Histone Acetylation and Methylation at Sites Initiating Divergent Polycistronic Transcription in Trypanosoma cruzi

Name: Work Video:
Duration: 3 min 30 s
Patricia Respuela; Marcela Ferella; Álvaro Rada-Iglesias; Lena Åslund
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3329, 3403, 3470, 3482, 3579, 3595, 3606, 3657, 3703, 3816, 3849, 3906, 4028, 4044, 4095, 4132, 4157, 4225, 4325, 4412, 4430], 'which': [6, 110, 202, 306, 1007, 1157, 1183, 1384, 2099, 2960, 3270, 3660, 4309], 'the': [7, 35, 97, 100, 104, 146, 166, 169, 203, 231, 293, 296, 300, 342, 362, 365, 669, 870, 943, 979, 1010, 1056, 1062, 1071, 1075, 1127, 1137, 1193, 1248, 1256, 1269, 1368, 1483, 1617, 1632, 1671, 1690, 1704, 1713, 1771, 1870, 1877, 1937, 1971, 2000, 2034, 2039, 2064, 2071, 2106, 2110, 2170, 2246, 2262, 2265, 2273, 2284, 2332, 2342, 2348, 2353, 2378, 2387, 2390, 2397, 2433, 2450, 2564, 2611, 2657, 2751, 2839, 2858, 2865, 2902, 2905, 2915, 2924, 2951, 2976, 2985, 2995, 3093, 3100, 3113, 3142, 3146, 3157, 3169, 3209, 3247, 3275, 3311, 3339, 3368, 3384, 3390, 3395, 3428, 3440, 3451, 3462, 3468, 3483, 3487, 3502, 3514, 3521, 3540, 3546, 3556, 3585, 3638, 3651, 3662, 3744, 3755, 3774, 3780, 3789, 3801, 3817, 3833, 3866, 3869, 3881, 3913, 3968, 3984, 4017, 4038, 4057, 4065, 4073, 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1999, 2197, 2855, 3136, 3897], 'an': [26, 222, 974, 1094, 2209, 2544, 2571, 3046, 3222, 3406, 3805, 4214], 'effort': [27, 223], 'to': [28, 44, 47, 63, 122, 224, 240, 243, 259, 318, 660, 665, 919, 936, 1009, 1123, 1136, 1149, 1187, 1200, 1214, 1247, 1254, 1268, 1329, 1391, 1494, 1512, 1664, 1688, 1854, 2051, 2058, 2069, 2103, 2213, 2272, 2385, 2404, 2416, 2442, 2524, 3274, 3419, 3458, 3480, 3608, 3614, 3912, 4067, 4110, 4118, 4173, 4312, 4368], 'reveal': [29, 225], 'transcriptional': [30, 182, 226, 378, 648, 874, 928, 1315, 1677, 3887], 'initiation': [31, 118, 227, 314, 1612, 1678, 3888, 4085], 'sites,': [32, 119, 228, 315], 'we': [33, 54, 229, 250, 1627, 1655, 2913, 3787, 3878, 3988], 'examined': [34, 230], 'Trypanosoma': [36, 232, 394, 396], 'cruzi': [37, 177, 233, 373, 1647, 1673, 1736, 2172, 2192, 2280, 2489, 2621, 3095, 3332, 3819, 3851, 3986, 4320], 'genome': [38, 234, 1369], 'for': [39, 165, 181, 235, 361, 377, 1332, 1394, 1697, 1869, 1876, 1959, 1967, 2028, 2321, 2436, 2457, 2470, 2502, 2534, 2570, 2636, 2653, 2677, 2720, 2747, 2894, 2927, 3181, 3213, 3435, 3490, 3495, 3873, 4087, 4239, 4330, 4388, 4423], 'histone': [40, 188, 236, 384, 685, 704, 742, 761, 961, 976, 1138, 1373, 1468, 1530, 1534, 1620, 1642, 1681, 1895, 1902, 2095, 2214, 2222, 2227, 2241, 2281, 2411, 2444, 3134, 3343, 3415, 3437, 3455, 3507, 4126], 'modification': [41, 237, 952, 1312, 3870], 'patterns': [42, 238], 'shown': [43, 239, 798, 1390, 1684, 3187, 3567], 'be': [45, 64, 123, 241, 260, 319, 661, 666, 1330, 1392, 1495, 1689, 3272, 3459], 'linked': [46, 242, 1186, 1511], 'active': [48, 244, 1144, 1188, 1476], 'genes': [49, 153, 245, 349, 434, 1364, 1477, 3280, 3758, 3918, 4463], 'various': [51, 247], 'organisms.': [52, 248, 1702], 'Here,': [53, 249, 1654], 'show': [55, 251, 1656], 'that': [56, 186, 252, 382, 410, 620, 3389, 3513, 3539, 3773, 3841, 3853, 3883, 4112, 4335], 'acetylated': [57, 253, 703, 760, 1637, 2084, 2089, 2286, 3076, 3217, 3263, 3551, 3580, 3747, 3824, 3854, 4045], 'and': [58, 80, 150, 190, 254, 276, 346, 386, 398, 416, 421, 854, 892, 896, 933, 950, 956, 963, 1146, 1317, 1362, 1387, 1397, 1426, 1462, 1478, 1503, 1505, 1533, 1640, 1696, 1707, 1717, 1728, 1840, 1873, 1900, 1909, 1915, 1940, 1965, 1989, 2038, 2061, 2093, 2175, 2254, 2319, 2345, 2460, 2463, 2467, 2473, 2568, 2588, 2592, 2610, 2629, 2656, 2699, 2733, 2758, 2813, 2832, 2890, 2934, 2968, 3007, 3019, 3043, 3062, 3079, 3085, 3118, 3163, 3192, 3195, 3219, 3225, 3264, 3288, 3293, 3303, 3352, 3430, 3446, 3475, 3532, 3542, 3566, 3572, 3592, 3602, 3759, 3776, 3782, 3797, 3827, 3852, 3955, 3972, 3978, 4005, 4022, 4031, 4048, 4104, 4116, 4136, 4191, 4364], 'methylated': [59, 255, 3265], 'histones': [60, 256, 967, 1638, 2085, 2108, 2173, 2252, 3077, 3115, 3174, 3266, 3472, 3492, 3516, 3581, 3748, 3825, 3855, 4047], 'were': [61, 257, 1327, 1389, 1628, 1731, 1738, 1765, 1834, 1883, 1891, 1926, 1931, 1957, 2005, 2026, 2077, 2100, 2233, 2329, 2439, 2491, 2584, 2623, 2659, 2668, 2710, 2728, 2753, 2769, 2782, 2805, 2815, 2825, 2885, 2946, 3034, 3110, 3232, 3323, 3393, 3433, 3493, 3518, 3600, 3641, 3856, 4165], 'found': [62, 142, 258, 338, 1154, 1163, 1253, 1328, 1481, 1541], 'enriched': [65, 261, 3111, 3434, 3578, 3601, 4043, 4156], 'at': [66, 75, 143, 158, 262, 271, 339, 354, 1044, 1501, 1507, 1537, 1710, 1962, 1976, 1981, 1986, 1996, 2087, 2091, 2097, 2499, 2531, 2608, 2712, 2723, 2776, 3099, 3370, 3383, 3461, 3520, 3619, 3754, 3804, 3813, 3831, 3859, 3891, 3959, 4100, 4168, 4218], 'strand': [67, 105, 263, 301, 672, 681, 738, 4390], 'switch': [68, 106, 264, 302, 673, 682, 739], 'regions': [69, 82, 265, 278, 1665, 2933, 3313, 3432, 3577, 3604, 4030, 4111, 4188], 'of': [70, 99, 145, 171, 266, 295, 341, 367, 424, 432, 656, 699, 756, 850, 865, 869, 873, 948, 958, 1013, 1048, 1097, 1192, 1195, 1216, 1258, 1272, 1370, 1383, 1485, 1619, 1636, 1660, 1712, 1773, 1845, 1858, 1867, 1936, 1952, 1993, 2011, 2033, 2042, 2049, 2063, 2190, 2231, 2264, 2278, 2356, 2377, 2389, 2396, 2402, 2421, 2427, 2432, 2559, 2641, 2715, 2745, 2779, 2852, 2864, 2904, 2917, 2970, 2975, 3075, 3133, 3168, 3172, 3238, 3246, 3250, 3277, 3310, 3342, 3350, 3378, 3397, 3401, 3423, 3442, 3453, 3485, 3505, 3548, 3555, 3627, 3637, 3650, 3654, 3665, 3746, 3757, 3784, 3792, 3795, 3823, 3843, 3868, 3886, 3915, 3964, 3970, 3983, 3999, 4020, 4052, 4122, 4147, 4185, 4199, 4206, 4208, 4234, 4342, 4360, 4374, 4405, 4414, 4461], 'divergent': [71, 267, 792, 970, 1667, 3524, 4425], 'gene': [72, 101, 268, 297, 793, 860, 1668, 3802], 'arrays,': [73, 269], 'not': [74, 270, 1152, 1212, 