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1915], 'proteins': [2, 136, 3576, 4076, 4243], '(AKAPs)': [3, 137, 515], 'immobilize': [4, 138], 'and': [5, 23, 83, 107, 124, 139, 157, 217, 241, 258, 319, 343, 352, 500, 966, 1118, 1153, 1175, 1207, 1277, 1333, 1339, 1443, 1495, 1508, 1631, 1791, 1862, 1898, 1922, 1932, 1945, 1955, 1965, 1977, 2010, 2016, 2071, 2160, 2170, 2182, 2210, 2338, 2390, 2434, 2440, 2457, 2471, 2511, 2526, 2561, 2577, 2592, 2601, 2653, 2658, 2687, 2756, 2804, 2861, 2899, 2949, 2963, 3049, 3106, 3123, 3336, 3351, 3376, 3408, 3475, 3608, 3623, 3629, 3662, 3716, 3719, 3733, 3813, 3878, 3923, 3958, 4020, 4089, 4160, 4175, 4193, 4209, 4211, 4263, 4273, 4302], 'concentrate': [6, 140], 'protein': [7, 72, 141, 206, 269, 273, 283, 291, 336, 1119, 1383, 2327, 3047, 3535, 4025], 'kinase': [8, 142, 270, 284, 287, 337], 'A': [9, 143, 338, 2250, 4208], '(PKA)': [10, 144], 'isoforms': [11, 145], 'at': [12, 74, 146, 208, 312, 323, 664, 1182, 1413, 1469, 1482, 1789, 1896, 2013, 2078, 2447, 2675, 2932, 3108, 3721, 3984, 4035, 4097, 4117, 4151, 4157, 4164, 4181, 4191, 4317], 'specific': [13, 147, 4092, 4233], 'subcellular': [14, 148, 1390], 'compartments.': [15, 149], 'Intracellular': [16, 150], 'targeting': [17, 151, 1193, 3564], 'of': [18, 26, 32, 45, 53, 69, 78, 152, 160, 166, 179, 187, 203, 212, 306, 335, 350, 508, 651, 660, 973, 1115, 1157, 1194, 1200, 1267, 1403, 1421, 1424, 1431, 1459, 1503, 1511, 1734, 1740, 1782, 1794, 1866, 1887, 1904, 2034, 2215, 2222, 2225, 2332, 2336, 2342, 2367, 2504, 2533, 3012, 3021, 3029, 3113, 3144, 3150, 3159, 3171, 3347, 3358, 3384, 3402, 3415, 3423, 3451, 3480, 3497, 3504, 3565, 3575, 3589, 3605, 3611, 3621, 3631, 3672, 3701, 3775, 3790, 3811, 3832, 3846, 3857, 3860, 3866, 3874, 3882, 3926, 3938, 3946, 3965, 3991, 4008, 4038, 4073, 4114, 4121, 4128, 4140, 4149, 4168, 4178, 4189, 4202, 4220, 4297, 4311, 4321, 4329, 4345], 'PKA': [19, 40, 100, 102, 114, 153, 174, 234, 236, 248, 356, 494, 657, 665, 1625, 1736, 1806, 1820, 1916, 2862, 3013, 3359, 3410, 3612, 3777, 4009, 4034, 4336], 'holoenzyme': [20, 154, 342], 'elicits': [21, 155], 'rapid': [22, 156], 'efficient': [24, 158], 'phosphorylation': [25, 68, 159, 202, 1788, 1804, 1895, 4071, 4148, 4177, 4188, 4224, 4265, 4284, 4296, 4331, 4340, 4355], 'target': [27, 161, 3425], 'proteins,': [28, 162], 'thereby': [29, 163], 'increasing': [30, 164], 'sensitivity': [31, 165, 3704], 'downstream': [33, 167, 1154, 2355, 3858, 4006], 'effectors': [34, 168, 3859], 'to': [35, 41, 62, 104, 121, 169, 175, 196, 238, 255, 309, 1196, 1388, 1808, 1872, 1910, 2356, 2538, 2848, 3098, 3380, 3390, 3399, 3411, 3477, 3506, 3530, 3568, 3705, 3712, 3869, 3943, 4012, 4094, 4204, 4334], 'cAMP': [36, 119, 170, 253, 321, 329, 652, 661, 1870, 3023, 3343, 3388, 3992], 'action.': [37, 171], 'AKAP121': [38, 54, 64, 89, 117, 172, 188, 198, 223, 251, 967, 1409, 1811, 1867, 1888, 1891, 1906, 2081, 2092, 2106, 2167, 3445, 3468, 3510, 3515, 3559, 3594, 3606, 3641, 3651, 3692, 3702, 3751, 3764, 3793, 3835, 3947, 3971, 4169, 4221, 4278, 4307, 4309, 4352], 'targets': [39, 173, 666, 3409], 'the': [42, 70, 105, 122, 176, 204, 239, 256, 313, 327, 331, 341, 576, 649, 974, 981, 1110, 1164, 1172, 1176, 1183, 1192, 1197, 1380, 1400, 1419, 1470, 1488, 1512, 1738, 1779, 1864, 1869, 1873, 1885, 1918, 2024, 2032, 2101, 2112, 2190, 2238, 2329, 2339, 2343, 2382, 2478, 2502, 2515, 2527, 2534, 2916, 2941, 3010, 3019, 3041, 3148, 3152, 3172, 3369, 3382, 3395, 3412, 3432, 3449, 3478, 3498, 3507, 3602, 3618, 3627, 3656, 3670, 3689, 3699, 3742, 3773, 3776, 3788, 3855, 3861, 3872, 3875, 3879, 3883, 3980, 3988, 4005, 4028, 4070, 4231, 4335, 4346], 'cytoplasmic': [43, 177, 353, 3413], 'surface': [44, 178, 1402, 3414], 'mitochondria.': [46, 63, 180, 197, 1416, 3391, 3614], 'Here': [47, 181], 'we': [48, 182, 1875, 3017, 3146, 3393, 3616, 4000, 4237], 'show': [49, 183], 'that': [50, 92, 113, 184, 226, 247, 1108, 1379, 1480, 1908, 3044, 3406, 3443, 3536, 3691, 3727, 3750, 3763, 3979, 4004, 4276], 'conditional': [51, 185, 1879], 'expression': [52, 186, 1886, 1903, 2267, 3401, 3595, 3652, 3752, 3972, 4219], 'in': [55, 131, 189, 265, 497, 980, 989, 1203, 1208, 1337, 1392, 1410, 1487, 1737, 1822, 1868, 1883, 1995, 2031, 2055, 2075, 2185, 2200, 2467, 2514, 2543, 2556, 2570, 2594, 2615, 2897, 2901, 2913, 3014, 3025, 3101, 3127, 3137, 3332, 3368, 3386, 3427, 3448, 3470, 3517, 3539, 3626, 3635, 3669, 3674, 3772, 3782, 3794, 3854, 3919, 3929, 3986, 4104, 4267, 4274], 'PC12': [56, 190, 1880, 1986, 2893, 3370, 3439, 3481, 3622, 3812], 'cells': [57, 85, 191, 219, 1206, 1211, 1992, 2021, 2047, 2187, 2383, 2444, 2479, 2505, 2528, 2553, 2567, 2894, 2917, 3027, 3115, 3350, 3625, 3639, 3673, 3754, 3817, 3833, 3933, 4082, 4110, 4203, 4247, 4270, 4275], 'selectively': [58, 192, 3537], 'enhances': [59, 193], 'cAMP·PKA': [60, 194, 1111, 1158, 1386, 3173], 'signaling': [61, 103, 195, 237, 1387, 1871, 4228], 'induction': [65, 199, 1892], 'stimulates': [66, 200, 1893], 'PKA-dependent': [67, 201], 'proapoptotic': [71, 205, 3807, 4017], 'BAD': [73, 207, 1473, 1493, 1627, 1787, 1803, 1894, 1934, 4039, 4095, 4115, 4135, 4150, 4179, 4190, 4223, 4312, 4330], 'Ser155,': [75, 209], 'inhibits': [76, 210, 1632], 'release': [77, 211, 1502, 3845, 3953], 'cytochrome': [79, 213, 1504, 3847, 3939], 'c': [80, 214, 1505, 2767, 3940], 'from': [81, 86, 215, 220, 969, 1506, 1928, 1938, 1950, 1961, 1971, 1982, 2085, 3578, 3941, 4078, 4244], 'mitochondria,': [82, 123, 216, 257, 1201, 1874, 3522, 3569], 'protects': [84, 218, 3753], 'apoptosis.': [87, 109, 221, 243, 1924], 'An': [88, 222], 'derivative': [90, 224], 'mutant': [91, 225, 1907, 2166], 'localizes': [93, 227], 'on': [94, 228, 1399, 2042, 3183, 3521, 3703, 3993, 3997, 4027, 4241, 4289], 'mitochondria': [95, 106, 229, 240, 1276, 1336, 1404, 1507, 1809, 1911, 