Title: Differentiation of monoamine oxidase and diamine oxidase
Abstract: In kidney of cats pretreated with inhibitors of monoamine oxidase and diamine oxidase the activity of these enzymes was measured simultaneously, using typical cell fractions and substrates. After iproniazid pretreatment inhibition of diamine oxidase occurred somewhat earlier and was of shorter duration than inhibition of monoamine oxidase (7 days for diamine oxidase and 21 days for monoamine oxidase). Both amine oxidases may be inhibited independently in vivo: d, l-frans-phenyl-cyclo-propyl-amine and N-methyl-N-benzyl-2-propinylamine inhibit mainly monoamine oxidase, whereas aminoguanidine interferes only with diamine oxidase. These results suggest that diamine oxidase is an enzyme with specific characteristics in vivo.
Publication Year: 1962
Publication Date: 1962-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 24
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