2257, 2340, 2351, 2373, 2381, 2480, 3315, 3335, 3394, 3846, 3950, 4117], 'convergent': [76, 272], 'or': [78, 154, 157, 274, 350, 353, 671, 1023, 1069, 1190, 3028, 3399, 3523, 3835, 4083], 'intra-': [79, 275], 'intergenic': [81, 277, 670, 4029], 'within': [83, 279, 3800, 4032, 4338, 4370], 'clusters.': [84, 280], 'The': [85, 281, 392, 647, 848, 1489, 2031, 2047, 2180, 2365, 2520, 2539, 2666, 2726, 2998, 3073, 3165, 3204, 3307, 3359, 3509, 3553, 4011, 4124], 'modified': [86, 282, 1259, 2107, 3114, 3173, 3410, 3471, 3491, 3515], 'region': [87, 283, 674, 3982, 4013, 4059, 4134, 4140, 4180, 4216, 4232, 4355], 'showed': [88, 284, 3130, 3149, 3208, 3259, 3295, 3512, 4064, 4129], 'a': [89, 285, 406, 1051, 1088, 1119, 1160, 1202, 1221, 1311, 1420, 1657, 1855, 1949, 1990, 2009, 2206, 2267, 2516, 2525, 2690, 2713, 2742, 2777, 2785, 2793, 2861, 2891, 2962, 3150, 3197, 3236, 3348, 3376, 3421, 3609, 3648, 3793, 3810, 3916, 3975, 3980, 3990, 3996, 4119, 4231, 4339], 'bimodular': [90, 286], 'profile': [91, 287, 1683, 3979, 4098, 4128], 'with': [92, 134, 178, 288, 330, 374, 405, 1016, 1061, 1070, 1087, 1093, 1143, 1165, 1220, 1314, 1474, 1676, 1830, 1837, 1923, 2056, 2208, 2331, 2347, 2449, 2476, 2574, 2650, 2662, 2670, 2735, 2741, 2755, 2772, 2792, 2857, 2979, 3065, 3112, 3156, 3381, 3501, 3550, 3751, 3865, 3908, 3920], 'two': [93, 289, 791, 1324, 1385, 2043, 3278, 4197, 4210], 'peaks': [94, 290, 4198], 'centered': [95, 291], 'over': [96, 292], '5′-regions': [98, 294], 'pair': [102, 298, 2897], 'flanking': [103, 299, 4187, 4465], 'region.': [107, 303, 2930], 'This': [108, 304, 1680, 2312], 'pattern,': [109, 305], 'demarcates': [111, 307], 'transcription': [113, 192, 309, 388, 852, 1189, 1217, 1486, 1513, 1611, 1652, 1699, 3875, 3909, 3923, 4089, 4314, 4336, 4416], 'units': [114, 310], 'originating': [115, 311], 'bidirectional': [117, 191, 313, 387, 4088], 'is': [120, 316, 938, 1042, 1083, 1310, 1686, 2882, 3949, 4150], 'likely': [121, 317, 1687], 'common': [124, 320], 'kinetoplastid': [126, 322, 1694], 'well': [129, 325, 1466, 1615, 1724, 2225, 3412, 3701, 4182, 4202], 'other': [132, 328, 897, 1701, 2247, 3330, 3893], 'organisms': [133, 329], 'transcription.': [136, 332, 1124], 'contrast,': [138, 334], 'no': [139, 335, 1017, 2370, 2477], 'acetylation': [140, 336, 955, 1464, 1500, 1532, 1705, 2445, 3297, 3308, 3345, 3618, 3767, 3790, 3844, 3971, 4066, 4097], 'was': [141, 337, 1849, 1862, 2036, 2045, 2054, 2067, 2269, 2314, 2372, 2414, 2424, 2513, 2522, 2541, 2566, 2598, 2613, 2644, 2686, 2802, 2836, 2873, 2898, 2955, 2965, 2982, 3001, 3054, 3090, 3417, 3477, 3559, 3589, 3622, 3829, 4014, 4041, 4054, 4348, 4382, 4392, 4420], 'promoters': [144, 340, 1711, 3948, 4243], 'highly': [147, 343, 1714, 4042], 'expressed': [148, 344, 616, 1715], 'rRNA': [149, 345, 1716], 'spliced': [151, 347, 712, 769, 1718], 'leader': [152, 348, 1719], 'satellite': [155, 351, 1726], 'DNA': [156, 352, 856, 930, 937, 949, 1263, 1432, 1727, 1861, 1939, 2868, 2918, 2926, 2977, 3000, 3006, 3030, 3050, 3588], 'tested': [159, 355, 3560], 'retrotransposonal': [160, 356], 'elements.': [161, 357], 'These': [162, 358, 3535, 3862], 'results': [163, 359, 3322, 3392, 3863], 'reveal,': [164, 360], 'first': [167, 363], 'time,': [168, 364], 'presence': [170, 366, 3276, 3441], 'specific': [172, 368, 960, 3631], 'epigenetic': [173, 369, 877, 1121, 1270], 'marks': [174, 370], 'T.': [176, 372, 506, 534, 1049, 1206, 1265, 1322, 1380, 1438, 1646, 1672, 2171, 2191, 2279, 2488, 3094, 3331, 3679, 3818, 3850, 3898, 3985, 4319, 4343], 'potential': [179, 375], 'implications': [180, 376], 'regulation;': [183, 379], 'they': [184, 380], 'indicate': [185, 381], 'modifications': [189, 385, 882, 1472, 1663, 2423], 'evolutionarily': [194, 390, 1496], 'conserved.': [195, 391], 'trypanosomatids,': [393], 'cruzi,': [395, 4344], 'brucei,': [397, 1207, 1266, 1323, 1381, 3899], 'Leishmania': [399], 'major': [400, 802, 4432], 'human': [402], 'parasitic': [403], 'pathogens': [404], 'complex': [407], 'life': [408], 'cycle': [409, 1319, 1335, 1402, 2883], 'comprises': [411], 'passage': [412], 'through': [413, 863, 880, 946], 'different': [414, 1045, 1203, 1645, 2013, 3170, 3814], 'hosts': [415, 1068], 'morphological': [417], 'states,': [418], 'requiring': [419], 'rapid': [420], 'selective': [422], 'modulation': [423], 'transcriptomes.': [425], 'Recent': [426], 'genomic': [427, 1648, 2932, 3576, 3997, 4012], 'sequences': [428, 857, 3621, 3640], 'have': [429, 1151, 1184, 1201, 1251, 1376, 1539], 'confirmed': [430, 3623], 'arrangement': [431], 'trypanosome': [433, 1014], 'co-directional': [437], '(1El-Sayed': [439], 'N.M.': [440, 4276], 'Myler': [441, 813, 836, 4443], 'P.J.': [442, 814, 837, 4444], 'Bartholomeu': [443], 'D.C.': [444], 'Nilsson': [445], 'D.': [446, 514, 528, 808, 833, 1408, 1810, 4438], 'Aggarwal': [447], 'G.': [448, 458, 504, 552, 1743, 1788], 'Tran': [449], 'A.N.': [450], 'Ghedin': [451], 'E.': [452, 462, 472, 478, 484, 520, 580, 1104, 1449, 3929, 4286], 'Worthey': [453], 'E.A.': [454], 'Delcher': [455], 'A.L.': [456], 'Blandin': [457], 'Westenberger': [459], 'S.J.': [460, 4255], 'Caler': [461], 'Cerqueira': [463], 'G.C.': [464, 991, 4245], 'Branche': [465], 'C.': [466, 591, 1281, 1782, 1804, 1818, 3931], 'Haas': [467], 'B.': [468, 595, 605], 'Anupama': [469], 'A.': [470, 540, 572, 904, 1778, 1784], 'Arner': [471], 'Åslund': [473], 'L.': [474, 516, 566, 801, 983, 985, 4431], 'Attipoe': [475], 'P.': [476, 482, 498, 1443, 1447, 1806], 'Bontempi': [477], 'Bringaud': [479], 'F.': [480, 1228, 1747, 1812, 4290], 'Burton': [481], 'Cadag': [483], 'Campbell': [485], 'D.A.': [486], 'Carrington': [487], 'M.': [488, 508, 522, 554, 556, 560, 810, 989, 1285, 2146, 3681, 3708, 4274, 4440], 'Crabtree': [489], 'J.': [490, 564, 576, 597, 987, 1171, 1233, 1451, 1753, 1814, 2126, 4288], 'Darban': [491], 'H.': [492, 526, 532, 1549, 1592], 'da': [493], 'Silveira': [494], 