3416, 3540, 3581, 3849, 3942], 'but': [96, 230, 510, 1179, 1912, 4285, 4299], 'does': [97, 231, 1913], 'not': [98, 232, 1800, 1914, 3513, 3654, 3684, 3974, 4213, 4300, 4350], 'bind': [99, 233, 584], 'down-regulates': [101, 235, 3421], 'promotes': [108, 242], 'These': [110, 244, 3976], 'findings': [111, 245], 'indicate': [112, 246, 3978], 'anchored': [115, 249, 1807, 1821], 'by': [116, 250, 355, 655, 1624, 1810, 1819, 2110, 2270, 2374, 2428, 2482, 2492, 2500, 2603, 2673, 2683, 2729, 2760, 2837, 3118, 3430, 3458, 3485, 3525, 3572, 3593, 3758, 3792, 3970, 4033, 4085, 4226, 4306, 4343], 'transduces': [118, 252], 'signals': [120, 254, 1152, 2726, 3389], 'it': [125, 259, 1798, 1814, 4002], 'may': [126, 260], 'play': [127, 261], 'an': [128, 262, 1263, 1905, 2486, 3404, 4023], 'important': [129, 263], 'role': [130, 264, 1407, 1733, 1865, 3011, 3383], 'mitochondrial': [132, 266, 1489, 1919, 2805, 4030], 'physiology.': [133, 267], 'cAMP-dependent': [268], 'A-kinase': [271, 513], 'chloramphenicol': [274], 'acetyl': [275], 'transferase': [276], 'phosphate-buffered': [277, 2388], 'saline': [278, 2389], 'fluorescence-activated': [279], 'cell': [280, 314, 359, 984, 1394, 1881, 1900, 2517, 3015, 3138, 3184, 3372, 3657, 3695, 3994], 'sorter': [281], 'mitogen-activated': [282], 'extracellular': [285, 307], 'signal-regulated': [286], 'cAMP-response': [288], 'element': [289], 'CRE-binding': [290], '8-(4-chlorophenylthio)adenosine': [292], '3′,5′-cyclic': [293], 'monophosphate': [294], 'nerve': [295, 2402], 'growth': [296, 2403, 3030, 3619], 'factor': [297, 2027, 2404, 3363, 3707], 'doxycyclin': [298, 2211, 2216, 3505, 3715], '12-O-tetradecanoylphorbol-13-acetate': [299], '1,4-piperazinediethanesulfonic': [300], 'acid': [301, 1167, 1435, 1438], 'Rous': [302], 'sarcoma': [303], 'virus': [304], 'Binding': [305], 'ligand': [308, 578], 'G-protein-coupled': [310], 'receptors': [311], 'membrane': [315, 1199, 1824], 'activates': [316, 1917], 'adenylate': [317], 'cyclase': [318], 'increases': [320, 1899], 'levels': [322, 3479], 'discrete': [324], 'points': [325], 'along': [326], 'membrane.': [328, 4031], 'binds': [330, 1494, 1909, 3407, 4019], 'regulatory': [332], '(R)': [333], 'subunits': [334], '(PKA),1': [339], 'dissociating': [340], 'releasing': [344], 'free': [345], 'catalytic': [346, 2863], 'subunit': [347, 2864, 3567], '(C-PKA).': [348], 'Phosphorylation': [349, 1623, 4032, 4153], 'nuclear': [351], 'substrates': [354], 'controls': [357, 3646, 3682], 'multiple': [358], 'functions': [360, 1461], '(1Edelman': [361], 'A.M.': [362], 'Blumenthal': [363], 'D.K.': [364], 'Krebs': [365], 'E.G.': [366], 'Annu.': [367, 415, 462, 1519], 'Rev.': [368, 416, 463, 1520], 'Biochem.': [369, 400, 417, 1095, 1674], '1987;': [370], '56:': [371], '567-613Crossref': [372], 'PubMed': [373, 390, 408, 421, 469, 489, 526, 541, 570, 601, 622, 642, 687, 713, 745, 770, 794, 811, 828, 866, 885, 905, 931, 960, 1010, 1034, 1060, 1082, 1102, 1139, 1229, 1251, 1302, 1322, 1372, 1453, 1525, 1541, 1572, 1588, 1605, 1618, 1663, 1679, 1724, 1768, 1852, 2293, 2318, 2719, 2797, 2828, 2888, 3003, 3076, 3092, 3198, 3224, 3241, 3269, 3299, 3325, 3912, 4063], 'Scopus': [374, 391, 409, 422, 470, 490, 542, 571, 602, 623, 643, 688, 714, 746, 771, 795, 812, 829, 867, 886, 906, 932, 961, 1011, 1035, 1061, 1083, 1103, 1140, 1230, 1252, 1303, 1323, 1373, 1454, 1526, 1542, 1573, 1589, 1606, 1619, 1664, 1680, 1699, 1725, 1769, 1853, 2294, 2319, 2720, 2829, 2889, 3004, 3199, 3225, 3242, 3270, 3300, 3326, 3913, 4064], '(1017)': [375], 'Google': [376, 393, 411, 424, 449, 472, 492, 527, 544, 554, 573, 604, 625, 645, 690, 716, 748, 773, 797, 814, 831, 869, 888, 908, 934, 963, 1013, 1037, 1063, 1085, 1105, 1142, 1232, 1254, 1305, 1325, 1375, 1456, 1528, 1544, 1575, 1591, 1608, 1621, 1666, 1682, 1701, 1727, 1771, 1855, 2296, 2321, 2722, 2798, 2831, 2891, 3006, 3077, 3093, 3201, 3227, 3244, 3272, 3302, 3328, 3557, 3915, 4066], 'Scholar,': [377, 394, 412, 425, 450, 473, 528, 545, 555, 605, 626, 691, 717, 749, 774, 798, 815, 832, 870, 889, 909, 935, 1014, 1038, 1064, 1086, 1233, 1306, 1529, 1545, 1576, 1592, 1609, 1667, 1683, 1702, 2297, 3078, 3202, 3228, 3245, 3273, 3303], '2Brandon': [378], 'E.P.': [379, 435], 'Idzerda': [380, 440], 'R.L.': [381, 441, 701, 872, 2789, 3068], 'McKnight': [382], 'G.S.': [383, 427], 'Curr.': [384, 560, 760, 805, 950, 1582, 1689, 2308], 'Opin.': [385, 806, 1583], 'Neurobiol.': [386, 807, 1584], '1997;': [387, 402, 418, 762, 1002, 1052, 1221, 2310, 2820, 3089], '7:': [388, 763, 2311], '397-403Crossref': [389], '(175)': [392], '3Houslay': [395], 'M.D.': [396, 921, 1355, 2702, 2986], 'Milligan': [397], 'G.': [398, 727, 850, 852, 1088, 1289, 1578, 1708, 4047], 'Trends': [399], 'Sci.': [401, 522], '22:': [403], '217-224Abstract': [404], 'Full': [405, 565, 567, 596, 598, 637, 639, 682, 684, 708, 710, 740, 742, 765, 767, 861, 863, 955, 957, 1005, 1007, 1029, 1031, 1055, 1057, 1077, 1079, 1134, 1136, 1224, 1226, 1246, 1248, 1317, 1319, 1600, 1602, 1658, 1660, 1694, 1696, 1719, 1721, 1763, 1765, 1847, 1849, 2288, 2290, 2313, 2315, 2823, 2825, 2883, 2885, 3219, 3221, 3264, 3266, 3294, 3296, 3320, 3322, 3554, 4058, 4060], 'Text': [406, 566, 568, 597, 599, 638, 640, 683, 685, 709, 711, 741, 743, 766, 768, 862, 864, 956, 958, 1006, 1008, 1030, 1032, 1056, 1058, 1078, 1080, 1135, 1137, 1225, 1227, 1247, 1249, 1318, 1320, 1601, 1603, 1659, 1661, 1695, 1697, 1720, 1722, 1764, 1766, 1848, 1850, 2289, 2291, 2314, 2316, 2824, 2826, 2884, 2886, 3220, 3222, 3265, 3267, 3295, 3297, 3321, 3323, 3555, 4059, 4061], 'PDF': [407, 569, 600, 641, 686, 712, 744, 769, 865, 959, 1009, 1033, 1059, 1081, 1138, 1228, 1250, 1321, 1604, 1662, 1698, 1723, 1767, 1851, 2292, 2317, 2827, 2887, 3223, 3268, 3298, 3324, 3556, 4062], '(404)': [410], '4Montminy': [413], 'M.': [414, 693, 788, 834, 