Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1970127316', 'doi': 'https://doi.org/10.1093/qjmed/94.8.423', 'title': 'Haematopoietic growth factor in antithyroid-drug-induced agranulocytosis', 'display_name': 'Haematopoietic growth factor in antithyroid-drug-induced agranulocytosis', 'publication_year': 2001, 'publication_date': '2001-08-01', 'ids': {'openalex': 'https://openalex.org/W1970127316', 'doi': 'https://doi.org/10.1093/qjmed/94.8.423', 'mag': '1970127316', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11493719'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/qjmed/94.8.423', 'pdf_url': 'https://academic.oup.com/qjmed/article-pdf/94/8/423/4340878/940423.pdf', 'source': {'id': 'https://openalex.org/S139075330', 'display_name': 'QJM', 'issn_l': '1460-2393', 'issn': ['1460-2393', '1460-2725'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/qjmed/article-pdf/94/8/423/4340878/940423.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026993413', 'display_name': 'Emmanuel Andrès', 'orcid': 'https://orcid.org/0000-0002-7914-7616'}, 'institutions': [{'id': 'https://openalex.org/I68947357', 'display_name': 'Université de Strasbourg', 'ror': 'https://ror.org/00pg6eq24', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I68947357']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'E. Andres', 'raw_affiliation_strings': ['Department of Internal Medicine, University of Strasbourg, Strasbourg, France.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, University of Strasbourg, Strasbourg, France.', 'institution_ids': ['https://openalex.org/I68947357']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5026993413'], 'corresponding_institution_ids': ['https://openalex.org/I68947357'], 'apc_list': {'value': 3043, 'currency': 'GBP', 'value_usd': 3732, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.735, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 68, 'citation_normalized_percentile': {'value': 0.910437, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '94', 'issue': '8', 'first_page': '423', 'last_page': '428'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12919', 'display_name': 'Blood disorders and treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12919', 'display_name': 'Blood disorders and treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11725', 'display_name': 'Immunodeficiency and Autoimmune Disorders', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 0.9897, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/carbimazole', 'display_name': 'Carbimazole', 'score': 0.7931128}, {'id': 'https://openalex.org/keywords/absolute-neutrophil-count', 'display_name': 'Absolute neutrophil count', 'score': 0.4954344}, {'id': 'https://openalex.org/keywords/antithyroid-agent', 'display_name': 'Antithyroid agent', 'score': 0.4153578}, {'id': 'https://openalex.org/keywords/atypical-pneumonia', 'display_name': 'Atypical pneumonia', 'score': 0.41343924}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8919834}, {'id': 'https://openalex.org/C2779442721', 'wikidata': 'https://www.wikidata.org/wiki/Q414013', 'display_name': 'Carbimazole', 'level': 4, 'score': 0.7931128}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.66954356}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.6621806}, {'id': 'https://openalex.org/C2777914695', 'wikidata': 'https://www.wikidata.org/wiki/Q12192', 'display_name': 'Pneumonia', 'level': 2, 'score': 0.5068374}, {'id': 'https://openalex.org/C74133956', 'wikidata': 'https://www.wikidata.org/wiki/Q4669824', 'display_name': 'Absolute neutrophil count', 'level': 4, 'score': 0.4954344}, {'id': 'https://openalex.org/C2776652619', 'wikidata': 'https://www.wikidata.org/wiki/Q16483', 'display_name': "Graves' disease", 'level': 3, 'score': 0.47916213}, {'id': 'https://openalex.org/C2777767877', 'wikidata': 'https://www.wikidata.org/wiki/Q419327', 'display_name': 'Granulocyte colony-stimulating factor', 'level': 3, 'score': 0.46815422}, {'id': 'https://openalex.org/C2776606491', 'wikidata': 'https://www.wikidata.org/wiki/Q1365501', 'display_name': 'Antithyroid agent', 'level': 4, 'score': 0.4153578}, {'id': 'https://openalex.org/C2779673711', 'wikidata': 'https://www.wikidata.org/wiki/Q2633267', 'display_name': 'Atypical pneumonia', 'level': 3, 'score': 0.41343924}, {'id': 'https://openalex.org/C2777063308', 'wikidata': 'https://www.wikidata.org/wiki/Q1435822', 'display_name': 'Neutropenia', 'level': 3, 'score': 0.3641588}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.2236386}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.21293396}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.2110239}], 'mesh': [{'descriptor_ui': 'D000380', 'descriptor_name': 'Agranulocytosis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D013956', 'descriptor_name': 'Antithyroid Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D016179', 'descriptor_name': 'Granulocyte Colony-Stimulating Factor', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000380', 'descriptor_name': 'Agranulocytosis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D000380', 'descriptor_name': 'Agranulocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000380', 'descriptor_name': 'Agranulocytosis', 'qualifier_ui': 'Q000191', 'qualifier_name': 'economics', 'is_major_topic': False}, {'descriptor_ui': 'D013956', 'descriptor_name': 'Antithyroid Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003362', 'descriptor_name': 