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1646], 'nonsmokers.': [840], 'Heart': [842], '147,': [845], 'E5.': [846], '10.1016/S0002-8703(03)00468-X': [847], '8Lopez-Sepulveda,': [852], 'R.,': [853, 855, 1078, 1189, 1737, 2091, 2248], 'Jimenez,': [854], 'Romero,': [856], 'Zarzuelo,': [858], 'Wine': [863], 'improve': [865, 902, 2516], 'large': [869], 'vessels': [870], 'female': [872], 'spontaneously': [873], 'rats.': [875, 2422], 'Hypertension': [876, 1031], '2008,': [877, 941, 1958, 1997, 2082, 2525, 2573], '51,': [878], '1088–1095.': [879], '10.1161/HYPERTENSIONAHA.107.107672': [880], '9Karatzi,': [885], 'Papamichael,': [887], 'E.': [892, 1473, 1828, 1860, 1968, 2334, 2586, 2620], 'Constituents': [895], 'other': [899], 'than': [900], 'alcohol': [901], 'Coron.': [911], 'Artery': [912], 'Dis.': [913], '15,': [915], '485–490.': [916], '10.1097/00019501-200412000-00005': [917], 'PubMedWeb': [918, 2186], '10Grassi,': [922], 'Aggio,': [924], 'Onori,': [926], 'Croce,': [928, 1014], 'G.': [929, 1015, 2255], 'Tea,': [932], 'flavonoids,': [933], 'nitric': [935, 1096], 'oxide-mediated': [936], 'vascular': [937, 965, 1132, 2517], 'reactivity.': [938], '138,': [942], '1554S–1560S.': [943], '10.1093/jn/138.8.1554S': [944], '11Hodgson,': [949], 'Burke,': [952], 'V.,': [953, 2287, 2480, 2583], 'Puddey,': [954, 2441], 'I.': [955, 1246, 1898, 2166, 2442, 2745, 2775], 'B.,': [956, 1206, 1527, 1824, 2036, 2443, 2644, 2670], 'Acute': [957, 1050], 'tea': [960, 1212, 1681, 1684, 2352, 2377, 2380, 2490], 'fasting': [962], 'postprandial': [964], 'humans.': [971, 1135, 1218, 1245, 1294, 2234, 2466], 'Hypertens.': [973, 999], '23,': [975, 1001], '47–54.': [976], '10.1097/00004872-200501000-00012': [977], '12Fisher,': [982], 'N.': [983, 987, 1196, 1778, 2436], 'Hollenberg,': [986], 'Flavanols': [989], 'health:': [992], 'science': [994], 'behind': [995], 'sweetness.': [997], '1453–1459.': [1002], '10.1097/01.hjh.0000174605.34027.9d': [1003], '13Grassi,': [1008], 'Necozione,': [1010], 'Lippi,': [1012], 'Cocoa': [1018], 'insulin': [1023], 'resistance': [1024], 'endothelium-dependent': [1027], 'vasodilation': [1028], 'hypertensives.': [1030], '46,': [1033, 1068], '398–405.': [1034], '10.1161/01.HYP.0000174990.46027.70': [1035], '14Heiss,': [1040], 'Kleinbongard,': [1042, 1120], 'P.,': [1043, 1198, 1352, 1377, 1668, 1672, 1976, 2093, 2097, 2285, 2338, 2365, 2407, 2621], 'Dejam,': [1044], 'Perre,': [1046], 'S.': [1047, 1532], 'flavanol-rich': [1053, 1129], 'cocoa': [1054, 1089, 1130], 'reversal': [1057], 'smokers.': [1062], 'Coll.': [1065], 'Cardiol.': [1066], '1276–1283.': [1069], '10.1016/j.jacc.2005.06.055': [1070], '15Taubert,': [1075], 'Roesen,': [1077], 'Lehmann,': [1079], 'Jung,': [1081], 'N.,': [1082, 1154, 2332, 2701], 'Schomig,': [1083], 'Effects': [1085], 'low': [1087], 'habitual': [1088], 