Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969990934', 'doi': 'https://doi.org/10.1093/brain/aws180', 'title': 'Single nucleotide polymorphisms associated with sporadic brain arteriovenous malformations: where do we stand?', 'display_name': 'Single nucleotide polymorphisms associated with sporadic brain arteriovenous malformations: where do we stand?', 'publication_year': 2012, 'publication_date': '2012-09-13', 'ids': {'openalex': 'https://openalex.org/W1969990934', 'doi': 'https://doi.org/10.1093/brain/aws180', 'mag': '1969990934', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22975391'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/aws180', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/136/2/665/11136968/aws180.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/brain/article-pdf/136/2/665/11136968/aws180.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5025873393', 'display_name': 'Carmelo Lucio Sturiale', 'orcid': 'https://orcid.org/0000-0002-4080-2492'}, 'institutions': [{'id': 'https://openalex.org/I103320735', 'display_name': 'Università Cattolica del Sacro Cuore', 'ror': 'https://ror.org/03h7r5v07', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I103320735']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'C. L. Sturiale', 'raw_affiliation_strings': ['Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy', 'institution_ids': ['https://openalex.org/I103320735']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047434717', 'display_name': 'A. Puca', 'orcid': 'https://orcid.org/0009-0001-8643-4939'}, 'institutions': [{'id': 'https://openalex.org/I103320735', 'display_name': 'Università Cattolica del Sacro Cuore', 'ror': 'https://ror.org/03h7r5v07', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I103320735']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'A. Puca', 'raw_affiliation_strings': ['Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy', 'institution_ids': ['https://openalex.org/I103320735']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003627453', 'display_name': 'Paola Sebastiani', 'orcid': 'https://orcid.org/0000-0001-6419-1545'}, 'institutions': [{'id': 'https://openalex.org/I111088046', 'display_name': 'Boston University', 'ror': 'https://ror.org/05qwgg493', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111088046']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P. Sebastiani', 'raw_affiliation_strings': ['Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I111088046']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071213712', 'display_name': 'Ilaria Gatto', 'orcid': 'https://orcid.org/0000-0002-0299-9538'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'I. Gatto', 'raw_affiliation_strings': ['Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079118269', 'display_name': 'Alessio Albanese', 'orcid': 'https://orcid.org/0000-0001-8783-2974'}, 'institutions': [{'id': 'https://openalex.org/I103320735', 'display_name': 'Università Cattolica del Sacro Cuore', 'ror': 'https://ror.org/03h7r5v07', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I103320735']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'A. Albanese', 'raw_affiliation_strings': ['Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy', 'institution_ids': ['https://openalex.org/I103320735']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110296089', 'display_name': 'Concezio Di Rocco', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I103320735', 'display_name': 'Università Cattolica del Sacro Cuore', 'ror': 'https://ror.org/03h7r5v07', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I103320735']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'C. Di Rocco', 'raw_affiliation_strings': ['Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy', 'institution_ids': ['https://openalex.org/I103320735']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006463590', 'display_name': 'G. Maira', 'orcid': 'https://orcid.org/0000-0001-9214-3911'}, 'institutions': [{'id': 'https://openalex.org/I103320735', 'display_name': 'Università Cattolica del Sacro Cuore', 'ror': 'https://ror.org/03h7r5v07', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I103320735']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'G. Maira', 'raw_affiliation_strings': ['Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy', 'institution_ids': ['https://openalex.org/I103320735']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5025658524', 'display_name': 'Roberto Pola', 'orcid': 'https://orcid.org/0000-0001-5224-2931'}, 'institutions': [{'id': 