Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969952312', 'doi': 'https://doi.org/10.1016/j.mcna.2010.04.004', 'title': 'Severe Cutaneous Adverse Reactions: Acute Generalized Exanthematous Pustulosis, Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome', 'display_name': 'Severe Cutaneous Adverse Reactions: Acute Generalized Exanthematous Pustulosis, Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome', 'publication_year': 2010, 'publication_date': '2010-06-21', 'ids': {'openalex': 'https://openalex.org/W1969952312', 'doi': 'https://doi.org/10.1016/j.mcna.2010.04.004', 'mag': '1969952312', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20609860'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mcna.2010.04.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33396077', 'display_name': 'Medical Clinics of North America', 'issn_l': '0025-7125', 'issn': ['0025-7125', '1557-9859'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067344289', 'display_name': 'Thomas Harr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210100468', 'display_name': 'University Hospital of Zurich', 'ror': 'https://ror.org/01462r250', 'country_code': 'CH', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210100468']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Thomas Harr', 'raw_affiliation_strings': ['Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, Zurich 8031, Switzerland. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, Zurich 8031, Switzerland. [email protected]', 'institution_ids': ['https://openalex.org/I4210100468']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021906809', 'display_name': 'Lars E. French', 'orcid': 'https://orcid.org/0000-0002-4629-1486'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lars E French', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.951, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 52, 'citation_normalized_percentile': {'value': 0.604848, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '94', 'issue': '4', 'first_page': '727', 'last_page': '742'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11117', 'display_name': 'Hypersensitivity Reactions to Drugs and Medications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11117', 'display_name': 'Hypersensitivity Reactions to Drugs and Medications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11033', 'display_name': 'Skin Sensitization and Contact Allergy Research', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12438', 'display_name': 'Diagnosis and Management of Urticaria', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/drug-reaction', 'display_name': 'Drug reaction', 'score': 0.70940775}, {'id': 'https://openalex.org/keywords/skin-sensitization', 'display_name': 'Skin Sensitization', 'score': 0.592497}, {'id': 'https://openalex.org/keywords/drug-hypersensitivity', 'display_name': 'Drug Hypersensitivity', 'score': 0.54741}, {'id': 'https://openalex.org/keywords/stevens-johnson-syndrome', 'display_name': 'Stevens-Johnson Syndrome', 'score': 0.5442}, {'id': 'https://openalex.org/keywords/toxic-epidermal-necrolysis', 'display_name': 'Toxic Epidermal Necrolysis', 'score': 0.50205}, {'id': 'https://openalex.org/keywords/drug-eruption', 'display_name': 'Drug eruption', 'score': 0.4167693}], 'concepts': [{'id': 'https://openalex.org/C2780664588', 'wikidata': 'https://www.wikidata.org/wiki/Q1878682', 'display_name': 'Toxic epidermal necrolysis', 'level': 2, 'score': 0.9857626}, {'id': 'https://openalex.org/C2780425889', 'wikidata': 'https://www.wikidata.org/wiki/Q1980528', 'display_name': 'Acute generalized exanthematous pustulosis', 'level': 2, 'score': 0.98508066}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9295726}, {'id': 'https://openalex.org/C16005928', 'wikidata': 'https://www.wikidata.org/wiki/Q171171', 'display_name': 'Dermatology', 'level': 1, 'score': 0.85742676}, {'id': 'https://openalex.org/C2779234776', 'wikidata': 'https://www.wikidata.org/wiki/Q7262033', 'display_name': 'Pustulosis', 'level': 4, 'score': 0.8265461}, {'id': 'https://openalex.org/C2993432071', 'wikidata': 'https://www.wikidata.org/wiki/Q45959', 'display_name': 'Drug reaction', 'level': 3, 'score': 0.70940775}, {'id': 'https://openalex.org/C2779515644', 'wikidata': 'https://www.wikidata.org/wiki/Q718675', 'display_name': 'Drug eruption', 'level': 3, 'score': 0.4167693}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.32299733}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.14298105}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.05420077}, {'id': 'https://openalex.org/C2780551157', 'wikidata': 'https://www.wikidata.org/wiki/Q938983', 'display_name': 'Osteomyelitis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2781343496', 'wikidata': 'https://www.wikidata.org/wiki/Q1178507', 'display_name': 'Osteitis', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D056150', 'descriptor_name': 'Acute Generalized Exanthematous Pustulosis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D055553', 'descriptor_name': 'Prescription Drugs', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D013262', 'descriptor_name': 'Stevens-Johnson Syndrome', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D013262', 'descriptor_name': 'Stevens-Johnson Syndrome', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D056150', 'descriptor_name': 