'Cost-Benefit Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016179', 'descriptor_name': 'Granulocyte Colony-Stimulating Factor', 'qualifier_ui': 'Q000191', 'qualifier_name': 'economics', 'is_major_topic': False}, {'descriptor_ui': 'D016179', 'descriptor_name': 'Granulocyte Colony-Stimulating Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017048', 'descriptor_name': 'Health Care Costs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007902', 'descriptor_name': 'Length of Stay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007958', 'descriptor_name': 'Leukocyte Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009504', 'descriptor_name': 'Neutrophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018709', 'descriptor_name': 'Statistics, Nonparametric', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/qjmed/94.8.423', 'pdf_url': 'https://academic.oup.com/qjmed/article-pdf/94/8/423/4340878/940423.pdf', 'source': {'id': 'https://openalex.org/S139075330', 'display_name': 'QJM', 'issn_l': '1460-2393', 'issn': ['1460-2393', '1460-2725'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11493719', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/qjmed/94.8.423', 'pdf_url': 'https://academic.oup.com/qjmed/article-pdf/94/8/423/4340878/940423.pdf', 'source': {'id': 'https://openalex.org/S139075330', 'display_name': 'QJM', 'issn_l': '1460-2393', 'issn': ['1460-2393', '1460-2725'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 16, 'referenced_works': ['https://openalex.org/W1965545144', 'https://openalex.org/W1990247331', 'https://openalex.org/W2008463095', 'https://openalex.org/W2011748225', 'https://openalex.org/W2028266864', 'https://openalex.org/W2038624525', 'https://openalex.org/W2044679783', 'https://openalex.org/W2108323889', 'https://openalex.org/W2110545352', 'https://openalex.org/W2122479998', 'https://openalex.org/W2162024756', 'https://openalex.org/W2166257823', 'https://openalex.org/W2169280430', 'https://openalex.org/W2238685482', 'https://openalex.org/W2290685943', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4246450242', 'https://openalex.org/W3141162703', 'https://openalex.org/W2413360557', 'https://openalex.org/W2397604647', 'https://openalex.org/W2114989931', 'https://openalex.org/W2061928026', 'https://openalex.org/W2037087317', 'https://openalex.org/W2008116099', 'https://openalex.org/W1978575167', 'https://openalex.org/W1970127316'], 'abstract_inverted_index': {'Drug-induced': [0], 'agranulocytosis': [1], '(DIA)': [2], 'is': [3], 'often': [4], 'caused': [5], 'by': [6], 'antithyroid': [7], 'drugs.': [8], 'We': [9], 'retrospectively': [10], 'studied': [11], 'the': [12, 52, 58, 93], 'use': [13], 'of': [14, 41, 69, 99, 113, 163, 197], 'granulocyte': [15], 'colony-stimulating': [16], 'factor': [17], '(G-CSF)': [18], 'therapy': [19, 167], 'in': [20, 195], 'antithyroid-DIA.': [21], 'Data': [22], 'for': [23, 110, 122], '20': [24], 'patients': [25, 43], '(10': [26], 'treated': [27], 'with': [28, 30, 173], 'G-CSF)': [29], 'antithyroid-DIA': [31], '(neutrophil': [32], 'count': [33, 54, 155], '<0.5x10(9)/l)': [34], 'were': [35, 66, 92, 120, 170], 'extracted': [36], 'from': [37], 'a': [38, 111], 'cohort': [39], 'study': [40], 'DIA': [42], '(n=110).': [44], 'G-CSF': [45, 191], '(300': [46], 'microg/day': [47], 'subcutaneously)': [48], 'was': [49, 55, 60, 77, 85, 156], 'used': [50], 'where': [51], 'neutrophil': [53, 154], '<0.1x10(9)/l,': [56], 'or': [57, 64, 71, 145], 'patient': [59, 75, 159], 'aged': [61], '>70': [62], 'years,': [63], 'there': [65], 'severe': [67], 'features': [68, 137], 'infection': [70], 'underlying': [72], 'disease.': [73], 'Mean': [74, 153, 161], 'age': [76], '62': [78], 'years': [79], '(range': [80, 102, 107, 116], '34-87);': [81], 'sex': [82], 'ratio': [83], '(M/F)': [84], '0.05.': [86], 'Carbimazole': [87], '(n=19)': [88], 'and': [89, 104, 132, 149, 168, 183], 'benzylthiouracile': [90], '(n=1)': [91], 'causative': [94], 'drugs,': [95], 'at': [96], 'mean': [97, 112], 'doses': [98], '30': [100], 'mg/day': [101, 106], '20-60)': [103], '100': [105], '50-150),': [108], 'respectively,': [109], '37': [114], 'days': [115, 176, 180, 185], '31-90).': [117], 'Antithyroid': [118], 'drugs': [119], 'prescribed': [121], "Graves'": [123], 'disease': [124], '(n=8),': [125], 'thyrotoxicosis': [126], 'related': [127], 'to': [128], 'amiodarone': [129], 'intake': [130], '(n=6)': [131], 'multinodular': [133], 'goitre': [134], '(n=6).': [135], 'Clinical': [136], 'included': [138], 'isolated': [139], 'fever': [140], '(n=7),': [141], 'pneumonia': [142], '(n=5),': [143], 'septicaemia': [144], 'septic': [146], 'shock': [147], '(n=5)': [148], 'acute': [150], 'tonsillitis': [151], '(n=3).': [152], '0.07+/-0.1x10(9)/l.': [157], 'No': [158], 'died.': [160], 'durations': [162], 'haematological': [164], 'recovery,': [165], 'antibiotic': [166], 'hospitalization': [169], 'significantly': [171], 'reduced': [172, 200], 'G-CSF:': [174], '6.8+/-4': [175], 'vs.': [177, 181, 186], '11.6+/-5;': [178], '7.5+/-3.8': [179], '12+/-4.5;': [182], '7.3+/-4.8': [184], '13+/-6.1,': [187], 'respectively': [188], '(all': [189], 'p<0.05).': [190], 'induced': [192], 'flu-like': [193], 'symptoms': [194], '30%': [196], 'patients,': [198], 'but': [199], 'overall': [201], 'costs.': [202]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1970127316', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-13T11:22:55.848127', 'created_date': '2016-06-24'}