 'https://openalex.org/W2469250300', 'https://openalex.org/W2252376317', 'https://openalex.org/W2135850184', 'https://openalex.org/W2022891666', 'https://openalex.org/W174748315', 'https://openalex.org/W1486405406', 'https://openalex.org/W1480025177'], 'abstract_inverted_index': {'EmrE': [0, 77, 186, 263, 349, 426, 535, 612], 'is': [1, 21, 42, 51, 78, 95, 108, 169, 211, 253, 310, 314, 350, 370, 391, 400, 427, 444, 457, 518, 560, 602, 659, 663], 'a': [2, 33, 52, 116, 171, 199, 245, 328, 336, 351, 382, 401, 465, 520, 548, 594, 677, 685], 'small,': [3, 352], '12-kDa,': [4, 353], 'highly': [5, 354], 'polyspecific': [6, 355], 'antiporter,': [7, 356], 'which': [8, 70, 122, 357, 419, 471], 'exchanges': [9, 358], 'hydrogen': [10, 359], 'ions': [11, 360], 'with': [12, 80, 85, 161, 185, 195, 221, 240, 267, 277, 361, 429, 434, 510, 534, 544, 570, 589, 616, 626], 'aromatic': [13, 362], 'cations': [14, 363], 'such': [15, 364], 'as': [16, 234, 365, 583], 'methyl': [17, 366], 'viologen.': [18, 367], 'EmrE-mediated': [19, 368], 'transport': [20, 98, 369, 447], 'inhibited': [22, 371], 'by': [23, 32, 372, 381], 'the': [24, 45, 48, 55, 64, 72, 126, 132, 149, 178, 196, 209, 214, 218, 222, 231, 241, 259, 268, 281, 285, 295, 307, 317, 325, 341, 373, 394, 397, 404, 413, 421, 475, 481, 498, 527, 545, 558, 563, 567, 571, 580, 590, 608, 617, 630, 634, 644, 656, 666, 674, 690], 'sulfhydryl-reactive': [25, 374], 'reagent': [26, 210, 375, 559], '4-(chloromercuri)benzoic': [27, 376], 'acid': [28, 167, 377, 516], '(PCMB)': [29, 378], 'but': [30, 157, 275, 379, 506, 624], 'not': [31, 158, 238, 276, 304, 380, 507, 587, 625, 653], 'variety': [34, 383], 'of': [35, 54, 71, 93, 104, 111, 125, 142, 148, 177, 217, 262, 284, 294, 327, 345, 384, 403, 420, 442, 453, 460, 474, 491, 497, 526, 566, 611, 633, 643, 676, 694], 'other': [36, 133, 385, 482], 'sulfhydryl': [37, 386], 'reagents.': [38, 66, 387, 415], 'This': [39, 388], 'differential': [40, 389], 'effect': [41, 390], 'due': [43, 392], 'to': [44, 63, 135, 228, 230, 288, 298, 316, 332, 393, 412, 484, 577, 579, 637, 647, 665, 681], 'fact': [46, 395], 'that': [47, 91, 146, 255, 302, 312, 396, 440, 495, 604, 651, 661], 'organic': [49, 398], 'mercurial': [50, 399], 'substrate': [53, 112, 260, 342, 402, 461, 609, 691], 'transporter': [56, 405], 'and': [57, 87, 155, 190, 220, 264, 273, 334, 406, 436, 504, 539, 569, 613, 622, 683], 'can': [58, 407], 'reach': [59, 408], 'domains': [60, 409], 'otherwise': [61, 410], 'inaccessible': [62, 411], 'different': [65, 414], 'To': [67, 416], 'find': [68, 417], 'out': [69, 418], 'three': [73, 150, 422, 499], 'cysteine': [74, 423], 'residues': [75, 106, 424, 455], 'in': [76, 121, 152, 187, 203, 213, 425, 470, 501, 536, 552, 562], 'reacting': [79, 428], 'PCMB,': [81, 430], 'each': [82, 431], 'was': [83, 89, 129, 432, 438, 478], 'replaced': [84, 433], 'serine': [86, 136, 435, 485], 'it': [88, 181, 236, 309, 437, 530, 585, 658], 'shown': [90, 439], 'none': [92, 441], 'them': [94, 443], 'essential': [96, 445], 'for': [97, 339, 446, 688], 'activity.': [99, 448], 'A': [100, 163, 449, 512], 'protein': [101, 243, 450, 592], 'completely': [102, 451], 'devoid': [103, 452], 'Cys': [105, 151, 201, 247, 454, 500, 550, 596], '(CL)': [107, 456], 'also': [109, 138, 458, 487], 'capable': [110, 459], 'accumulation': [113, 462], 'albeit': [114, 463], 'at': [115, 248, 464, 597], 'slower': [117, 466], 'rate.': [118, 467], 'Mutated': [119, 468], 'proteins': [120, 144, 469, 493], 'only': [123, 170, 207, 225, 331, 472, 519, 556, 574, 680], 'one': [124, 473], 'native': [127, 476], 'cysteines': [128, 477], 'left': [130, 479], 'whereas': [131, 480], 'changed': [134, 483], 'were': [137, 486], 'constructed.': [139, 488], 'The': [140, 322, 489, 671], 'use': [141, 490], 'these': [143, 492], 'demonstrated': [145, 494], 'two': [147, 269, 496, 618], 'EmrE,': [153, 502], 'Cys-41': [154, 313, 503, 662], 'Cys-95,': [156, 505], 'Cys-39,': [159, 278, 508, 627], 'react': [160, 239, 509, 588], 'PCMB.': [162, 511], 'related': [164, 513], 'mercurial,': [165, 514], '4-(chloromercuri)benzenesulfonic': [166, 515], '(PCMBS),': [168, 517], 'very': [172, 521], 'poor': [173, 522], 'inhibitor,': [174, 523], 'probably': [175, 524], 'because': [176, 293, 525, 642], 'negative': [179, 528], 'charge': [180, 529], 'bears.': [182, 531], 'PCMBS': [183, 532], 'reacts': [184, 194, 266, 533, 543, 615], 'an': [188, 300, 346, 537, 649, 695], 'asymmetric': [189, 296, 538, 645], 'unique': [191, 337, 540, 686], 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