'bioactive': [1095], 'oxide:': [1097], 'randomized': [1099], 'Med.': [1104, 2274, 2426, 2688], 'Assoc.': [1105], '2007,': [1106, 1339, 1615, 1651, 1724, 2150, 2498, 2635, 2656, 2733], '298,': [1107], '49–60.': [1108], '10.1001/jama.298.1.49': [1109], '16Schroeter,': [1114], 'Heiss,': [1116], 'Balzer,': [1118], 'J.,': [1119, 1350, 1403, 1497, 1554, 1630, 1858, 1969, 2068, 2130, 2542, 2668], '(−)-Epicatechin': [1124], 'mediates': [1125], 'beneficial': [1126], 'Proc.': [1136], 'Natl.': [1137], 'Acad.': [1138], 'Sci.': [1139, 1957, 2610], 'USA': [1140], '2006,': [1141, 1456, 1690, 1842, 2025, 2611], '103,': [1142], '1024–1029.': [1143], '10.1073/pnas.0510168103': [1144], '17Kroon,': [1149], 'Clifford,': [1152], 'Crozier,': [1155], 'Day,': [1157], 'How': [1162, 2512], 'should': [1163], 'we': [1164], 'assess': [1165, 2722], 'exposure': [1169, 2599, 2681], 'vitro?': [1174], '80,': [1180], '15–21.': [1181], '10.1093/ajcn/80.1.15': [1182], '18Olthof,': [1187], 'Hollman,': [1190], 'C.': [1192, 1197, 1664, 1853, 1917, 2067, 2197, 2292, 2414], 'Buijsman,': [1194], 'Amelsvoort,': [1200, 2370], 'Katan,': [1204], 'Chlorogenic': [1207], 'quercetin-3-rutinoside': [1209], 'black': [1211, 1683, 2351, 2376], 'phenols': [1213], 'are': [1214, 2202], 'extensively': [1215], 'metabolized': [1216], '2003,': [1221, 1391, 1544, 1813, 2322, 2427, 2761], '133,': [1222, 1545, 2323], '1806–1814.': [1223], '10.1093/jn/133.6.1806': [1224], '19Manach,': [1229], 'Williamson,': [1231, 1266], 'Morand,': [1233], 'Scalbert,': [1235], 'Remesy,': [1237], 'Bioavailability': [1239, 1288], 'bioefficacy': [1241, 1290], 'Review': [1247, 1296], '97': [1249], 'bioavailability': [1250, 1271], 'studies.': [1251, 1300, 1949], '230S–242S.': [1258], '10.1093/ajcn/81.1.230S': [1259], '20Scalbert,': [1264], 'Dietary': [1268, 2645], '2000,': [1276, 1365, 2214, 2355], '130,': [1277, 2215], '2073S–2085S.': [1278], '10.1093/jn/130.8.2073S': [1279], '21Williamson,': [1284], 'Manach,': [1286, 2291], 'II.': [1295], '93': [1298], '243S–255S.': [1307], '10.1093/ajcn/81.1.243S': [1308], '22De': [1313], 'Vos,': [1314], 'R.': [1315, 1379, 1405, 1861, 2256], 'Moco,': [1317], 'Lommen,': [1319], 'Keurentjes,': [1321], 'Untargeted': [1326], 'large-scale': [1327, 1383], 'plant': [1328, 1360], 'liquid': [1331], 'chromatography': [1332], 'coupled': [1333], 'mass': [1335], 'spectrometry.': [1336], 'Nat.': [1337, 1363, 1513, 1906, 2757, 2785], 'Protoc.': [1338], '2,': [1340, 2762], '778–791.': [1341], '10.1038/nprot.2007.95': [1342], '23Fiehn,': [1347], 'O.,': [1348, 1590, 1826, 2412], 'Kopka,': [1349], 'Dormann,': [1351], 'Altmann,': [1353], 'Metabolite': [1357], 'functional': [1361, 1387, 1442], 'genomics.': [1362], 'Biotechnol.': [1364, 1424], '18,': [1366], '1157–1161.': [1367], '10.1038/81137': [1368], '24Sumner,': [1373], 'L.': [1374, 1632, 1707, 