'J.F.': [495], 'de': [496, 1571, 2296], 'Jong': [497], 'Edwards': [499], 'K.': [500, 512, 550, 812, 835, 1790, 1800, 2124, 2154, 3710, 4282, 4442], 'Englund': [501], 'P.T.': [502], 'Fazelina': [503], 'Feldblyum': [505], 'Ferella': [507], 'Frasch': [509], 'A.C.': [510], 'Gull': [511], 'Horn': [513, 1407], 'Hou': [515], 'Huang': [517], 'Y.': [518, 542], 'Kindlund': [519], 'Klingbeil': [521], 'Kluge': [523], 'S.': [524, 546, 548, 586, 589, 804, 806, 831, 1106, 1575, 1786, 1792, 2120, 2300, 3683, 3712, 3718, 4272, 4434, 4436], 'Koo': [525], 'Lacerda': [527], 'Levin': [529], 'M.J.': [530], 'Lorenzi': [531], 'Louie': [533], 'Machado': [535], 'C.R.': [536], 'McCulloch': [537], 'R.': [538, 574, 584, 1102, 1283, 1287, 1551, 1802], 'McKenna': [539], 'Mizuno': [541], 'Mottram': [543], 'J.C.': [544], 'Nelson': [545], 'Ochaya': [547], 'Osoegawa': [549], 'Pai': [551], 'Parsons': [553], 'Pentony': [555], 'Pettersson': [557, 994], 'U.': [558, 995], 'Pop': [559], 'Ramirez': [561], 'J.L.': [562], 'Rinta': [563], 'Robertson': [565], 'Salzberg': [567], 'S.L.': [568, 3685, 3727], 'Sanchez': [569], 'D.O.': [570], 'Seyler': [571], 'Sharma': [573], 'Shetty': [575], 'Simpson': [577], 'A.J.': [578, 1027], 'Sisk': [579], 'Tammi': [581], 'M.T.': [582], 'Tarleton': [583], 'Teixeira': [585], 'Van': [587], 'Aken': [588], 'Vogt': [590], 'Ward': [592], 'P.N.': [593], 'Wickstead': [594], 'Wortman': [596], 'White': [598], 'O.': [599, 1780], 'Fraser': [600], 'C.M.': [601], 'Stuart': [602, 811, 834, 4441], 'K.D.': [603], 'Andersson': [604], 'Science.': [606, 4258], '2005;': [607, 1236, 1290, 1822, 2137, 3692, 3731, 4259, 4296], '309:': [608, 4260], '409-415Crossref': [609], 'PubMed': [610, 642, 825, 843, 912, 1002, 1033, 1113, 1177, 1239, 1298, 1355, 1414, 1455, 1561, 1582, 1605, 1757, 1825, 2140, 2160, 2307, 3695, 3739, 3938, 4262, 4304, 4455], 'Scopus': [611, 643, 826, 844, 913, 1003, 1034, 1114, 1178, 1240, 1299, 1356, 1415, 1456, 1524, 1562, 1583, 1606, 1758, 1826, 2141, 2161, 2308, 3696, 3740, 3939, 4263, 4305, 4456], '(1117)': [612], 'Google': [613, 645, 828, 846, 915, 1005, 1036, 1116, 1180, 1242, 1301, 1358, 1417, 1458, 1526, 1564, 1585, 1608, 1760, 1828, 2143, 2163, 2310, 3698, 3742, 3941, 4265, 4307, 4458], 'Scholar),': [614, 1006, 1117, 4308], 'presumably': [615], 'transcripts': [619, 4391], 'processed': [622], 'rapidly': [623], 'into': [624, 1020, 3015, 3021], 'individual': [625], 'mRNAs': [626], 'regulated': [627], 'mainly': [628], 'by': [629, 940, 1307, 1851, 2218, 2316, 2375, 2407, 2446, 2876, 3036, 3346, 3375, 3498, 3624, 4213], 'post-transcriptional': [630], 'events': [631], '(2Palenchar': [632], 'J.B.': [633], 'Bellofatto': [634], 'V.': [635, 1588], 'Mol.': [636, 815, 996, 1107, 1288, 1345, 1409, 1576, 1599, 1820, 2134, 2301, 3932, 4445], 'Biochem.': [637, 997, 1108, 1577, 1600, 2302], 'Parasitol.': [638, 998, 1109, 1578, 1601, 2303], '2006;': [639, 909, 1347, 1558, 1579, 2304], '146:': [640], '135-141Crossref': [641], '(103)': [644], 'Scholar).': [646, 847, 916, 1037, 1181, 1243, 1302, 1359, 1418, 1459, 1527, 1609, 1761, 2164, 2311, 3942, 4459], 'mechanisms': [649], 'trypanosomes': [651, 895, 1131, 1543], 'poorly': [653, 4114], 'understood.': [654], 'Promoters': [655], 'defined,': [662], 'proposed': [664], 'located': [667, 3605, 3656, 4026], '(SSR)': [675], '4The': [676, 733], 'abbreviations': [677, 734], 'used': [678, 735, 1766, 1927, 2068, 2514, 2580, 2711, 3418, 3558], 'are:': [679, 736], 'SSR,': [680, 737], 'region;': [683, 722, 740, 779], 'HDAC,': [684, 741], 'deacetylase;': [686, 743], 'ChIP,': [687, 744], 'chromatin': [688, 745, 866, 881, 921, 944, 1015, 1040], 'immunoprecipitation;': [689, 746], 'HH,': [690, 747], 'head-to-head;': [691, 748], 'TT,': [692, 749], 'tail-to-tail;': [693, 750], 'H3K4me3,': [694, 751, 4049], 'trimethylated': [695, 752, 1641, 1912, 2094, 4125], 'H3K4;': [696, 753], 'contig,': [697, 754], 'group': [698, 755], 'overlapping': [700, 757], 'clones;': [701, 758], 'acH3,': [702, 759], 'H3;': [705, 762], 'bis-Tris,': [706, 763], '2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol;': [707, 764], 'MES,': [708, 765], '4-morpholineethanesulfonic': [709, 766], 'acid;': [710, 767], 'SL,': [711, 768], 'leader;': [713, 770], 'Q-PCR,': [714, 771], 'quantitative': [715, 772], 'PCR;': [716, 773], 'PBS,': [717, 774], 'phosphate-buffered': [718, 775], 'saline;': [719, 776], 'UTR,': [720, 777], 'untranslated': [721, 778], 'pol,': [723, 780], 'polymerase;': [724, 781], 'SIRE,': [725, 782], 'short': [726, 783], 'interspersed': [727, 784], 'repetitive': [728, 785], 'element;': [729, 786], 'CZAR,': [730, 787], 'cruzi-associated': [731, 788], 'retrotransposon.': [732, 789], 'between': [790, 2953, 3473, 4418], 'arranged': [795], 'head-to-head,': [796], 'previously': [799, 2102, 4238], '(3Martinez-Calvillo': [803, 4433], 'Yan': [805, 4435], 'Nguyen': [807, 832, 4437], 'Fox': [809, 4439], 'Cell.': [816, 839, 907, 1289, 1346, 2135, 3730, 3933, 4295, 4446], '2003;': [817, 1452, 4447], '11:': [818, 4448], '1291-1299Abstract': [819, 4449], 'Full': [820, 822, 1293, 1295, 1350, 1352, 3734, 3736, 4299, 4301, 4450, 4452], 'Text': [821, 823, 1294, 1296, 1351, 1353, 3735, 3737, 4300, 4302, 4451, 4453], 'PDF': [824, 1297, 1354, 3738, 4303, 4454], '(212)': [827, 4457], 'Scholar,': [829, 1565, 1586, 2144, 4266], '4Martinez-Calvillo': [830], 'Eukaryot.': [838], '2004;': [840, 1174, 3935], '3:': [841, 2158, 3693], '506-517Crossref': [842], '(123)': [845], 'rarity': [849], 'canonical': [851, 1128], 'factors': [853], 'regulatory': [855], 'points': [858], 'toward': [859], 'expression': [861], 'control': [862, 1336], 'modulations': [864], 'structures': [867], 'instead': [868, 1158], 'traditional': [871], 'modes': [872], 'control.': [875, 1320], 'Evidently,': [876], 'regulation': [878, 1403], 'mediated': [879, 1306], 'would': [883], 'influence': [884], 'important': [885, 925, 1331], 'processes': [886], 