842, 939, 1090, 1357, 1448, 1747, 1749, 1831, 1833, 2704, 2988], '66:': [419], '807-822Crossref': [420], '(860)': [423], '5McKnight': [426], 'Cummings': [428], 'D.E.': [429], 'Amieux': [430], 'P.S.': [431], 'Sikorski': [432], 'M.A.': [433, 776], 'Brandon': [434], 'Planas': [436], 'J.V.': [437], 'Motamed': [438], 'K.': [439, 483, 615, 628, 876, 1042, 1287, 1645, 1685], 'Recent': [442], 'Prog.': [443], 'Horm.': [444], 'Res.': [445, 790, 1097], '1998;': [446, 808, 1026, 1131, 1522, 1569, 1585, 3195, 3909], '53:': [447], '139-159PubMed': [448], '6Taylor': [451], 'S.S.': [452, 1048, 1295, 1310, 1753, 1837], 'Knighton': [453], 'D.R.': [454, 778, 1647], 'Zheng': [455], 'J.': [456, 520, 535, 590, 616, 631, 676, 734, 855, 879, 901, 927, 999, 1023, 1046, 1049, 1071, 1128, 1218, 1240, 1296, 1311, 1366, 1611, 1652, 1675, 1713, 2243, 2282, 2713, 2792, 2817, 2877, 2997, 3071, 3087, 3192, 3213, 3251, 3258, 3288, 3314, 3548, 4052], 'Ten': [457], 'Eyck': [458], 'L.F.': [459], 'Sowadski': [460], 'J.M.': [461, 1669], 'Cell': [464, 484, 521, 880, 1297, 1939, 2761, 2800, 3193], 'Biol.': [465, 537, 561, 591, 618, 632, 677, 735, 761, 856, 881, 951, 1000, 1024, 1050, 1072, 1129, 1219, 1241, 1298, 1312, 1368, 1653, 1690, 1714, 2283, 2309, 2715, 2818, 2878, 2999, 3194, 3214, 3259, 3289, 3315, 3549, 4053], '1992;': [466], '8:': [467, 809, 1586], '429-462Crossref': [468], '(303)': [471], '7Torgersen': [474], 'K.M.': [475], 'Vang': [476], 'T.': [477, 611, 1349, 1712, 2247, 2696, 2791, 2980, 3070, 3305, 4051], 'Abrahamsen': [478], 'H.': [479, 1743, 1827, 3309], 'Yaqub': [480], 'S.': [481, 844, 913, 1359, 1635, 2706, 2990], 'Tasken': [482, 614, 875], 'Signal.': [485], '2002;': [486, 562, 1314, 1369, 1597, 1655, 2716, 3000, 3238, 3291, 3317], '14:': [487], '1-9Crossref': [488], '(167)': [491], 'Scholar).': [493, 574, 646, 964, 1106, 1143, 1255, 1326, 1376, 1457, 1622, 1728, 1772, 1856, 2265, 2322, 2723, 2799, 2832, 2892, 3007, 3094, 3329, 3558, 3916, 4067], 'is': [495, 579, 1474, 1889, 2268, 2324, 2349, 3850], 'concentrated': [496], 'particulate': [498], 'membranes': [499, 2851], 'cellular': [501, 1426, 3165, 3587], 'organelles': [502], 'through': [503, 3766], 'interaction': [504], 'with': [505, 1274, 1331, 1335, 1629, 1774, 1998, 2100, 2172, 2387, 2431, 2454, 2462, 2476, 2507, 2573, 2579, 2587, 2859, 2909, 2920, 2940, 3164, 3339, 3488, 3528, 3562, 3613, 3681, 3819, 4040, 4249], 'a': [506, 1146, 1393, 1406, 1422, 1475, 1483, 1732, 1775, 1878, 2325, 2334, 2350, 2357, 2595, 2607, 3022, 3134, 3141, 3341, 3424, 3534, 3648, 3806, 3851, 3935, 4016, 4199], 'family': [507, 1478], 'distinct': [509, 1389], 'functionally': [511], 'homologous': [512], 'anchorproteins': [514], '(8Diviani': [516], 'D.': [517, 3230, 3253], 'Scott': [518, 558, 696, 702, 801, 822, 898, 924, 948, 1754, 1838], 'J.D': [519], '2001;': [523, 538, 791, 825, 928, 1691], '114:': [524], '1431-1437Crossref': [525], '9Feliciello': [529], 'A.': [530, 609, 671, 719, 721, 725, 836, 838, 1016, 1121, 1351, 1365, 1533, 1639, 2277, 2698, 2712, 2787, 2982, 2996, 3066, 3279], 'Gottesman': [531, 730, 756, 1021, 1126, 2304], 'M.E.': [532, 731, 757, 1022, 1127, 1361, 1535, 2305, 2708, 2992], 'Avvedimento': [533, 674, 732, 754, 853, 1019, 1124, 1362, 2280, 2302, 2709, 2993], 'V.E.': [534, 1020, 1125, 1363, 2710, 2994], 'Mol.': [536, 617, 1367, 1595, 1758, 1842, 2714, 2998], '308:': [539], '99-114Crossref': [540], '(241)': [543], '10Rubin': [546], 'C.S.': [547, 589, 759, 1018, 1070, 1123, 1239, 2307, 2876], 'Biochim.': [548, 1566, 3906], 'Biophys.': [549, 1096, 1567, 3907], 'Acta.': [550, 1568, 3908], '1994;': [551], '1224:': [552], '467-479PubMed': [553], '11Smith': [556], 'F.D.': [557], 'J.D.': [559, 703, 802, 823, 899, 925, 949, 1755, 1839], '12:': [563], 'R32-R40Abstract': [564], '(96)': [572], 'Although': [575], 'preferred': [577], 'RII/PKAII,': [580], 'several': [581, 990, 3438], 'AKAPs': [582, 647], 'also': [583, 1329, 3366], 'RI/PKAI': [585], '(12Angelo': [586], 'R.G.': [587], 'Rubin': [588, 758, 997, 1017, 1069, 1122, 1216, 1238, 2306, 2815, 2875, 3188], 'Chem.': [592, 633, 678, 736, 857, 1001, 1025, 1051, 1073, 1130, 1220, 1242, 1313, 1654, 1715, 2284, 2819, 2879, 3215, 3260, 3290, 3316, 3550, 4054], '2000;': [593, 619, 705, 737, 882, 902, 952, 1615, 1676, 1716, 3261, 4055], '275:': [594, 738, 1717, 3262, 4056], '4351-4362Abstract': [595], '(32)': [603, 1324], '13Herberg': [606], 'F.W.': [607], 'Maleszka': [608], 'Eide': [610], 'Vossebein': [612], 'L.': [613, 1346, 1581, 2693, 2977, 3082, 3206, 3311], '298:': [620], '329-339Crossref': [621], '(163)': [624], '14Miki': [627], 'Eddy': [629], 'E.M.': [630], '1999;': [634, 679, 858, 1299, 1450, 1538, 1760, 1844, 2285, 2794, 3073], '274:': [635, 680, 859, 2286], '29057-29062Abstract': [636], '(72)': [644], 'enhance': [648, 3694], 'efficiency': [650, 2371], 'signal-transducing': [653], 'pathways': [654, 1430], 'localizing': [656], 'near': [658], 'sites': [659, 1259], 'generation': [662], 'or': [663, 1414, 1812, 1988, 2165, 2231, 2398, 2411, 2491, 2953, 2960, 3179, 3677, 4080, 4100, 4119, 4132, 4255], '(15Cassano': [667, 2273], 'S.,': [668, 2274], 'Di': [669, 2275], 'Lieto': [670, 2276], 'Cerillo': [672, 2278], 'R.': [673, 917, 1649, 2279], 'E.V.': [675, 733, 755, 854, 919, 2281, 2303], '32574-32579Abstract': [681, 2287], '(20)': [689, 2295], '16Colledge': [692], 'Dean': [694], 'R.A.': [695, 1557, 3545, 3897], 'G.K.': [697], 'Langeberg': [698, 896, 922], 'L.K.': [699, 897, 923, 3287], 'Huganir': [700], 'Neuron.': [704], '27:': [706], '107-119Abstract': [707], '(418)': [715], '17Feliciello': [718], 'Gallo': [720], 'Mele': [722], 'E.': [723, 848], 'Porcellini': [724, 837], 'Troncone': [726], 'Garbi': [728, 839, 1352, 2699, 2983], 'C.': [729, 784, 840, 846, 1094, 1353, 2700, 2984, 3283, 3307], '303-311Abstract': [739], '(41)': [747], '18Feliciello': [750, 