2340], 'W.,': [1375, 1438, 2038], 'Mendes,': [1376], 'Dixon,': [1378], 'Plant': [1381], 'metabolomics:': [1382, 1410], 'phytochemistry': [1384], 'genomics': [1388], 'era.': [1389], 'Phytochemistry': [1390], '62,': [1392], '817–836.': [1393], '10.1016/S0031-9422(02)00708-2': [1394], '25van': [1399], 'der': [1400, 2537, 2592], 'Werf,': [1401], 'Jellema,': [1404], 'Hankemeier,': [1407], 'Microbial': [1409, 2295], 'replacing': [1411], 'trial-and-error': [1412], 'unbiased': [1415], 'selection': [1416, 2017], 'ranking': [1418], 'targets.': [1420], 'Ind.': [1422], 'Microbiol.': [1423, 2787], '32,': [1426], '234–252.': [1427], '10.1007/s10295-005-0231-4': [1428], '26Griffin,': [1433], 'Nicholls,': [1436], 'Metabolomics': [1439, 1564, 2081], 'as': [1440, 1536, 2344, 2718], 'genomic': [1443], 'tool': [1444, 2720], 'understanding': [1446], 'lipid': [1447], 'diabetes,': [1450], 'obesity': [1451], 'related': [1453], 'disorders.': [1454], 'Pharmacogenomics': [1455], '7,': [1457, 1998], '1095–1107.': [1458], '10.2217/14622416.7.7.1095': [1459], '27Sabatine,': [1464], 'Liu,': [1467], 'Morrow,': [1469], 'Heller,': [1472], 'Metabolomic': [1476], 'novel': [1479], 'biomarkers': [1480], 'myocardial': [1482], 'ischemia.': [1483], '112,': [1486], '3868–3875.': [1487], '10.1161/CIRCULATIONAHA.105.569137': [1488], '28Nicholson,': [1493], 'Connelly,': [1496], 'Lindon,': [1498, 1894], 'Holmes,': [1501, 1827, 1892, 2772], 'Metabonomics:': [1503], 'platform': [1505], 'studying': [1507], 'drug': [1508], 'toxicity': [1509], 'gene': [1511], 'Rev.': [1514, 2758, 2786], 'Drug': [1515, 2759], 'Discov.': [1516, 2760], '2002,': [1517], '1,': [1518], '153–161.': [1519], '10.1038/nrd728': [1520], '29German,': [1525], 'Roberts,': [1528], 'Watkins,': [1531], 'Personal': [1534], 'next': [1538], 'generation': [1539], 'nutritional': [1540, 1991], 'assessment.': [1541], '4260–4266.': [1546], '10.1093/jn/133.12.4260': [1547], '30Gibney,': [1552], 'Walsh,': [1555], 'Brennan,': [1557, 1701], 'Roche,': [1559], 'human': [1566, 1716, 1808, 1833, 1944, 1990, 2205, 2729], 'nutrition:': [1567], 'opportunities': [1568], 'challenges.': [1570], '82,': [1576], '497–503.': [1577], '10.1093/ajcn/82.3.497': [1578], '31Bertram,': [1583], 'Hoppe,': [1586], 'Petersen,': [1588], 'B.': [1589, 1633, 1782, 1927, 1952, 2161], 'Duus,': [1591], 'An': [1596], 'NMR-based': [1597], 'metabonomic': [1598, 1747, 1795], 'investigation': [1599], 'milk': [1603], 'meat': [1605], 'protein': [1606], 'diets': [1607], 'given': [1608], '8-year-old': [1610], 'boys.': [1611], 'Br.': [1612], '97,': [1616], '758–763.': [1617], '10.1017/S0007114507450322': [1618], '32Rezzi,': [1623], 'Ramadan,': [1625], 'Z.,': [1626], 'Martin,': [1627], 'F.': [1628, 1661, 1921, 1979, 2708], 'Fay,': [1631], 'Human': [1636, 2671], 'phenotypes': [1638, 1835], 'directly': [1640], 