'such': [887, 3666], 'antigen': [889, 1278, 3646], 'variation,': [890], 'virulence,': [891], 'differentiation': [893], 'protozoan': [898, 2111], '(5Sullivan': [900], 'Jr.,': [901, 2128], 'W.J.': [902, 2129], 'Naguleswaran': [903], 'Angel': [905], 'S.O.': [906], 'Microbiol.': [908, 1410], '8:': [910], '1850-1861Crossref': [911], '(69)': [914], 'From': [917], 'bacteria': [918], 'man,': [920], 'conformation': [922], 'often': [923], 'plays': [924], 'roles': [926], 'control,': [929], 'replication,': [931], 'repair,': [932, 1433], 'recombination.': [934], 'Access': [935], 'modulated': [939], 'changes': [941], 'structure': [945], 'methylation': [947, 3299], 'post-translational': [951], '(such': [953], 'methylation)': [957], 'histones,': [959, 1130], 'variants,': [962], 'chromatin-remodeling': [964], 'proteins.': [965], 'Trypanosome': [966], 'unusually': [969], 'sequence,': [972], 'e.g.': [973], 'atypical': [975], 'H1': [977], 'lacking': [978], 'globular': [980], 'domain': [981], '(6Åslund': [982], 'Carlsson': [984], 'Henriksson': [986], 'Rydåker': [988], 'Toro': [990], 'Galanti': [992], 'N.': [993, 1808, 2116, 3687], '1994;': [999], '65:': [1000], '317-330Crossref': [1001], '(50)': [1004, 3940], 'contributes': [1008], 'limited': [1011], 'compaction': [1012, 1053], 'further': [1018, 2260, 4166], 'packaging': [1019], '30-nm': [1021], 'fibers': [1022], 'metaphase': [1024], 'chromosomes': [1025, 3244], '(7Solari': [1026], 'Chromosoma': [1028], '(Berl.).': [1029], '1980;': [1030], '78:': [1031], '239-255Crossref': [1032], '(73)': [1035], 'However,': [1038, 3285, 3877], 'altered': [1039], 'condensation': [1041], 'observed': [1043, 1084, 3830, 4196], 'developmental': [1046], 'stages': [1047], 'cruzi;': [1050], 'higher': [1052, 2956, 3460, 4169], 'occurs': [1054], 'non-replicative': [1057], 'trypomastigote': [1058], 'stage': [1059, 1065, 1073, 3102], 'compared': [1060, 3155, 3380], 'intracellular': [1063], 'amastigote': [1064], 'mammalian': [1067], 'epimastigotes': [1072, 1737, 2490, 2622], 'insect': [1076], 'vector.': [1077], 'Variation': [1078], 'total': [1080, 1878, 1950, 2010, 2221, 3424, 3436, 3454, 3506, 3596], 'mRNA': [1081], 'levels': [1082, 3132, 3504], 'during': [1085], 'development,': [1086], 'reduction': [1089], 'trypomastigotes': [1091], 'correlating': [1092, 1675], 'increased': [1095, 3374, 3921], 'amount': [1096, 2916, 3484], 'heterochromatin': [1098, 1196], '(8Elias': [1099], 'M.C.': [1100], 'Marques-Porto': [1101], 'Freymuller': [1103], 'Schenkman': [1105, 1574, 2299], '2001;': [1110], '112:': [1111], '79-90Crossref': [1112], '(99)': [1115], 'suggesting': [1118], 'possible': [1120], 'contribution': [1122], 'Apart': [1125], 'core': [1129], 'also': [1132, 2234, 2244, 2440, 2770, 2874, 3290, 3537, 4229, 4421], 'harbor': [1133, 1159, 3661], 'variants.': [1134], 'Homologs': [1135], 'H3': [1139, 1161, 1461, 1535, 1911, 1917, 2086, 2096, 2174, 2215, 2253, 2412, 3218, 3344, 3416, 3456, 3617, 3826, 4127], 'variants': [1140], '(H3.3,': [1141], 'associated': [1142, 1164, 1313, 1473, 3919], 'transcription,': [1145], 'CenH3,': [1147], 'binding': [1148, 2323, 4316], 'centromeres)': [1150], 'been': [1153, 1185, 1252, 1377, 1435, 1540, 3904], 'trypanosomes,': [1156, 1626], 'variant': [1162, 1224, 1273], 'telomeres': [1166], '(9Lowell': [1167], 'J.E.': [1168, 1226, 1342], 'Cross': [1169, 1231, 1284, 1343, 1554, 1597], 'G.A.': [1170, 1232, 1344, 1555, 1598], 'Cell': [1172, 1234], 'Sci.': [1173, 1235], '117:': [1175], '5937-5947Crossref': [1176], '(84)': [1179], 'H2AZ,': [1182], 'prevention': [1191], 'spread': [1194], 'yeast,': [1198], 'appears': [1199], 'function': [1204], 'where': [1208], 'its': [1209], 'homolog': [1210], 'does': [1211, 3845], 'co-localize': [1213], 'sites': [1215, 3885, 3945, 4086], 'but': [1218, 2243, 2419, 3145, 3365], 'dimerizes': [1219], 'novel': [1222], 'H2B': [1223], '(10Lowell': [1225], 'Kaiser': [1227], 'Janzen': [1229, 1593], 'C.J.': [1230, 1338, 1545, 1594], '118:': [1237], '5721-5730Crossref': [1238], '(60)': [1241, 1416], 'Chromatin-remodeling': [1244], 'proteins': [1245, 2186], 'relating': [1246], 'SWI/SNF2': [1249], 'family': [1250], 'regulate': [1255], 'synthesis': [1257], 'thymines': [1260], 'telomeric': [1262], 'contributing': [1267], 'silencing': [1271], 'surface': [1274, 3645], 'glycoproteins': [1275], 'involved': [1276, 1430], 'variation': [1279, 3481], '(11DiPaolo': [1280], 'Kieft': [1282], 'Sabatini': [1286], '17:': [1291, 1522], '441-451Abstract': [1292], '(54)': [1300], 'Histone': [1303, 1360, 1460, 3668], 'H3K79': [1304], 'methylation,': [1305], 'DOT1': [1308, 1325], 'methyltransferase,': [1309], 'activation': [1316], 'cell': [1318, 1334, 1401], 'homologs': [1326], 'mitotic': [1333], '(12Janzen': [1337], 'Hake': [1339, 1552, 1595], 'S.B.': [1340, 1553, 1596], 'Lowell': [1341], '23:': [1348], '497-507Abstract': [1349], '(104)': [1357], 'acetyl-transferase': [1361], 'deacetylases': [1363, 1374], 'present': [1366], 'trypanosomes.': [1371], 'Four': [1372], '(HDACs)': [1375], 'studied': [1378], 'out': [1382, 2007, 2688], '(DAC1': [1386], 'DAC3)': [1388], 'essential': [1393], 'parasite': [1395, 2112, 2398, 3318, 3644], 'survival': [1396], 'one': [1398, 3127, 3255, 4003, 4006], 'crucial': [1399], '(DAC4)': [1404], '(13Ingram': [1405], 'A.K.': [1406], '2002;': [1411], '45:': [1412], '89-97Crossref': [1413], 'Also': [1419], 'SIR2-related': [1421], 'protein': [1422, 2394, 2403, 2413, 2485, 2517], 'showing': [1423], 'ADP-ribosylation': [1425], '-deacetylation': [1427], 'activity,': [1428], 'possibly': [1429], 'has': [1434, 3903], 'identified': [1436, 2285], 'brucei': [1439], '(14Garcia-Salcedo': [1440], 'J.A.': [1441], 'Gijon': [1442], 'Nolan': [1444], 'D.P.': [1445], 'Tebabi': [1446], 'Pays': [1448], 'EMBO': [1450, 1752], '22:': [1453], '5851-5862Crossref': [1454], '(108)': [1457], 'H4': [1463, 1531, 2090, 2176, 2237, 2242, 2282, 2322, 2367, 3220, 3828], 