'https://openalex.org/I84470341', 'display_name': 'Catholic University of America', 'ror': 'https://ror.org/047yk3s18', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84470341']}, {'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R. Pola', 'raw_affiliation_strings': ['Department of Medicine, Catholic University School of Medicine, Rome, Italy', "Division of Cardiovascular Research, Department of Medicine, St. Elizabeth's Medical Centre, Tufts University School of Medicine, Boston, MA, USA", 'Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Catholic University School of Medicine, Rome, Italy', 'institution_ids': ['https://openalex.org/I84470341']}, {'raw_affiliation_string': 'Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy', 'institution_ids': []}, {'raw_affiliation_string': "Division of Cardiovascular Research, Department of Medicine, St. Elizabeth's Medical Centre, Tufts University School of Medicine, Boston, MA, USA", 'institution_ids': ['https://openalex.org/I121934306']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3658, 'currency': 'GBP', 'value_usd': 4486, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.493, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 70, 'citation_normalized_percentile': {'value': 0.730114, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '136', 'issue': '2', 'first_page': '665', 'last_page': '681'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11402', 'display_name': 'Vascular Malformations Diagnosis and Treatment', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11402', 'display_name': 'Vascular Malformations Diagnosis and Treatment', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12747', 'display_name': 'Moyamoya disease diagnosis and treatment', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11763', 'display_name': 'Intracerebral and Subarachnoid Hemorrhage Research', 'score': 0.982, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/candidate-gene', 'display_name': 'Candidate gene', 'score': 0.5365064}, {'id': 'https://openalex.org/keywords/genome-wide-association-study', 'display_name': 'Genome-wide Association Study', 'score': 0.47516435}], 'concepts': [{'id': 'https://openalex.org/C69991583', 'wikidata': 'https://www.wikidata.org/wiki/Q1423575', 'display_name': 'Candidate gene', 'level': 3, 'score': 0.5365064}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5000112}, {'id': 'https://openalex.org/C106208931', 'wikidata': 'https://www.wikidata.org/wiki/Q1098876', 'display_name': 'Genome-wide association study', 'level': 5, 'score': 0.47516435}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.4548765}, {'id': 'https://openalex.org/C153209595', 'wikidata': 'https://www.wikidata.org/wiki/Q501128', 'display_name': 'Single-nucleotide polymorphism', 'level': 4, 'score': 0.4515053}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.42114866}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.39432144}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.38707632}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38470423}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3145091}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.20993754}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D055106', 'descriptor_name': 'Genome-Wide Association Study', 'qualifier_ui': 'Q000639', 'qualifier_name': 'trends', 'is_major_topic': True}, {'descriptor_ui': 'D002538', 'descriptor_name': 'Intracranial Arteriovenous Malformations', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D055106', 'descriptor_name': 'Genome-Wide Association Study', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002538', 'descriptor_name': 'Intracranial Arteriovenous Malformations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002538', 'descriptor_name': 'Intracranial Arteriovenous Malformations', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D002538', 'descriptor_name': 'Intracranial Arteriovenous Malformations', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/aws180', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/136/2/665/11136968/aws180.