'specific': [1642], 'preferences': [1644], 'individuals.': [1647], 'Proteome': [1649, 1840, 1995, 2182], '6,': [1652], '4469–4477.': [1653], '10.1021/pr070431h': [1654], '33van': [1659], 'Daykin,': [1663], 'Mulder,': [1666], 'Metabonomics': [1673], 'approach': [1674], 'determine': [1676], 'differences': [1678], 'between': [1679], 'green': [1680, 2379], 'J': [1686, 2181, 2467], 'Agric.': [1687, 1763, 2468], 'Chem.': [1689, 1765], '6929–6938.': [1692], '10.1021/jf061016x': [1693], '34Walsh,': [1698], 'Pujos-Guillot,': [1703], 'Sebedio,': [1705], 'Influence': [1710, 2264], 'phytochemical': [1713], 'metabolomic': [1718], 'profiles.': [1719], '86,': [1725], '1687–1693.': [1726], '10.1093/ajcn/86.5.1687': [1727], '35Wang,': [1732], 'Tang,': [1735], 'Nicholson,': [1738], 'Hylands,': [1741], 'strategy': [1748], 'detection': [1751], 'chamomile': [1757], '(Matricaria': [1758], 'recutita': [1759], 'L.)': [1760], 'ingestion.': [1761], '53,': [1767], '191–196.': [1768], '10.1021/jf0403282': [1769], '36Solanky,': [1774], 'Bailey,': [1777], 'Beckwith-Hall,': [1781, 1823], 'Davis,': [1784], 'Application': [1788], 'biofluid': [1790], 'H-1': [1791], 'nuclear': [1792], 'magnetic': [1793], 'resonance-based': [1794], 'techniques': [1796], 'biochemical': [1802], 'isoflavones': [1806], 'plasma': [1809], 'profile.': [1810], 'Anal.': [1811, 2147], 'Biochem.': [1812, 2523, 2632], '323,': [1814], '197–204.': [1815], '10.1016/j.ab.2003.08.028': [1816], '37Stella,': [1821], 'Cloarec,': [1825], 'Susceptibility': [1831], 'modulation.': [1838], '5,': [1843], '2780–2788.': [1844], '10.1021/pr060265y': [1845], '38Wopereis,': [1850], 'Rubingh,': [1852], 'Erk,': [1856], 'Verheij,': [1859], 'Metabolic': [1864], 'response': [1868], 'an': [1870, 2383, 2460], 'oral': [1871], 'glucose': [1872], 'tolerance': [1873], 'test': [1874], 'detects': [1875], 'subtle': [1876], 'changes.': [1878], 'PLoS': [1879], 'ONE': [1880], '2009,': [1881], '4,': [1882, 2083], 'e4525.': [1883], '10.1371/journal.pone.0004525': [1884], '39Nicholson,': [1889], 'Wilson,': [1897, 2744, 2774], 'challenges': [1901], 'modeling': [1903], 'mammalian': [1904, 2779], 'biocomplexity.': [1905], 'Biotech.': [1907], '1268–1274.': [1910], '10.1038/nbt1015': [1911], '40Grun,': [1916], 'Le,': [1926], 'methods': [1932], 'microbial': [1937, 2268], 'fermentation': [1938, 2269], 'products': [1939], 'vitro': [1947], 'Chromatogr.': [1951], 'Analyt.': [1953], 'Technol.': [1954], 'Biomed.': [1955, 2732], 'Life': [1956, 2609], '871,': [1959], '212–219.': [1960], '10.1016/j.jchromb.2008.04.039': [1961], '41van': [1966], 'Westerhuis,': [1970], 'Multilevel': [1983], 'data': [1984], 'crossover': [1988], 'designed': [1989], 'study.': [1993], '4483–4491.': [1999], '10.1021/pr800145j': [2000], '42Anderssen,': [2005], 'Dyrstad,': [2007], 'Westad,': [2009], 'F.,': [2010, 2034, 2164], 