2298], 'A.,': [751, 2299], 'Li,': [752, 2300], 'Y.': [753, 945, 1285, 1308, 1555, 1594, 1706, 2301, 3895, 4045], '1011-1014Abstract': [764, 2312], '(62)': [772, 2320], '19Fink': [775], 'Zakhary': [777], 'Mackey': [779], 'J.A.': [780, 1044], 'Desnoyer': [781], 'R.W.': [782], 'Apperson-Hansen': [783], 'Damron': [785], 'D.S.': [786, 3204], 'Bond': [787], 'Circ.': [789], '88:': [792], '291-297Crossref': [793], '(118)': [796], '20Gray': [799], 'P.C.': [800], 'Catterall': [803], 'W.A.': [804], '330-334Crossref': [810], '(143)': [813, 1304], '21Lester': [816], 'L.B.': [817], 'Faux': [818], 'M.C.': [819], 'Nauert': [820], 'J.B.': [821], 'Endocrinology.': [824], '142:': [826, 3196], '1218-1227Crossref': [827], '(75)': [830, 1590], '22Paolillo': [833], 'Feliciello': [835, 1364, 2711, 2995], 'Bifulco': [841], 'Schinelli': [843], 'Ventra': [845], 'Stabile': [847], 'Ricciardelli': [849], 'Schettini': [851], '6546-6552Abstract': [860], '(33)': [868], '23Steen': [871], 'Martins': [873], 'S.B.': [874, 1068, 1237, 2874], 'Collas': [877], 'P.': [878, 1641, 1673, 3234], '150:': [883], '1251-1262Crossref': [884], '(136)': [887], '24Westphal': [890], 'R.S.': [891], 'Soderling': [892], 'S.H.': [893], 'Alto': [894], 'N.M.': [895], 'EMBO': [900, 926], '19:': [903, 2795, 3074], '4589-4600Crossref': [904], '(180)': [907], '25Dodge': [910], 'K.L.': [911, 3191], 'Khouangsathiene': [912], 'Kapiloff': [914], 'M.S.': [915], 'Mouton': [916], 'Hill': [918], 'Houslay': [920], '20:': [929], '1921-1930Crossref': [930], '(399)': [933], '26Fraser': [936], 'I.D.': [937], 'Cong': [938], 'Kim': [940, 2776, 3055], 'J': [941], 'Rollins': [942], 'E.N.': [943], 'Daaka': [944], 'Lefkowitz': [946], 'R.J.': [947], '10:': [953, 1692], '409-412Abstract': [954], '(188)': [962], 'S-AKAP84': [965, 1268], 'derive': [968], 'alternatively': [970], 'spliced': [971], 'products': [972, 2157], 'same': [975, 1165, 1381, 2102], 'gene.': [976], 'They': [977], 'are': [978, 1418, 1462, 1466, 2123], 'expressed': [979, 3444, 3516, 4277], 'male': [982, 1204], 'germ': [983, 1205], 'lineage': [985], 'as': [986, 988, 2124, 2689, 2770, 2809, 2841, 2868, 2974, 3456, 3483, 3523, 3570, 3805], 'well': [987], 'other': [991, 1257, 1823, 4227], 'tissues': [992], '(27Chen': [993, 1212, 2811], 'Q.': [994, 1213, 2812], 'Lin': [995, 1214, 2813], 'R.Y.': [996, 1066, 1215, 1235, 2814, 2872], 'CS.': [998, 1217, 2816], '272:': [1003, 1053, 1222, 2821], '15247-51527Abstract': [1004, 1223, 2822], '(132)': [1012, 1231, 2830], '28Feliciello': [1015], '273:': [1027, 1132], '23361-23366Abstract': [1028, 1133], '(52)': [1036, 1141], '29Huang': [1039], 'L.J.': [1040, 1281, 1751, 1835], 'Durick': [1041, 1286], 'Weiner': [1043], 'Chun': [1045], 'Taylor': [1047, 1294, 1309, 1752, 1836], '8057-8064Abstract': [1054], '(257)': [1062], '30Lin': [1065, 1234], 'Moss': [1067, 1236, 2873], '1995;': [1074, 1243, 2880], '270:': [1075, 1244, 2881], '27804-27811Abstract': [1076, 1245, 2882], '(160)': [1084, 1253, 2890], '31Trendelenburg': [1087], 'Hummel': [1089], 'Riecken': [1091], 'E.O.': [1092], 'Hanski': [1093], 'Commun.': [1098], '1996;': [1099, 3216], '225:': [1100], '313-319Crossref': [1101], '(68)': [1104], 'Hormones': [1107], 'activate': [1109], 'pathway': [1112, 1514, 1921, 3176, 3982], 'induce': [1113], 'accumulation': [1114, 2221, 3149, 3469, 3560, 3607], 'S-AKAP84/AKAP121': [1116, 1195, 1328], 'transcripts': [1117], '(28Feliciello': [1120], 'This': [1144, 1377, 1500], 'suggests': [1145, 1378], 'positive': [1147], 'feedback': [1148], 'loop': [1149], 'between': [1150, 2328], 'membrane-generated': [1151], 'effector': [1155, 4007], 'molecules': [1156], 'signals.': [1159], 'All': [1160], 'splice': [1161, 1265], 'variants': [1162], 'share': [1163], '525-amino': [1166], 'NH2-terminal': [1168, 1189, 1271], 'core,': [1169], 'which': [1170, 1884], 'includes': [1171, 3045], 'anchoring': [1173], 'domain': [1174, 1178, 1781, 2331, 2341], 'R-binding': [1177], 'diverge': [1180], 'significantly': [1181], 'COOH': [1184], 'terminus.': [1185], 'The': [1186, 2361, 3111, 3157, 3355, 3585, 3844, 3864], 'first': [1187], '30': [1188, 4165], 'residues': [1190], 'mediate': [1191], 'outer': [1198, 1401, 4029], 'both': [1202, 1275, 4182, 4268], 'transfected': [1209, 2184], 'heterologous': [1210], 'However,': [1256, 1797], 'localization': [1258], 'have': [1260, 1876], 'been': [1261], 'observed.d-AKAP1,': [1262], 'alternative': [1264], 'product': [1266], 'carrying': [1269, 2353], 'additional': [1270], 'residues,': [1272], 'colocalizes': [1273], 'endoplasmic': [1278], 'reticulum': [1279], '(32Huang': [1280], 'Wang': [1282, 3284], 'L.,': [1283], 'Ma,': [1284, 3248], 'Perkins': [1288], 'Deerinck': [1290], 'T.J.': [1291], 'Ellisman': [1292], 'M.H.': [1293], '145:': [1300], '951-959Crossref': [1301], '33Ma': [1307], '277:': [1315, 1656, 3292, 3318], '27328-36273Abstract': [1316], 'Furthermore,': [1327], 'interacts': [1330], 'microtubules': [1332], 'associates': [1334], 'interphase': [1338], 'mitotic': [1340], 'spindles': [1341], 'during': [1342], 'metaphase': [1343], 'transition': [1344], '(34Cardone': [1345, 2692, 2976], 'de': [1347, 2694, 2978], 'Cristofaro': [1348, 2695, 2979], 'Affaitati': [1350, 2697, 2981], 'Ginsberg': [1354, 2701, 2985], 'Saviano': [1356, 2703, 2987], 'Varrone': [1358, 2705, 2989], 'Gottesmam': [1360, 2707, 2991], '320:': [1370, 2717, 3001], '663-675Crossref': [1371, 2718, 3002], '(40)': [1374, 2721, 3005], 'might': [1384, 3693], 'focus': [1385], 'compartments': [1391, 1825], 'cycle-dependent': [1395], 'manner.': [1396], 'Its': [1397], 'location': [1398], 'implies': [1405], 'for': [1408, 2217, 2459, 2547, 2598, 2679, 2765, 2802, 2904, 2929, 3453], 'cAMP-mediated': [1411], 'reactions': [1412], 'within': [1415], 'Mitochondria': [1417], 'seat': [1420], 'number': [1423, 3473, 3671], 