Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1970191983', 'doi': 'https://doi.org/10.3109/10428190009148392', 'title': 'Leptin Receptor and Leukemia', 'display_name': 'Leptin Receptor and Leukemia', 'publication_year': 2000, 'publication_date': '2000-01-01', 'ids': {'openalex': 'https://openalex.org/W1970191983', 'doi': 'https://doi.org/10.3109/10428190009148392', 'mag': '1970191983', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10784389'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/10428190009148392', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27064115', 'display_name': 'Leukemia & lymphoma/Leukemia and lymphoma', 'issn_l': '1026-8022', 'issn': ['1026-8022', '1029-2403', '1042-8194'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001816724', 'display_name': 'Masayuki Hino', 'orcid': 'https://orcid.org/0000-0002-9128-7750'}, 'institutions': [{'id': 'https://openalex.org/I317356780', 'display_name': 'Osaka City University', 'ror': 'https://ror.org/02skfsw40', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I317356780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masayuki Hino', 'raw_affiliation_strings': ['Department of Clinical Hematology, Osaka City University Medical School, Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Hematology, Osaka City University Medical School, Osaka, Japan', 'institution_ids': ['https://openalex.org/I317356780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010890436', 'display_name': 'Takafumi Nakao', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takafumi Nakao', 'raw_affiliation_strings': ['Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112249249', 'display_name': 'Takahisa Yamane', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takahisa Yamane', 'raw_affiliation_strings': ['Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071085125', 'display_name': 'Kensuke Ohta', 'orcid': 'https://orcid.org/0009-0008-5620-7090'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kensuke Ohta', 'raw_affiliation_strings': ['Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110784265', 'display_name': 'Takayuki Takubo', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takayuki Takubo', 'raw_affiliation_strings': ['Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103399834', 'display_name': 'Noriyuki Tatsumi', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Noriyuki Tatsumi', 'raw_affiliation_strings': ['Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Hematology, Osaka dry University Medical School, 1-5-7, Asahimachi, Abeno-ku, Osaka, 545-8586, Japan', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.279, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 61, 'citation_normalized_percentile': {'value': 0.575342, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '36', 'issue': '5-6', 'first_page': '457', 'last_page': '461'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10528', 'display_name': 'Adipokines, Inflammation, and Metabolic Diseases', 'score': 0.9816, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11584', 'display_name': 'Biochemical Analysis and Sensing Techniques', 'score': 0.9705, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/leptin-receptor', 'display_name': 'Leptin receptor', 'score': 0.7148184}, {'id': 'https://openalex.org/keywords/acute-myeloblastic-leukemia', 'display_name': 'Acute myeloblastic leukemia', 'score': 0.7008596}], 'concepts': [{'id': 'https://openalex.org/C2780613262', 'wikidata': 'https://www.wikidata.org/wiki/Q223739', 'display_name': 'Leptin', 'level': 3, 'score': 0.8575572}, {'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.73122466}, {'id': 'https://openalex.org/C14372207', 'wikidata': 'https://www.wikidata.org/wiki/Q7072306', 'display_name': 'Leptin receptor', 'level': 4, 'score': 0.7148184}, {'id': 'https://openalex.org/C2779378344', 'wikidata': 'https://www.wikidata.org/wiki/Q264118', 'display_name': 'Acute myeloblastic leukemia', 'level': 3, 'score': 0.7008596}, {'id': 'https://openalex.org/C2778461978', 'wikidata': 'https://www.wikidata.org/wiki/Q29496', 'display_name': 'Leukemia', 'level': 2, 'score': 0.67908686}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.63373923}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.6019407}, {'id': 'https://openalex.org/C7876069', 'wikidata': 'https://www.wikidata.org/wiki/Q14873666', 'display_name': 'Paracrine signalling', 'level': 3, 'score': 0.51930183}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5131865}, {'id': 'https://openalex.org/C2779282312', 'wikidata': 'https://www.wikidata.org/wiki/Q1956561', 'display_name': 'Myeloid', 'level': 2, 'score': 0.49533954}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.47518364}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.45349133}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39640084}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39461783}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.38894957}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.3655936}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.13276842}, {'id': 