'Martens,': [2011], 'Reducing': [2013], 'over-optimism': [2014], 'variable': [2016, 2050], 'cross-model': [2019], 'validation.': [2020, 2080], 'Chemometr.': [2021, 2053], 'Intell.': [2022], 'Lab.': [2023], 'Syst.': [2024], '84,': [2026], '69–74.': [2027], '10.1016/j.chemolab.2006.04.021': [2028], 'CASWeb': [2029, 2058, 2086, 2737], '43Lindgren,': [2033], 'Hansen,': [2035], 'Karcher,': [2037], 'Sjostrom,': [2039], 'Eriksson,': [2041], 'Model': [2043], 'validation': [2044], 'permutation': [2046], 'tests:': [2047], 'applications': [2048], 'selection.': [2051], '1996,': [2054], '10,': [2055], '521–532.': [2056], '10.1002/(SICI)1099-128X(199609)10:5/6<521::AID-CEM448>3.0.CO;2-J': [2057], '44Westerhuis,': [2062], 'Hoefsloot,': [2065, 2131], 'Smit,': [2069], 'Vis,': [2071], 'Assessment': [2076], 'PLSDA': [2078], 'cross': [2079], '81–89.': [2084], '10.1007/s11306-007-0099-6': [2085], '45Breitling,': [2090], 'Armengaud,': [2092], 'Amtmann,': [2094], 'Herzyk,': [2096], 'Rank': [2098], 'products:': [2099], 'simple,': [2101], 'yet': [2102], 'powerful,': [2103], 'new': [2104], 'method': [2105], 'detect': [2107], 'differentially': [2108], 'regulated': [2109], 'genes': [2110], 'replicated': [2112], 'microarray': [2113], 'experiments.': [2114], 'FEBS': [2115], 'Lett.': [2116], '573,': [2118], '83–92.': [2119], '10.1016/j.febslet.2004.07.055': [2120], '46Smit,': [2125], 'Breemen,': [2128], 'Smilde,': [2134], 'Assessing': [2139], 'statistical': [2141], 'validity': [2142], 'proteomics': [2144], 'based': [2145], 'biomarkers.': [2146], 'Chim.': [2148], 'Acta': [2149], '592,': [2151], '210–217.': [2152], '10.1016/j.aca.2007.04.043': [2153], '47Grove,': [2158], 'Jorgensen,': [2160], 'Jessen,': [2163], 'Sondergaard,': [2165], 'Combination': [2169], 'Statistical': [2171], 'Approaches': [2172], 'Analysis': [2174], '2-DE': [2176], 'Data': [2177], 'Gives': [2178], 'Complementary': [2179], 'Results.': [2180], '2008.': [2184], '10.1021/pr800424c': [2185], '48Deprez,': [2190], 'Brezillon,': [2192], 'Rabot,': [2194], 'Philippe,': [2196], 'Polymeric': [2200], 'proanthocyanidins': [2201, 2464], 'catabolized': [2203], 'colonic': [2206, 2680], 'microflora': [2207], 'into': [2208, 2391], 'low-molecular-weight': [2209], '2733–2738.': [2216], '10.1093/jn/130.11.2733': [2217], '49Manach,': [2222], 'Donovan,': [2224, 2288, 2408], 'Pharmacokinetics': [2227], 'metabolism': [2229, 2260, 2629, 2780], 'flavonoids': [2232], 'Free': [2235, 2271, 2423, 2685], 'Radic.': [2236, 2272, 2424, 2686], '38,': [2239, 2690], '771–785.': [2240], '10.1080/10715760410001727858': [2241], '50Rechner,': [2246], 'Smith,': [2249], 'Kuhnle,': [2252], 'Gibson,': [2254], 'Colonic': [2259], 'polyphenols:': [2263, 2646], 'structure': [2266], 'products.': [2270], 'Biol.': [2273, 2425, 2687], '36,': [2276], '212–225.': [2277], '10.1016/j.freeradbiomed.2003.09.022': [2278], '51Gonthier,': [2283], 