'Acute Generalized Exanthematous Pustulosis', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D056150', 'descriptor_name': 'Acute Generalized Exanthematous Pustulosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003937', 'descriptor_name': 'Diagnosis, Differential', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064420', 'descriptor_name': 'Drug-Related Side Effects and Adverse Reactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016756', 'descriptor_name': 'Immunoglobulins, Intravenous', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D016756', 'descriptor_name': 'Immunoglobulins, Intravenous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007155', 'descriptor_name': 'Immunologic Factors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007155', 'descriptor_name': 'Immunologic Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055553', 'descriptor_name': 'Prescription Drugs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013262', 'descriptor_name': 'Stevens-Johnson Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013262', 'descriptor_name': 'Stevens-Johnson Syndrome', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D013262', 'descriptor_name': 'Stevens-Johnson Syndrome', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mcna.2010.04.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S33396077', 'display_name': 'Medical Clinics of North America', 'issn_l': '0025-7125', 'issn': ['0025-7125', '1557-9859'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20609860', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W149167874', 'https://openalex.org/W170752843', 'https://openalex.org/W1964891410', 'https://openalex.org/W1971784282', 'https://openalex.org/W1977395308', 'https://openalex.org/W1979259860', 'https://openalex.org/W1993523497', 'https://openalex.org/W1994584625', 'https://openalex.org/W2006223140', 'https://openalex.org/W2008784877', 'https://openalex.org/W2009543259', 'https://openalex.org/W2009786098', 'https://openalex.org/W2017732881', 'https://openalex.org/W2021384711', 'https://openalex.org/W2022250655', 'https://openalex.org/W2023706681', 'https://openalex.org/W2025161685', 'https://openalex.org/W2025376373', 'https://openalex.org/W2025598475', 'https://openalex.org/W2027789719', 'https://openalex.org/W2031125773', 'https://openalex.org/W2031301975', 'https://openalex.org/W2033403591', 'https://openalex.org/W2034259064', 'https://openalex.org/W2035623408', 'https://openalex.org/W2045391651', 'https://openalex.org/W2048486696', 'https://openalex.org/W2049902892', 'https://openalex.org/W2050109150', 'https://openalex.org/W2054764892', 'https://openalex.org/W2061751608', 'https://openalex.org/W2062490752', 'https://openalex.org/W2071566315', 'https://openalex.org/W2073057919', 'https://openalex.org/W2074577456', 'https://openalex.org/W2076398887', 'https://openalex.org/W2083508836', 'https://openalex.org/W2084245124', 'https://openalex.org/W2084259700', 'https://openalex.org/W2087636179', 'https://openalex.org/W2090787547', 'https://openalex.org/W2091090528', 'https://openalex.org/W2091918038', 'https://openalex.org/W2093453837', 'https://openalex.org/W2103213111', 'https://openalex.org/W2105579754', 'https://openalex.org/W2109018114', 'https://openalex.org/W2109696646', 'https://openalex.org/W2115832251', 'https://openalex.org/W2117113806', 'https://openalex.org/W2118621632', 'https://openalex.org/W2121050460', 'https://openalex.org/W2121712956', 'https://openalex.org/W2124835695', 'https://openalex.org/W2136249667', 'https://openalex.org/W2140341198', 'https://openalex.org/W2140726051', 'https://openalex.org/W2142000672', 'https://openalex.org/W2156525348', 'https://openalex.org/W2182780838', 'https://openalex.org/W2321102680', 'https://openalex.org/W2400139361', 'https://openalex.org/W29230346', 'https://openalex.org/W3202930913', 'https://openalex.org/W4231616044', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W62381600', 'https://openalex.org/W3162071210', 'https://openalex.org/W3031030507', 'https://openalex.org/W2980716025', 'https://openalex.org/W2338837530', 'https://openalex.org/W2151812628', 'https://openalex.org/W2097079015', 'https://openalex.org/W2089218783', 'https://openalex.org/W206262219', 'https://openalex.org/W1969952312'], 'abstract_inverted_index': {'Most': [0], 'drug': [1], 'hypersensitivity': [2], 'reactions': [3], 'show': [4], 'skin': [5, 16], 'symptoms.': [6], 'The': [7], 'most': [8], 'severe': [9], 'cutaneous': [10], 'manifestations': [11, 20], 'include': [12], 'pustular': [13], 'and': [14, 31, 53], 'bullous': [15], 'eruptions.': [17], 'These': [18, 35], '2': [19], 'can': [21], 'lead': [22], 'to': [23, 43], 'acute': [24], 'generalized': [25], 'exanthematous': [26], 'pustulosis': [27], 'or': [28], 'Stevens-Johnson': [29], 'syndrome': [30], 'toxic': [32], 'epidermal': [33], 'necrolysis.': [34], 'complications': [36], 'are': [37, 50], 'rare,': [38], 'but': [39], 'should': [40], 'be': [41], 'known': [42], 'any': [44], 'doctor': [45], 'prescribing': [46], 'drugs': [47], 'because': [48], 'they': [49], 'life': [51], 'threatening': [52], 'early': [54], 'stoppage': [55], 'of': [56], 'treatment': [57], 'is': [58], 'mandatory.': [59]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969952312', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-09-19T20:09:02.946521', 'created_date': '2016-06-24'}