'https://openalex.org/C511355011', 'wikidata': 'https://www.wikidata.org/wiki/Q12174', 'display_name': 'Obesity', 'level': 2, 'score': 0.05656591}], 'mesh': [{'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020738', 'descriptor_name': 'Leptin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009765', 'descriptor_name': 'Obesity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018121', 'descriptor_name': 'Receptors, Cytokine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018121', 'descriptor_name': 'Receptors, Cytokine', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018121', 'descriptor_name': 'Receptors, Cytokine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054411', 'descriptor_name': 'Receptors, Leptin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/10428190009148392', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27064115', 'display_name': 'Leukemia & lymphoma/Leukemia and lymphoma', 'issn_l': '1026-8022', 'issn': ['1026-8022', '1029-2403', '1042-8194'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10784389', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.82, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W124601896', 'https://openalex.org/W1967104566', 'https://openalex.org/W1996713062', 'https://openalex.org/W200722710', 'https://openalex.org/W2013583119', 'https://openalex.org/W2014093920', 'https://openalex.org/W2016994959', 'https://openalex.org/W2017223857', 'https://openalex.org/W201744686', 'https://openalex.org/W2021052947', 'https://openalex.org/W2025846514', 'https://openalex.org/W2044153433', 'https://openalex.org/W2051192888', 'https://openalex.org/W2056352776', 'https://openalex.org/W2060682066', 'https://openalex.org/W2063379611', 'https://openalex.org/W2065670117', 'https://openalex.org/W2067935095', 'https://openalex.org/W2069038722', 'https://openalex.org/W207944929', 'https://openalex.org/W2086124769', 'https://openalex.org/W2090977677', 'https://openalex.org/W2103779405', 'https://openalex.org/W2118590328', 'https://openalex.org/W2135225737', 'https://openalex.org/W2137736712', 'https://openalex.org/W2142430176', 'https://openalex.org/W2144635291', 'https://openalex.org/W2218441948', 'https://openalex.org/W2337628474', 'https://openalex.org/W27140539', 'https://openalex.org/W4256002763', 'https://openalex.org/W69990049'], 'related_works': ['https://openalex.org/W2623631892', 'https://openalex.org/W2166890779', 'https://openalex.org/W2144624376', 'https://openalex.org/W2138466941', 'https://openalex.org/W2130768355', 'https://openalex.org/W2094349474', 'https://openalex.org/W2047971516', 'https://openalex.org/W2023381149', 'https://openalex.org/W2015872450', 'https://openalex.org/W1988098212'], 'abstract_inverted_index': {'AbstractThe': [0], 'receptor': [1, 97], 'for': [2], 'leptin,': [3], 'the': [4, 8, 35, 48, 51, 63, 86, 131, 138], 'gene': [5], 'product': [6], 'of': [7, 34, 50, 55, 69, 91, 95, 120, 140], 'obese': [9], 'gene,': [10], 'is': [11, 25, 98], 'expressed': [12], 'in': [13, 38, 47, 62, 104, 110, 137], 'hematopoietic': [14, 57], 'stem': [15], 'cells.': [16], 'Leptin': [17, 40, 107, 143], 'stimulates': [18], 'normal': [19], 'myeloid': [20, 81], 'and': [21, 24, 53, 79, 109], 'erythroid': [22], 'development,': [23], 'secreted': [26], 'from': [27], 'bone': [28, 64], 'marrow': [29, 36, 65], 'adipocytes,': [30], 'which': [31], 'occupy': [32], 'most': [33], 'cavity': [37], 'humans.': [39], 'might': [41], 'thus': [42], 'play': [43], 'an': [44], 'important': [45], 'role': [46], 'control': [49], 'expansion': [52], 'differentiation': [54], 'primitive': [56], 'cells': [58, 68, 122], 'through': [59], 'paracrine': [60], 'interaction': [61], 'microenvironment.': [66], 'Leukemic': [67], 'some': [70], 'patients': [71], 'with': [72, 112], 'acute': [73, 76], 'myeloblastic': [74], 'leukemia,': [75, 78], 'lymphoblastic': [77], 'chronic': [80, 105], 'leukemia': [82, 121], '(CML)': [83], 'also': [84], 'express': [85], 'leptin': [87, 96, 134], 'receptor.': [88], 'In': [89], 'cases': [90], 'CML,': [92], 'higher': [93], 'expression': [94], 'observed': [99], 'during': [100], 'blast': [101], 'crisis': [102], 'than': [103], 'phase.': [106], 'alone': [108], 'combination': [111], 'other': [113], 'cytokines': [114], 'has': [115], 'stimulative': [116], 'effects': [117], 'on': [118], 'proliferation': [119], 'as': [123, 125], 'well': [124], 'anti-apoptotic': [126], 'effects.': [127], 'These': [128], 'findings': [129], 'suggest': [130], 'possibility': [132], 'that': [133], 'plays': [135], 'roles': [136], 'pathophysiology': [139], 'leukemia.Key': [141], 'Words:': [142], 'receptorhematopoiesisleukemia': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1970191983', 'counts_by_year': [{'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-06T07:26:50.325533', 'created_date': '2016-06-24'}