'Cheynier,': [2286], 'aromatic': [2296, 2683], 'metabolites': [2298], 'formed': [2299], 'gut': [2302], 'account': [2303], 'major': [2306, 2346], 'fraction': [2307], 'rats': [2315, 2558], 'fed': [2316, 2556], '461–467.': [2324], '10.1093/jn/133.2.461': [2325], '52Clifford,': [2330], 'Copeland,': [2333], 'Bloxsidge,': [2336], 'Mitchell,': [2339], 'Hippuric': [2342], 'product': [2348], 'associated': [2349], 'Xenobiotica': [2354], '30,': [2356], '317–326.': [2357], '10.1080/004982500237703': [2358], '53Mulder,': [2363], 'Rietveld,': [2366], 'Consumption': [2373], 'results': [2381, 2452], 'urine.': [2392], '256S–260S.': [2399], '10.1093/ajcn/81.1.256S': [2400], '54Gonthier,': [2405], 'Texier,': [2411], 'Felgines,': [2413], 'Metabolism': [2417], 'procyanidins': [2420], '35,': [2428, 2636], '837–844.': [2429], '10.1016/S0891-5849(03)00394-0': [2430], '55Ward,': [2435], 'Croft,': [2438], 'Hodgson,': [2444], 'Supplementation': [2447], 'seed': [2450], 'increased': [2454, 2564], '3-hydroxyphenylpropionic': [2458], 'Acid,': [2459], 'important': [2461], 'Chem': [2470], '52,': [2472], '5545–5549.': [2473], '10.1021/jf049404r': [2474], '56Stangl,': [2479], 'Dreger,': [2481], 'Stangl,': [2483], 'Lorenz,': [2485], 'targets': [2488], 'system.': [2495], '73,': [2499, 2657], '348–358.': [2500], '10.1016/j.cardiores.2006.08.022': [2501], '57Schewe,': [2506], 'Steffen,': [2508], 'Y.,': [2509], 'Sies,': [2510], 'do': [2513], 'flavanols': [2515], 'function?': [2518], 'position': [2520], 'paper.': [2521], 'Arch.': [2522], 'Biophys.': [2524], '476,': [2526], '102–106.': [2527], '10.1016/j.abb.2008.03.004': [2528], '58Dihal,': [2533], 'Woude,': [2538, 2593], 'Hendriksen,': [2540], 'Charif,': [2543], 'Transcriptome': [2547], 'proteome': [2549], 'colon': [2552], 'mucosa': [2553], 'quercetin': [2555, 2598], 'F344': [2557], 'point': [2559], 'tumor': [2561], 'preventive': [2562], 'mechanisms,': [2563], 'mitochondrial': [2565], 'fatty': [2566, 2601], 'degradation': [2568], 'decreased': [2570], 'glycolysis.': [2571], 'Proteomics': [2572], '8,': [2574], '45–61.': [2575], '10.1002/pmic.200700364': [2576], '59de': [2581], 'Boer,': [2582], 'Schothorst,': [2585], 'Dihal,': [2588], 'Chronic': [2597], 'affects': [2600], 'catabolism': [2603], 'rat': [2605], 'lung.': [2606], 'Cell': [2607], 'Mol.': [2608], '2847–2858.': [2613], '10.1007/s00018-006-6316-z': [2614], '60Wijekoon,': [2619], 'Brosnan,': [2622, 2625], 'Homocysteine': [2628], 'diabetes.': [2631], 'Soc.': [2633], 'Trans.': [2634], '1175–1179.': [2637], '10.1042/BST0351175': [2638], '61Halliwell,': [2643], 'good,': [2647], 'bad,': [2648], 'indifferent': [2650], 'health?': [2653], '341–347.': [2658], '10.1016/j.cardiores.2006.10.004': [2659], '62Jenner,': [2664], 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