'major': [1425], 'functions,': [1427], 'including': [1428], 'essential': [1429], 'intermediate': [1432], 'metabolism,': [1433, 1441], 'amino': [1434], 'biosynthesis,': [1436], 'fatty': [1437], 'oxidation,': [1439], 'steroid': [1440], 'apoptosis,': [1442, 3145, 3181], 'oxidative': [1444], 'energy': [1445], 'metabolism': [1446], '(35Yaffe': [1447], 'Science.': [1449, 3237], '283:': [1451], '1493-1497Crossref': [1452], '(417)': [1455], 'Several': [1458], 'these': [1460, 3768, 3962, 4122, 4186], 'constitutive,': [1463], 'whereas': [1464], 'others': [1465], 'finely': [1467], 'regulated': [1468], 'post-translational': [1471], 'level.': [1472], 'BH3-proapoptotic': [1476], 'Bcl-2': [1477, 1498], 'member': [1479], 'acts': [1481], 'key': [1484], 'nodal': [1485], 'point': [1486, 2121], 'apoptotic': [1490, 1513, 3042, 3114, 3738, 3824, 3862], 'pathway.': [1491, 3863], 'Unphosphorylated': [1492], 'inactivates': [1496, 4021], 'antiapoptotic': [1497, 4024], 'homologs.': [1499], 'allows': [1501], 'consequent': [1509], 'activation': [1510, 2330, 3360, 3856, 3881, 3964], '(36Chao': [1515], 'D.T.': [1516], 'Korsmeyer': [1517, 1756, 1840], 'S.J.': [1518, 1757, 1841, 3187], 'Immunol.': [1521], '16:': [1523], '395-419Crossref': [1524], '(1510)': [1527], '37Datta': [1530], 'S.R.': [1531], 'Brunet': [1532], 'Greenberg': [1534], 'Genes': [1536], 'Dev.': [1537], '13:': [1539], '2905-2927Crossref': [1540], '(3718)': [1543], '38Lemasters': [1546], 'J.J.': [1547, 3887], 'Nieminen': [1548, 3888], 'A-L.': [1549, 3889], 'Trost': [1550, 3890], 'L.C.': [1551, 3891], 'Elmore': [1552, 3892], 'S.P.': [1553, 3893], 'Nishimura': [1554, 3894], 'Crowe': [1556, 3896], 'Cascio': [1558, 3898], 'W.E.': [1559, 3899], 'Bradham': [1560, 3900], 'C.A.': [1561, 3901], 'Brenner': [1562, 3902], 'D.A.': [1563, 3903], 'Herman': [1564, 3904], 'B.': [1565, 1745, 1829, 3277, 3905], '1366:': [1570, 3910], '177-196Crossref': [1571, 3911], '(1223)': [1574, 3914], '39Nunez': [1577], 'del': [1579], 'Peso': [1580], '613-618Crossref': [1587], '40Shi': [1593], 'Cell.': [1596, 1759, 1843], '9:': [1598], '459-470Abstract': [1599], '(1449)': [1607], '41Yuan': [1610], 'Yankner': [1612], 'B.A.': [1613], 'Nature.': [1614], '407:': [1616], '802-809Crossref': [1617], '(1600)': [1620], 'blocks': [1626], 'association': [1628, 3610, 4037], 'BCL-2': [1630], 'apoptosis': [1633, 1741, 1793, 2497, 3166, 3756, 3840], '(42Dramsi': [1634], 'Scheid': [1636], 'M.P.': [1637], 'Maiti': [1638], 'Hojabrpour': [1640], 'Chen': [1642], 'X.': [1643], 'Schubert': [1644], 'Goodeltt': [1646], 'Aebersold': [1648], 'Duronio': [1650], 'V.': [1651], '6399-6405Abstract': [1657], '(70)': [1665], '43Lizcano': [1668], 'Morrice': [1670], 'N.': [1671], 'Cohen': [1672], '349:': [1677], '547-557Crossref': [1678], '(256)': [1681], '44Virdee': [1684], 'Parone': [1686], 'P.A.': [1687], 'Tolkovsky': [1688], '1151-1154Abstract': [1693], '(122)': [1700], '45Zhou': [1703], 'X-M.': [1704, 4043], 'Liu': [1705, 4044], 'Payne': [1707, 4046], 'Lutz': [1709, 4048], 'J.R.': [1710, 4049], 'Chittenden': [1711, 4050], '25046-25051Abstract': [1718, 4057], '(200)': [1726, 4065], 'Previous': [1729], 'observations': [1730], 'suggested': [1731], 'mitochondria-anchored': [1735], 'inhibition': [1739], '(46Harada': [1742, 1826], 'Becknell': [1744, 1828], 'Wilm': [1746, 1830], 'Mann': [1748, 1832], 'Huang': [1750, 1834, 3256], '3:': [1761, 1845], '413-422Abstract': [1762, 1846], '(556)': [1770, 1854], 'Treatment': [1773], 'synthetic': [1776, 2359], 'peptide': [1777], 'spanning': [1778], 'RII-binding': [1780], 'thyroid': [1783], 'AKAP': [1784, 3385, 3405], '(Ht-31)': [1785], 'decreased': [1786], 'Ser112': [1790, 4194, 4264, 4283], 'increased': [1792, 3345, 3563, 3609, 3642, 4147], 'FL12.5': [1795], 'cells.': [1796, 3796], 'was': [1799, 1926, 2083, 2094, 2108, 2372, 2426, 2498, 2671, 2937, 3116, 3500, 3591, 3967, 4010, 4161, 4195, 4304, 4314, 4332, 4341], 'clear': [1801], 'whether': [1802, 1813, 4218], 'necessitates': [1805], 'can': [1815, 3177], 'be': [1816, 4013, 4137, 4155], 'carried': [1817, 2938], 'out': [1818, 2939], 'To': [1857, 2519, 3008, 3761, 4068], 'further': [1858], 'analyze': [1859, 3009], 'this': [1860, 3428, 4303], 'mechanism': [1861], 'investigate': [1863], 'established': [1877], 'line': [1882, 3373], 'regulated.': [1890], 'Ser155': [1897, 4180, 4262, 4298], 'survival.': [1901, 3995], 'Conversely,': [1902], 'caspase': [1920, 3884], 'provokes': [1923], 'Anti-caspase-3': [1925], 'purchased': [1927, 1937, 1949, 1960, 1970, 1981], 'Pharmingen;': [1929], 'anti-caspase-9,': [1930], 'anti-BAD,': [1931], 'anti-phospho-specific': [1933], 'antibodies': [1935, 1968, 1979, 2968, 4093, 4234], 'were': [1936, 1948, 1959, 1969, 1980, 1993, 2029, 2040, 2053, 2158, 2168, 2198, 2235, 2384, 2445, 2480, 2524, 2545, 2554, 2568, 2585, 2613, 2727, 2738, 2768, 2807, 2835, 2846, 2857, 2895, 2918, 2969, 2972, 3096, 3365, 3710, 3770, 3799, 4083], 'Signaling;': [1940], 'anti-phospho-ERK,': [1941], 'anti-ERK,': [1942], 'anti-p21/Waf,': [1943], 'anti-RII,': [1944], 'anti-cytochrome': [1946, 2766], 'cantibodies': [1947], 'Santa': [1951, 1972], 'Cruz': [1952, 1973], 'Biotechnology,': [1953, 1974], 'Inc.;': [1954, 1975], 'anti-manganese': [1956], 'superoxide': [1957, 3532], 'dismutase': [1958, 2945], 'Bender': [1962], 'MedSystems.': [1963], 'Anti-RII': [1964], 'anti-AKAP121': [1966, 2950, 3489], 'polyclonal': [1967, 2957], 'CREB': [1976, 2272], 'anti-phospho136CREB': [1978], 'Upstate': [1983], 'Biotechnology': [1984], 'Inc.': [1985], 'wild-type': [1987, 2164], 'PC12-tet': [1989, 2019], 'off': [1990, 2020], '(Clontech)': [1991, 2098, 2188], 'maintained': [1994, 2054], 'DMEM': [1996], 'supplemented': [1997], '10%': [1999], 'heat-inactivated': [2000], 'horse': [2001], 'serum,': [2002, 2006, 2064, 3105], '5%': [2003, 2017, 2076], 'fetal': [2004, 2062], 