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22975391', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/brain/aws180', 'pdf_url': 'https://academic.oup.com/brain/article-pdf/136/2/665/11136968/aws180.pdf', 'source': {'id': 'https://openalex.org/S118357697', 'display_name': 'Brain', 'issn_l': '0006-8950', 'issn': ['0006-8950', '1460-2156'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 99, 'referenced_works': ['https://openalex.org/W115895558', 'https://openalex.org/W123362299', 'https://openalex.org/W1484776715', 'https://openalex.org/W1490344091', 'https://openalex.org/W1504746250', 'https://openalex.org/W1522834891', 'https://openalex.org/W1534082283', 'https://openalex.org/W1576694462', 'https://openalex.org/W164082173', 'https://openalex.org/W1969592131', 'https://openalex.org/W1969616329', 'https://openalex.org/W1970293798', 'https://openalex.org/W1970614272', 'https://openalex.org/W1971326215', 'https://openalex.org/W1974024509', 'https://openalex.org/W1974975509', 'https://openalex.org/W1978753072', 'https://openalex.org/W1979406818', 'https://openalex.org/W1985186312', 'https://openalex.org/W1989137916', 'https://openalex.org/W1990275904', 'https://openalex.org/W1993339376', 'https://openalex.org/W1994416263', 'https://openalex.org/W1996112813', 'https://openalex.org/W1998348002', 'https://openalex.org/W1998557118', 'https://openalex.org/W1999325438', 'https://openalex.org/W2002052069', 'https://openalex.org/W2002536490', 'https://openalex.org/W2010032376', 'https://openalex.org/W2010713942', 'https://openalex.org/W2013519546', 'https://openalex.org/W2014295273', 'https://openalex.org/W2021547032', 'https://openalex.org/W2024008844', 'https://openalex.org/W2025570171', 'https://openalex.org/W2031434429', 'https://openalex.org/W2032374935', 'https://openalex.org/W2032686344', 'https://openalex.org/W2036744218', 'https://openalex.org/W2042869855', 'https://openalex.org/W2043894008', 'https://openalex.org/W2045439582', 'https://openalex.org/W2049468108', 'https://openalex.org/W2049768059', 'https://openalex.org/W2052767765', 'https://openalex.org/W2055737465', 'https://openalex.org/W2060377922', 'https://openalex.org/W2064772139', 'https://openalex.org/W2065212546', 'https://openalex.org/W2066750311', 'https://openalex.org/W2071529367', 'https://openalex.org/W2075706997', 'https://openalex.org/W2076633056', 'https://openalex.org/W2084110843', 'https://openalex.org/W2084479478', 'https://openalex.org/W2086840459', 'https://openalex.org/W2089022749', 'https://openalex.org/W2090324585', 'https://openalex.org/W2091068214', 'https://openalex.org/W2092506210', 'https://openalex.org/W2094647748', 'https://openalex.org/W2095928540', 'https://openalex.org/W2102093684', 'https://openalex.org/W2111648479', 'https://openalex.org/W2114481915', 'https://openalex.org/W2117446594', 'https://openalex.org/W2118203609', 'https://openalex.org/W2118295589', 'https://openalex.org/W2118373912', 'https://openalex.org/W2119154276', 'https://openalex.org/W2125264782', 'https://openalex.org/W2126047917', 'https://openalex.org/W2126333436', 'https://openalex.org/W2127974676', 'https://openalex.org/W2128146309', 'https://openalex.org/W2128610684', 'https://openalex.org/W2135124706', 'https://openalex.org/W2135171261', 'https://openalex.org/W2135431987', 'https://openalex.org/W2141163534', 'https://openalex.org/W2142546697', 'https://openalex.org/W2142799499', 'https://openalex.org/W2144301584', 'https://openalex.org/W2146376792', 'https://openalex.org/W2146750742', 'https://openalex.org/W2148946647', 'https://openalex.org/W2152443178', 'https://openalex.org/W2152641745', 'https://openalex.org/W2152745352', 'https://openalex.org/W2187181884', 'https://openalex.org/W2326398416', 'https://openalex.org/W2338858604', 'https://openalex.org/W2413494055', 'https://openalex.org/W4210647378', 'https://openalex.org/W4238265681', 'https://openalex.org/W4254189121', 'https://openalex.org/W4255733162', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4283582241', 'https://openalex.org/W3132065130', 'https://openalex.org/W3103888630', 'https://openalex.org/W2900730647', 'https://openalex.org/W2400017200', 'https://openalex.org/W2373670798', 'https://openalex.org/W2185171978', 'https://openalex.org/W2065112873', 'https://openalex.org/W1864400744', 'https://openalex.org/W172227456'], 'abstract_inverted_index': {'Brain': [0], 'arteriovenous': [1, 95, 111, 208, 242, 265, 341], 'malformations': [2, 112, 209, 243, 266, 306], 'are': [3, 21, 169], 'characterized': [4], 'by': [5, 325], 'a': [6, 58, 88, 99, 125, 222, 317, 351], 'tangle': [7], 'of': [8, 31, 93, 102, 124, 155, 180, 184, 194, 198, 206, 225, 279, 288, 294, 299, 304, 320, 346, 387], 'abnormal': [9], 'vessels': [10], 'directly': [11], 'shunting': [12], 'blood': [13], 'from': [14], 'the': [15, 29, 37, 91, 107, 138, 173, 178, 185, 192, 204, 255, 268, 273, 286, 292, 301, 305, 321, 326, 333, 356, 369, 392], 'arterial': [16], 'to': [17, 23, 140, 236, 258, 285], 'venous': [18], 'circulation.': [19], 'They': [20], 'known': [22, 397], 'occur': [24], 'either': [25], 