'H3K4': [1469, 1508, 1643], 'trimethylation': [1470, 1506, 1536, 3973, 4204], 'transcriptionally': [1475], 'typically': [1480, 2848], 'proximity': [1484, 3607], 'start': [1487], 'sites.': [1488, 1679, 4317], 'so-called': [1490], '"histone': [1491], 'code"': [1492], 'tends': [1493], 'conserved;': [1497], 'particular,': [1499], 'H3K9/K14': [1502, 1896], 'H4K5/K12': [1504], '(H3K4me3)': [1509], 'rate': [1514], '(15Rando': [1515], 'O.J.': [1516, 3689, 4257], 'Curr.': [1517], 'Opin.': [1518], 'Genet.': [1519, 1821], 'Dev.': [1520], '2007;': [1521, 1602, 2157], '1-6Crossref': [1523], '(88)': [1525], 'Of': [1528, 3594], 'these,': [1529], 'Lys-4': [1538, 1913], '(16Janzen': [1544], 'Fernandez': [1546, 1589], 'J.P.': [1547, 1568, 1590, 2293, 3925], 'Deng': [1548, 1591], 'Diaz': [1550], 'FEBS': [1556], 'Lett.': [1557], '580:': [1559], '2306-2310Crossref': [1560], '(75)': [1563], '17da': [1566], 'Cunha': [1567, 2292], 'Nakayasu': [1569, 2294], 'E.S.': [1570, 2295, 3729], 'Almeida': [1572, 2297], 'I.C.': [1573, 2298], '150:': [1580, 2305], '268-277Crossref': [1581, 2306], '(61)': [1584, 2309], '18Mandava': [1587], '156:': [1603], '41-50Crossref': [1604], '(70)': [1607], 'Because': [1610], 'mechanisms,': [1613], 'role': [1618], 'modifications,': [1621], 'largely': [1623], 'unknown': [1624], 'interested': [1629], 'mapping': [1631], 'vivo': [1634, 3907], 'location': [1635, 3752], 'H3/H4': [1639, 3061, 3078, 3954, 4046], 'loci': [1649], 'implicated': [1650], 'regulation.': [1653], 'striking': [1658], 'association': [1659], 'all': [1661, 3106, 3123], 'three': [1662, 1886, 2181], 'separating': [1666], 'parasite,': [1674], 'code': [1682], 'here': [1685], 'general': [1691], 'pattern': [1692, 2355, 3791, 3871], 'Also,': [1703], 'status': [1706, 3309], 'nucleosome': [1708, 3182, 3425, 3496], 'occupancy': [1709, 3183, 3497, 4121], '(SL)': [1720], 'RNA': [1721, 3900], 'some': [1729, 1831, 3260, 4130], 'retrotransposons,': [1730], 'investigated.': [1732], 'Chromatin': [1733], 'Immunoprecipitation': [1734, 2383], '(ChIP)—T.': [1735], 'grown': [1739], 'described': [1741, 2828, 3562, 4237], '(19Kendall': [1742], 'Wilderspin': [1744], 'A.F.': [1745], 'Ashall': [1746], 'Miles': [1748], 'M.A.': [1749, 2133], 'Kelly': [1750, 2147], 'J.M.': [1751, 2152], '1990;': [1754], '9:': [1755], '2751-2758Crossref': [1756], '(100)': [1759], 'Approximately': [1762], '109': [1763], 'per': [1767], 'ChIP': [1768, 1871, 1881, 1889, 2024, 2853, 2859, 2925, 2971, 3138, 3327, 3391, 3628, 3993], 'experiment': [1769], 'following': [1770, 1972, 2994], 'protocol': [1772, 2583], 'Rada-Iglesias': [1774], 'et': [1775], 'al.': [1776], '(20Rada-Iglesias': [1777], 'Wallerman': [1779], 'Koch': [1781], 'Ameur': [1783], 'Enroth': [1785], 'Clelland': [1787], 'Wester': [1789], 'Wilcox': [1791], 'Dovey': [1793], 'O.M.': [1794], 'Ellis': [1795], 'P.D.': [1796], 'Wraight': [1797], 'V.L.': [1798], 'James': [1799], 'Andrews': [1801], 'Langford': [1803], 'Dhami': [1805], 'Carter': [1807], 'Vetrie': [1809], 'Ponten': [1811], 'Komorowski': [1813], 'Dunham': [1815], 'I.': [1816], 'Wadelius': [1817], 'Hum.': [1819], '14:': [1823], '3435-3447Crossref': [1824], '(64)': [1827], 'Scholar)': [1829, 3699, 3743], 'modifications.': [1832], 'Parasites': [1833], 'washed': [1835, 2567, 2624], 'twice': [1836, 2625], '1×': [1838, 2627, 2705, 2731, 2756], 'PBS': [1839, 2628, 2632, 2732, 2757], 'resuspended': [1841, 1863, 1938, 2642], '25': [1843], 'ml': [1844], 'serum-free': [1846], 'medium.': [1847], 'Cross-linking': [1848], 'performed': [1850, 1892, 1932, 2078, 2599, 2826, 2947, 3989, 4349], 'adding': [1852], 'formaldehyde': [1853], 'final': [1856, 1991], 'concentration': [1857], '1%.': [1859], 'Precipitated': [1860], '50': [1865], 'μl': [1866, 1875, 1935, 2851], 'dH20': [1868], 'reactions': [1872, 1956, 2945], '500': [1874], 'inputs.': [1879], 'All': [1880, 2165, 2708, 2931, 2943], 'assays': [1882, 2076, 2189], 'done': [1884, 2027, 3055], 'independent': [1887, 2023], 'replicates.': [1888], 'experiments': [1890, 2025, 2044, 2384, 3328, 3536], 'using': [1893, 1933, 2008, 2079, 2543, 2600, 2784, 2807, 2817, 2830, 2838, 2849, 2984, 3003, 3056, 3103, 3355, 3630, 4016, 4171, 4350], 'α-acetylated': [1894, 1901], '(catalogue': [1897, 1904], 'no.': [1898, 1905], '06-599)': [1899], 'H4K5/K8/K12/K16': [1903], '06-866)': [1906], 'antibodies': [1907, 1919, 2080, 2182, 2204, 2238, 2250, 2318, 2328, 2338, 2358, 2379, 2391, 2709, 3148, 3159, 3544, 3557, 4021], '(Upstate)': [1908], 'α-histone': [1910, 1916], '(ab8580)': [1914], '(ab1791)': [1918], '(AbCam).': [1920], 'Additional': [1921], 'ChIPs': [1922], '"no': [1924], 'antibody"': [1925], 'controls.': [1929], 'PCRs': [1930, 2004], '0.5': [1934, 2850], 'corresponding': [1941, 2212, 2271, 2866], 'primers': [1942, 2935, 3632], '(0.3': [1943, 2455], 'μm)': [1944], '(supplemental': [1945, 2019, 2177, 2194, 2200, 2334, 2362, 3267, 3300, 3529, 3633, 4159, 4356], 'Table': [1946, 2020, 2941, 3190, 3530, 4160], 'S1)': [1947], 'volume': [1951], '30': [1953, 1974, 2535, 2654], 'μl.': [1954], 'PCR': [1955, 2823, 3005, 3625], 'heated': [1958], '10': [1960, 2468], 'min': [1961, 1980, 1995, 2504, 2536], '95': [1963, 1977], '°C': [1964], 'run': [1966, 2837, 3044], '15–32': [1968], 'cycles': [1969], 'under': [1970, 3563], 'conditions:': [1973], 's': [1975, 1985], '°C,': [1978, 1983, 1988], '1': [1979, 2557, 2748, 4429], '60': [1982], '45': [1984], '72': [1987, 1997], 'step': [1992, 2685], '7': [1994], '°C.': [1998], 'long': [2001, 3991], 'range': [2002, 3992], 'analysis,': [2003], 'carried': [2006, 2687], '17': [2012, 4023], 'primer': [2014, 2896, 4024, 4101], 'pairs': [2015, 4025, 4102], 'spanning': [2016, 4353], 'contig': [2017, 3998, 4149], '7617': [2018], 'S1).': [2021], 'Two': [2022, 4093, 4162], 'each': [2029, 2647, 2888, 2895, 2928, 4207], 'antibody.': [2030, 2576], 'intensity': [2032], 'bands': [2035, 2230, 3231], 'measured,': [2037], 