'bovine': [2005, 2063, 2926], '1': [2007, 2626, 2629, 2930, 3129, 3168, 3825], 'mm': [2008, 2619, 2627, 2630, 2655, 2662, 2744, 2749, 2754], 'glutamine,': [2009, 2067], '1%': [2011, 2632], 'penicillin-streptomycin': [2012], '37': [2014, 2079], '°C': [2015], 'CO2.': [2018], 'stably': [2022, 2183], 'expressing': [2023, 3640, 3834], 'doxycyclin-regulated': [2025], 'transcription': [2026, 2346, 3422, 3434], '(tTA)': [2028], 'grown': [2030, 3097, 3711], 'presence': [2033, 3628, 3774], 'G-418': [2035, 2204], '(100': [2036, 2205, 2406], 'μg/ml,': [2037], 'Invitrogen).': [2038, 2195], 'Cells': [2039, 2584, 2612, 3095, 3709], 'cultured': [2041, 3447], 'poly-l-lysine-coated': [2043], 'plates.': [2044], 'SK-N-BE': [2045, 3349], 'neuroblastoma': [2046, 3034], '(American': [2048], 'Type': [2049], 'Culture': [2050], 'Collection': [2051], '(ATTC))': [2052], 'RPMI': [2056], '1640': [2057], 'medium': [2058, 2202, 3102, 3508], '(Invitrogen)': [2059], 'containing': [2060, 2120, 2203, 2559, 2641, 2923, 3103], '16%': [2061], '100': [2065, 2068, 2072], 'μg/ml': [2066, 2069, 2645, 2648, 2651], 'streptomycin,': [2070], 'units/ml': [2073], 'penicillin': [2074], 'CO2': [2077], '°C.': [2080], 'cDNA': [2082, 2093, 2161], 'excised': [2084], 'pCEP4-AKAP121': [2086], 'vector': [2087], 'using': [2088, 2111, 2189, 2229, 2237, 2485, 2606, 2740, 3801, 4091], 'SacII/BamHI': [2089], 'restriction': [2090, 2103], 'enzymes.': [2091, 2104], 'subcloned': [2095], 'into': [2096], 'pTRE-vector': [2097], 'predigested': [2099], 'Mutant': [2105], '(AKAP121m)': [2107], 'generated': [2109], 'QuikChangeTM': [2113], 'site-directed': [2114], 'mutagenesis': [2115], 'kit': [2116, 2176], '(Stratagene).': [2117], 'Oligonucleotide': [2118], 'primers': [2119], 'mutations': [2122], 'follows:': [2125], 'forward,': [2126], '5′-GCT': [2127], 'GCC': [2128], 'TTC': [2129, 2144], 'CAG': [2130, 2134], 'CCC': [2131], 'ATC': [2132, 2136], 'TCC': [2133], 'GTG': [2135], 'CCG': [2137], 'GAA': [2138, 2153], 'GCA': [2139], 'ACT-3′;': [2140], 'reverse,': [2141], '5′-AGT': [2142], 'TGC': [2143], 'CGG': [2145], 'GAT': [2146, 2150], 'CAC': [2147], 'CTG': [2148, 2152], 'GGA': [2149], 'GGG': [2151], 'GGC': [2154], 'AGC-3′.': [2155], 'Amplification': [2156], 'sequenced,': [2159], 'vectors': [2162, 2234], 'encoding': [2163], 'prepared': [2169, 2739, 2769, 2808], 'purified': [2171, 3580], 'Qiagen': [2173], 'Plasmid': [2174], 'Maxi': [2175], 'tips': [2177], 'columns': [2178], '(Qiagen,': [2179], 'Chatworth,': [2180], 'CA)': [2181], 'PC12-Tet-off': [2186], 'Lipofectin': [2191], 'procedure': [2192, 2241], '(Lipofectin': [2193], 'reagent,': [2194], 'Positive': [2196], 'clones': [2197, 3472], 'selected': [2199], 'complete': [2201], 'μg/ml),': [2206, 2209], 'hygromycin': [2207], '(200': [2208, 2422, 3821], '(10': [2212, 2661], 'ng/ml).': [2213], 'Removal': [2214], '2': [2218, 2650, 2748, 3418, 3462, 3492, 3542, 3583, 3597], 'days': [2219], 'induces': [2220, 3871], 'significant': [2223, 3667, 4112], 'amounts': [2224, 4113], 'AKAP121.': [2226], 'Transient': [2227], 'transfections': [2228], 'CRE-CAT': [2230, 2266], 'pBD-Elk/GAL4-CAT': [2232], '(Stratagene)': [2233], 'performed': [2236, 2546, 3800, 4238], 'calcium': [2239], 'phosphate': [2240], '(47Sambrook': [2242], 'Fritsch': [2244], 'E.F.': [2245], 'Maniatis': [2246], 'Molecular': [2248, 2409], 'Cloning:': [2249], 'Laboratory': [2251, 2258], 'Manual.': [2252], '2nd': [2253], 'Ed.': [2254], 'Cold': [2255, 2260], 'Spring': [2256, 2261], 'Harbor': [2257], 'Press,': [2259], 'Harbor,': [2262], 'NY1989:': [2263], '16.32-16.67Google': [2264], 'enhanced': [2269, 4282, 4305], 'phosphorylated': [2271, 4096, 4116, 4134], 'pBD-Elk1': [2323], 'fusion': [2326], 'Elk1,': [2333], 'substrate': [2335], 'MAPK,': [2337], 'DNA-binding': [2340], 'yeast': [2344], 'GAL4': [2345], 'factor.': [2347, 3435], 'GAL-CAT': [2348], 'reporter': [2351], 'plasmid': [2352], 'CAT': [2354], 'GAL-4': [2358], 'promoter.': [2360], 'promoter': [2362], 'contains': [2363], 'five': [2364], 'tandem': [2365], 'repeats': [2366], 'GAL4-binding': [2368], 'sites.': [2369, 4124], 'Transfection': [2370], 'analyzed': [2373, 2427, 2481, 2602, 2973], 'co-transfecting': [2375], 'RSV-β-galactosidase': [2376], 'vector.': [2377], '24': [2378, 3959, 4142], 'h': [2379, 2931, 4127, 4143], 'after': [2380, 2450, 3827, 4144, 4198], 'transfection,': [2381], 'washed': [2385, 2452], 'twice': [2386, 2453], 'serum-starved': [2391, 3718], 'overnight.': [2392], 'Drug': [2393], 'concentrations': [2394, 3511, 4320], 'were:': [2395], 'CPT-cAMP': [2396, 4141, 4205, 4256, 4322, 4327], '(50': [2397, 2465, 2582, 2590, 2743, 4323], '250': [2399], 'μm,': [2400, 2423], 'Sigma),': [2401, 2417], '(NGF)': [2405], 'ng/ml,': [2407, 2416], 'Roche': [2408], 'Biochemicals)': [2410], 'phorbol': [2412, 4252], 'ester': [2413, 4253], '(TPA,': [2414], '220': [2415], 'H89': [2418, 3786], '(5': [2419, 2644], 'μm,Calbiochem),': [2420], 'H2O2': [2421, 3820], 'CarloErba).': [2424], 'Apoptosis': [2425], 'double': [2429, 3526], 'staining': [2430], 'propidium': [2432, 2463, 2508, 2588], 'iodide': [2433, 2464, 2509, 2589], 'annexin': [2435, 2512, 2593], '(Apoptosis': [2436], 'detection': [2437], 'kit,': [2438], 'Medical': [2439], 'Biological': [2441], 'Laboratories).': [2442], 'Briefly,': [2443], 'harvested': [2446, 2555, 3107, 3720], 'indicated': [2448], 'times': [2449], 'treatment,': [2451], '1×': [2455, 2468, 2557, 2921], 'PBS,': [2456, 2469, 2477, 2571], 'incubated': [2458, 2919], '10': [2460, 2647], 'min': [2461, 2600, 4159], 'ng/ml': [2466], 'Sigma)': [2470], 'annexin.': [2472], 'After': [2473, 2907, 4125], 'three': [2474, 4123], 'washes': [2475], 'fluorescence': [2483], 'microscopy': [2484, 3120], 'Axiovert': [2487], 'microscope': [2488], 'IX70': [2489], '(Olympus)': [2490], 'FACS': [2493, 2551, 3660], 'analysis.': [2494], 'For': [2495, 