'sporadically': [26], 'or': [27, 76, 128, 210], 'in': [28, 62, 72, 90, 132, 151, 172, 177, 203, 211, 221, 260, 267, 328], 'context': [30], 'well-defined': [32], 'genetic': [33, 60, 103, 246, 296], 'disorders.': [34], 'Haemorrhage': [35], 'represents': [36], 'most': [38, 183], 'severe': [39], 'clinical': [40, 277], 'manifestation,': [41], 'whereas': [42], 'other': [43, 212], 'common': [44], 'symptoms': [45], 'include': [46], 'headache,': [47], 'seizures': [48], 'and': [49, 74, 84, 113, 144, 163, 176, 244, 253, 276, 291, 307, 311, 339, 344, 368, 385, 390, 414], 'neurological': [50], 'deficits.': [51], 'Although': [52], 'sporadic': [53, 110, 263], 'forms': [54], 'do': [55], 'not': [56], 'recognize': [57], 'specific': [59, 245], 'cause,': [61], 'recent': [63], 'years,': [64], 'it': [65, 233], 'has': [66, 105, 227], 'been': [67, 158, 189, 228], 'hypothesized': [68], 'that': [69, 330], 'genes': [70, 156, 168, 196], 'involved': [71, 171], 'angiogenesis': [73], 'inflammation': [75], 'coding': [77], 'for': [78], 'proteins,': [79], 'such': [80], 'as': [81, 398], 'fibronectins,': [82], 'laminins': [83], 'integrins,': [85], 'may': [86, 136], 'play': [87], 'role': [89, 202], 'pathophysiology': [92], 'brain': [94, 207, 241, 264, 340], 'malformations.': [96], 'More': [97], 'recently,': [98], 'new': [100], 'trend': [101], 'studies': [104, 327], 'investigated': [106, 186, 257], 'association': [108, 219, 261, 334, 354], 'between': [109, 120, 129, 240, 335, 355, 391], 'single': [114, 117, 336], 'nucleotide': [115, 337], 'polymorphisms,': [116], 'base': [118], 'variations': [119], 'genomes': [121], 'within': [122], 'members': [123], 'biological': [126], 'species': [127], 'paired': [130], 'chromosomes': [131], 'an': [133], 'individual,': [134], 'which': [135], 'determine': [137], 'susceptibility': [139, 343], 'develop': [141], 'complex': [142], 'diseases': [143], 'influence': [145], 'their': [146, 199, 309], 'natural': [147, 312], 'history.': [148, 313], 'Several': [149], 'polymorphisms': [150, 187, 256, 338, 384], 'two': [152], 'different': [153], 'families': [154], 'have': [157, 188, 331], 'associated': [159], 'with': [160, 262, 282], 'disease': [161, 415], 'susceptibly': [162], 'increased': [164], 'haemorrhagic': [165, 289], 'risk.': [166], 'These': [167], 'mainly': [170], 'inflammatory': [174], 'cascade': [175], 'regulation': [179], 'angiogenesis.': [181], 'However,': [182], 'selected': [190], 'on': [191], 'basis': [193], 'candidate': [195], 'because': [197], 'potential': [200], 'functional': [201], 'pathogenesis': [205], 'cerebrovascular': [213], 'diseases.': [214], 'Only': [215], 'one': [216], 'hypothesis-free': [217], 'genome-wide': [218], 'study': [220], 'small': [223], 'number': [224], 'patients': [226], 'performed': [229], 'so': [230], 'far,': [231], 'but': [232], 'was': [234], 'unable': [235], 'identify': [237], 'significant': [238, 353], 'associations': [239], 'loci.': [247], 'In': [248], 'this': [249], 'article,': [250], 'we': [251], 'review': [252], 'analyse': [254], 'date': [259], 'medical': [269], 'literature.': [270], 'We': [271, 314], 'discuss': [272], 'biological,': [274], 'pathophysiological': [275], 'implications': [278], 'these': [280], 'studies,': [281], 'particular': [283], 'attention': [284], 'prediction': [287], 'risk': [290, 322, 345, 386], 'possibility': [293], 'building': [295], 'profiles': [297], 'capable': [298], 'defining': [300], 'architectural': [302], 'features': [303], 'predict': [308], 'evolution': [310], 'also': [315], 'present': [316], 'joint': [318], 'analysis': [319, 349], 'estimates': [323], 'found': [324], 'literature': [329], 'evaluated': [332], 'malformation': [342], 'bleeding.': [347], 'This': [348], 'shows': [350], 'statistically': [352], 'interleukin': [357], '6': [358], '−174G>C': [359], '(odds': [360, 375, 404], 'ratio': [361, 376, 405], '=': [362, 377, 406], '1.97;': [363], '95%': [364, 379, 408], 'confidence': [365, 380, 409], 'interval:': [366, 381, 410], '1.15–3.38)': [367], 'tumour': [370], 'necrosis': [371], 'factor': [372], 'α': [373], '−238G>A': [374], '2.19;': [378], '1.25–3.83)': [382], 'gene': [383, 412], 'intracranial': [388], 'haemorrhage': [389], 'activin-like': [393], 'kinase': [394], '1': [395], '(also': [396], 'ACVRL1)': [399], 'intervening': [400], 'sequence': [401], '3': [402], '−35A>G': [403], '2.42;': [407], '1.54–3.8)': [411], 'polymorphism': [413], 'susceptibility.': [416]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969990934', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 3}], 'updated_date': '2025-01-08T10:41:19.793009', 'created_date': '2016-06-24'}