'mean': [2040], 'value': [2041], 'calculated.': [2046], 'ratio': [2048], 'positive': [2050], 'input': [2052, 2867, 2906], 'values': [2053, 2066, 2879, 2903, 3207, 3369, 3489], 'normalized': [2055], 'respect': [2057], 'their': [2059, 3282], 'mean,': [2060], 'log2': [2062], 'resulting': [2065, 2999, 3510], 'build': [2070], 'graph': [2072], '(Fig.': [2073, 3116, 3160, 3357, 3444, 3837, 4009, 4060, 4106, 4141, 4189, 4408], '3A).': [2074, 4010, 4061], 'Antibodies—ChIP': [2075], 'raised': [2081], 'against': [2082, 2220], 'Tetrahymena': [2083], 'Lys-9/Lys-14,': [2088], 'Lys-5/Lys-8/Lys-12/Lys-16,': [2092], 'Lys-4,': [2098], 'reported': [2101, 4422], 'recognize': [2104, 2341], 'specifically': [2105], 'Toxoplasma': [2113], 'gondii': [2114], '(21Saksouk': [2115], 'Bhatti': [2117], 'M.M.': [2118], 'Kieffer': [2119], 'Smith': [2121], 'A.T.': [2122], 'Musset': [2123], 'Garin': [2125], 'Sullivan': [2127], 'Cesbron-Delauw': [2130], 'M.F.': [2131, 4249], 'Hakimi': [2132], 'Biol.': [2136, 3691, 3934], '25:': [2138], '10301-10314Crossref': [2139], '(152)': [2142], '22Gissot': [2145], 'K.A.': [2148], 'Ajioka': [2149], 'J.W.': [2150], 'Greally': [2151], 'Kim': [2153, 3680], 'PLoS': [2155, 3690], 'Pathog.': [2156], 'e77Crossref': [2159], '(93)': [2162], 'lysines': [2166, 2287], 'conserved': [2168], 'Fig.': [2178, 2195, 2201, 2335, 2363, 3120, 3193, 3202, 3268, 3301, 3304, 3448, 3533, 3634, 4193, 4357], 'S9).': [2179], 'recognized': [2183, 2205, 2217, 2245, 2251, 2315, 2374, 3545], 'only': [2184], 'nuclear': [2185, 4345], 'immunofluorescence': [2188], 'S9A).': [2196], 'Western': [2198, 2325, 2360, 2482, 2546], 'blot': [2199, 2326], 'S9B),': [2202], 'anti-acH3': [2203, 2980], 'band': [2207, 3009], 'expected': [2210, 3872], 'size': [2211, 2435, 2518], '(also': [2216], 'antibody': [2219, 2578, 2596, 2605, 2774, 2981, 3408], 'H3)': [2223], 'H4.': [2228], 'Weaker': [2229], 'H2A/H2B': [2232, 2255], 'detected.': [2235], 'Anti-acetylated': [2236], 'bound': [2239], 'preferentially': [2240, 3857], 'histones.': [2248, 3552], 'Anti-H3K4me3': [2249], '(data': [2256, 2380, 2479, 3334], 'shown).': [2258, 2382, 2481, 3336], 'To': [2259, 3387, 3465, 3574, 3763, 4333], 'test': [2261], 'specificity': [2263, 3554], 'antibodies,': [2266], 'peptide': [2268, 2313, 2333, 2349], 'designed': [2270], '23': [2274], 'N-terminal': [2275, 2422], 'amino': [2276], 'acids': [2277], 'containing': [2283, 2633, 2693], '(Lys-4,': [2288], 'Lys-10,': [2289], 'Lys-14)': [2290], '(17da': [2291], 'α-acH4': [2317, 2591, 3158], 'competed': [2320], 'when': [2327], 'preincubated': [2330], 'S10).': [2336, 2364], 'Anti-acH3': [2337], 'did': [2339, 2350, 3314], 'acH4': [2343, 3543], 'peptide,': [2344, 2368], 'preincubation': [2346], 'affect': [2352], 'recognition': [2354], 'α-acH3': [2357, 2587, 2831, 3147, 3326, 3587], 'blots': [2361, 4400], 'same': [2366, 4018], 'including': [2369, 4137], 'acetylation,': [2371], 'any': [2376, 3583], 'study': [2386], 'targets': [2388], 'native': [2393], 'extracts': [2395, 2486], 'yielded': [2399, 3221], 'insufficient': [2400], 'amounts': [2401], 'allow': [2405], 'analysis': [2406, 3053, 3626, 3994, 4347], 'mass': [2408, 2417], 'spectrometry.': [2409], 'Total': [2410], 'subjected': [2415], 'spectrometry,': [2418], 'characterization': [2420], 'impeded': [2425], 'because': [2426, 3245], 'difficulties': [2428], 'generating': [2430], 'peptides': [2431], 'appropriate': [2434], 'analysis.': [2437], 'Attempts': [2438], 'made': [2441], 'enrich': [2443], 'treating': [2447], 'HDAC': [2451], 'inhibitors': [2452], 'trichostatin': [2453], 'A': [2454, 2797, 3162], 'μm': [2456], '0,': [2458, 2471], '6,': [2459, 2472], '24': [2461, 2474, 3082, 3086], 'h)': [2462, 2475], 'butyric': [2464], 'acid': [2465], '(5': [2466], 'mm': [2469], 'success': [2478], 'Blot': [2483], 'Analysis—Total': [2484], 'fractionated': [2492], 'NuPAGE': [2494], '4–12%': [2495], 'bis-Tris': [2496], 'gel': [2497, 2521, 3008], '(Invitrogen)': [2498, 2512], '200': [2500], 'V': [2501, 2533], '35': [2503], 'MES': [2506], 'running': [2507], 'buffer.': [2508], 'MultiMark': [2509], 'multicolored': [2510], 'standard': [2511, 2892], 'marker.': [2519], 'transferred': [2523], 'polyvinylidene': [2526], 'fluoride': [2527], 'membrane': [2528, 2540, 2565], '(GE': [2529, 2606, 2618, 3012], 'Healthcare)': [2530, 2607, 3013], '80': [2532], 'ice.': [2538], 'developed': [2542], 'ECL': [2545, 2617], 'blotting': [2547], 'detection': [2548, 2842], 'kit': [2549], '(see': [2550, 3128, 3184], "manufacturer's": [2551, 2996], 'instructions;': [2552], 'GE': [2553], 'Healthcare).': [2554, 2619], 'Briefly,': [2555], 'after': [2556], 'h': [2558, 2722], 'incubation': [2560, 2597], 'blocking': [2562, 2678, 2684, 2718], 'solution,': [2563], 'incubated': [2569, 2734], 'additional': [2572, 2682, 3884], 'hour': [2573], 'primary': [2575], 'Primary': [2577], 'dilutions': [2579], 'this': [2582, 4148], 'follows:': [2586], 'α-H3,': [2589], '1:2000;': [2590], 'α-H3K4me3,': [2593], '1:5000.': [2594], 'Secondary': [2595], 'rabbit': [2601], 'IgG': [2602], 'horseradish': [2603], 'peroxidase-linked': [2604], '1:5000,': [2609], 'result': [2612, 3237, 3396], 'detected': [2614], 'Hyperfilm': [2616], 'Immunostaining—T.': [2620], 'fixed': [2630], '4%': [2634], 'paraformaldehyde': [2635], '20': [2637], 'min.': [2638], 'One': [2639], 'drop': [2640], 'spotted': [2645], 'onto': [2646], 'coverslips': [2648, 2727, 2752], 'pretreated': [2649], 'poly-lysine': [2651], '(Sigma)': [2652, 2993], 'min,': [2655], 'cells': [2658], 'then': [2660], 'permeabilized': [2661], 'PBS/0.3%': [2663], 'Triton': [2664, 2702], 'X-100.': [2665], 'slides': [2667], 'treated': [2669], 'Image-iT': [2671], 'FX': [2672], 'signal': [2673, 4387], 'enhancer': [2674], '(Molecular': [2675, 2739, 2764], 'Probes)': [2676, 2740], 'background': [2679], 'staining.': [2680], 'An': [2681], 'overnight': [2683], 'filtered': [2691, 2706], 'solution': [2692, 