2550, 2734], 'microscopy,': [2496], 'quantified': [2499, 2728], 'scoring': [2501], 'percentage': [2503, 3112], 'stained': [2506, 2586], '(red)': [2510], '(green)': [2513], 'adherent': [2516], 'population.': [2518], 'avoid': [2520], 'unbiased': [2521], 'counting,': [2522], 'plates': [2523], 'coded,': [2525], 'scored': [2529], 'blind': [2530], 'without': [2531], 'knowledge': [2532], 'treatment': [2535, 3338], 'performed.': [2536], 'Four': [2537], 'six': [2539], 'independent': [2540], 'experiments': [2541, 3769, 3798], 'made': [2542], 'triplicate': [2544], 'each': [2548], 'treatment.': [2549, 3828], 'analysis,': [2552], 'PBS': [2558, 2898, 2922], 'trypsin': [2560], '20': [2562, 2599, 2665, 2905], 'mmEDTA.': [2563], '3': [2564, 3474, 3637, 3725, 3784, 3842], '×': [2565, 2677], '106': [2566], 'resuspended': [2569], 'fixed': [2572, 2900], 'cold': [2574], '100%': [2575], 'ethanol,': [2576], 'treated': [2578, 3818], 'RNase-DNase-free': [2580], 'enzyme': [2581], 'μg/ml).': [2583], 'μg/ml)': [2591], 'dark': [2596], 'room': [2597, 2933], 'flow': [2604], 'cytometry': [2605], 'BD': [2608], 'Biosciences': [2609], 'FACScan': [2610], 'apparatus.': [2611], 'homogenized': [2614], 'lysis': [2616, 2741], 'buffer': [2617, 2742], '(20': [2618], 'Tris-HCl,': [2620], 'pH': [2621, 2746], '7.9,': [2622], '150': [2623], 'm': [2624], 'NaCl,': [2625], 'EDTA,': [2628, 2750], 'EGTA,': [2631], 'Triton': [2633, 2911], 'X-100,': [2634], '0.05%': [2635], 'Tween': [2636], '20,': [2637], '0.02%': [2638], 'sodium': [2639, 2663], 'azide)': [2640], 'protease': [2642, 2757], 'inhibitor': [2643, 2660], 'aprotinin,': [2646], 'leupeptin,': [2649], 'pepstatin,': [2652], '0.5': [2654], 'phenylmethylsulfonyl': [2656], 'fluoride)': [2657], 'phosphatase': [2659], 'fluoride,': [2664], 'mmβ-glycerol-phosphate).': [2666], 'Total': [2667], 'lysate': [2668], '(0.1': [2669], 'mg)': [2670], 'cleared': [2672], 'centrifugation': [2674], '15,000': [2676], 'g': [2678], '15': [2680, 4158], 'min,': [2681, 2915], 'resolved': [2682], 'SDS-PAGE': [2684, 2839], 'gel': [2685, 2840, 4087], 'electrophoresis,': [2686], 'immunoblotted': [2688, 4090], 'described': [2690, 2771, 2810, 2842, 2869, 2975, 4235], 'previously': [2691, 2870], 'Chemiluminescent': [2724], '(ECL)': [2725], 'scanning': [2730], 'densitometry': [2731], '(Amersham': [2732], 'Biosciences).': [2733], 'caspase-9,': [2735], 'total': [2736, 3586, 4075, 4242], 'extracts': [2737], 'PIPES/KOH,': [2745], '6.5,': [2747], '0.1%': [2751, 3104], 'Chaps,': [2752], '5': [2753], 'dithiothreitol,': [2755], 'inhibitors)': [2758], 'provided': [2759], 'Signaling.': [2762], 'Cytosolic': [2763], 'fractions': [2764, 2806], '(48Kim': [2772, 3051], 'Y-M.': [2773, 3052], 'Chung': [2774, 3053], 'H-T.': [2775, 3054], 'S-S.': [2777, 3056], 'Han': [2778, 3057], 'J-A.': [2779, 3058], 'Yoo': [2780, 3059], 'K-M.': [2781, 3060], 'Lee': [2782, 3061], 'G-H.': [2783, 3062], 'Yun': [2784, 3063], 'H-Y.': [2785, 3064], 'Green': [2786, 3065], 'Simmons': [2788, 3067], 'Billiar': [2790, 3069], 'Neurosci.': [2793, 3072, 3088], '6740-6747Crossref': [2796, 3075], 'fractionation': [2801], 'cytosolic': [2803], 'Protein': [2833], 'samples': [2834], 'size-fractionated': [2836, 4084], '8%': [2838], 'above.': [2843], 'Resolved': [2844], 'polypeptides': [2845], 'transferred': [2847], 'polyvinylidene': [2849], 'difluoride': [2850], '(Immobilon': [2852], 'P,': [2853], 'Millipore).': [2854], 'RII': [2855, 3459, 3566, 3590], 'probes': [2856], 'labeled': [2858], '[32P]ATP': [2860], '(1': [2865], 'unit)': [2866], '(Sigma),': [2867], '(30Lin': [2871], 'rinsed': [2896], '3.7%': [2902], 'formaldehyde': [2903], 'min.': [2906, 4166], 'permeabilization': [2908], '0.5%': [2910], 'X-100': [2912], 'PBS/5': [2914], '0.1': [2924], 'mg/ml': [2925], 'serum': [2927, 3038, 3131, 3759, 4129, 4145], 'albumin': [2928], 'temperature.': [2934], 'Double': [2935], 'immunofluorescence': [2936], 'following': [2942], 'antibodies:': [2943], 'anti-superoxide': [2944], 'monoclonal': [2946], 'antibody': [2947, 3490, 3529], '(1/250)': [2948], '(dilution': [2951, 2955], '1/250)': [2952, 2956], 'RII∂': [2954], 'antibodies.': [2958], 'Fluorescein-': [2959], 'rhodamine-tagged': [2961], 'anti-rabbit': [2962], 'anti-mouse': [2964], 'IgG': [2965], '(Technogenetics)': [2966], 'secondary': [2967], 'used.': [2970], 'Coverslips': [2971], 'survival,': [3016], 'investigated': [3018], 'effects': [3020, 3357, 3604, 3700, 3990], 'analogue': [3024], 'neuronal': [3026], 'deprived': [3028], 'factors.': [3031], 'In': [3032, 3829], 'human': [3033], '(SK-N-BE)': [3035], 'cells,': [3036], 'prolonged': [3037], 'starvation': [3039], 'triggers': [3040], 'program': [3043], 'stress-activated': [3046], 'kinases': [3048], 'caspases': [3050], '49Troy': [3079], 'C.M.': [3080], 'Stefanis': [3081, 3205], 'Greene': [3083, 3211], 'L.A.': [3084, 3212], 'Shelanski': [3085], 'M.L.': [3086], '17:': [3090], '1911-1918Crossref': [3091], 'subconfluence,': [3099], 'starved': [3100], 'different': [3109, 3722], 'times.': [3110, 3723], 'determined': [3117, 3617], 'fluorescent': [3119], '(see': [3121], '"Materials': [3122], 'Methods").': [3124], 'As': [3125, 3140, 3330, 3633, 3780, 3917, 4102, 4291, 4325], 'shown': [3126, 3331, 3457, 3524, 3634, 3781, 3918, 4103, 4292], 'Fig.': [3128, 3333, 3636, 3724, 3783, 3920, 4105], 'A,': [3130, 3638, 4107], 'deprivation': [3132, 3925, 4146], 'induced': [3133, 3757, 3934, 4225, 4295], 'time-dependent': [3135, 3936], 'increase': [3136], 'death.': [3139], 'second': [3142], 'monitor': [3143], 'followed': [3147], 'p17,': [3151], 'cleaved': [3153], 'active': [3154], 'caspase-3': [3155, 3160, 3353], 'fragment.': [3156], 'kinetics': [3158], 'activity': [3161], 'roughly': [3162], 'coincided': [3163, 3561], '(Fig.': [3167, 3374, 3417, 3461, 3491, 3541, 3582, 3596, 3841, 3954, 4206, 4257], 'B).': [3169], 