2719], '2%': [2694], '(w/v)': [2695], 'bovine': [2696], 'serum': [2697], 'albumin': [2698], '0.1%': [2700], '(v/v)': [2701], 'X-100': [2703], 'PBS.': [2707], 'dilution': [2714, 2743, 2778, 2863], '1:200': [2716], '1–2': [2721], 'room': [2724], 'temperature.': [2725], 'rinsed': [2729, 2754], 'anti-rabbit': [2736], 'Alexa': [2737], '488': [2738], 'factor': [2744, 3377, 3910, 4315], '1:150': [2746], 'h.': [2749], 'Finally': [2750], 'mounted': [2759], 'ProLong': [2761], 'Gold': [2762], 'Antifade': [2763], 'Probes).': [2765], 'For': [2766], 'controls,': [2767], 'stained': [2771], 'secondary': [2773], 'alone': [2775], '1:150.': [2780], 'Images': [2781, 2804], 'acquired': [2783], '510': [2786], 'Meta': [2787], 'confocal': [2788], 'microscope': [2789], '(Zeiss)': [2790], 'equipped': [2791], 'charge-coupled': [2794], 'device': [2795], 'camera.': [2796], '×63': [2798], 'oil': [2799], 'immersion': [2800], 'objective': [2801], 'used.': [2803], 'collected': [2806], 'LSM': [2808], '5': [2809], 'Image': [2810], 'Browser': [2811], 'software': [2812], 'subsequently': [2814], 'prepared': [2816], 'Adobe': [2818], 'Photoshop': [2819], 'Elements': [2820], '2.0.': [2821], 'Quantitative': [2822], '(Q-PCR)—ChIPs': [2824], 'above,': [2829], 'α-H3K4me3': [2833], 'antibodies.': [2834], 'Q-PCR': [2835, 2944], 'SYBR': [2840], 'Green': [2841], 'system': [2843], 'ABI': [2845, 3047], 'PRISM': [2846], '7900HT,': [2847], 'DNA/reaction.': [2854], 'parallel': [2856], 'DNA,': [2860], 'serial': [2862, 2907], '(1:2,': [2869], '1:10,': [2870], '1:50,': [2871], '1:250)': [2872], 'analyzed': [2875, 2929, 3091, 3107, 3312, 4167], 'Q-PCR.': [2877], 'Ct': [2878, 2881], '(where': [2880], 'threshold)': [2884], 'obtained': [2886, 3234, 3324], 'case,': [2889], 'curve': [2893], 'calculated': [2899], 'based': [2900], 'dilution.': [2908], 'Based': [2909], 'those': [2911, 3382], 'curves': [2912], 'inferred': [2914], '(expressed': [2919], 'arbitrary': [2921], 'units)': [2922], 'employed': [2936], 'listed': [2938], 'supplemental': [2940, 3119, 3189, 3201, 3447, 3569, 4192], 'S1.': [2942], 'duplicate,': [2949], 'unless': [2950], 'S.D.': [2952], 'signals': [2954, 4417], 'than': [2957, 3894], '1,': [2958, 3161], 'case': [2961], 'third': [2963], 'replicate': [2964], 'obtained.': [2966], 'Cloning': [2967], 'Sequencing': [2969], 'Material—About': [2972], '100': [2973], 'ng': [2974], 'precipitated': [2978], 'amplified': [2983, 3137, 4115], 'GenomePlex®': [2986], 'Complete': [2987], 'Whole': [2988], 'Genome': [2989], 'Amplification': [2990], '(WGA)': [2991], 'Kit': [2992], 'instructions.': [2997], 'purified': [3002], 'GFX™': [3004], 'purification': [3010], 'columns': [3011], 'ligated': [3014], 'pGEM-T': [3016], 'vector': [3017], '(Promega)': [3018], 'transformed': [3020], 'Epicurian': [3022], 'Coli': [3023], 'XL1-Blue': [3024], '(Stratagene).': [3025], 'Amplified': [3026], 'inserts': [3027], 'plasmid': [3029], 'recombinant': [3032], 'clones': [3033], 'sequenced': [3035], 'BigDye®': [3037], 'Terminator': [3038], 'version': [3039], '3.1': [3040], '(Applied': [3041], 'Biosystems)': [3042], 'PRISM®': [3048], '3700': [3049], 'analyzer.': [3051], 'Sequence': [3052], 'Sequencher™': [3057], 'software.': [3058], 'Acetylated': [3059, 3952], 'Histones': [3060, 3953], 'H3K4me3': [3063, 3080, 3140, 3214, 3956, 4158], 'Associate': [3064], 'Strand': [3066], 'Switch': [3067], 'Regions': [3068], 'Separating': [3069], 'Divergent': [3070], 'Gene': [3071], 'Clusters—': [3072], 'distribution': [3074, 3154, 3745, 3842], 'head-to-head': [3083], '(HH)': [3084], 'tail-to-tail': [3087], '(TT)': [3088], 'SSRs': [3089, 3109, 3125, 3354, 3373, 3655, 3778, 4164, 4322, 4426], 'CL': [3096, 3251], 'Brener': [3097, 3252], 'strain': [3098], 'epimastigote': [3101], 'ChIP.': [3104], 'Invariably,': [3105], 'HH': [3108, 3176, 3351, 3363, 3372, 3429, 3463, 3474, 3522, 3610, 3775, 3811, 3860, 3895, 3976, 4004, 4039, 4074, 4145, 4163, 4179, 4220, 4321, 4340, 4375], '1A': [3117, 3445], 'S5),': [3121, 3269, 3449], 'whereas': [3122, 3216], 'TT': [3124, 3178, 3256, 3353, 3385, 3404, 3431, 3476, 3777, 4007, 4139], 'except': [3126], 'below)': [3129], 'low': [3131], 'modification.': [3135], 'material,': [3139], 'gave': [3141], 'strongest': [3143], 'signal,': [3144], 'more': [3151, 4155], 'pronounced': [3152], 'differential': [3153], 'C).': [3164], 'numerical': [3166], 'data': [3167, 3511], 'enrichments': [3171], 'versus': [3177], 'SSRs,': [3179, 3364, 3525], 'corrected': [3180, 3494], 'below),': [3185], 'S2': [3191, 3531], '1C': [3194], 'box': [3198], 'plot': [3199], 'S6.': [3203], 'estimated': [3205], 'average': [3206, 3367, 3806], 'highest': [3210], 'enrichment': [3211, 3227, 3261, 3340, 3360, 3452, 3488, 3503, 3822, 4131], 'level': [3212, 3341], '(10-fold),': [3215], 'approximate': [3223], '7-': [3224], '6-fold': [3226], 'levels,': [3228], 'respectively.': [3229], 'Double': [3230], 'sometimes': [3233], 'sequence': [3239], 'length': [3240], 'polymorphism': [3241], 'among': [3242, 3317, 3362], 'homologous': [3243], 'hybrid': [3248], 'nature': [3249], 'strain.': [3253], 'Only': [3254], '(contig': [3257], '7271)': [3258], 'could': [3271, 4228], 'due': [3273, 3479, 4109], 'tRNA': [3279], 'carrying': [3281], 'own': [3283], 'TTs': [3286], '6288': [3287], '7869': [3289], 'contain': [3291], 'tRNAs': [3292], 'neither': [3296], 'nor': [3298], 'S5': [3302], '1A,': [3305], 'respectively).': [3306], 'differ': [3316, 3847], 'strains,': [3319], 'similar': [3321], 'strains': [3333], 'We': [3337, 3839, 4195], 'quantified': [3338], 'analyzing': [3347], 'subset': [3349], 'ChIP/Q-PCR': [3356, 4172], '1B).': [3358], 'varied': [3361], 'these': [3371, 3500, 3620, 3944], '18': [3379], 'regions.': [3386, 3464, 3762], 'confirm': [3388], 'absence': [3398], 'inaccessibility': [3400], 'nucleosomes': [3402, 3443, 3549, 4053], 'regions,': [3405, 3659], 'α-H3': [3407], 'recognizing': [3409], 'unmodified': [3414, 4215, 4372], 'provide': [3420], 'measure': [3422], 'occupancy.': [3426], 'Both': [3427], 'H3,': [3438], 'confirming': [3439], 'although': [3450, 4050, 4385], 'appeared': [3457, 4367], 'analyze': [3466], 'whether': [3467, 3765], 'difference': [3469, 4411], 'simply': [3478], 'nucleosomes,': [3486, 4235], 'dividing': [3499], 'H3.': [3508], 'indeed': [3517], 'overrepresented': [3519], 'mentioned': [3527], 'above': [3528], '1C).': [3534], 'verified': [3538], 'acH3': [3541], 'subpopulation': [3547], '"Experimental': [3564], 'Procedures"': [3565], 'Figs.': [3570], 'S9': [3571], 'S10.': [3573], 'identify': [3575], 'without': [3582], 'preselection,': [3584], 'immunoprecipitated': [3586], 'amplified,': [3590], 'cloned,': [3591], 'sequenced.': [3593], 'nine': [3597], 'sequences,': [3598], 'seven': [3599], 'represented': [3603], 'SSR': [3611, 3812, 3977, 4008, 4040, 4075, 4146, 4341, 4376, 4381, 4407, 4466], '(50': [3612], 'bp': [3613], '6': [3615, 4070], 'kb).': [3616], 'material': [3629], 'S11).': [3635], 'Several': [3636], 'cloned': [3639], 'derived': [3642], 'reflection': [3649], 'number': [3653], 'subtelomeric': [3658], 'main': [3663], 'arsenal': [3664], 'genes.': [3667], 'Acetylation': [3669], 'Distribution': [3670], 'Does': [3671], 'Not': [3672], 'Differ': [3673], 'Intragenically—In': [3674], 'yeast': [3675, 4240, 4331], '(23Liu': [3676], 'C.L.': [3677], 'Kaplan': [3678], 'Buratowski': [3682], 'Schreiber': [3684, 3726], 'Friedman': [3686], 'Rando': [3688, 4256], 'e328Crossref': [3694], '(394)': [3697], 'mammals': [3704], '(24Bernstein': [3705], 'B.E.': [3706], 'Kamal': [3707], 'Lindblad-Toh': [3709], 'Bekiranov': [3711], 'Bailey': [3713], 'D.K.': [3714, 4268, 4292], 'Huebert': [3715], 'D.J.': [3716], 'McMahon': [3717], 'Karlsson': [3719], 'E.K.': [3720], 'Kulbokas': [3721], 'III,': [3722], 'E.J.': [3723], 'Gingeras': [3724], 'T.R.': [3725], 'Lander': [3728], '120:': [3732], '169-181Abstract': [3733], '(1163)': [3741], 'differs': [3749], 'intragenically,': [3750], 'predominantly': [3753], '5′-ends': [3756], 'near': [3760], 'promoter': [3761], 'examine': [3764], 'intragenic': [3766], 'had': [3768], 'influenced': [3769], 'our': [3770], 'results,': [3771], 'given': [3772], 'comprise': [3779, 4313], '5′-': [3781, 3796, 3834], '3′-ends': [3783, 3914], 'respectively,': [3786], 'determined': [3788], 'set': [3794, 4019], '3′-UTRs': [3798, 3836], 'positioned': [3799], 'arrays': [3803], '20-kb': [3807], 'distance': [3808], 'locations': [3815, 3892], 'genome.': [3820], 'No': [3821], 'either': [3832], '2).': [3838], 'concluded': [3840], 'intragenically': [3848], 'localized': [3858, 4217], 'SSRs.': [3861, 3896, 4221], 'concur': [3864], 'notion': [3867], 'units.': [3876], 'cannot': [3879], 'exclude': [3880], 'possibility': [3882], 'do': [3889], 'occur': [3890], 'pol': [3901, 4241], 'II': [3902, 4242], 'co-localized': [3905], 'TRF4': [3911], 'few': [3917], 'local': [3922], '(25Ruan': [3924], 'Arhin': [3926], 'G.K.': [3927], 'Ullu': [3928], 'Tschudi': [3930], '24:': [3936], '9610-9618Crossref': [3937], 'Whether': [3943], 'cryptic': [3947], 'known.': [3951], 'Are': [3957], 'Present': [3958], 'Sites': [3960], 'Initiating': [3961], 'Bidirectional': [3962], 'Transcription': [3963, 4359, 4378, 4460], 'Polycistronic': [3965], 'Units—To': [3966], 'determine': [3967], 'extent': [3969], 'surrounding': [3974], 'larger': [3981], 'genome,': [3987], 'covering': [3995, 4177], '250': [4000], 'kb': [4001, 4071], 'comprising': [4002], 'probed': [4015], 'predicted': [4033], 'open': [4034], 'reading': [4035], 'frames.': [4036], 'Again,': [4037], 'loading': [4051], 'equal': [4055], 'along': [4056], 'whole': [4058], 'Conservative': [4062], 'estimates': [4063], 'extend': [4068], 'about': [4069, 4152], 'around': [4072], 'encompassing': [4076], 'juxtaposed': [4078], 'supposedly': [4080], 'embracing': [4081], 'shared': [4082], 'separate': [4084], 'strands.': [4092], 'dips': [4094], 'appearing': [4099], '12': [4103], '14': [4105, 4153], '3A)': [4107], 'lower': [4120], 'nucleosomes.': [4123], 'preceding': [4135], '3A);': [4142], 'however,': [4143], 'still': [4151], 'times': [4154], 'S2).': [4161], 'resolution': [4170], 'amplify': [4174], '∼150-bp-long': [4175], 'fragments': [4176], 'parts': [4184], '3B': [4190], 'S7).': [4194], 'hyperacetylation': [4200], 'downstream': [4205], 'ATGs': [4211], 'separated': [4212], 'Alternatively,': [4222], 'dip': [4224], 'profiles': [4227], 'imply': [4230], 'depleted': [4233], '(26Yuan': [4244], 'Liu': [4246], 'Y.J.': [4247], 'Dion': [4248], 'Slack': [4250], 'M.D.': [4251], 'Wu': [4252], 'L.F.': [4253], 'Altschuler': [4254], '626-630Crossref': [4261], '(902)': [4264], '27Pokholok': [4267], 'Harbison': [4269], 'C.T.': [4270], 'Levine': [4271], 'Cole': [4273], 'Hannett': [4275], 'Lee': [4277], 'T.I.': [4278], 'Bell': [4279], 'G.W.': [4280], 'Walker': [4281], 'Rolfe': [4283], 'P.A.': [4284], 'Herbolsheimer': [4285], 'Zeitlinger': [4287], 'Lewitter': [4289], 'Gifford': [4291], 'Young': [4293], 'R.A.': [4294], '122:': [4297], '517-527Abstract': [4298], '(1083)': [4306], 'known': [4311], 'Similarly,': [4318], 'rich': [4324], 'poly(dA-dT)': [4326], 'stretches': [4327], 'seen': [4329, 4396], 'verify': [4334], 'initiates': [4337], 'run-on': [4346], 'strand-specific': [4351], 'oligomers': [4352], 'S8).': [4358], 'sense': [4363, 4389], 'antisense': [4365], 'strands': [4366, 4419], 'initiate': [4369], 'part': [4373], '7739.': [4377], 'thus': [4383], 'bidirectional,': [4384], 'much': [4393], 'weaker,': [4394], 'dot': [4399], 'right': [4403], 'segment': [4404], 'S8A).': [4409], 'Such': [4410], 'strength': [4413], 'chromosome': [4428], 'immediately': [4464], '7739': [4467], 'w': [4468]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1970022594', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-27T10:29:23.262591', 'created_date': '2016-06-24'}
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