'Activation': [3170], 'signal': [3174], 'transduction': [3175], 'suppress': [3178], 'promote': [3180], 'depending': [3182], 'type': [3185], '(50Neame': [3186], 'L.L.': [3189], 'Philpott': [3190], '1583-1593Crossref': [3197], '(140)': [3200], '51Park': [3203], 'Yan': [3207], 'C.Y.': [3208, 3285], 'Farinelli': [3209], 'S.E.': [3210], '271:': [3217], '21898-21905Abstract': [3218], '(195)': [3226], '52Vaudry': [3229], 'Stork': [3231], 'P.J.S.': [3232], 'Lazarovici': [3233], 'Eiden': [3235], 'L.E.': [3236], '296:': [3239], '1648-1649Crossref': [3240], '(708)': [3243], '53Gu': [3246], 'C.,': [3247], 'Y.C.': [3249], 'Benjamin': [3250], 'Littman': [3252], 'Chao': [3254], 'M.V.': [3255], 'X.Y.': [3257], '20726-20733Abstract': [3263], '(98)': [3271], '54Chen': [3274], 'H.L.': [3275], 'Demiralp': [3276], 'Schneider': [3278], 'Koh': [3280], 'A.J.': [3281], 'Silve': [3282], 'McCauley': [3286], '19374-19381Abstract': [3293], '(139)': [3301], '55Sandal': [3304], 'Stapnes': [3306], 'Kleivdal': [3308], 'Hedin': [3310], 'Doskeland': [3312], 'S.O.': [3313], '20783-20793Abstract': [3319], '(56)': [3327], '1,': [3334], 'C': [3335], 'D,': [3337], 'CPT-cAMP,': [3340], 'potent': [3342], 'analogue,': [3344], 'survival': [3346, 3791], 'serum-deprived': [3348, 3795, 4245], 'inhibited': [3352, 3969], 'activation.': [3354], 'protective': [3356, 3989], 'toward': [3361], 'trophic': [3362, 3706, 3927], 'withdrawal': [3364], 'demonstrated': [3367, 3484, 3571], 'pheochromocytoma': [3371], '1,E': [3375], 'F).': [3377], 'We': [3378, 3436, 3599, 3686, 3697, 3748, 4215], 'wished': [3379], 'determine': [3381, 4069], 'transmitting': [3387], 'Accordingly,': [3392], 'used': [3394], 'tet-off': [3396], 'inducible': [3397], 'system': [3398, 3429], 'regulate': [3400], 'AKAP121,': [3403], 'A).': [3419], 'Doxycyclin': [3420, 3466], 'gene': [3426], 'inactivating': [3431], 'tetA': [3433], 'isolated': [3437, 4077], 'stable': [3440], 'transfectants': [3441], '(PC-A121)': [3442], 'when': [3446, 3679], 'absence': [3450, 3630], 'doxycycline': [3452], '48': [3454], 'h,': [3455], 'overlay': [3460], 'B,': [3463, 3493, 4210], 'left': [3464], 'panel).': [3465, 3495], 'down-regulated': [3467], 'PC-A121': [3471, 3518, 3624, 3734, 3814, 3930, 4109, 4246], '11': [3476], 'controls,': [3482], 'immunoblot': [3486, 3573, 4239], 'analysis': [3487, 3574, 3661, 4240], 'right': [3494], 'Expression': [3496, 3945, 4167], 'transgene': [3499], 'reversible': [3501], 'since': [3502, 3659], 'readdition': [3503], 'reduced': [3509], '(data': [3512, 3683, 3973, 4349], 'shown).': [3514, 3685, 3975, 4214, 4351], 'localized': [3519], 'principally': [3520], 'labeling': [3527], 'manganese': [3531], 'dismutase,': [3533], 'accumulates': [3538], 'C)': [3543], '(56Weisiger': [3544], 'Fridovich': [3546], 'I.': [3547], '1973;': [3551], '24:': [3552], '4793-4796Abstract': [3553], 'extracted': [3577], 'partially': [3579], 'D).': [3584, 3598, 3843], 'content': [3588], 'unaffected': [3592, 4342], 'then': [3600, 3717], 'assessed': [3601], 'biological': [3603], 'First,': [3615], 'rates': [3620], 'doxycylin.': [3632], 'more': [3643, 3739, 4120, 4162], 'rapidly': [3644, 3740], 'than': [3645, 3741], 'over': [3647], '96-h': [3649], 'period.': [3650], 'did': [3653], 'accelerate': [3655], 'cycle': [3658], '[3H]thymidine': [3663], 'incorporation': [3664], 'showed': [3665, 3838], 'no': [3666, 4133, 4287], 'difference': [3668], 'G1,': [3675], 'S,': [3676], 'G2/M': [3678], 'compared': [3680], 'thus': [3687], 'considered': [3688], 'possibility': [3690], 'viability.': [3696], 'measured': [3698], 'deprivation.': [3708, 3760], 'semiconfluence': [3713], '±': [3714, 3731], 'Bshows': [3726], 'control': [3728, 4079, 4269], 'cultures': [3729], '(PC12': [3730], 'dox': [3732, 3816, 3932], '+': [3735, 3815, 3931], 'dox)': [3736, 3837, 3950, 4172, 4272], 'became': [3737, 3823], 'experimental': [3743], 'culture': [3744], '(PC-A121': [3745, 3948], '−': [3746, 3949, 4171], 'dox).': [3747, 4280], 'conclude': [3749], 'against': [3755], 'demonstrate': [3762], 'acted': [3765], 'PKA,': [3767], 'repeated': [3771], 'inhibitor,': [3778, 4337], 'H89.': [3779, 4338], 'C,': [3785], 'abrogated': [3787], 'enhancement': [3789, 4310], 'Parallel': [3797], 'hydrogen': [3802], 'peroxide': [3803], '(H2O2)': [3804], 'stimulus.': [3808], 'About': [3809], '30%': [3810], 'μm)': [3822], 'day': [3826], 'contrast,': [3830], '20%': [3831], '(PC-A121−': [3836], 'H2O2-induced': [3839], 'cfrom': [3848], 'critical': [3852], 'step': [3853], 'binding': [3865], 'released': [3867], 'cytochromec': [3868, 3952], 'Apaf-1': [3870], 'formation': [3873], '"apoptosome"': [3876], 'complex': [3877], 'sequential': [3880], 'cascade': [3885], '(38Lemasters': [3886], '3,': [3921, 3955], 'E': [3922], 'F,': [3924], 'factors': [3928], 'translocation': [3937], 'cytosol.': [3944], 'delayed': [3951], 'see': [3956], '6': [3957, 4126], 'h).': [3960], 'Under': [3961, 4185], 'conditions,': [3963, 4187], 'pro-caspase-3': [3966], 'partly': [3968], 'data': [3977, 4212], 'AKAP121·PKA': [3981], 'mediates,': [3983], 'least': [3985], 'part,': [3987], 'Based': [3996], 'previous': [3998], 'reports,': [3999], 'thought': [4001], 'likely': [4003, 4011], 'BAD.': [4014], 'BAD,': [4015, 4074], 'protein,': [4018], 'Bcl,': [4022], 'located': [4026], 'Ser155blocks': [4036], 'Bcl': 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'CTP-cAMP': [4294], 'expression.': [4308], 'Ser155phosphorylation': [4313], 'detectable': [4315], 'very': [4318], 'low': [4319], 'μm).': [4324], 'expected,': [4326], 'stimulation': [4328], 'sensitive': [4333], 'any': [4344], 'stimuli': [4347], 'applied': [4348], 'specifically': [4353], 'o': [4356]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969972660', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-01T19:59:33.407882', 'created_date': '2016-06-24'}